were inversely correlated with tumor multiplicity, advanced N classification, high proliferation index, and poor survival.” Over-expression of PINX1 reduced UCB cell proliferation and G1/S phase arrest. Knockdown PINX1 led to increased cell proliferation and accelerated G1/S transition. PinX1 in other cancers: Ovarian PINX1 in 100% of normal ovarian tissue and 66.2% of ovarian carcinomas Decreased PINX1 expression related to poor prognostic factors and presence of lymph node metastasis Gastric Loss of heterozygosity of PINX1 gene more common in lymph node metastasis and higher TNM stage Microstatellite instability of PINX1 gene less frequent in cases with lymph node metastasis Suppression of telomerase activity mediated by Mad1/c-Myc pathway Esophageal Over-expression of PINX1 inhibited cell growth, arrested cells at G0/G1, and induced apoptosis Nasopharyngeal Over-expression of PINX1 decreased hTERT mRNA, reduced telomerase activity, inhibited cell growth, migration and would healing ability, arrested cells in G0/G1 phase, increased apoptosis Down-regulation of PINX1 did not alter any of these characteristics Colorectal Intact PINX1 and PINX1 without G-patch motif induce apoptosis, G1 arrest, and cellular senescence Truncated PINX1 does not affect telomerase Cervical Regulated by p53 References Further reading