 It is typically associated with high-T3 syndrome, increased plasma protein binding of thyroid hormones and an elevated set point of the homeostatic system.It represents a response to type 2 allostatic load.Causes of classical euthyroid sick syndrome include a number of acute and chronic conditions, including pneumonia, fasting, starvation, anorexia nervosa, sepsis, trauma, cardiopulmonary bypass, malignancy, stress, heart failure, hypothermia, myocardial infarction, kidney failure, cirrhosis, diabetic ketoacidosis, surgery, infection, brain injury, shock, cancer, and HIV.