 Similar to how plant peroxisomal enzymes bind propionyl-CoA and isobutyryl-CoA, Gen5, an acetyltransferase in humans, binds to propionyl-CoA and butyl-CoA.These specifically bind to the catalytic domain of Gen5L2.This conserved acetyltransferase is responsible for the regulation of transcription by lysine acetylation of the histone N-terminal tails.