the Sinister Six in order to get revenge on Doctor Octopus for turning him into glass in "The Return of the Sinister Six" storyline. The Sinister Six are defeated again, and Venom subsequently attacks the various members of the group after being betrayed by them. He nearly kills the Sandman and badly injures Electro and Kraven the Hunter before he and his symbiote are briefly separated from each other by the mysterious Senator Ward. Sinister Twelve In Marvel Knights Spider-Man, Norman Osborn is unmasked to the public as the Green Goblin and imprisoned. Osborn contacts a group of supervillains who also bear grudges against Spider-Man, all of whom had been financed by Osborn's fortunes for years. Eager to retaliate, the villains agree to band together, and the Sinister Twelve is formed. Mac Gargan is the de facto leader of the Twelve while Osborn is in prison, and he kidnaps Peter Parker's Aunt May and threatens to kill her if Spider-Man does not help Osborn escape from jail. Spider-Man, with help from Black Cat, breaks Osborn out only to be confronted by the Vulture, the Sandman, Electro, the Chameleon, the Lizard, Hydro-Man, the Shocker, Hammerhead, Boomerang and Tombstone. Osborn, now in the guise of the Goblin, introduces them as the Sinister Twelve. Spider-Man and Black Cat are rescued by Captain America, Iron Man, Daredevil, Yellowjacket and the Fantastic Four. Furious, Goblin rockets away and kidnaps Mary Jane Watson and Spider-Man pursues him. Spider-Man and the Goblin clash upon a bridge (not the one where Gwen Stacy was killed). Finally, Osborn gives a vital clue as to Aunt May's whereabouts before being knocked into the river below. In the aftermath, Aunt May is found and saved. The rest of the Sinister Twelve are subdued by the other heroes and arrested. Civil War's Sinister Six A new version of the Sinister Six apparently bands together during the Civil War storyline. The line-up consists of Doctor Octopus, Grim Reaper, Lizard, Shocker, Trapster and Vulture. They are stopped by Captain America and his Secret Avengers off-panel and discovered bound and subdued by S.H.I.E.L.D. "Big Time" Sinister Six Following the events of the "Origin of the Species" storyline which involves Doctor Octopus assembling Spider-Man's enemies into targeting Harry Osborn's baby (who Doctor Octopus thought had some of Norman Osborn's DNA), only the Chameleon, Electro, Mysterio, the Rhino, and the Sandman remain with Doctor Octopus to reform