 Both HYPA and LYQA are high-producing haplotypes, LYPA intermediate-producing haplotype and LXPA low-producing haplotype, whereas LYPB, LYQC and HYPD are defective haplotypes, which cause a severe MBL deficiency.Both MBL2 and MBL1P1 genes has been repeatedly hit throughout evolution of primates.The latter silenced eventually by mutations in the glycine residues of the collagen-like region.