 Salazar died from smallpox in 1870 and Garayo committed his first murder shortly after.Garayo married a third time, again shortly after the death of his previous wife, and this marriage was even more plagued by conflict, as the woman was an alcoholic.After only five years of marriage, in 1876, Garayo found his wife bedridden and in agony upon returning from work; he called for a doctor but was told that nothing could be done about it.