 The Sanctum Sanctorum has appeared in various media adaptations of the Marvel Universe including the Marvel Cinematic Universe.It first appeared with Doctor Strange in his debut in "Strange Tales" #110 (July 1963).The details of the building have varied by artist, with one reviewer noting, for example, of "Marvel Premiere #3" (July 1972) that "[n]ot since the heady days of Ditko for instance, did the doctor's sanctum sanctorum appear in such scrumptious detail, laden it seemed, with the heavy odor of burning incense".