 Another hypothesis regarding the fate of propionyl-CoA, in "M. tuberculosis"is, is that since propionyl-CoA is produced by beta odd chain fatty acid catabolism, the methylcitrate cycle is activated subsequently to negate any potential toxicity, acting as a buffering mechanism.Propionyl-CoA has can have many adverse and toxic affects on different species, including bacterium.For example, inhibition of pyruvate dehydrogenase by an accumulation of propionyl-CoA in "Rhodobacter sphaeroides" can prove deadly.