 Although they are sensitive to certain factors such as quality of inorganic substrate, they are able to thrive under some of the most inhospitable conditions in the world, such as temperatures above 110 degrees Celsius and below 2 pH.The most important requirement for chemolithotropic life is an abundant source of inorganic compounds, which provide a suitable electron donor with relatively weak bonds or the ability to unlock the chemical energy of O2 in order to fix CO2 and produce the energy the microorganism needs to survive.Since chemosynthesis can take place in the absence of sunlight, these organisms are found mostly around hydrothermal vents and other locations rich in inorganic substrate.