per week, as opposed to daily as with methadone. In 2001, levacetylmethadol was removed from the European market due to reports of life-threatening ventricular rhythm disorders. In 2003, Roxane Laboratories, Inc. discontinued Orlaam in the US. See also Benzodiazepine withdrawal syndrome Doctor shopping Hyperkatifeia, hypersensitivity to emotional distress in the context of opioid abuse Prescription drug abuse References Further reading Seabra, P., Sequeira, A., Filipe, F., Amaral, P., Simões, A., & Sequeira, R. (2022). Substance addiction consequences: outpatients severity indicators in a medication-based program. International Journal of Mental Health & Addiction, 20(3), 1837–1853. https://doi.org/10.1007/s11469-021-00485-3 External links Heroin information from the National Institute on Drug Abuse Opioid Dependence Treatment and Guidelines Substance dependence Dependence Wikipedia medicine articles ready to translate