 Propionyl-CoA accumulation can prove toxic to different organisms.Since different cycles have been proposed regarding how propionyl-CoA is transformed into pyruvate, one studied mechanism is the methylcitrate cycle.The initial reaction is beta-oxidation to form the propionyl-CoA which is further broken down by the cycle.This pathway involves the enzymes both related to the methylcitrate cycle as well as the citric acid cycle.