 A study in 1993 compared the mouse "NF1" cDNA to the human transcript and found that both the untranslated regions and coding regions were highly conserved.It was verified that there are two "NF1" polyadenylated transcripts that differ in size because of the length of the 3’ UTR, which is consistent with what has been found in the mouse gene.A study conducted in 2000 examined whether the involvement of the 3’ UTR in post-transcriptional gene regulation had an effect on the variation of "NF1" transcript quantity both spatially and temporally.