 Perpiniadis was born in Tinos, and in 1923 moved to Piraeus, where he came into contact with "rebetiko" musicians from Asia Minor.He worked together with other well-known rebetiko musicians such as Vassilis Tsitsanis, and recorded duets with well-known singers such as Rosa Eskenazi, Marika Ninou, Ioanna Georgakopoulou, and Dimitris Perdikopoulos.He died in Athens.