 "Borrelia burgdorferi" infection may be relevant for the induction of a distinct autoimmune type of scleroderma; it may be called ""Borrelia"-associated early onset morphea" and is characterized by the combination of disease onset at younger age, infection with "B. burgdorferi", and evident autoimmune phenomena as reflected by high-titer antinuclear antibodies.Throughout the years, many different treatments have been tried for morphea including topical, intra-lesional, and systemic corticosteroids.Antimalarials such as hydroxychloroquine or chloroquine have been used.