 The opening of the depot was the culmination of a 30-year effort to relocate of the Coast Line of the Southern Pacific Railroad away from the heavy traffic of the downtown area around the Market Street Depot, located at Market and Bassett Streets, to the eastern edge of Willow Glen, an industrial area in the 19th century and the former location of rail facilities belonging to other railroads, in 1935.The new depot replaced the Fourth Street line's station.The Cahill Depot was a stop for several Southern Pacific passenger trains, including the famous San Francisco–Los Angeles train, the "Coast Daylight".