 The earliest alignment in Bristol came to the state line on Pennsylvania Avenue in Bristol, Tennessee (still US 421 today) and turned west on State Street to end at U.S. Route 11E a few blocks later, at or near Edgemont Avenue.This was initially part of U.S. Route 321 but soon became US 421.When it was extended west, it was taken along US 11E to Piedmont Avenue (U.S. Route 11) and U.S. Route 11W to Euclid Avenue, where it curved northwest onto what had been U.S. Route 411.