although some cases have been reported; their rarity is probably due to the male's smaller size and proportionally smaller fangs, rather than its being incapable of biting or lacking potent venom. The bite from both juvenile and mature females appears to have similar potency. The male bite usually only produces short-lived, mild pain. Most bites occur in the warmer months between December and April, in the afternoon or evening. As the female redback is slow-moving and rarely leaves her web, bites generally occur as a result of placing a hand or other body part too close to the spider, such as when reaching into dark holes or wall cavities. Bites often also occur when a hidden spider is disturbed in items such as clothes, shoes, gloves, building materials, garden tools or children's outdoor toys. A 2004 review reported 46% of bites occurring on distal extremities of the limbs, 25% on proximal areas of limbs (upper arms and thighs), 21% on the trunk, and 7% on the head or neck. In some cases the same spider bites a victim multiple times. Historically, victims were often bitten on the genitalia, though this phenomenon disappeared as outhouses were superseded by plumbed indoor toilets. Conversely, bites on the head and neck have increased with use of safety helmets and ear muffs. Precautions to avoid being bitten include wearing gloves and shoes while gardening, not leaving clothes on the floor, and shaking out gloves or shoes before putting them on. Also, children can be educated not to touch spiders. Venom The redback and its relatives in the genus Latrodectus are considered dangerous, alongside funnel-web spiders (Atrax and Hadronyche), mouse spiders (Missulena), banana spiders (Phoneutria) and recluse spiders (Loxosceles). Venom is produced by holocrine glands in the spider's chelicerae (mouth parts). Venom accumulates in the lumen of the glands and passes through paired ducts into the spider's two hollow fangs. The venom of the redback spider is thought to be similar to that of the other Latrodectus spiders. It contains a complex mixture of cellular constituents, enzymes and a number of high-molecular-weight toxins, including insect toxins and a vertebrate neurotoxin called alpha-latrotoxin, which causes intense pain in humans. In vertebrates, alpha-latrotoxin produces its effect through destabilisation of cell membranes and degranulation of nerve terminals, resulting in excessive release of neurotransmitters, namely acetylcholine, norepinephrine and GABA. Excess neurotransmitter activity leads to clinical manifestations of envenomation, although the