 Lead, mercury, arsenic, copper, cadmium, and thallium have been detected in TCM products sold in the U.S. and China.To avoid its toxic adverse effects "Xanthium sibiricum" must be processed.Hepatotoxicity has been reported with products containing "Reynoutria multiflora" (synonym "Polygonum multiflorum"), glycyrrhizin, "Senecio" and "Symphytum".