In 2014, Crest Fresh and White were introduced as a replacement for the discontinued Gleem brand. Manufacturing plants Crest products are made in North America according to Procter & Gamble. Their main manufacturing plant is located in Greensboro, NC. A few products are manufactured in Guanajuato, Mexico. Product line Crest has also been associated with about twenty brands of dental care products, including toothpaste, toothbrushes, mouthwash, dental floss, and a tooth-whitening product called Crest Whitestrips. Crest Toothpaste has a total of eight product lines: Gum Health 3D White Kid's Crest Pro-Health Sensitivity Enamel Clean + Fresh Future-Proof Crest Pro-Health mouthwash side effects Tooth staining Crest Pro-Health mouthwash contains cetylpyridinium chloride which is known to cause tooth staining in approximately 3 percent of users. Crest has noted that this staining is actually an indication that the product is working as intended, as the stains are a result of bacteria dying on the teeth. Crest stated that because of the low incidence of staining, there was no need to label Pro-Health mouthwash as a potential tooth stainer. However, after numerous complaints and a federal class-action lawsuit, which was later dismissed, the mouthwash now contains a label warning consumers of its potential to stain teeth. Reducing premature birth The use of Crest Pro-Health mouthwash during pregnancy has been shown to be associated with a decrease in preterm births, presumably because the mouthwash reduces the severity of periodontal disease, which is directly linked to preterm births. Timeline 1955, Crest with Fluoristan was launched in a number of test markets in the United States. In January 1956, Crest was launched nationally. In 1960, the American Dental Association issued a report confirming that toothpaste is effective in preventing tooth decay. In 1976, the American Chemical Society names Crest with fluoride one of the greatest discoveries in the past 100 years. See also Crest Whitestrips List of toothpaste brands Index of oral health and dental articles References External links Product details and history of Crest toothpaste—from its manufacturer, Procter & Gamble, via the Wayback Machine Birth of an Icon: CREST —P&G's current history page Crest brand website Brands of toothpaste Procter & Gamble brands Products introduced in 1955