 Isesi-ankh may have been a son of Djedkare Isesi, as suggested by his name and his title of "King's son".In addition, similarities in the titles and locations of the tombs of Isesi-ankh and Kaemtjenent have led Egyptologists such as William Stevenson Smith to propose that the two were brothers and sons of Meresankh IV.Alternatively, Isesi-ankh may have been a son of Kaemtjenent.