In genetics, Rs1805054, also called C267T, is a name used for a specific genetic variation, a single nucleotide polymorphism (SNP), in the HTR6 gene. It is one of the few investigated polymorphisms of its gene. C267T is a synonymous polymorphism. As of 2008 meta-analysis of the polymorphism and Alzheimer's disease indicates that there probably is no association between the two, though individual studies report such an association, e.g., a Chinese study found an association with late-onset Alzheimer's disease. Another reported association in neuropsychiatry disorders is with treatment response in depression. C267T has also been examined in relation to personality traits, with a Korean study finding some evidence for an association with the trait self-transcendence. A Japanese study reported no association with personality traits using the NEO PI-R personality inventory. References SNPs on chromosome 1