 His son Prince Ercole succeeded him.In 1721, he married Charlotte Aglaé d'Orléans (1700–1761), a daughter of Philippe d'Orléans, Duke of Orléans and Françoise Marie de Bourbon (illegitimate daughter of Louis XIV and Madame de Montespan) and had ten children.He acted as proxy groom for his sister Henrietta Maria d'Este in 1728 who was marrying Antonio Farnese, Duke of Parma.