RYR2 channel activity, allowing Ca2+ leaks and the development of CPVT. A deletion of amino acids in the TRDN gene can result in an early stop codon. A premature stop codon can either prevent the gene from being translated into the Triadin protein, or can result in a shortened, nonfunctional Triadin protein. A replacement of the amino acid Arginine for the amino acid Threonine at position 59 of the TRDN gene (pT59R) causes instability of Triadin, leading to degradation of the protein. Any of these naturally occurring mutations result in an absence of functional Triadin protein, resulting in CPVT in patients. References Further reading External links