U.S. Route 63 (US 63) is a , north–south United States Highway primarily in the Midwestern and Southern United States. The southern terminus of the route is at Interstate 20 (I-20) in Ruston, Louisiana; the northern terminus is at US 2 west of Ashland, Wisconsin. Route description Louisiana US 63 runs concurrently with US 167 for its entire route in Louisiana, from Ruston north, to Junction City, at the Arkansas state line, a distance of . Arkansas U.S. 63 enters into Arkansas from Louisiana concurrent with US 167 in Junction City. Just a few miles into the state, the two highways run on the eastern edge of El Dorado as an expressway. US 167 splits here, traveling towards Hampton. US 63 bypasses the town of Warren, crossing US 270. US 63 passes through the rural Cleveland County, then enters into Jefferson County. In Jefferson County, US 63 serves the city of Pine Bluff. US 63 bypasses the city, running on the last 3 miles of I-530. Also in Pine Bluff, the highway overlaps with US 65 and US 79. US 63 runs northeast with US 79 until Stuttgart, where the highway runs north to Hazen. Just north of Hazen, US 63 overlaps with I-40 to Brinkley. In Brinkley, US 63 begins an overlap with US 49 north to Jonesboro. US 63 leaves US 49 and follows I-555 until I-555 terminates, together serving as a bypass for southern Jonesboro. In Hoxie, US 63 intersects with US 67 (Future I-57). Northwest of here near Portia the highway overlaps with US 412. In Imboden US 62 joins this overlap. In Hardy, US 63 leaves the two highways. In Mammoth Spring, US 63 crosses into Missouri, traveling to West Plains. While historically there were many non-concurrencies on US 63, many of those have been resolved. In 2016, US 63 from Jonesboro (including the US 49 concurrency) to Turrell was designated as I-555. As a result, US 63 was rerouted to run concurrently with US 49 from Brinkley to Jonesboro. US 63 then runs concurrently with US 49 and I-555 until Southwest Drive in Jonesboro, where it then continues northwest alone to its concurrency with US 412 at Portia, just northwest of Walnut Ridge. Missouri The highway passes south-to-north through Missouri, from Arkansas to Iowa, serving cities such as Rolla, Jefferson City, Columbia, Moberly, Macon, and Kirksville. Notable routes that are intersected include US 60