 cisplatin, carboplatin or oxaliplatin) (see Lung cancer chemotherapy) that cause interstrand DNA crosslinks.Among individuals with NSLC, low expression of the breast cancer 1 gene ("BRCA1)" in the primary tumor has correlated with improved survival after platinum-containing chemotherapy.This correlation implies that low BRCA1 in the cancer, and the consequent low level of DNA repair, causes vulnerability of the cancer to treatment by the DNA crosslinking agents.