Blue Jackets || 2–5 || Phoenix Coyotes || 22–28–6–2 || 52 || |- align="center" bgcolor="#ffbbbb" |59 || February 19 || Columbus Blue Jackets || 0–2 || Mighty Ducks of Anaheim || 22–29–6–2 || 52 || |- align="center" bgcolor="#ffbbbb" |60 || February 21 || Columbus Blue Jackets || 0–6 || San Jose Sharks || 22–30–6–2 || 52 || |- align="center" bgcolor="#ffbbbb" |61 || February 23 || Columbus Blue Jackets || 2–7 || Vancouver Canucks || 22–31–6–2 || 52 || |- align="center" bgcolor="#ffbbbb" |62 || February 25 || Columbus Blue Jackets || 0–5 || Nashville Predators || 22–32–6–2 || 52 || |- align="center" bgcolor="#bbffbb" |63 || February 27 || Los Angeles Kings || 1–3 || Columbus Blue Jackets || 23–32–6–2 || 54 || |- |- align="center" |64 || March 1 || Edmonton Oilers || 3–3 || Columbus Blue Jackets || 23–32–7–2 || 55 || |- align="center" bgcolor="#ffbbbb" |65 || March 3 || Detroit Red Wings || 3–2 || Columbus Blue Jackets || 23–33–7–2 || 55 || |- align="center" bgcolor="#bbffbb" |66 || March 6 || Vancouver Canucks || 4–5 || Columbus Blue Jackets || 24–33–7–2 || 57 || |- align="center" bgcolor="#ffffbb" |67 || March 8 || Calgary Flames || 3–2 || Columbus Blue Jackets || 24–33–7–3 || 58 || |- align="center" bgcolor="#ffbbbb" |68 || March 10 || Columbus Blue Jackets || 5–6 || Carolina Hurricanes || 24–34–7–3 || 58 || |- align="center" bgcolor="#ffbbbb" |69 || March 11 || Dallas Stars || 2–0 || Columbus Blue Jackets || 24–35–7–3 || 58 || |- align="center" bgcolor="#ffbbbb" |70 || March 13 || Colorado Avalanche || 5–1 || Columbus Blue Jackets || 24–36–7–3 || 58 || |- align="center" bgcolor="#bbffbb" |71 || March 15 || Minnesota Wild || 0–5 || Columbus Blue Jackets || 25–36–7–3 || 60 || |- align="center" bgcolor="#ffbbbb" |72 || March 17 || Columbus Blue Jackets || 2–3 || Atlanta Thrashers || 25–37–7–3 || 60 || |- align="center" bgcolor="#bbffbb" |73 || March 20 || Toronto Maple Leafs || 3–4 || Columbus Blue Jackets || 26–37–7–3 || 62 || |- align="center" bgcolor="#ffbbbb" |74 || March 22 || Atlanta Thrashers || 3–2 || Columbus Blue Jackets || 26–38–7–3 || 62 || |- align="center" bgcolor="#ffbbbb" |75 || March 24 || Columbus Blue Jackets || 0–5 || Mighty Ducks of Anaheim || 26–39–7–3 || 62 || |- align="center" bgcolor="#bbffbb" |76 || March 25 || Columbus Blue Jackets || 2–1 || Los Angeles Kings || 27–39–7–3 || 64 || |-