Plakophilin-3 is a protein that in humans is encoded by the PKP3 gene. Function This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. Interactions PKP3 has been shown to interact with: DSC3, DSG1, DSG2 and DSG3. References Further reading Armadillo-repeat-containing proteins