 Dr. Cafiso is also interested in determining the membrane interactions made by protein domains such as C2 domains, which are found in a wide range of proteins involved in cell signaling.C2 domains function to attach their parent proteins to membranes in a Ca ++ dependent fashion.C2 domains perform critical roles in membrane trafficking, membrane fusion and membrane repair, and defects in these domains result in forms of muscular dystrophy and deafness.