The HFMD cat has a deletion in the promoter region of the DMD gene. Muscle histology shows necrosis but no fibrosis. Extensive hypertrophy has been observed which is thought to be responsible for shorter lifespans. Due to the hypertrophy, this model may have limited uses for DMD studies. Therapeutic Microdystrophin Delandistrogene Moxeparvovec - Systemic Gene Transfer with rAAVrh74.MHCK7.micro-dystrophin. Interactions Dystrophin has been shown to interact with: DTNA, SNTA1, and SNTB1. Neanderthal admixture A variant of the DMD gene, which is on the X chromosome, named B006, appears to be an introgression from a Neanderthal-modern human mating. References Further reading External links GeneReviews/NCBI/NIH/UW entry on Dystrophinopathies LOVD mutation database: DMD, DMD (whole exon changes) Cytoskeleton Muscular dystrophy Cell adhesion proteins