German again, until 1918 (end of World War I), when it reverted to France. After the defeat of France in 1940 (World War II), Strasbourg came under German control again through formal annexation into the Gau Baden-Elsaß under the Nazi Gauleiter Robert Wagner; since the end of 1944, it has again been a French city. In 2016, Strasbourg was promoted from capital of Alsace to capital of Grand Est. Strasbourg played an important part in the Protestant Reformation, with personalities such as John Calvin, Martin Bucer, Wolfgang Capito, Matthew and Katharina Zell, but also in other aspects of Christianity such as German mysticism, with Johannes Tauler, Pietism, with Philipp Spener, and Reverence for Life, with Albert Schweitzer. Delegates from the city took part in the Protestation at Speyer. It was also one of the first centres of the printing industry with pioneers such as Johannes Gutenberg, Johannes Mentelin, and Heinrich Eggestein. Among the darkest periods in the city's long history were the years 1349 (Strasbourg massacre), 1518 (Dancing plague), 1793 (Reign of Terror), 1870 (Siege of Strasbourg) and the years 1940–1944 with the Nazi occupation (atrocities such as the Jewish skull collection) and the British and American bombing raids. Some other notable dates were the years 357 (Battle of Argentoratum), 842 (Oaths of Strasbourg), 1538 (establishment of the university), 1605 (world's first newspaper printed by Johann Carolus), 1792 (La Marseillaise), and 1889 (pancreatic origin of diabetes discovered by Minkowski and Von Mering). Strasbourg has been the seat of European Institutions since 1949: first of the International Commission on Civil Status and of the Council of Europe, later of the European Parliament, of the European Science Foundation, of Eurocorps, and others as well. Districts Strasbourg is divided into the following districts: Bourse, Esplanade, Krutenau Centre Ville (Downtown Strasbourg) Gare, Tribunal (Central Station, Court) Conseil des XV, Orangerie Cronenbourg Hautepierre, Poteries Koenigshoffen, Montagne-Verte (Green Hill) Elsau Meinau Neudorf-Musau Neuhof 1 (including Ganzau) Neuhof 2 Robertsau Port du Rhin (Rhin's Harbor) Main sights Architecture The city is chiefly known for its sandstone Gothic Cathedral with its famous astronomical clock, and for its medieval cityscape of Rhineland black and white timber-framed buildings, particularly in the Petite France district or Gerberviertel ("tanners' district") alongside the Ill and in the streets and squares surrounding the cathedral, where the renowned Maison Kammerzell stands out. Notable medieval streets include Rue Mercière, Rue des Dentelles, Rue du Bain aux