 After military participation in Texas, Lindheimer moved to St. Louis, Missouri to partner in botanical research with George Engelmann and Asa Gray.His research brought him in touch with John O. Meusebach, after which Lindheimer moved back to Texas where he spent the rest of his life.Lindheimer built his timber-framed house in 1852, in the saltbox style, with the roof at the back of his house sloping lower than the roof at the front of the house.