 The creek was named after Peter Huff, an early settler.Huff Creek rises in northern Wyoming County, approximately northwest of Kopperston, and flows generally westward through the unincorporated communities of Lacoma, Cyclone, and Campus in Wyoming County; and Gillman Bottom, Claypool, Mineral City, Davin, and Mallory in Logan County, to Huff Junction, where it flows into the Guyandotte River from the east, approximately southeast of the town of Man.Downstream from Lacoma, the creek is paralleled by West Virginia Route 10.