without any assumptions about space-time structure. But when transitions from the far-past to the far-future occur in one step with no intermediate steps, it becomes difficult to calculate anything. In quantum field theory, the intermediate steps are the fluctuations of fields or equivalently the fluctuations of virtual particles. In this proposed S-matrix theory, there are no local quantities at all. Heisenberg proposed to use unitarity to determine the S-matrix. In all conceivable situations, the sum of the squares of the amplitudes must equal 1. This property can determine the amplitude in a quantum field theory order by order in a perturbation series once the basic interactions are given, and in many quantum field theories the amplitudes grow too fast at high energies to make a unitary S-matrix. But without extra assumptions on the high-energy behavior, unitarity is not enough to determine the scattering, and the proposal was ignored for many years. Heisenberg's proposal was revived in 1956 when Murray Gell-Mann recognized that dispersion relations—like those discovered by Hendrik Kramers and Ralph Kronig in the 1920s (see Kramers–Kronig relations)—allow the formulation of a notion of causality, a notion that events in the future would not influence events in the past, even when the microscopic notion of past and future are not clearly defined. He also recognized that these relations might be useful in computing observables for the case of strong interaction physics. The dispersion relations were analytic properties of the S-matrix, and they imposed more stringent conditions than those that follow from unitarity alone. This development in S-matrix theory stemmed from Murray Gell-Mann and Marvin Leonard Goldberger's (1954) discovery of crossing symmetry, another condition that the S-matrix had to fulfil. Prominent advocates of the new "dispersion relations" approach included Stanley Mandelstam and Geoffrey Chew, both at UC Berkeley at the time. Mandelstam discovered the double dispersion relations, a new and powerful analytic form, in 1958, and believed that it would provide the key to progress in the intractable strong interactions. 1959–1968: Regge theory and bootstrap models By the late 1950s, many strongly interacting particles of ever higher spins had been discovered, and it became clear that they were not all fundamental. While Japanese physicist Shoichi Sakata proposed that the particles could be understood as bound states of just three of them (the proton, the neutron and the Lambda; see Sakata model), Geoffrey Chew believed that none of these particles are fundamental