 On 18 December 2010 de Guzmán scored a stunning goal to tie game in the 28th minute against Villarreal, although the game finished in a 3–1 Villarreal victory.De Guzmán had a very strong first season in Spain although his team finished in 17th place one out of relegation.De Guzmán made 33 league starts while scoring 5 goals, including one in the last game of the season against Atlético Madrid in a 4–3 loss in which Sergio Agüero scored a hat-trick.