CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene. Function CRTC2, initially called TORC2, is a transcriptional coactivator for the transcription factor CREB and a central regulator of gluconeogenic gene expression in response to cAMP. CRTC2 is thought to drive tumorigenesis in LKB11/STK11-null non-small cell lung cancers (NSCLC). Interactions CRTC2 has been shown to interact with SNF1LK2 and YWHAQ. References Further reading External links Gene expression Transcription coregulators