 Continuing northeast through the center of East Lyme, the freeway enters into areas of mixed development with suburban elements before crossing the Pattagansett River within its interchange with Route 161, in the village of Flanders.Shorty afterward, there is an interchange with US 1, and the road crosses the Niantic River just before meeting the southern terminus of I-395.Here, the Connecticut Turnpike splits to the northeast along I-395, which heads toward Worcester, Massachusetts.