 They discovered several novel classes of cytostatic agents with nanomolar antitumor activities based on substituted or fused deazapurine nucleosides.In the field of chemical biology, Hocek and his laboratories have developed a simple two-step synthesis of base-modified DNA through cross-coupling reactions of 2'-deoxyribonucleoside triphosphates (dNTPs) followed by polymerase incorporation.They have discovered some modified dNTPs that are better substrates for polymerases than natural nucleotides.