power spread around the globe. Painting and sculpture Early Netherlandish painting often included complicated iconography, and art historians have debated the "hidden symbolism" of works by artists like Hubert and Jan van Eyck. The detailed realism of Early Netherlandish painting, led by Robert Campin and Jan van Eyck in the 1420s and 1430s, is today generally considered to be the beginning of the early Northern Renaissance in painting. This detailed realism was greatly respected in Italy, but there was little reciprocal influence on the North until nearly the end of the 15th century. Despite frequent cultural and artistic exchange, the Antwerp Mannerists (1500–1530)—chronologically overlapping with but unrelated to Italian Mannerism—were among the first artists in the Low Countries to clearly reflect Italian formal developments. Around the same time, Albrecht Dürer made his two trips to Italy, where he was greatly admired for his prints. Dürer, in turn, was influenced by the art he saw there and is agreed to be one of the first Northern High Renaissance painters. Other notable northern painters such as Hans Holbein the Elder and Jean Fouquet, retained a Gothic influence that was still popular in the north, while highly individualistic artists such as Hieronymus Bosch and Pieter Bruegel the Elder developed styles that were imitated by many subsequent generations. Later in the 16th century Northern painters increasingly looked and travelled to Rome, becoming known as the Romanists. The High Renaissance art of Michelangelo and Raphael and the late Renaissance stylistic tendencies of Mannerism that were in vogue had a great impact on their work. Renaissance humanism and the large number of surviving classical artworks and monuments encouraged many Italian painters to explore Greco-Roman themes more prominently than northern artists, and likewise the famous 15th-century German and Dutch paintings tend to be religious. In the 16th century, mythological and other themes from history became more uniform amongst northern and Italian artists. Northern Renaissance painters, however, had new subject matter, such as landscape and genre painting. As Renaissance art styles moved through northern Europe, they changed and were adapted to local customs. In England and the northern Netherlands the Reformation brought religious painting almost completely to an end. Despite several very talented artists of the Tudor Court in England, portrait painting was slow to spread from the elite. In France the School of Fontainebleau was begun by Italians such as Rosso Fiorentino in the latest Mannerist style,