 Increasing the dosage of an antidepressant is a common strategy to treat depression that does not respond after adequate treatment duration.Practitioners who use this strategy will usually increase the dose until the person reports intolerable side effects, symptoms are eliminated, or the dose is increased to the limit of what is considered safe.Studies have shown a wide variability in the effectiveness of switching antidepressants, with anywhere from 25–70% of people responding to a different antidepressant.