Argyreia nervosa is a perennial climbing vine native to the Indian subcontinent and introduced to numerous areas worldwide, including Hawaii, Africa, and the Caribbean. Though it can be invasive, it is often prized for its aesthetic and medicinal value. Common names include Hawaiian baby woodrose, adhoguda अधोगुडा or vidhara विधारा (Sanskrit), elephant creeper and woolly morning glory. Its seeds are known for their powerful entheogenic properties, greater or similar to those of Ipomoea species, with users reporting significant psychedelic and spiritual experiences. The two botanical varieties are A. n. var. nervosa described here, and A. n. var. speciosa, which are used in Ayurvedic medicine for their medicinal value. Argyreia nervosa seeds contain various ergoline alkaloids such as ergine. A study reported stereoisomers of ergine to be found in the seeds at a concentration of 0.325% of dry weight. A more recent study reported presence of ergometrine, lysergol, lysergic acid and other alkaloids that contribute to its pharmacological effects. History While several other plants in the family Convolvulaceae, such as Ipomoea corymbosa (ololiuhqui) and Ipomoea tricolor (tlitliltzin), were used in shamanic rituals of Latin America for centuries, A. nervosa was not traditionally used for this purpose. Its properties were first brought to attention in the 1960s. Cultivation Where temperatures fall below 13 °C (55 °F), Argyreia nervosa is grown in a warm greenhouse. Elsewhere, it is grown on arbours, pergolas, walls, or trees. It is often grown professionally under glass in a loam-based potting compost (John Innes No. 3) in full light, and watered freely from spring to autumn, with a balanced liquid fertilizer applied monthly and reduced water in winter. It is grown outdoors in moderately fertile, moist but well-drained soil in full sun. Pruning is done in late winter. Glycosides Argyroside, (24R)-ergost-5-en-11-oxo-3β-ol-α-D-glucopyranoside, a steroidal glycoside unique to Argyreia nervosa Ergolines Hydroxycinnamic acids Fatty acids Entheogen Certain New Age sources claim that, according to 'various oral histories' Huna shamans used the powdered seeds to prepare an entheogenic drink. This is unlikely to reflect an authentic practice having once formed a part of traditional Hawaiian Religion, given that Huna has been widely discredited as a culturally appropriative New Age religion invented by Max Freedom Long. The seeds of Argyreia nervosa can produce psychoactive effects, but it has not yet been demonstrated satisfactorily that their use as an entheogen predates the various countercultural movements of the 1960s. Given that A. nervosa is