 On April 16, 1865, Dr. Janvier Woodward and Dr. Edward Curtis autopsied, and Dr. Charles D. Brown embalmed, Abraham Lincoln in this room.First Lady Eliza Johnson used the small eastern chamber as her bedroom, while the First Family used the larger bedroom (later to be the President's Dining Room) as a living room.The large room was later used as a bedroom by Nellie Grant (daughter of President Ulysses S. Grant); Fanny Hayes (daughter of President Rutherford B. Hayes); Mary "Mollie" Garfield (daughter of President James Garfield); Ellen "Nell" Arthur (daughter of President Chester Arthur); President Grover Cleveland and First Lady Frances Cleveland; James Robert and Mary Harrison McKee and their two small children; President William McKinley and his wife, Ida; Alice Roosevelt (daughter of President Theodore Roosevelt); Ethel Roosevelt (daughter of President Theodore Roosevelt); First Lady Helen Taft; Eleanor Wilson (daughter of President Woodrow Wilson); and Calvin Coolidge, Jr.;

The room was used as a surgery in 1907 when newly-married Alice Roosevelt (now Alice Roosevelt Longworth) was stricken by appendicitis.