inhibitors (especially gamma-secretase inhibitors) as cancer treatments which are in different phases of clinical trials. at least 7 notch inhibitors were in clinical trials. MK-0752 has given promising results in an early clinical trial for breast cancer. Preclinical studies showed beneficial effects of gamma-secretase inhibitors in endometriosis, a disease characterised by increased expression of notch pathway constituents. Several notch inhibitors, including the gamma-secretase inhibitor LY3056480, are being studied for their potential ability to regenerate hair cells in the cochlea, which could lead to treatments for hearing loss and tinnitus. References External links Diagram: notch signaling pathway in Homo sapiens Diagram: Notch signaling in Drosophila Netpath – A curated resource of signal transduction pathways in humans Alagille syndrome Signal transduction