 A major effect of c-myc is B cell proliferation, and gain of MYC has been associated with B cell malignancies and their increased aggresivness, including histological transformation.c-Myc induces MTDH(AEG-1) gene expression and in turn itself requires AEG-1 oncogene for its expression.Myc-nick is a cytoplasmic form of Myc produced by a partial proteolytic cleavage of full-length c-Myc and N-Myc.