 The phenotypes seen oppose the effects of normal aging and are shared with many other long-lived mouse models such as CR (calorie restriction) ames dwarf, rapamycin, metformin and resveratrol.One study found that Myc and p53 genes were key to the survival of chronic myeloid leukaemia (CML) cells.Targeting Myc and p53 proteins with drugs gave positive results on mice with CML.