Diabetes Calcineurin along with NFAT, may improve the function of diabetics' pancreatic beta cells. Thus tacrolimus contributes to the frequent development of new diabetes following renal transplantation. Calcineurin/NFAT signaling is required for perinatal lung maturation and function. Organ transplantation Calcineurin inhibitors such as tacrolimus are used to suppress the immune system in organ allotransplant recipients to prevent rejection of the transplanted tissue. Interactions Calcineurin has been shown to interact with DSCR1 and AKAP5. References Further reading External links Signal transduction EC 3.1.3