 On September 9, 1513 - at the request of King Ferdinand, husband of Queen Isabella - Pope Leo X appointed him Bishop of Santa María de La Antigua del Darién On January 29, 1514, he was consecrated by bishop by Diego de Deza, Archbishop of Seville.He left for the Indies in 1514 along with Hernando de Luque on a fleet commanded by Pedro Arias Dávila.Conflict between Quevedo and Arias Dávila soon ensued as Quevedo strongly protested against the cruel acts committed by the governor and his officers, not only against the Indians, but also against rivals, such as the beheading of Vasco Nuñez de Balboa, the discoverer of the Pacific Ocean.