 In experiments with male rats, sub-chronic exposure to inhaled B"a"P has been shown to generally reduce the function of testicles and epididymis with lower sex steroid/testosterone production and sperm production.B"a"P's metabolites are mutagenic and highly carcinogenic, and it is listed as a Group 1 carcinogen by the IARC.Chemical agents and related occupations, Volume 10, A review of Human Carcinogens, IARC Monographs, Lyon France 2009 

In June 2016, B"a"P was added as benzo["def"]chrysene to the REACH Candidate List of Substances of very high concern for Authorisation.