 "General Price" departed Grand Gulf for the Red River on 3 May and took part in the capture of Alexandria, Louisiana, and assisted in the partial destruction of Fort De Russy, Louisiana between 3 May and 17 May.During this period, "General Price" acted briefly as Admiral Porter's flagship, and on 10 May she was sent on a reconnaissance up the Black River, where she engaged strong Confederate batteries at Harrisonburg, Louisiana.On 22 June 1863 the Sterling price received 8 replacements to augment the 12 aboard that were fit for duty, the remainder of the crew being ill.

As Union pressure against Vicksburg mounted, "General Price" played a major part in the continuing bombardment of the city and in gunfire support of the Union troops until the Confederacy's river stronghold finally surrendered on 4 July.