 From Highway 57, the highway turns south and meanders to the southeast as it passes the access to the town of Coté (km 365) and through the towns of Runnymede (km 374) and Togo (km 387), where it also intersects Highway 357 and Highway 369.The Manitoba border is at km 388, where Highway 5 becomes Provincial Road 363.The early Red River cart trail traversed the North West Territory prairies between Portage la Prairie and Edmonton via Humboldt and Battleford, intersecting the future location of Highway 5 at Humboldt.