access is provided by I-10, via the Claiborne and Pontchartrain Expressways. When I-10 curves to the east by the Louisiana Superdome and becomes the Claiborne Expressway, elevated above N. Claiborne Avenue, the Pontchartrain Expressway continues as U.S. Route 90 Business and crosses the Mississippi River on the twin-bridge Crescent City Connection. Significant thoroughfares in the CBD include St. Charles Avenue, Camp Street, Carondelet Street, Gravier Street, Poydras Street, Tchoupitoulas Street, Howard Avenue, and Canal Street. Prior to the 1980s, the intersection of Gravier and Carondelet streets was the de facto heart of the city's financial district. Though still a vibrant area, that part of the CBD witnessed the migration of much business slightly upriver to Poydras Street, as many modern high-rise office towers were constructed there in the 1970s and 1980s. The widening of Loyola Avenue, Poydras Street and O'Keefe Avenue aimed to simultaneously create an effective downtown circulator high capacity road network for automobile traffic and make room for large-scale redevelopment (e.g., Duncan Plaza, Superdome). However, many of the development sites created in the wake of these improvements were never built upon, leaving a noticeable and unfortunate quantity of surface parking lots along these widened streets. Economy Entergy, the region's sole Fortune 500 firm, maintains its headquarters in the CBD, as does Reily Foods Company, which markets Luzianne products and Standard Coffee. Other local companies headquartered downtown include McMoRan Exploration, Pan American Life Insurance, Superior Energy Services, TurboSquid, iSeatz, Historic Restoration Inc. (HRI Properties), Tidewater Marine, Energy Partners Ltd., Intermarine, IMTT, International Coffee Corp., and The Receivables Exchange. The CBD also hosts the New Orleans I.P., an "Intellectual Property", home to numerous creative industries firms, and numerous bioscience companies are established at the New Orleans BioInnovation Center, located within BioDistrict New Orleans. The regional economic alliance Greater New Orleans, Inc. (GNO Inc.), the New Orleans metropolitan area's lead economic development entity for the ten-parish New Orleans region, is also headquartered downtown, as is the New Orleans Business Alliance (NOLA BA), the public-private partnership agency leading economic development efforts for the city proper. The World Trade Center of New Orleans (WTCNO) has been located in the CBD since its establishment in 1943. The WTCNO facilitates the addition of wealth and jobs in Louisiana through international trade, economic development, and allied activities by supporting a prosperous international business climate in Louisiana. Diplomatic missions The Consulate of Mexico in New Orleans is