 From intravenous (IV) animal studies the toxic dose (LD50) of palytoxin via IV for humans has been estimated by extrapolation to be between 2.3–31.5 micrograms (µg) of palytoxin.An acute oral reference dose has been suggested to be 64 µg for a person with weight of 60 kg.Acute reference dose means a dose that can be safely ingested over a short period of time, usually during one meal or one day.