that subjects with the val/val genotype had higher mean intelligence. The same study found no association with personality traits as measured with the Tridimensional Personality Questionnaire. Also a Polish 2007 study observed no significant relationship between the polymorphism and personality in healthy females. A German 2005 study could though find an association with personality traits measured with NEO-Five Factor Inventory, with Val/Val subjects scoring higher on anxiety and neuroticism dimensions. Large studies and a meta-analysis inclusive of over 15,000 subjects, however, found no association between the Val66Met and Neuroticism. Other studies A study in transgenic mice has found that met/met mice exhibits increased anxiety-related behaviors. References SNPs on chromosome 11 Biology of bipolar disorder