SH2B adapter protein 1 is a protein that in humans is encoded by the SH2B1 gene. Interactions SH2B1 has been shown to interact with: Grb2, Insulin receptor, Janus kinase 2, and TrkA. Clinical significance Variations close to or in the SH2B1 gene have been found to associate with obesity in two very large genome wide association studies of body mass index (BMI). Furthermore, SH2B1 deletions are associated with severe early-onset obesity. See also Genetics of obesity References Further reading