 Born in Krasnodar, Papadopoulos started his professional career with Iraklis.An All-EuroLeague Second Team selection in 2007, he played for several teams in Europe throughout his professional career, most notably winning the EuroLeague twice, in 2002 with Panathinaikos and in 2012 with Olympiacos.Papadopoulos represented Greece regularly, winning the gold medal in the 2005 EuroBasket, and the silver medal in the 2006 FIBA World Championship.