 From these data, the starting material or product concentration over time may be obtained by simply taking the integral of a polynomial fit to the experimental curve.With increases in the availability of spectrometers with "in situ" monitoring capabilities, FT-IR has seen increasing use in recent years.Examples of note include mechanistic analysis of the amido-thiourea catalyzed asymmetric Strecker synthesis of unnatural amino acids and of the Lewis base catalyzed halolactonization and cycloetherification.