 During NTIS, there are alterations in the concentrations of thyroid hormone transporters such as MCT8 and MCT10, although whether the levels are increased or decreased depends on the study.It is suggested that the altered concentrations are a result of NTIS, rather than a cause; a study in rabbits showed that administering thyroid hormones normalized transporter expression.There is decreased Thyroxine-binding globulin (TBG) following bypass surgery, and in chronic illness a less effective form of TBG with lower affinity for thyroxine is synthesized.