 The genus is placed in the tribe Antirrhineae; within this tribe, it is closely related to "Lophospermum", "Maurandya" (including "Maurandella") and "Mabrya".It has been included in "Lophospermum" as section "Rhodochiton".A number of molecular phylogenetic studies have shown that subtribe Maurandyinae, defined by Elisens to consist of the five North American genera "Holmgrenanthe", "Lophospermum", "Mabrya", "Maurandya" and "Rhodochiton", forms a monophyletic group, which is related to the Old World genera "Cymbalaria" and "Asarina".