daily, and that it causes severe nausea in some patients, especially when therapy is initiated. As of 2015, Byetta was recommended only for patients with Type 2 Diabetes. Liraglutide Liraglutide (Saxenda) is another GLP-1 analogue for daily administration, approved 2014. Orlistat Orlistat (Xenical) reduces intestinal fat absorption by inhibiting the enzyme pancreatic lipase. Frequent oily bowel movements steatorrhea is a possible side effect of using Orlistat. But if fat in the diet is reduced, symptoms often improve. Originally available only by prescription, it was approved by the FDA for over-the-counter sale in February 2007. On 26 May 2010, the U.S. Food and Drug Administration (FDA) has approved a revised label for Xenical to include new safety information about cases of severe liver injury that have been reported rarely with the use of this medication. Of the 40 million users of orlistat worldwide, 13 cases of severe liver damage have been reported. Cetilistat Cetilistat is a medication designed to treat obesity. It acts in the same way as the older medication orlistat by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are excreted undigested. A 2010 phase 2 trial found cetilistat significantly reduced weight and was better tolerated than orlistat. It has not been approved in the US. Phentermine/topiramate The combination of phentermine and topiramate, brand name Qsymia (formerly Qnexa) was approved by the U.S. FDA on 17 July 2012, as an obesity treatment complementary to a diet and exercise regimen. In October 2012, the European Medicines Agency, by contrast, rejected the combination (Qsiva) as a treatment for obesity, citing concerns about long-term effects on the heart and blood vessels, mental health and cognitive side-effects. Naltrexone/bupropion Naltrexone/bupropion is a combination medication used for weight loss in those that have either obesity or overweight with some weight-related illnesses. It combines low doses of bupropion and naltrexone. Both medications have individually shown some evidence of effectiveness in weight loss, and the combination has been shown to have some synergistic effects on weight. In September 2014, a sustained release formulation of the medication was approved for marketing in the United States under the brand name Contrave. The combination was approved for use in the European Union in March 2015, under the brand name Mysimba. Gelesis100 Gelesis100 (sold under the brand name "Plenity")