Prince Philip of Spain and the Princess of Portugal, thus ending a hope of bringing these two countries together, and resulting in his retirement as duke, handing his title to his son, Carlos. By then 33 years old, he had retired to his native place and devoted himself to religious activities. Jesuit priest In 1546 his wife Eleanor died, and Francis then decided to enter the newly formed Society of Jesus, after making adequate provisions for his children. He put his affairs in order circa 1551, renounced his titles in favour of his eldest son Carlos de Borja-Aragon y de Castro-Melo, and became a Jesuit priest. He helped in the establishment of what is now the Gregorian University in Rome. Upon Francis’ return from a journey to Peru, Pope Julius III made known his intention to make him a cardinal. To prevent this, Borgia decided, in agreement with St. Ignatius, to leave the city secretly and go to the Basque Country, where it was thought he would be safe from the papal desires. He felt incompletion to spend time in seclusion and prayer, but his administrative talents also made him a natural for other tasks. In time his friends persuaded him to accept the leadership role that nature and circumstances had destined him for: in 1554, he became the Jesuit commissary-general in Spain, where he founded a dozen colleges. After only two years, St. Francis was crowned for missions in the East and West Indies. In 1565, he was elected the third "Father General" or Superior General of the Society of Jesus, after the death in January 1565 of Diego Laynez, (Almazán, Spain, 1512 – January 1565). His successes during the period 1565–1572 made historians to describe Francis as the greatest General after Saint Ignatius. He founded the Collegium Romanum, which was to become the Gregorian University, advised kings and popes, and closely supervised all the affairs of the mushrooming order. Yet, despite being the supreme, Francis led a humble life and was acclaimed in his own lifetime as a saint. Francis Borgia died in 1572. Death and legacy Francis Borgia died on 30 September 1572, in Rome. His mortal remains were repatriated to Spain in 1617 and kept from 1627 at the Jesuit professed house in Madrid that was newly built for that purpose north of Plaza Mayor on a donation from Francisco Gómez de Sandoval y Rojas, 1st