 Pair-wise comparison between α- and β-dystrobrevin sequences revealed that the two dystrobrevins have 76% identity.α- and β-Dystrobrevin proteins structure consisted of four major domains, a ZZ -type zinc finger domain, two EF-hand regions, an α-helical coiled-coil domain containing a dystrophin binding site, and a tyrosine kinase substrate domain.α-Dystrobrevin 1, α-Dystrobrevin 2, and α-dystrobrevin 3 binds to the dystrophin-glycoprotein complex via the amino-terminus region.