The Canadian Medical Association Journal (French Journal de l'Association Médicale Canadienne) is a peer-reviewed open-access general medical journal published by the Canadian Medical Association. It publishes original clinical research, analyses and reviews, news, practice updates, and editorials. Notable articles The journal has published the following notable articles: Banting and Best's 1922 report, "Pancreatic extracts in the treatment of diabetes mellitus". Banting and Macleod were awarded a Nobel Prize for the discovery of insulin in 1923. 1926 – the first use of liver as a treatment for anemia, which led to the isolation of vitamin B12. 1938 – CMAJ warns about the relationship between sun exposure and skin cancer. 2003 – CMAJ responds rapidly to SARS (severe acute respiratory syndrome), publishing timely information during the outbreak. 2009 – CMAJ publishes a research paper on the increased risk of reinfarction associated with proton pump inhibitors and clopidogrel, which has been widely cited and generated related research studies on the topic. CMAJ Open CMAJ Open, an online open-access offshoot established in January 2013 with Diane Kelsall as its editor-in-chief, has an open peer-review system which makes reviewer comments, author responses, and previous versions available online along with the final versions of contributions. History A prime mover behind establishment of the Canadian Medical Association Journal was Andrew Macphail, chair of the history of medicine at McGill University and editor of the Montreal Medical Journal. At the Canadian Medical Association's 1907 annual meeting held in Montreal, "Macphail argued that without a journal to express its views and record its proceedings the association would have little impact", and was successful in getting a clause urging the founding of a journal put into the CMA constitution. At the 1910 meeting an executive report was adopted urging immediate steps to found a journal. Macphail was appointed the first editor. The Montreal Medical Journal was acquired, and the Maritime Medical News agreed to suspend publication. The first issue of the new Canadian Medical Association Journal was published in January 1911. In 1913, for the first time, the journal showed a profit, which was sufficient to liquidate the previous deficit. Subscriptions had increased 60% over the 1911 level and were being purchased by 20% of Canadian doctors. On February 20, 2006, the editor-in-chief, John Hoey, was fired over an editorial independence dispute with the then owners of the journal, CMA Media. The journal sent 13 women to buy the emergency