role in macrophage survival. Similarly, HIGD1A could become a key target for treating Alzheimer’s disease by inhibiting γ-secretase, and by extension, amyloid beta production. Notably, HIGD1A inhibits γ-secretase without interfering with Notch cleavage, thus minimizing detrimental side effects from targeting this protein. Interactions HIGD1A is known to interact with: AIF, γ-secretase and OPA1. References Further reading