 Therefore, the utilization of propionyl-CoA through the methylcitrate cycle decreases its concentration, while subsequently increasing the concentration of polyketides.A polyketide differs from the more commonly known compound, the polypeptide, in that a polyketide is a structure commonly found in fungi that is made of acetyl- and malonyl-CoAs.They hold certain properties that have increased the research into their medicinal and potentially harmful attributes, by limiting polyketide toxicity to crops in agriculture through phytopathogenic fungi.