 Hyaluronan synthase

Hyaluronan synthases (HAS) are membrane-bound enzymes which use UDP-α-N-acetyl-D-glucosamine and UDP-α-D-glucuronate as substrates to produce the glycosaminoglycan hyaluronan at the cell surface and extrude it through the membrane into the extracellular space.There are three mammalian hyaluronan synthases described to date - HAS1, HAS2 and HAS3.