 He was an instructor at New York Polyclinic Hospital, and a consultant at Mount Sinai Hospital, the Montefiore Home for Chronic Disease, and Manhattan State Hospital.In addition, he was publisher of the "Journal of Nervous and Mental Disease" (1886–1911) and president of the American Neurological Association (1894 and 1932).The condition known as Tay–Sachs disease is named after Sachs along with English ophthalmologist Waren Tay.