In 2013, oral ketoconazole was withdrawn in Europe and Australia, and strict restrictions were placed on the use of oral ketoconazole in the United States and Canada. Oral ketoconazole is now only indicated for use in these countries when the indication is a severe or life-threatening systemic infection and alternatives are unavailable. However, topical ketoconazole, which does not distribute systemically, is safe and widely used still. Ketoconazole HRA was approved for use in the European Union for treatment of Cushing's syndrome in November 2013. As of March 2019, oral levoketoconazole (developmental code name COR-003, tentative brand name Recorlev) is phase III clinical trials for the treatment of Cushing's syndrome. Oral levoketoconazole may have a lower risk of liver toxicity than oral ketoconazole. Society and culture Generic names Ketoconazole is the generic name of the drug and its , , , and . Brand names Ketoconazole has been marketed under a large number of brand names. Availability Ketoconazole is available widely throughout the world. In 2013, the European Medicines Agency's Committee on Medicinal Products for Human Use (CHMP) recommended that a ban be imposed on the use of oral ketoconazole for systemic use in humans throughout the European Union, after concluding that the risk of serious liver injury from systemic ketoconazole outweighs its benefits. Veterinary use Ketoconazole is sometimes prescribed as an antifungal by veterinarians for use in pets, often as unflavored tablets that may need to be cut to smaller size for correct dosage. References External links 7α-Hydroxylase inhibitors 11β-Hydroxylase inhibitors 21-Hydroxylase inhibitors Acetamides Aldosterone synthase inhibitors Antifungals for dermatologic use Antiglucocorticoids Aromatase inhibitors Belgian inventions Chloroarenes Cholesterol side-chain cleavage enzyme inhibitors CYP2D6 inhibitors CYP3A4 inhibitors CYP17A1 inhibitors Dioxolanes Disulfiram-like drugs Endocrine disruptors Hair loss medications Hepatotoxins Hormonal antineoplastic drugs Imidazole antifungals Phenylethanolamine ethers Janssen Pharmaceutica Johnson & Johnson brands Lanosterol 14α-demethylase inhibitors Nonsteroidal antiandrogens Para-Methoxyphenylpiperazines Pregnane X receptor antagonists Wikipedia medicine articles ready to translate General cytochrome P450 inhibitors