to reduce symptomatic knee pain in patients with RA 24 hours and 4 months post treatment, the reviewers concluded that the poor quality of the trial, including the small sample size preclude its recommendation. The reviewers further conclude that acupuncture has no effect on ESR, CRP, pain, patient's global assessment, number of swollen joints, number of tender joints, general health, disease activity and reduction of analgesics. These conclusions are limited by methodological considerations such as the type of acupuncture (acupuncture vs electroacupuncture), the site of intervention, the low number of clinical trials and the small sample size of the included studies." A 2016 systematic review and meta-analysis found inconclusive evidence that electroacupuncture was effective for nausea and vomiting and hyperemesis gravidarum during pregnancy. Regarding EAV devices, "results are not reproducible when subject to rigorous testing and do not correlate with clinical evidence of allergy". There is no credible evidence of diagnostic capability. The American Cancer Society has concluded that the evidence does not support the use of EAV "as a method that can diagnose, cure, or otherwise help people with cancer" or "as a reliable aid in diagnosis or treatment of .. other illness" In double-blind trials, "A wide variability of the measurements was found in most patients irrespective of their allergy status and of the substance tested. Allergic patients showed more negative skin electrical response at the second trial, compared to normal controls, independent of the tested substance. No significant difference in skin electrical response between allergens and negative controls could be detected." The use of electroacupuncture in veterinary medicine has been studied as well. A literature review in the journal Animals found that on dogs with spinal cord injury, "electroacupuncture can be an excellent complementary therapy for veterinary patients’ pain control." Safety Researchers at the U.S. Food and Drug Administration (FDA) Center for Devices and Radiological Health (Rockville, Maryland) evaluated three representative devices intended for electrostimulation of acupuncture needles. The abstract at PubMed summarizes their findings: "Three representative electrostimulators were evaluated to determine whether they meet the manufacturers' labeled nominal output parameters and how the measured parameters compare with a safety standard written for implanted peripheral nerve stimulators. The pulsed outputs (pulse width, frequency, and voltage) of three devices were measured with an oscilloscope across a 500-ohm resistance, meant to simulate subdermal tissue stimulated during electroacupuncture. For each device, at least two measured parameters were not within 25%