MAD protein is a protein that in humans is encoded by the MXD1 gene. MAD-MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex, acts as a transcriptional repressor (while MYC appears to function as an activator) and is a candidate tumor suppressor. Interactions MXD1 has been shown to interact with Histone deacetylase 2, SMC3, MLX, SIN3A and MAX. References Further reading External links