style="| | style="| Cardinals 18–15 (OT) | style="| Cardinals 20–10 | 49ers 29–24 | |- | | style="| | style="| Cardinals 18–15 | style="| Cardinals 28–18 | 49ers 29–26 | Cardinals win 8 straight meetings (2015–18). |- | | style="| | style="| 49ers 28–25 | style="| 49ers 36–26 | 49ers 31–26 | 49ers lose Super Bowl LIV. |- |- | | Tie 1–1 | style="| 49ers 20–12 | style="| Cardinals 24–20 | 49ers 32–27 | |- | | style="| | style="| Cardinals 17–10 | style="| Cardinals 31–17 | 49ers 32–29 | |- | | style="| | style="| 49ers 38–10 | style="| 49ers 38–13 | 49ers 34–29 | Cardinals home game played in Mexico City, at Estadio Azteca on Monday Night Football. |- |- | Regular season | style="| | Tie 15–15 | 49ers 19–14 | 49ers won series in St. Louis 4–2. Teams are tied 1–1 in Mexico City, officially Cardinals home games. |- References Arizona Cardinals San Francisco 49ers National Football League rivalries Arizona Cardinals rivalries San Francisco 49ers rivalries American football in St. Louis