 The most common complication of severe palytoxin poisoning is rhabdomyolysis.This involves skeletal muscle breakdown and the leakage of intracellular contents into the blood.Other symptoms in humans are bitter/metallic taste, abdominal cramps, nausea, vomiting, diarrhea, mild to acute lethargy, tingling, slow heart rate, kidney failure, impairment of sensation, muscle spasms, tremor myalgia, cyanosis, and respiratory distress.