 In human, the Duchenne muscular dystrophy is a well-known muscle disease which highlights the importance of dystrophin/ dystrobrevin protein to function of muscle tissue.Duchenne muscular dystrophy (DMD) is a fatal progressive disease of both cardiac and skeletal muscle resulting from the mutations in the DMD gene and loss of the protein dystrophin.The lack of dystrophin that causes Duchenne muscular dystrophy results in secondary loss of other dystrophin-complex components from the membrane.