De La Cruz joined her National Senior Team winning the 2010 Final Four Cup gold medal. De la Cruz played with the local team Navarrete from Santiago, Dominican Republic, taking the team to the final series. During the final series, Bethania left the team to participate with Mirador at the World Club Championship, taking the fourth place. Later Navarrete would take the Santiago Intermunicipal Championship. 2011 Bethania joined the Canadian Stacey Gordon and countrymate Brenda Castillo at the Puerto Rican team Criollas de Caguas to play the 2011 Puerto Rican League season, leading the team to win the regular season with a 20-2 record. De la Cruz set a new record in serving, with 57 aces, topped the scorers with 392 points and won the Most Valuable Player award. Despite of all these awards, Bethania said she wasn't in plenty physically shape. During the quarterfinals, she set another record with 9 aces in a playoff match. Bethania crowned the season winning the Puerto Rico League Championship, sweeping the final series against the Mets de Guaynabo. De La Cruz win the MVP award and the silver medal at the 2011 NORCECA Championship. One month later, Bethania participated with her home team at the 2011 Pan American Games held in Guadalajara, Mexico. She won the Best Scorer award and her team finished in 4th place. The Japanese club Denso Airybees, announced her joining in November 2011. Bethania win the Best Scorer and Best Server awards at the 2011 World Cup played in November in Japan. As the key player for her team, she was four times the Top Scorer by day and had three of the five best performances during the competition, including 42 points Vs. Germany on November 12. Her national team finished in the 8th place. 2012-2015 For her performances during 2011, De la Cruz was named Volleyball Player of the Year and nominated for the top national award of Athlete of the Year, later won by taekwondo practitioner and Olympic medalist Gabriel Mercedes and was awarded by the Dominican Republic Guild of Sport Writers among the 2011 Vollyeball Athlete of the Year. De la Cruz joined the Turkish club Eczacıbaşı VitrA and help them win the 2014–15 CEV Champions League by defeating 3-0 to the Italian Yamamay Busto Arsizio. She was named one of the Best Outside Spikers from the competition. This championship qualified her club to the 2015