problematic topical antibiotic for the aforementioned conditions. Some bacteria also display 'FusB-type' resistance, which has been found to be the most prevalent in Staphylococcus spp. in many clinical isolates. This resistance mechanism is mediated by fusB, fusC, and fusD genes found primarily on plasmids, but have also been found in chromosomal DNA. The product of fusB-type resistance genes is a 213-residue cytoplasmic protein which interacts in a 1:1 ratio with EF-G. FusB-type proteins bind in a region distinct from fusidic acid to induce a conformational change which results in liberation of EF-G from the ribosome, allowing the elongation factor to participate in another round of ribosome translocation. Interactions Fusidic acid should not be used with quinolones, with which they are antagonistic. Although clinical practice over the past decade has supported the combination of fusidic acid and rifampicin, a recent clinical trial showed that there is an antagonic interaction when both antibiotics are combined. It has been reported on August 8, 2008, that the Irish Medicines Board was investigating the death of a 59-year-old Irish man who developed rhabdomyolysis after combining atorvastatin and fusidic acid, and three similar cases. In August, 2011, the UK's Medicines and Healthcare products Regulatory Agency issued a Drug Safety Update warning that "Systemic fusidic acid (Fucidin) should not be given with statins because of a risk of serious and potentially fatal rhabdomyolysis." Trade names and preparations Fucidin (of Leo in Canada) Fucidin H (topical cream with hydrocortisone - Leo) Fucidin (of Leo in UK/ Leo-Ranbaxy-Croslands in India) Fucidine (of Leo in France) Fucidin (of Leo in Norway and Israel) Fucidin (of Adcock Ingram, licensed from Leo, in South Africa) Fucithalmic (of Leo in the UK, the Netherlands, Denmark and Portugal) Fucicort (topical mixture with hydrocortisone) Fucibet (fusidic acid/betamethasone valerate topical cream) Ezaderm (topical mixture with betamethasone)(of United Pharmaceutical "UPM" in Jordan) Fuci (of pharopharm in Egypt) Fucizon (topical mixture with hydrocortisone of pharopharm in Egypt) Foban (topical cream in New Zealand) Betafusin (fusidic acid/betamethasone valerate topical cream in Greece) Betafucin (2% fusidic acid/1% betamethasone valerate topical cream in Egypt)(of Delta Pharma S.A.E., A.R.E. (Egypt)) Fusimax (of Roussette in India) Fusiderm (topical cream and ointment by Indi Pharma in India) Fusid (in Nepal) Fudic (topical cream in India) Fucidin (, of Donghwa Pharm in South Korea) Dermy (Topical cream of W. Woodwards in Pakistan) Fugen Cream ( in Taiwan) Phudicin Cream (in China; 夫西地酸) Fucidin Fusidic Acid