 For any thorough mechanistic evaluation it is necessary to conduct kinetic analysis of both the catalytic process and its individual steps (when possible) in concert with other forms of analysis such as evaluation of linear free energy relationships, isotope effect studies, computational analysis, or any number of alternative approaches.Finally, it is important to note that no mechanistic hypothesis can ever be proven; alternative mechanistic hypothesis can only be disproven.It is, therefore, essential to conduct any investigation in a hypothesis-driven manner.