The Rogue Valley is a valley region in southwestern Oregon in the United States. Located along the middle Rogue River and its tributaries in Josephine and Jackson counties, the valley forms the cultural and economic heart of Southern Oregon near the California border. The largest communities in the Rogue Valley are Medford, Ashland and Grants Pass. The most populated part of the Rogue Valley is not along the Rogue proper, but along the smaller Bear Creek tributary. The Rogue Valley is a popular fall destination in Oregon because of the hardwood forests there. The valley forms a relatively isolated enclave west of the Cascade Range along the north side of the Siskiyou Mountains. It is separated from the nearby coast by a high section of the Southern Oregon Coast Range. The valley is characterized by a mild climate that allows a long growing season, especially for many varieties of fruits, nuts and herbs. A regional manufacturing industry is centered in Medford, the most highly populated area of the valley. In recent years the valley has emerged as a wine-growing region and it is the location of the Rogue Valley AVA (American Viticultural Area). The mild climate and relative isolation have made the valley a popular retirement destination. The community of Ashland is famous for the Oregon Shakespeare Festival. Interstate 5 follows the valley through Ashland, Medford and Grants Pass. History In the early 19th century the first European Americans began to pass through the valley, inhabited by the Shasta, Takelma, and Rogue River Athabaskan tribes of Native Americans. The early fur traders named this river the "River of the Rogues". White settlers began to arrive in the valley after the Donation Land Act, which allocated of land to each married couple. Between 1836 and 1856, the valley was the scene of a series of bloody conflicts between European Americans and the Rogue River tribes. In 1850 gold was discovered on the Rogue River and the next year in the nearby mountains. Early mining activity was centered on the lower Rogue River, on Althouse Creek in Josephine County, and near the now-restored town of Jacksonville, west of Medford. During the gold rush some $70 million was extracted from the area. Climate Unlike the rest of Western Oregon, because of the rain shadow effect resulting from the close range of the Cascades and Siskiyous, the Rogue Valley is relatively dry when compared