and likely NRA due to bupropion's major metabolite hydroxybupropion) Cocaine Fluorenol (extremely weak) Medifoxamine (relatively weak) Metaphit (irreversible; depletes dopamine) Methylphenidate (has a mild degree of selectivity for dopamine over norepinephrine reuptake inhibition, although it significantly affects both) Nomifensine (Dual selective norepinephrine–dopamine reuptake inhibitor (NDRI) is a drug used for the treatment of clinical depression, attention deficit hyperactivity disorder (ADHD), narcolepsy, and the management of Parkinson's disease. Phenylpiracetam Isopropylphenidate Rimcazole Venlafaxine (weak) Solriamfetol (also norepinephrine reuptake inhibitor) Other DRIs Chaenomeles speciosa (Flowering quince) Oroxylin A (found in Oroxylum indicum and Scutellaria baicalensis (Skullcap)) See also Monoamine reuptake inhibitor Dopamine agonist References