catastrophe Genetic drift Genetic load Muller's ratchet References Further reading (This paper describes computer simulations of small populations with variations in mutation rate and other factors, and produces results that are dramatically different from Haldane's low substitution limit except in certain limited situations). Population genetics Evolutionary biology Mathematical and theoretical biology Works by J. B. S. Haldane Dilemmas it:Disegno intelligente#Dilemma di Haldane