ground substance; numerous blood vessels. In the skin and mucous membranes, it is more compact and sometimes difficult to distinguish from dense irregular connective tissue. Function Areolar connective tissue holds organs in place and attaches epithelial tissue to other underlying tissues. It also serves as a reservoir of water and salts for surrounding tissues. Almost all cells obtain their nutrients from and release their wastes into areolar connective tissue. Clinical significance Organs that are rich in loose connective tissue (such as the eyelids) are usually sites that undergo oedema, indicating kidney failure or nephrotic syndrome. Therefore, periorbital swelling is one characteristic finding in severe kidney disease. See also Dense connective tissue References Connective tissue