 The studies suggested that DD genotype and *D allele of LRPAP gene showed increased frequency for degenerative dementias on comparison with the control group and that LRPAP1-D allele remarkably increases the vulnerability to degenerative dementias.On genotyping of LRPAP1 polymorphism is observed because of 37 base pair insertion in intron 5.Also insertion allele being larger than deletion allele makes possible in detecting difference by gel electrophoresis.