this peaceful period was shattered with the rise of Qara Iskander between 1420 and 1436, who reportedly made Armenia a "desert" and subjected it to "devastation and plunder, to slaughter, and captivity". The wars of Iskander and his eventual defeat against the Timurids, invited further destruction in Armenia, as many more Armenians were taken captive and sold into slavery and the land was subjected to outright pillaging, forcing many of them to leave the region. Following the fall of the Armenian Kingdom of Cilicia in 1375, the seat of the Armenian Church was transferred from Sis back to Vagharshapat near Yerevan in 1441. Thus, Yerevan became the main economic, cultural and administrative centre in Armenia. Iranian rule In 1501–02, most of the Eastern Armenian territories including Yerevan were swiftly conquered by the emerging Safavid dynasty of Iran led by Shah Ismail I. Soon after in 1502, Yerevan became the centre of the Erivan Province, a new administrative territory of Iran formed by the Safavids. For the following 3 centuries, it remained, with brief intermissions, under the Iranian rule. Due to its strategic significance, Yerevan was initially often fought over, and passed back and forth, between the dominion of the rivaling Iranian and Ottoman Empire, until it permanently became controlled by the Safavids. In 1555, Iran had secured its legitimate possession over Yerevan with the Ottomans through the Treaty of Amasya. In 1582–1583, the Ottomans led by Serdar Ferhad Pasha took brief control over Yerevan. Ferhad Pasha managed to build the Erivan Fortress on the ruins of one thousand-years old ancient Armenian fortress, on the shores of Hrazdan river. However, Ottoman control ended in 1604 when the Persians regained Yerevan as a result of first Ottoman-Safavid War. Shah Abbas I of Persia who ruled between 1588 and 1629, ordered the deportation of hundreds of thousands of Armenians including citizens from Yerevan to mainland Persia. As a consequence, Yerevan significantly lost its Armenian population who had declined to 20%, while Muslims including Persians, Turks, Kurds and Tatars gained dominance with around 80% of the city's population. Muslims were either sedentary, semi-sedentary, or nomadic. Armenians mainly occupied the Kond neighbourhood of Yerevan and the rural suburbs around the city. However, the Armenians dominated over various professions and trade in the area and were of great economic significance to the Persian administration. During the second Ottoman-Safavid War, Ottoman troops under the command of Sultan