usually need to be fairly heavy, although the level of nutrients does not need to be exceptional. In general, these conditions are met within the seasonally dry tropics and subtropics in the Northern and Southern hemispheres, but a large proportion of the cotton grown today is cultivated in areas with less rainfall that obtain the water from irrigation. Production of the crop for a given year usually starts soon after harvesting the preceding autumn. Cotton is naturally a perennial but is grown as an annual to help control pests. Planting time in spring in the Northern hemisphere varies from the beginning of February to the beginning of June. The area of the United States known as the South Plains is the largest contiguous cotton-growing region in the world. While dryland (non-irrigated) cotton is successfully grown in this region, consistent yields are only produced with heavy reliance on irrigation water drawn from the Ogallala Aquifer. Since cotton is somewhat salt and drought tolerant, this makes it an attractive crop for arid and semiarid regions. As water resources get tighter around the world, economies that rely on it face difficulties and conflict, as well as potential environmental problems. For example, improper cropping and irrigation practices have led to desertification in areas of Uzbekistan, where cotton is a major export. In the days of the Soviet Union, the Aral Sea was tapped for agricultural irrigation, largely of cotton, and now salination is widespread. Cotton can also be cultivated to have colors other than the yellowish off-white typical of modern commercial cotton fibers. Naturally colored cotton can come in red, green, and several shades of brown. Water footprint The water footprint of cotton fibers is substantially larger than for most other plant fibers. Cotton is also known as a thirsty crop; on average, globally, cotton requires 8,000–10,000 liters of water for one kilogram of cotton, and in dry areas, it may require even more such as in some areas of India, it may need 22,500 liters. Genetic modification Genetically modified (GM) cotton was developed to reduce the heavy reliance on pesticides. The bacterium Bacillus thuringiensis (Bt) naturally produces a chemical harmful only to a small fraction of insects, most notably the larvae of moths and butterflies, beetles, and flies, and harmless to other forms of life. The gene coding for Bt toxin has been inserted into cotton, causing cotton, called Bt cotton, to produce