 β-dystrobrevin coimmunoprecipitates with the dystrophin isoforms Dp71 and Dp140 in the brain.Dp140 is concentrated in the brain microvasculature while the Dp71 transcript is found throughout the brain but is particularly abundant in the dentate gyrus of the temporal lobe, and the olfactory bulb.The consequences of null mutation are known for humans and rodents in the case of dystrophin, utrophin, and α-dystrobrevin, and for nematode in the case of dystrophin and dystrobrevin.