 Throughout the week, different segments feature musical performances, packages featuring curated lists of videos on YouTube, and interviews with high-profile celebrities and YouTube talent.Guests have included will.i.am, Larry King, Mark Cuban, Lisa Kudrow, Stan Lee, Kevin Smith, Jason Mewes, Burnie Burns, Drew Carey, iJustine, Spoken Reasons, Cimorelli, Kendrick Lamar, Talib Kweli, Big Sean, Jenna Marbles, Tony Hsieh, Dustin Lance Black, Jon Landeau, The Gregory Brothers, Antoine Dodson, Incubus, George Takei, Orlando Jones, Riff Raff, Skylar Grey, Danny Trejo, Felicia Day, Paul Scheer, Gilbert Gottfried, Cody Simpson, Snoop Dogg, Jon M. Chu, T.J. Miller, John Cena, Shaquille O'Neal, Billy Corgan, Robert Rodriguez, Common, Chris Hardwick, Margaret Cho, Eve, Russell Simmons, Bobak Ferdowsi, Adam DeVine, Anders Holm, Blake Anderson, Dominic Monaghan, Pentatonix, Romany Malco, Mia Rose, Chelsea Kane and Greg Grunberg.