dopaminergic and serotonergic receptors and blocks alpha-adrenoreceptors. Current studies imply that the major effect of hydergine may be the modulation of synaptic neurotransmission rather than solely increasing blood flow as was once thought. A prominent feature that accompanies aging is an increase in monoamine oxidase (MAO) levels. This results in decreased availability of catecholamines in the synaptic cleft. In one study, an interaction between age and hydergine treatment was observed in the hypothalamus, hippocampus and cerebellum. The hydergine effect was more pronounced in the aged group in the hypothalamus and cerebellum, and more pronounced in the adult in the hippocampus. These findings imply that increased brain MAO activity in aging can be modified by hydergine treatment in some brain regions. Chemistry The four constituents differ only in which of four proteinogenic amino acids is used in biosynthesis: Society and culture Brand names Brand names include Hydergine, Hydergina, Gerimal, Niloric, Redizork, Alkergot, Cicanol, Redergin, and Hydrine. References External links Ergoloid Mesylates (University of Maryland Medical Center) Ergoloid Mesylates (Mayo Foundation for Medical Education and Research (MFMER).) Antidementia agents Drugs with unknown mechanisms of action GABAA receptor positive allosteric modulators Lactams Lysergamides Nootropics Oxazolopyrrolopyrazines