 In 1854, Noble was elected as a Democrat from Michigan's 2nd congressional district to the 33rd United States Congress, serving from March 4, 1853 to March 3, 1855.He was an unsuccessful candidate for re-election in 1854 to the Thirty-fourth Congress, losing to Republican Henry Waldron in the general election.In 1858, Noble was appointed manager of the Louisville, New Albany & Chicago Railroad and served four years.