 The creek was the site of the Buffalo Creek Flood in 1972.Buffalo Creek's entire course and drainage area are in eastern Logan County.It rises near the common boundary of Logan, Wyoming, and Boone counties and flows generally west-southwestward through the unincorporated communities of Saunders, Pardee, Lorado, Craneco, Lundale, Stowe, Crites, Latrobe, Robinette, Amherstdale, Becco, Braeholm, Accoville, Crown, and Kistler, to the town of Man, where it flows into the Guyandotte River from the northeast.