 In the late 1920s, the role of phosphorylated compounds in glycolysis had not yet been fully explained.Lee’s work touched on early aspects of intermediary carbohydrate metabolism, which was also the subject of Nobel Prize-winning research by Otto Fritz Meyerhof, Otto Heinrich Warburg, and Hans Adolf Krebs.Lee maintained an interest in factors affecting glucose metabolism upon his return to Korea, where he continued his research with published studies of the Korean diet.