 Sambuca di Sicilia is located at .The city has a total area of 37 square miles (95.88 km²).The territory of Sambuca di Sicilia is located in the South-West of Sicily, 42.25 miles (68 km) from Palermo, about 21 miles (34 km) from the archaeological park of Selinunte, and about 13 miles (21 km) from Menfi, that has beaches still pristine and the Blue Flag beach for its sea.