in 2012, with approximately a 50% oversubscription rate averaged over the operational beamlines. By 2012 the user community spanned all regions of Canada and around 20 other countries. That year a high school group from La Loche Saskatchewan became the first to use the purpose built educational beamline IDEAS. Also in 2012 the CLS signed an agreement with the Advanced Photon Source synchrotron in the USA to allow Canadian researchers access to their facilities. Science An international team led by University of Calgary professor Ken Ng solved the detailed structure of RNA polymerase using X-ray crystallography at the CLS. This enzyme replicates itself as the Norwalk virus spreads through the body, and has been linked to other superviruses such as hepatitis C, West Nile virus and the common cold. Its duplication is responsible for the onset of such viruses. CLS scientist Luca Quaroni and University of Saskatchewan professor Alan Casson used infrared microscopy to identify biomarkers inside individual cells from tissue associated with Barrett's esophagus. This disease can lead to an aggressive form of cancer known as esophageal adenocarcinoma. Researchers from Lakehead University and the University of Saskatchewan used the CLS to investigate the deaths of Royal Navy sailors buried in Antigua in the late 1700s. They used X-ray fluorescence to look for trace elements such as lead and strontium in bones from a recently excavated naval cemetery Scientists from Stanford University worked with CLS scientists to design a cleaner, faster battery. The new battery charges in less than two minutes, thanks to a newly developed carbon nanostructure. The team grew nanocrystals of iron and nickel on carbon. Traditional batteries lack this structure, mixing iron and nickel with conductors more or less randomly. The result was a strong chemical bond between the materials, which the team identified and studied at the synchrotron. A team led by the Politecnico di Milano, including scientists from the University of Waterloo and the University of British Columbia, found the first experimental evidence that a charge density wave instability competes with superconductivity in high-temperature superconductors. They used four synchrotrons including the REIXS beamline at CLS. Using the X-ray spectromicroscopy beamline, a research team led by scientists from the State University of New York, Buffalo produced images of graphene showing how folds and ripples act as speed bumps for electrons, affecting its conductivity. This has implications for the use of graphene in a variety of future