Various sources, including the Intergovernmental Panel on Climate Change, use the year 1750 as a baseline year for the end of the pre-industrial era. Events January–March January 13 – The Treaty of Madrid between Spain and Portugal authorizes a larger Brazil than had the Treaty of Tordesillas of 1494, which originally established the boundaries of the Portuguese and Spanish territories in South America. January 24 – A fire in Istanbul destroys 10,000 homes. February 15 – After Spain and Portugal agree that the Uruguay River will be the boundary line between the two kingdoms' territory in South America, the Spanish Governor orders the Jesuits to vacate seven Indian missions along the river (San Angel, San Nicolas, San Luis, San Lorenzo, San Miguel, San Juan and San Borja). March 5 – The Murray-Kean Company, a troupe of actors from Philadelphia, gives the first performance of a play announced in advance in a newspaper, presenting Richard III at New York City's Nassau Street Theatre. March 20 – The first number of Samuel Johnson's The Rambler appears. April–June April 7 – Alagumuthu brothers raise slogans against the British tax collection report. Due to this a war breaks out between the British and the Alagumuthu brothers, in which the British are defeated. April 13 – Dr. Thomas Walker and five other men (Ambrose Powell, Colby Chew, William Tomlinson, Henry Lawless and John Hughes) cross through the Cumberland Gap, a mountain pass through the Appalachian Mountains, to become the first white people to venture into territories that had been inhabited exclusively by various Indian tribes. On April 17, Walker's party continues through what is now Kentucky and locates the Cumberland River, which Walker names in honor of Prince William, Duke of Cumberland. April 14 A group of West African slaves, bound for America, successfully overpowers the British crew of the slave ship Snow Ann, imprisons the survivors, and then navigates the ship back to Cape Lopez in Gabon. Upon regaining their freedom, the rebels leave the survivors on the Gabonese coast. The Viceroy of New Spain, Juan Francisco de Güemes, issues a notice to the missionaries in Nuevo Santander (which includes parts of what are now the U.S. state of Texas, including San Antonio, and the Mexican state of Tamaulipas) to work peacefully to convert the indigenous Karankawa people to Roman Catholicism. April 25 – The Acadian settlement in Beaubassin, Nova Scotia, is burnt by