TV movie of the family's surrogacy story. Alex is diagnosed with breast cancer, which leads her to doing a standup comedy act about her cancer experience. Frankie and Mitch divorce and spar over custody of Thomas George. Season Four Cat is attacked and raped by a college acquaintance; James Falconer (George Clooney) is assigned to investigate the case. He is able to help Cat remember her attacker, Kyle, and he is arrested. However the prosecution cannot prove its case and Kyle is found not guilty only to be shot and killed on the courthouse steps by a previous victim. Frankie quits her executive job and buys the Sweet Sixteen diner. Teddy and Falconer run into each other at an AA meeting and begin dating. Trevor rebels and is sent to boarding school, then runs away from the school and disappears. Georgie falls into a depression about her perceived failure as a parent and considers suicide, but decides against it and asks for help. Truman is diagnosed with Alzheimer's disease and initially refuses to tell Beatrice. The stress of Trevor's disappearance leads Georgie and John to separate. Alex gets her own talk show with a lesbian producer named Norma (Nora Dunn). Alex meets Big Al (Robert Klein) when he agrees to sponsor her talk show; she initially dislikes him but they soon begin dating. A fifth sister, Charlotte Bennett (Jo Anderson), is introduced. Charlotte is a cancer patient who needs a bone marrow donation from a relative. Although none of the sisters are a match, she receives the bone marrow from an unrelated donor. Keeping the customary manner in which her half-sisters go by male versions of their full names, Charley is brought into the family and welcomed, primarily through Frankie's effort and determination. Alex and Big Al marry; on their wedding night he is arrested for tax evasion. Georgie and John reunite after realizing they cannot control what happens to Trevor. Reed returns for a visit and gives birth to Halsey. Trevor finally returns from the streets when Winnetka is hit by a tornado, and Falconer and Teddy marry on a plane that is caught in the storm. Season Five Falconer is killed. His murder was ordered by a criminal he was about to testify against in court. Georgie begins seeing a new therapist, Dr. Caspian (Daniel Gerroll), who manipulates her into believing she had been molested by her father.