 METLIN is the largest repository of tandem mass spectrometry data of its kind.2005 was also the year in which the dedicated academic journal Metabolomics first appeared, founded by its current editor-in-chief Professor Roy Goodacre.In 2005, the Siuzdak lab was engaged in identifying metabolites associated with sepsis and in an effort to address the issue of statistically identifying the most relevant dysregulated metabolites across hundreds of LC/MS datasets, the first algorithm was developed to allow for the nonlinear alignment of mass spectrometry metabolomics data.