 By 1951, US 421 had re-entered Virginia, this time splitting from US 58 at Dot to cross into Kentucky, causing State Route 66 to be truncated at Clinchport.US 58 was moved to Interstate 81 between Bristol and Abingdon by the end of 1965, leaving US 421 on its own from I-81 west of Bristol to U.S. Route 11W at the intersection of State Street and Euclid Avenue west of downtown Bristol.