 Like the closely related "KRT6A" and "KRT6B" genes, the "KRT6C" gene consists of 9 exons separated by 8 introns and is located in the type II keratin gene cluster on human "chromosome" 12q.Keratin 6A and keratin 6B are encoded by the neighbouring genes, which are identical in intron-exon organization to "KRT6C" and are more than 99% identical in their DNA coding sequences.Mutations in K6C have been identified as being able to cause diffuse and focal palmoplantar keratodermas.