 Clustered Pcdhs proteins are detected throughout the neuronal soma, dendrites and axons and are observed in synapses and growth cones.Like classical cadherins, members of Pcdhs family were also shown to mediate cell-cell adhesion in cell-based assays and most of them showed to engage in homophilic trans-interactions.Schreiner and Weiner showed that Pcdhα and γ proteins can form multimeric complexes.