as fevers. It is known as the "Cotswold System" or "Modified Ann Arbor Staging System". Solid For solid tumors, TNM is by far the most commonly used system, but it has been adapted for some conditions. Breast cancer: In breast cancer classification, staging is usually based on TNM, but staging in I–IV may be used as well. Cervical and ovarian cancers: the "FIGO" system has been adopted into the TNM system. For premalignant dysplastic changes, the CIN (cervical intraepithelial neoplasia) grading system is used. Colon cancer: originally consisted of four stages: A, B, C, and D (the Dukes staging system). More recently, colon cancer staging is indicated either by the original A-D stages or by TNM. Kidney cancer: uses TNM. Cancer of the larynx: Uses TNM. Liver cancer: Uses TNM. Lung cancer: uses TNM. Melanoma: TNM used. Also of importance are the "Clark level" and "Breslow depth" which refer to the microscopic depth of tumor invasion ("Microstaging"). Prostate cancer: TNM almost universally used. Testicular cancer: uses TNM along with a measure of blood serum markers (TNMS). Non-melanoma skin cancer: uses TNM. Bladder cancer: uses TNM. Overall stage grouping Overall Stage Grouping is also referred to as Roman Numeral Staging. This system uses numerals I, II, III, and IV (plus the 0) to describe the progression of cancer. Stage 0: carcinoma in situ, abnormal cells growing in their normal place ("in situ" from Latin for "in its place"). Stage I: cancers are localized to one part of the body. Stage I cancer can be surgically removed if small enough. Stage II: cancers are locally advanced. Stage II cancer can be treated by chemotherapy, radiation, or surgery. Stage III: cancers are also locally advanced. Whether a cancer is designated as Stage II or Stage III can depend on the specific type of cancer; for example, in Hodgkin's Disease, Stage II indicates affected lymph nodes on only one side of the diaphragm, whereas Stage III indicates affected lymph nodes above and below the diaphragm. The specific criteria for Stages II and III therefore differ according to diagnosis. Stage III can be treated by chemotherapy, radiation, or surgery. Stage IV: cancers have often metastasized, or spread to other organs or throughout the body. Stage IV cancer can be treated by chemotherapy, radiation, or surgery. Despite treatment, a patient's mortality rate can be significantly higher with Stage IV cancer, e.g., the cancer can progress to