an approach for treatment of hepatic cell carcinoma (HCC). The FACL4 pathway is also important in colon carcinogenesis; the development of selective inhibitors for FACL4 may be a worthy effort in the prevention and treatment of colon cancer. FACL4 up-regulation appears to occur during the transformation from the cancer from adenoma to adenocarcinoma. Additionally, some colon tumor promoters significantly induced FACL4 expression. Neuronal development FACL4 was the gene shown to be involved in nonspecific intellectual disability and fatty-acid metabolism. Since the ASCL4 gene is highly expressed in brain, where it encodes a brain specific isoform, a FACL4 mutation may be an efficient diagnostic tool in intellectually disabled males. FACL4was discovered to bedeleted in a family with Alport syndrome and elliptocytosis. Interactions ACSL4 expression is regulated by SHP2 activity. Additionally, ACSL4 interacts with ACSL3, APP, DSE, ELAVL1, HECW2, MINOS1, PARK2, SPG20, SUMO2, TP53, TUBGCP3, UBC, UBD, and YWHAQ. References Further reading External links Human proteins