 In the middle of the 3rd century BC, an independent, Hellenistic state was declared in Bactria and eventually the control of the Seleucids and Mauryans was overthrown in western and southern Afghanistan.Graeco-Bactrian rule spread until it included a large territory which stretched from Turkmenistan in the west to the Punjab in India in the east by about 170 BC.Graeco-Bactrian rule was eventually defeated by a combination of internecine disputes that plagued Greek and Hellenized rulers to the west, continual conflict with Indian kingdoms, as well as the pressure of two groups of nomadic invaders from Central Asia—the Parthians and Sakas.