health, problematizing "women's weakness" of emotionality and "hysteria". Some of the original product advertised such notions as encouraging sexual activity with husbands, encouraging reproduction, and "restoring women's pep" so that they might prove better wives and mothers. Medical experts dismissed Pinkham's claims as quackery. In 1922, it was described as a "valueless preparation kept on the market for about fifty years by means of lying advertisements and worthless testimonials." The popularity of Pinkham's compound long after her death is testament to its acceptance by women who sought relief from menstrual and menopausal symptoms. The company continued under family control until the 1930s. Although Lydia Pinkham's company continued increasing profit margins 50 years after her death, eventually the advent of the Food and Drug Administration (FDA) caused changes in the formula. In 2005–6 the National Institutes of Health performed a "12-month randomized, double-blind, placebo-controlled trial, [which] compared several herbal regimens and menopausal hormone therapy (estrogen with or without progesterone) to placebo in women ages 45 to 55 [...] Newton and colleagues found no significant difference between the number of daily hot flashes and/or night sweats in any of the herbal supplement groups when compared to the placebo group." Original product and modern descendants The original formula for Lydia Pinkham's Vegetable Compound was: Unicorn root (Aletris farinosa L.) 8 oz. Life root (Senecio aureus L.) 6 oz. Black cohosh (Cimicifuga racemosa (L.) Nutt.) 6 oz. Pleurisy root (Asclepias tuberosa L.) 6 oz. Fenugreek seed (Trigonella foenum-graecum L.) 12 oz. Alcohol (18%) to make 100 U.S. pints , Numark Laboratories of Edison, New Jersey, markets a similar product named "Lydia Pinkham Herbal Compound". The product is carried by the Walgreens, CVS and Rite Aid drugstore chains. Ingredients listed in this product are: Motherwort (Leonorus cardiaca) Gentian (Gentiana lutea) Jamaican dogwood (Piscidia piscipula) Pleurisy root (Asclepias tuberosa) Licorice (Glycyrrhiza glabra) Black cohosh (Cimicifuga racemosa) Dandelion (Taraxacum officinale). Time of Your Life Nutraceuticals of St. Petersburg, Florida, produces a product named "Lydia's Secret" for Lydiapinkham.org. Said to be "based on" the original formula, it has these listed ingredients Black cohosh root (Cimicifuga racemosa) Dandelion root (Taraxacum officinale) Pleurisy root (Asclepias tuberosa) Chastetree berry (Vitex agnus-castus) False unicorn root (Chamaelirium luteum) Jamaica dogwood bark (Piscidia piscipula) Gentian root (Gentiana lutea) Vitamin E Vitamin B6 Magnesium Zinc Popular culture Drinking songs Pinkham and her "medicinal compound" are memorialized in the folk song "The Ballad of Lydia Pinkham",