 In 1523 a plague decimated the population of S. Severino and all its commercial and cultural activities.At that time the town was troubled by the conflicts between two nobles families Caccialupi and Gentili, which divided the people into two factions and required a direct intervention of Pope Paul III that resulted ineffective.Only in 1564 the two parties came to a peace agreement, as signed in the cathedral of San Severino at Castle, in front of the governor of the March.