 On 16 May 1605 their long-expected and only child Federico Ubaldo was born.Federico Ubaldo married Claudia de' Medici in 1621 and was made Duke by his father.However, Federico died in 1623 from an epileptic attack, leaving only a daughter, Vittoria Della Rovere, wife of Ferdinando II de' Medici, Grand Duke of Tuscany; their child was Cosimo III de' Medici, Grand Duke of Tuscany; none of Cosimo III's children had heirs.