 Once bound, MeCP2 will condense the chromatin structure, form a complex with histone deacetylases (HDAC), or block transcription factors directly.More recent studies have demonstrated that MeCP2 may also function as a transcriptional activator, through recruiting the transcription factor CREB1.This was an unexpected finding which suggests that MeCP2 is a key transcriptional regulator with potentially dual roles in gene expression.