muscle stiffness and power generation. Cardiac-specific ablation of Mlp84B caused decreased lifespan, impaired diastolic function and disturbances in cardiac rhythm. Overall, these animal models have provided critical evidence on the functional significance of MLP in striated muscle physiology and pathophysiology. Notes References External links GeneReviews/NIH/NCBI/UW entry on Familial Hypertrophic Cardiomyopathy Overview