The Latin maxim , meaning "we do not know and will not know", represents the idea that scientific knowledge is limited. It was popularized by Emil du Bois-Reymond, a German physiologist, in his 1872 address ("The Limits of Science"). Seven "World Riddles" Emil du Bois-Reymond first used the words and at the close of his keynote address to the 1872 Congress of German Scientists and Physicians. As he saw it, science was bounded by two limits: the ultimate nature of matter and the enigma of consciousness. Eight years later, in a speech before the Prussian Academy of Sciences, he expanded his list of conundrums to seven "world riddles" or "shortcomings" of science. Three of these he declared to be "transcendent", or permanently unknowable: "1. the ultimate nature of matter and energy, 2. the origin of motion, ... 5. the origin of simple sensations." Hilbert's reaction David Hilbert, a widely-respected German mathematician, suggested that such a conceptualization of human knowledge was too pessimistic, and that by considering questions unsolvable we limit our understanding. In 1900, during an address to the International Congress of Mathematicians in Paris, Hilbert suggested that answers to problems of mathematics are possible with human effort. He declared, "in mathematics there is no ", and he worked with other formalists to establish foundations for mathematics during the early 20th century. On 8 September 1930, Hilbert elaborated his opinion in a celebrated address to the Society of German Scientists and Physicians, in Königsberg: Answers to some of Hilbert's Program of 23 problems were found during the 20th century. Some have been answered definitively; some have not yet been solved; a few, most notably Cantor's continuum hypothesis, have been shown to be undecidable on the basis of currently accepted principles. In 1931, Gödel's incompleteness theorems showed that for any formal system of mathematics satisfying certain minimal requirements, there exist questions that cannot be answered within that system. While this does not exclude that the question can be answered unambiguously in another system, the incompleteness theorems are generally taken to imply that Hilbert's hopes for proving the consistency of mathematics using purely finitistic methods were unfounded. As this excludes the possibility of an absolute proof of consistency, there must always remain an ineliminable degree of insecurity about the foundations of mathematics: we will never be capable of knowing, once and for all, with a certainty unimpeachable even by the most stout