 In 1766 he succeeded his father as 2nd Baronet and inherited his interest in the banking firm of Amyand, Staples and Mercer.Amyand was educated at Eton College then at Christ Church, Oxford, where he graduated Master of Arts in 1769.On 18 July 1771 he married Catherine Cornewall, only daughter and heiress of Velters Cornewall of Moccas in Herefordshire, MP.