 The first to be discovered was its capability to drive cell proliferation (upregulates cyclins, downregulates p21), but it also plays a very important role in regulating cell growth (upregulates ribosomal RNA and proteins), apoptosis (downregulates Bcl-2), differentiation, and stem cell self-renewal.Nucleotide metabolism genes are upregulated by Myc, which are necessary for Myc induced proliferation or cell growth.There have been several studies that have clearly indicated Myc's role in cell competition.