 Upon induction by modified NSAIDS and other potent anti-inflammatory drugs, annexin A1 inhibits the NF-κB signal transduction pathway, which is exploited by cancerous cells to proliferate and avoid apoptosis.ANXA1 inhibits the activation of NF-κB by binding to the p65 subunit.The gene for annexin A1 (ANXA1) is upregulated in hairy cell leukemia.