 At Jefferson Street is a junction with Routes 5, 32, and 64.

Business Loop I-44 in the Waynesville-St. Robert area begins on the west side of Waynesville at Exit 156.The road briefly heads north on Ichord Avenue, then heads east in a duplex with Route 17.The road, at this point, also becomes Historic Route 66. Business I-44 continues east, past the Pulaski County Courthouse in the old part of the city (where Route 17 turns off north).