Dok-1 Max is a type of cold medicine manufactured by Marion Biotech Pvt. Ltd. Produced in India. It contains paracetamol, guaifenesin, and phenylephrine hydrochloride. Pharmacotherapeutic group Analgesic antipyretic belongs to the group, international pharmacological code ATX N02BE51. Pharmacological properties Pharmacokinetics Paracetamol is absorbed in the gastrointestinal tract (GIT), and reaches the highest plasma concentration 10-60 minutes after ingestion. Guaiphenesin is rapidly absorbed in the gastrointestinal tract (25-30 minutes after consumption). Metabolized in the liver. The half-life is 1 hour. It is excreted in the urine in the form of inactive metabolites. Phenylephrine hydrochloride – after oral administration, the elimination process is slow. It is metabolized by monoamine oxidase (MAO) during passage through the intestinal wall and liver. Part of the dose is excreted unchanged in the urine. Pharmacodynamics Paracetamol in the drug is an analgesic that does not require habituation. In addition, paracetamol is an antipyretic and weak anti-inflammatory drug. The mechanism of action is associated with inhibiting prostaglandin synthesis and blocking cyclooxygenase enzyme (COX-1, COX-2) in the central nervous system, thermoregulation center and Hypothalamus affects pain receptors in the hypothalamus. and guaifenesin is an expectorant. Reduces the surface tension and viscosity properties of sputum, which facilitates the evacuation of sputum from the respiratory tract. Phenylephrine hydrochloride has a vasoconstrictive effect, reduces swelling and hyperemia of the mucous membranes of the upper respiratory tract and nasal sinuses. Instructions for use ORVI, Cough in inflammations of the nasal area Method of administration and doses Syrup: Adults over 12 years old 10 ml 3-4 times a day 6-12 years old 5 ml 3-4 times a day 2-6 years old 2.5 ml 3-4 times a day. Side effects Observed in many cases: Headache Dizziness Rashes on the skin Nausea Note Epigastral pain in the area Observed in few cases: Acute pancreatitis Midriaz Glaucoma Depression Trombotsitopeniya Leykopeniya Gipoglikemiya Dizuriya When overdosed Diarrhea Bleeding from the stomach Psychomotor disorders Hypoglycemic coma Nephrotoxic conditions. Adverse effects Hypersensitivity to drug components Concomitant use of other paracetamol preservatives Hypothyroidism Arterial hypertension Ischemic heart disease Raynaud's syndrome Epilepsy Liver and kidney failure Bronchial asthma Hepatitis Pancreatitis Stomach and duodenal ulcer disease Diabetes Pregnancy and lactation period. The drug is produced in the form of tablets and syrup. Given without a doctor's prescription. As of December 27, 2022, the drug was withdrawn from sale in all pharmacies in Uzbekistan. See also Uzbekistan cough syrup scandal References Antitussives