 Walker Creek’s course and drainage area are entirely in eastern Wood County.It rises approximately east of the community of Deerwalk and flows generally southeastward, through the community of Walker, to join the Little Kanawha River approximately southeast of the community of Kanawha, upstream of the Little Kanawha River's mouth in Parkersburg.According to the West Virginia Department of Environmental Protection, approximately 91% of the Walker Creek watershed is forested, mostly deciduous.