 Chambers is considered a society painter, having done portraits of many of the leading socialites of the early 20th century such as Henry Flagler, actor Joseph Jefferson, members of the Vanderbilt family and others.In 1916 Chambers moved to Manhattan with his wife Anne, the niece of Archbishop Patrick Feehan of Chicago and established himself in the Carnegie Studios, Carnegie Hall, where he had a private studio.Chambers was a member of the Society of Illustrators, in New York City, and the Salmagundi Club, an important art club also in the city.