 The discovery of FTC was first published in 1992 in Antimicrobial Agents and Chemotherapy as another new anti-HIV compound.The mechanism of action of FTC is by incorporation of FTC-TP into the growing viral DNA strand results in chain termination, disrupting viral DNA synthesis.Disruption of this process results in rapid reduction of systemic viral loads to undetectable in HIV-infected individuals, effectively allowing for significant rebound of CD4+ T-cells, effectively providing a tandem mechanism resulting in control of systemic viremia and restoration of functional immunity.