 Having a value of "D" > 0 indicates an excess of homozygotes/deficiency of heterozygotes in the population, whereas "D" < 0 indicates an excess of heterozygotes/deficiency of homozygotes.When "D" = 0, the genotypes are considered to be in Hardy Weinberg Equilibrium.In practice, the estimated additive disequilibrium from a sample, formula_2 , will rarely be exactly 0, but it may be small enough to conclude that it is not significantly different from 0.