of adult patients with NSCLC whose tumors have a KRAS G12C mutation and who have received at least one prior systemic therapy; this was the first approved targeted therapy for tumors with any KRAS mutation. Similar approvals for sotorasib in NSCLC followed in January 2022 in Europe and Japan. In September 2022, data from a late-stage study showed the company's cancer pill Lumakras beating out chemotherapy. This was the first approved drug in the set of treatments that target KRAS, among the most common generic mutations found in cancers but one where researchers have struggled for years to design drugs to treat. The drug was approved in 2021 with a list price of $17,900 per month. Carbon footprint Amgen reported Total CO2e emissions (Direct + Indirect) for the twelve months ending 31 December 2020 at 243 Kt (-6 /-2.4% y-o-y) and aims to reach net zero emissions by 2027. Public-private engagement Amgen engages with the public and private sectors in a variety of settings including to promote research and development, academic funding, event sponsorship, philanthropy, and political lobbying. Academia Institute for Advanced Study - Donor to various IAS campaigns, including the IAS/Park City Mathematics Institute (PCMI), the Regional Initiative in Science and Education (RISE), and the Opportunity Equation (OE). LA Promise Fund - Sponsor of the Amgen Biotech Experience Los Angeles (ABE-LA). University of Toronto - Donor to U of T's Boundless campaign. University of Washington - Donor. Events and conferences Alberta Kidney Days - Virtual series sponsor. BC Kidney Days - Sponsor. Mentoring in IBD - Sponsor. Princess Margaret Cancer Centre (PMCC) Conference - Sponsor. Health care Kingston General Hospital - Donor. Princess Margaret Cancer Centre - Donor to the Princess Margaret Cancer Foundation. Providence Health Care - Donor. Scarborough Health Network - Donor to the SHN Foundation. SickKids - Donor to the SickKids Foundation. Sinai Health System - Donor to the Sinai Health Foundation. St. Michael's Hospital - Donor. Sunnybrook Health Sciences Centre - Donor to the Sunnybrook Foundation. Unity Health Toronto - Donor. University Health Network - Donor to the UHN Foundation. Women's College Hospital - Donor. Media National Geographic Society - Donor. Medical societies American Society of Hematology - Corporate funder. Arthritis Society (Canada) - Partner. Canadian Society of Hospital Pharmacists - Donor to the CSHP Foundation. Canadian Society of Nephrology - Corporate partner. Endocrine Society - Corporate liaison board member. European Society of Cardiology -