 Wasira served as Deputy Minister of Agriculture in the first phase Government under President Julius Nyerere and also served as the Deputy Minister for Local Government and later as the Minister of Agriculture and Livestock Development under second phase President Ali Hassan Mwinyi.He was appointed as Minister of Water on January 4, 2006, when Jakaya Kikwete, who had been elected President, named his new cabinet.He was then moved to the position of Minister for Agriculture, Food Security and Cooperatives on October 15, 2006, and on February 12, 2008, he was named Minister in the Prime Minister's Office for Regional Administration and Local Government.