 Great stripe-faced bats are predated on by visual predators that employ sit and wait ambush tactics such as owls and opossums.Great stripe-faced bats have been observed staying in their day roosts on nights in which they would typically feed in response to clear moonlit nights, as this makes them more vulnerable to predation.According to the IUCN, the great striped-faced bat is considered a species of least concern due to the fact that this bat species is very tolerant of a large variety of different habitats, and is widely dispersed across Central and South America.