 NMR spectroscopy is often the method of choice for monitoring reaction progress, where substrate consumption and/or product formation may be observed over time from the change of peak integration relative to a non-reactive standard.From the concentration data, the rate of reaction over time may be obtained by taking the derivative of a polynomial fit to the experimental curve.Reaction progress NMR may be classified as an integral technique as the primary data collected are proportional to concentration vs. time.