myeloma, myeloid metaplasia, polycythemia EM minor is regarded as being triggered by HSV in almost all cases. A herpetic etiology also accounts for 55% of cases of EM major. Among the other infections, Mycoplasma infection appears to be a common cause. Herpes simplex virus suppression and even prophylaxis (with acyclovir) has been shown to prevent recurrent erythema multiforme eruption. Treatment Erythema multiforme is frequently self-limiting and requires no treatment. The appropriateness of glucocorticoid therapy can be uncertain, because it is difficult to determine if the course will be a resolving one. See also Erythema multiforme major Erythema multiforme minor Toxic epidermal necrolysis Stevens–Johnson syndrome References External links Erythemas Herpes simplex virus–associated diseases