Durance said: "Everyone has their specific idea of who Lois Lane is for them, and you have your overall blueprint, but then you have to try to make it your own. That's the only way to try to stay truthful to what you're doing. It's an experience I will cherish always and never forget. Lois is a beloved character. I took that seriously and put my heart and soul into her for seven years. I enjoyed every minute and am forever changed by it." Durance appeared in the films The Butterfly Effect 2 (2006) and Island Heat: Stranded (2006). She was nominated for a Gemini Awards for the Lifetime movie I Me Wed (2007). She starred as Maid Marian in Beyond Sherwood Forest (2009) and appeared in the film Sophie and Sheba (2010) as an Aerial silk performer in the circus. In 2011, she guests starred in the television series Charlie's Angels as CIA operative Samantha Masters. She played twin sisters Angela and Christine in the Italian TV mini-series 6 passi nel giallo and appeared in the NBC series Harry's Law in 2012. In June 2012, Durance began starring in the lead role in the CTV medical drama television series Saving Hope, as Chief Surgical Dr. Alex Reid. She was also a producer on the series and directed the season four episode "Torn and Frayed". In season 3, Durance's real-life pregnancy was worked into her character Alex Reid and the series. Saving Hope ended its run in 2017. Durance starred in the Hallmark Movies & Mysteries channel movie Wedding Planner Mystery (2014). The movie is based on Deborah Donnelly's novel Veiled Threats and was supposed to be the first film in the channel's Mystery Wheel series adaptation. In 2015, she appeared in the thriller film Painkillers with Tahmoh Penikett. Durance appeared in The CW television series Supergirl in a recurring role as Kara's Kryptonian mother, Alura Zor-El, and as Agent Noel Neill in the episode "Midvale". Durance and her Smallville co-star Tom Welling reprised their roles as Lois and Clark in the Batwoman episode of the 2019 Arrowverse crossover event "Crisis on Infinite Earths". In 2022, Durance was cast in the Lifetime film Girl in the Shed: The Kidnapping of Abby Hernandez, which tells the real-life story the abduction of a 14 year old and how she survived against all odds. Part of the network's "Ripped from the Headlines" feature