Jeffords is a surname. Notable people with the surname include: Elza Jeffords (1826–1885), American representative prominent resident of Mississippi following the Civil War Harrison Jeffords (1834–1863), American colonel and hero of the American Civil War Jim Jeffords (1934–2014), American former U.S. Senator from Vermont Tom Jeffords (1832–1914), American United States Army scout, Indian agent, prospector, and prominent resident of the Arizona Territory See also Jefford