Chromosome 21 () is a Spanish crime thriller television series co-created by Matías Venables and Nico Martínez Bergen. The series traces a police investigation into a young man with down syndrome involved in a murder. It had its original run on Chilean network Canal 13 on 14 October 2022. Netflix then acquired global streaming rights, and released it on their platform on 8 February 2023. The series received four nominations at the 7th Caleuche Awards, with Sebastián Solorza winning the breakthrough actor award, and five nominations for the 10th Platino Awards. Plot Cast Main Sebastián Solorza as Tomás "Tomy" Ruiz: a young man with down syndrome who becomes involved in a crime because of his brother Valentina Muhr as Mariana Enríquez: the commissioner of the homicide brigade of the Investigations Police of Chile (PDI) Mario Horton as Bruno Durán: the deputy commissioner of the homicide brigade Gastón Salgado as Guillermo "Bekam" Ruiz: Tomy's younger brother Claudia di Girolamo as Sofía Lombardi: the director of the "Down Up Foundation" and Cristina's mother Pía Urrutia as Cristina Pérez: Sofía's daughter and Tomy's fiancée with down syndrome Daniel Muñoz as Ariel "Coya" Zavala: a former Carabinero who owns the factory where the murder occurred Alejandro Trejo as Rafael Santoro, PDI subprefect; Enríquez and Durán's boss Production The series was originally meant to tell the story of a 42-year-old nurse who finds out she is pregnant with a baby with down syndrome, and received a grant for it from the National Television Council. Filming took place in Santiago and began on 27 September 2021. Awards and nominations References External links Television shows based on books Police procedural television series Drama television series Thriller television series Television shows set in Santiago Spanish-language television shows Spanish-language Netflix original programming 2022 Chilean television series debuts 2020s Chilean television series 2022 television series debuts