is the main annual release and contains changes at the HLT level and above along with LLT and PT changes. The September release contains changes only at the LLT and PT level. The September 2022 Version 25.1 release is the current version. The MSSO frequently incorporates feedback from the user community to stay abreast of its unique perspectives and nuanced needs. Input from these constituencies helps MSSO adapt MedDRA accordingly. As global regulators expand the scope of product types they regulate, there is a corresponding increase in the adaptation of and interest in the proactive use of MedDRA before regulatory mandates. Such expansion has increased in MedDRA terms applicable to many product types. The addition of the 27th SOC Product issues in Version 19.0 has even further expanded use of MedDRA for product quality, supply, distribution, manufacturing and quality system issue as well as device issues. See also COSTART Systematized Nomenclature of Medicine (and SNOMED CT) WHOART the latest version of MedDRA is 20.1 updated in September-2017 Medicines and Healthcare products Regulatory Agency (MHRA) International Classification of Diseases (ICD) Medical Terminology Clinical trials Pharmacovigilance References https://www.meddra.org/how-to-use/support-documentation?current External links MedDRA webpage Pharmacology literature Pharmacological classification systems