 In 1524 he sent twelve missionaries to Mexico, among them Friar Juan Juárez, who later became the first bishop within the present territory of the United States.After the sack of Rome in 1527 and the imprisonment of Pope Clement VII (May, 1527), Quiñones, who was distantly related to the Emperor, and was also his confidant, seemed the man best able to effect the release of the pope, and a full reconciliation between him and the emperor.He was thrice sent to the emperor for this purpose, and his efforts were crowned with success by the deliverance of Pope Clement (December, 1527), and the Treaty of Barcelona (1528) and Cambrai (1529).