term leads to the automatic assignment of grouping terms higher in the hierarchy. Multi-axial links of terms are pre-assigned in MedDRA, ensuring comprehensive and consistent data retrieval, irrespective of which SOC is selected at data retrieval. As of MedDRA 25.1 (September 2022): SOC – 27 The 27 SOCs are: Blood and lymphatic system disorders; Cardiac disorders; Congenital, familial and genetic disorders; Ear and labyrinth disorders; Endocrine disorders; Eye disorders; Gastrointestinal disorders; General disorders and administration site conditions; Hepatobiliary disorders; Immune system disorders; Infections and infestations; Injury, poisoning and procedural complications; Investigations; Metabolism and nutrition disorders; Musculoskeletal and connective tissue disorders; Neoplasms benign, malignant and unspecified (incl cysts and polyps); Nervous system disorders; Pregnancy, puerperium and perinatal conditions; Product issues; Psychiatric disorders; Renal and urinary disorders; Reproductive system and breast disorders; Respiratory, thoracic and mediastinal disorders; Skin and subcutaneous tissue disorders; Social circumstances; Surgical and medical procedures; Vascular disorders. HLGT – 337 HLT – 1,737 PT – 25,592 LLT – 85,668 LLT count represents 76,364 current terms, including PTs, and 9,304 non-current terms. Maintenance of MedDRA MedDRA is hierarchical, multiaxial, multilingual, regularly-updated, and strictly maintained by the Maintenance and Support Services Organization (MSSO). ICH holds the intellectual property rights (ownership) of MedDRA. MedDRA is available free for all regulators worldwide, academics, health care providers, and non-profit organizations. The subscription price is based according to company revenue for the industry. The Japanese counterpart for the MSSO is called the Japanese Maintenance Organization (JMO). Four types of subscriptions are available from the MSSO: Regulatory Authority; Non-Profit/Non-Commercial (such as medical library, educational institution, organization engaged in not for profit activities); Commercial; System Developer (developer of software products that utilize MedDRA). The MSSO updates MedDRA according to subscriber change requests, for example, to add a new medical concept that is not yet in MedDRA or to change/modify an existing concept. The decisions on submitted change requests are made by a team of international medical officers on how to map the terminology within the grouping categories according to a general team consensus. The final decisions are based on multiple factors including the Points to Consider documentation, implications on legacy data, and language considerations internationally. The MSSO and JMO release updated MedDRA versions twice a year - in March and September. The English and Japanese translation are released on the 1st of March and September and all other translations are released on the 15th. The March release