 Assigned to the 15th Naval District, PC–456 arrived in the Panama Canal Zone 13 November 1940.Renamed and reclassified "Persistent" (PYc–48), 16 June 1943, she patrolled in and off the Canal Zone until the summer of 1944 when she sailed for Philadelphia, Pennsylvania and deactivation.Arriving 31 August, she decommissioned 27 September and was struck from the Navy List 14 October.