shortly afterwards she developed recurrent pianist's cramp, and although she performed in leading concert venues in London – the Bechstein, Steinway and St James's halls – by 1902 it was clear that a musical career would be impossible. She studied for the stage at the drama school run by Ben Greet, who engaged her for an American tour beginning in August 1904, in advance of which she made her professional début at Cambridge in June, as Palmis in W. S. Gilbert's The Palace of Truth. She remained in Greet's company for three years playing in Shakespearean repertory throughout the US. On her return to England, Thorndike was spotted by Bernard Shaw in a one-off Sunday night performance at the Scala Theatre in London; he invited her to join the company for a revival of his Candida to be given in Belfast by Annie Horniman's players. The company was based at the Gaiety Theatre, Manchester, where she first appeared in September 1908 as Bessie Carter in Basil Dean's Marriages are Made in Heaven. She played parts in nine other plays by authors ranging from Euripides to John Galsworthy. In the company she met, and formed a lifelong partnership with, the actor Lewis Casson. They married in December 1908 at her father's church. They had two daughters and two sons, all of whom went on the stage for some or all of their careers. Thorndike appeared at the Coronet Theatre, London, in June 1909 with the Horniman company, and at the Duke of York's Theatre in March 1910 with Charles Frohman's repertory company, appearing there as Winifred in The Sentimentalists, Emma Huxtable in The Madras House, Romp in Prunella and Maggie Massey in Chains. She then went to New York, where she appeared at the Empire Theatre in September 1910, as Emily Chapman in Smith opposite John Drew. Between her return to Britain and the outbreak of the First World War in 1914, Thorndike appeared in the West End at the Aldwych Theatre in June 1912 as Beatrice Farrar in Hindle Wakes, and at the Playhouse Theatre in July 1912 in the same role. She returned to Manchester for a second season at the Gaiety later in the year, playing a range of roles in nine plays. At the Court Theatre in London in May 1913 she played the title role in St John Ervine's Jane Clegg, and in October she appeared