lab space and consolidate all operations on the 14th and 15th floors of the Toronto Medical Discovery Tower (TMDT) in the MaRS Discovery District. TCAG was the first occupant of TMDT (in August, 2005), quickly followed by other SickKids scientists. Investments in computer infrastructure from the 2003 CFI/Ontario Innovation Trust competition resulted in the establishment of new phases of the high-performance computing cluster (HPF) that is currently used by TCAG and many other users, to allow analysis of large genomic datasets arising from new microarray and sequencing technologies. Further enhancements to the TCAG infrastructure were supported by a $10.7 million renewal grant from CFI's Leading Edge Fund competition, entitled "Integrative Genomics for Health Research – Phase II", awarded in June 2009. More recently, a CFI grant entitled "The Centre for Applied Genomics: Paediatric Genomes to Outcomes" provided further infrastructure support. In October 2013, TCAG moved to the Peter Gilgan Centre for Research and Learning, a new building housing the SickKids Research Institute. TCAG operates in large part on Science and Technology Innovation Centre (STIC) funds from Genome Canada, administered by the Ontario Genomics Institute. Research Current research at TCAG centres around large-scale projects performed by facility personnel, including support of Genome Canada projects, and a significant focus on the genetics of autism spectrum disorders and structural variation of the human genome. Service work is also performed for over 600 other academic, private sector and government labs each year, drawn from 30 different countries and spanning a wide variety of research disciplines. Past research at TCAG is reflected by numerous peer-reviewed scientific publications. In 2008, TCAG Scientific Directors, Associate Scientists and staff co-authored 58 peer-reviewed manuscripts dependent in some way (either entirely, or in part) on the platform infrastructure, as documented in PubMed. Since 2002, over 270 such papers have been published. Support of other researchers worldwide is found in many similar publications, with at least 145 papers in scholarly journals, book chapters, or graduate thesis dissertations acknowledging support or use of database resources during 2008 alone. Historical papers include: Discovery of genes involved in predisposition to medulloblastoma (Michael Taylor and James Rutka with TCAG support) Gene identification in Shwachman-Diamond syndrome (with Johanna Rommens and others) Gene identification in Lafora Epilepsy (with Berge Minassian) and its canine counterpart A disease-relevant MECP2 isoform involved in Rett syndrome Involvement of the SUMO4 gene in type I diabetes Severe expressive-language delay related to duplication