dominant Arab tribe; their territory ran from the Hejaz in the south to the Negev in the north through the period of Persian and Hellenistic dominion. Classical antiquity In the 330s BCE, Macedonian ruler Alexander the Great conquered the region, which changed hands several times during the wars of the Diadochi and later Syrian Wars. It ultimately fell to the Seleucid Empire between 219 and 200 BCE. During that period, the region became heavily hellenized, building tensions between Greeks and locals. In 167 BCE, the Maccabean Revolt erupted, leading to the establishment of an independent Hasmonean Kingdom in Judea. From 110 BCE, the Hasmoneans extended their authority over much of Palestine, including Samaria, Galilee, Iturea, Perea, and Idumea. The Jewish control over the wider region resulted in it also becoming known as Judaea, a term that had previously only referred to the smaller region of the Judaean Mountains. During the same period, the Edomites were converted to Judaism. Between 73 and 63 BCE, the Roman Republic extended its influence into the region in the Third Mithridatic War. Pompey conquered Judea in 63 BCE, splitting the former Hasmonean Kingdom into five districts. In around 40 BCE, the Parthians conquered Palestine, deposed the Roman ally Hyrcanus II, and installed a puppet ruler of the Hasmonean line known as Antigonus II. By 37 BCE, the Parthians withdrew from Palestine. Palestine is generally considered the "Cradle of Christianity". Christianity, a religion based on the life and teachings of Jesus of Nazareth, arose as a messianic sect from within Second Temple Judaism. The three-year Ministry of Jesus, culminating in his crucifixion, is estimated to have occurred from 28 to 30 CE, although the historicity of Jesus is disputed by a minority of scholars. In the first and second centuries CE, the Province of Judea became the site of two large-scale Jewish revolts against Rome. During the First Jewish-Roman War, which lasted from 66 to 73 CE, the Romans razed Jerusalem and destroyed the Second Temple. In Masada, Jewish zealots preferred to commit suicide than endure Roman captivity. In 132 CE, another Jewish rebellion erupted. The Bar Kokhba revolt took three years to put down, incurred massive costs on both the Romans and the Jews, and desolated much of Judea. The center of Jewish life in Palestine moved to the Galilee. During or after the revolt, Hadrian joined the province of Iudaea with Galilee and the