mapping to the query. By the amount of the score the shuffled sequences still attain PRSS now can predict the significance of the score of the original sequences. The higher the score of the shuffled sequences the less significant the matches found between original database and query sequence. The FASTA programs find regions of local or global similarity between Protein or DNA sequences, either by searching Protein or DNA databases, or by identifying local duplications within a sequence. Other programs provide information on the statistical significance of an alignment. Like BLAST, FASTA can be used to infer functional and evolutionary relationships between sequences as well as help identify members of gene families. See also BLAST FASTA format Sequence alignment Sequence alignment software Sequence profiling tool References Phylogenetics software