hopefuls from all over North America, and even the world, to the Sacramento River in search of fortunes, kicking off the California Gold Rush. People flocked to the region by the Oregon Trail-Siskiyou Trail, California Trail, Southern Emigrant Trail and various land and/or sea routes through the Isthmus of Panama and around southern South America by ship. Steamboats traveled up and down the Sacramento River carrying miners from San Francisco to the gold fields. As the miners expanded their diggings deeper into the Sierra Nevada and Klamath Mountains, Native Americans were pushed off their land and a long series of skirmishes and fights began that continued until intervention by the state and national governments. Post-Gold Rush development and effects The influx of migrants brought foreign diseases like malaria and smallpox, which American Indians had no immunity to. These diseases killed off a large proportion of their population within a few decades of the arrival of Sutter and the following settlers, the start of the gold rush, not to mention the numerous battles fought between the settlers and native bands as well as the forced relocation of some of the tribes to Indian reservations in several places scattered around the Sacramento Valley, mainly in the Coast Ranges. In the early 1850s, several treaties were signed between the U.S. government and the Native Americans involving their relocation onto a reservation in the Sierra foothills; this promise was broken. Therefore, in 1863, the tribes from the area surrounding the middle Sacramento and Feather rivers, the Konkow group, were removed and marched forcibly to the Round Valley Indian Reservation near the Eel River. A total of 461 people were forced from their homes, but only 277 made it to the reservation; the others perished of disease, starvation or exhaustion. As mining developed from simple methods such as panning and sluicing to a new form of commercialized extraction, hydraulic mining, profits from the petering gold rush made a second leap, earning more profits than placer miners in the early years had ever made. The city of Sacramento, founded on the original site of Sutter's fort, began to flourish as the center of an agricultural empire that provided food to feed the thousands of miners working in the hills as well as a place of financial exchange of all the gold that was mined. Sacramento was officially established in 1850 and was recognized as the state