 Amphiphysin is a brain-enriched protein with an N-terminal lipid interaction, dimerisation and membrane bending BAR domain, a middle clathrin and adaptor binding domain and a C-terminal SH3 domain.In the brain, its primary function is thought to be the recruitment of dynamin to sites of clathrin-mediated endocytosis.There are 2 mammalian amphiphysins with similar overall structure.