 In 2010 Sakihara, "et al"., evaluated the usefulness and accuracy of salivary, plasma, and urinary cortisol levels and determined salivary cortisol to be the “method of choice” for Cushing’s syndrome screening.In 2008 Restituto, "et al"., found early morning salivary cortisol to be “as good as serum” as an Addison’s disease screening technique.In 2010 Bagcim "et al"., determined that saliva melatonin levels “reflect those in serum at any time of the day” and are a reliable alternative to serum melatonin to study the pineal physiology in newborns.