 Le Febure was born and educated in Sedan, going to the Academy there.Vallot, first physician to Louis XIV, appointed him demonstrator of chemistry at the Jardin du Roi, Paris; Diarist John Evelyn is recorded as having attended a course of his lectures there in February 1647.In 1660 he was appointed Professor of Chemistry to Charles II of England in 1660, Apothecary in Ordinary to the Royal Family in 1660 and Manager of the laboratory at St James's Palace, London.