CBR.com said, "The Immortal She-Hulk #1 provides a welcome window into Jennifer Walters' psyche as she grapples her own mortality and place in the Marvel Universe. While positioning She-Hulk for a bigger role in the main Immortal Hulk series and its escalating battle against the story's true, sinister mastermind the issue provides a nice change of pace by leaning more into introspection and character study than entirely focusing on smashing – though there is smashing to be had! For She-Hulk fans that have been looking for a less savage iteration of the character, this special one-shot issue provides them the chance to see both sides of Jennifer Walters in full." Connor Casey of Comicbook.com gave Immortal She-Hulk #1 a grade of 4 out of 5, asserting, "Al Ewing brings the brilliance from his Immortal Hulk run to this Immortal She-Hulk one-shot, in which Jennifer Walters explores some of the biggest ideas that haunt comic characters from the margins. What does it mean to come back from the dead? Is immortality real or is it merely a longer life span. What happens when somebody who is immortal suddenly… isn't? Ewing doesn't answer every question here (how could he possibly?) but it's fascinating to see characters like She-Hulk, Wolverine and Thor discuss these concepts." She-Hulk – 2022 According to Diamond Comic Distributors, She-Hulk #1 was the 9th best selling comic book in January 2022. Sayantan Gayen of CBR.com described She-Hulk #1 as "lighthearted story," saying, "She-Hulk #1 provides a rare insight into the busy civilian life of Jennifer Walters. Much of the positive tone of the issue exudes from its lead, but there is also a sense of anxiousness as Walters interacts with a new environment – a point well made by Rowell throughout the book. While the story does not have an antagonist yet, there is no sluggishness in the narrative's pace. The story's plot matches the speed of Jennifer's hectic schedule. Whatever serenity Jen finds in this story quickly ends when a long-forgotten Marvel character crashes through her door, ending She-Hulk #1 on a shocking and rewarding cliffhanger." Joe Garza of SlashFilm included She-Hulk #1 in their "15 Best She-Hulk Comics You Need To Read" list, stating, "This new solo series is the perfect jumping-on point for casual fans, as it establishes a whole new status quo for She-Hulk, setting the stage for adventures that aren't beholden to past continuity.