of cells within cerebral organoids can inform on the underlying regulatory mechanisms governing human brain development. Kanton et al., describe an approach on obtaining meaningful scRNA seq and assay for transposase-accessible chromatin using sequencing (ATAC-seq) data from brain organoids. The protocol can likely translate to myelin organoids due to the similar biology between cerebral organoids and myelinoids. Orgo-Seq Orgo-seq is a framework through which bulk RNA (bRNA) and scRNA sequencing data of organoids can be integrated. This platform was developed by Lim et al. to address challenges associated with phenotyping organoids and demonstrated its ability to identify critical cell types and cell type specific driver genes involved with neurodevelopmental disorders and disease manifestation. Using the Orgo-Seq framework they developed, Lim et al., used, three datasets (bRNA-seq from donor derived organoids, scRNA-seq data from cerebral organoids and fetal brains in precious studies, and bRNA-seq from the BrainSpan Project of human post-mortem brains) to study copy number variants in autism spectrum disorder. They leveraged several datasets to identify the types of cells present and cell specific driver genes in patient derived organoids. Brain organoids serve as a human-derived model through which genetic variation and its impact on cell specific processes and association with neurodevelopmental and neurodegenerative disorders can be studied. Specifically, myelinoids provide a system to study the cell type specific effects in oligodendrocytes that are disrupted by genetic variants. Overall, Orgo-Seq provides a quantitative and validated framework for investigating driver genes and their role in neurological and neurological disorders. In the future, Lim et al., aim to develop a precision medicine framework to identify gene networks and effects of genetic variants in an organoid system, which would include myelinoids, that recapitulates the patient’s exact genetic background. Advantages With the absence of human brain tissue, myelinoids offer unprecedented opportunities for studying oligogenesis and myelination. While animal models are valuable for studying human diseases, they do not fully recapitulate human brain development and show many discrepancies affecting their translatability to human physiology. Considering resemblance of myelin organoids to the human brain, they have been proposed as models bridging between animal models and human physiology. Other hPSC derived oligodendrocytes systems have been established, such as the two dimensional (2D) monolayer oligodendrocytes models. However, when compared to 2D systems, myelin organoids more faithfully recapitulate the structure and functionality of the developing human brain containing a more physiologically relevant microenvironment including their 3D cytoarchitecture, neural circuits,