 Benzodiazepine abuse in patients taking them as prescribed on an as-needed basis for chronic/refractory anxiety, insomnia, and intermittent muscle spasms has occurred and generally occurs very slowly, becoming evident only after months or years since the initiation of therapy.Monitoring of patients actively using delorazepam should never be discontinued even if the patients has been stable on the medication for many months or years.Caution must be used when delorazepam is administered alongside other sedative medications (ex.