 The earliest populations in the Americas, before roughly 10,000 years ago, are known as Paleo-Indians.The peopling of the Americas is a long-standing open question, and while advances in archaeology, Pleistocene geology, physical anthropology, and DNA analysis have shed progressively more light on the subject, significant questions remain unresolved.While there is general agreement that the Americas were first settled from Asia, the pattern of migration, its timing, and the place(s) of origin in Eurasia of the peoples who migrated to the Americas remain unclear.