Right before the Runaways defeat a new incarnation of the Pride and Alex's resurrected father, Gertrude is fatally wounded. Before she passes, she transfers her power to control Old Lace to Chase. In the Civil War crossover event, the Young Avengers travel to Los Angeles to help the Runaways fight off the government agents and Flag-Smasher. The two teams encounter Noh-Varr, who works for S.H.I.E.L.D. and attempts to capture the teenagers. Chase then hatches a plan, without the consent of the rest of the team, to sacrifice himself to the Gibborim, but the team comes to save him, which then causes the Gibborim to be obliterated. When the Runaways are accidentally time-displaced in 1907, they encounter the deceased Runaway Gertrude Yorke's parents. After defeating the Yorkes and deadly gang war, plant-manipulator Klara Prast joins the Runaways when they return to the present. Upon returning from 1907, the Runaways find themselves in New York helping the Young Avengers during the Secret Invasion, where the Skrull Armada has invaded seeking Hulkling. Xavin pretended to be loyal to the Skrulls to protect her friends during an attack, but helps them retreat away from the battle. The Runaways are hunted by several remaining Majesdanian soldiers with the desire to capture Karolina for the problems caused on their planet; in a twisted turn of events, however, Xavin shape-shifts into Karolina and leaves with the Majesdanians. The Runaways also prevent a zombie epidemic in Los Angeles. Molly also visits the X-Men in San Francisco and reconciles with Wolverine. The team is attacked while staying in Chase's parent's beach house. Old Lace is critically wounded saving Klara, whose powers cause foliage to keep the house from crumbling, but trapping everybody. A man alleging to be Chase's uncle appears and tries to help, but is followed by the military. The team runs away, but Chase separates and is critically wounded in a car accident while running across the street chasing a figure reminiscent to Gertrude. The reunited Runaways later formed an uneasy alliance with Daken in order to take down Marcus Roston, a superpowered criminal with ties to the Pride. Then they appeared again at the Avengers Academy asking for help in finding Old Lace, who has been banished into a secret dimension. The Runaways partially disbanded afterwards, with Victor joining Hank Pym's Avengers A.I. team while Nico and Chase were both captured by Arcade and forced to