16. In North Carolina, US 21 originally entered the state along today's NC 51 into Pineville, then followed Old Pineville Road into Charlotte. In the mid-1930s, US 21 moved over to South Boulevard from Old Pineville Road. In 1969, US 21 was rerouted following today's I-77 alignment, the old route was replaced by an extension of US 521. From 1975–87, US 21 moved north in segments onto I-77 to its current alignment ending at exit 16A (Sunset Road). Further north, US 21 originally followed Old Statesville Road, replaced in 1956 by NC 115. In 1966, US 21 was bypassed around Jonesville and Elkin, replaced with US 21 Business. Major intersections Special routes and auxiliary routes There are currently four active business loops and two known connectors along its route. U.S. Route 21 Business (Beaufort, South Carolina) U.S. Route 21 Business (Orangeburg, South Carolina) U.S. Route 21 Connector (Orangeburg, South Carolina) U.S. Route 21 Connector (Columbia, South Carolina) U.S. Route 21 Business (Fort Mill, South Carolina) U.S. Route 21 Business (Elkin, North Carolina) Auxiliary routes of U.S. Route 21 U.S. Route 121 U.S. Route 221 U.S. Route 321 U.S. Route 421 U.S. Route 521 See also Blue Ridge Parkway Catawba River Carowinds Congaree River Hunting Island State Park Lake Norman Lake Norman State Park Lake Wateree Lake Wateree State Recreation Area Marine Corps Air Station Beaufort Mount Rogers National Recreation Area New River North Carolina Bicycle Route 4 Stone Mountain State Park Uptown Charlotte Yadkin River References External links Endpoints of U.S. Highway 21 21 21 21 21 Transportation in Grayson County, Virginia Transportation in Wythe County, Virginia Transportation in Alleghany County, North Carolina Transportation in Iredell County, North Carolina Transportation in Mecklenburg County, North Carolina Transportation in Surry County, North Carolina Transportation in Wilkes County, North Carolina Transportation in Yadkin County, North Carolina Transportation in Bamberg County, South Carolina Transportation in Beaufort County, South Carolina Transportation in Calhoun County, South Carolina Transportation in Chester County, South Carolina Transportation in Colleton County, South Carolina Transportation in Fairfield County, South Carolina Transportation in Hampton County, South Carolina Transportation in Lexington County, South Carolina Transportation in Orangeburg County, South Carolina Transportation in Richland County, South Carolina Transportation in York County, South Carolina 21 21