 Because of this the road is also known as the 3-C Highway, a designation which predates the Ohio state highway system.It is the only state route to enter all three of Ohio's largest cities, though it has largely been bypassed by Interstate 71 (I-71).The route's southern terminus is in downtown Cincinnati at the U.S. Route 27 (US 27)/US 52/US 127 concurrency, which is also the western terminus of US 22.