vision loss, eye movement abnormalities, seizures, dysphagia and lactic acidosis. One case report of a pathogenic mutation in NDUFS8 found that it resulted in complex I mitochondrial deficiency and a diagnosis of Leigh syndrome. The patient’s symptoms included apnea, cyanosis, hypercarbia, hypotonia, brisk tendon reflexes, ankle clonus, and erratic seizures. Further analysis revealed increased lactate, cerebral lesions, and a hypertrophic obstructive cardiomyopathy. Interactions In addition to co-subunits for complex I, NDUFS8 has protein-protein interactions with MLH1 and GEM. References Further reading External links Human proteins EC 1.6.5 EC 1.6.99