 Through different experiments performed by Lucas et al., it has been suggested that in plants, through peroxisomal enzymes, propionyl-CoA (and isobutyryl-CoA) are involved in the metabolism of many different substrates (currently being evaluated for identity), and not just valine.Propionyl-CoA production through the catabolism of fatty acids is also associated with thioesterifcation.In a study concerning "Aspergillus nidulans", it was found that with the inhibition of a methylcitrate synthase gene, "mcsA", of the pathway described above, production of distinct polyketides was inhibited as well.