 Speght, a feminist and a Calvinist, is perhaps best known for her tract "A Mouzell for Melastomus" (London, 1617).It is a prose refutation of Joseph Swetnam's misogynistic tract, "The Arraignment of Lewd, Idle, Froward, and Unconstant Women", and a significant contribution to the Protestant discourse of biblical exegesis, defending women's nature and the worth of womankind.Speght also published a volume of poetry, "Mortalities Memorandum with a Dreame Prefixed" (London, 1621), a Christian reflection on death and a defence of the education of women.