 Dr. Urschel has also completed a double-blind, placebo controlled study of Prometa's active ingredients, where 68 patients were randomized to active and 67 patients to placebo treatment for 30 days.The study reported a decrease in both cravings and methamphetamine use following the initial treatment and throughout the 30 days treatment period.The effects of the flumazenil/gabapentin combination in the treatment of alcohol dependence are less clear.