 The concept of a sentinel node was first described by Gould et al.1960 in a
patient with cancer of the parotid gland and was implemented clinically on a broad scale by Cabanas in penile cancer.The technique of sentinel node radiolocalization was co-founded by James C. Alex, MD, FACS and David N. Krag MD (University of Vermont Medical Center) and they were the first ones to pioneer this technique for the use of cutaneous melanoma, breast cancer, head and neck cancer and Merkel cell carcinoma.