implicated in prostate cancer development. In about 10% of all prostate cancers, CHD1 is mutated or deleted. In prostate cancer cells CHD1 also has an essential relationship with another cancer driver, the PTEN locus. In studies of prostate cancer patient data, when PTEN is mutated, Chd1 gains an essential role and is never deleted. Thus, CHD1 misfunction is evident in the majority of prostate cancers. Further, mutation of CHD1 alone is sufficient in some mice models to induce prostate tumorigenesis. Alterations in the CHD1 gene have been linked to hereditary gastric cancer. References Further reading External links