 People who suffer from schizophrenia often exhibit an inability to illustrate context-dependent memory, an inability to show affective valence – proper emotions, and an inability for attentional and temporal processes.Synaptic gating seems to illustrate why all of these inabilities develop.In particular, hippocampal input into the nucleus accumbens, a region of the basal ganglia, acts as a gate creating a more depolarized up state within the accumbens neurons allowing them to be more receptive to innervation from the prefrontal cortex (PFC).