 This deamination changes an arginine codon (CGA) to an in-frame translation stop codon (UGA).If the edited transcript is translated, it produces a protein that cannot function as a tumor suppressor because the N-terminal of the GRD is truncated.The editing site in "NF1" mRNA was shown to have high homology to the ApoB editing site, where double stranded mRNA undergoes editing by the ApoB holoenzyme.