|| |- align="center" bgcolor="#ffbbbb" |21 || November 23 || Columbus Blue Jackets || 2–5 || Ottawa Senators || 8–9–2–2 || 20 || |- align="center" bgcolor="#ffbbbb" |22 || November 27 || Edmonton Oilers || 3–1 || Columbus Blue Jackets || 8–10–2–2 || 20 || |- align="center" bgcolor="#bbffbb" |23 || November 29 || Columbus Blue Jackets || 4–2 || New York Islanders || 9–10–2–2 || 22 || |- align="center" bgcolor="#ffbbbb" |24 || November 30 || Carolina Hurricanes || 4–2 || Columbus Blue Jackets || 9–11–2–2 || 22 || |- |- align="center" bgcolor="#ffbbbb" |25 || December 3 || Columbus Blue Jackets || 3–5 || New York Rangers || 9–12–2–2 || 22 || |- align="center" bgcolor="#ffbbbb" |26 || December 6 || Columbus Blue Jackets || 2–3 || San Jose Sharks || 9–13–2–2 || 22 || |- align="center" bgcolor="#bbffbb" |27 || December 7 || Columbus Blue Jackets || 4–2 || Los Angeles Kings || 10–13–2–2 || 24 || |- align="center" |28 || December 9 || Columbus Blue Jackets || 2–2 || Phoenix Coyotes || 10–13–3–2 || 25 || |- align="center" bgcolor="#bbffbb" |29 || December 12 || New Jersey Devils || 2–4 || Columbus Blue Jackets || 11–13–3–2 || 27 || |- align="center" bgcolor="#ffbbbb" |30 || December 14 || Columbus Blue Jackets || 4–6 || Detroit Red Wings || 11–14–3–2 || 27 || |- align="center" bgcolor="#bbffbb" |31 || December 19 || Calgary Flames || 0–3 || Columbus Blue Jackets || 12–14–3–2 || 29 || |- align="center" bgcolor="#ffbbbb" |32 || December 20 || Columbus Blue Jackets || 1–3 || Chicago Blackhawks || 12–15–3–2 || 29 || |- align="center" bgcolor="#ffbbbb" |33 || December 23 || Detroit Red Wings || 1–0 || Columbus Blue Jackets || 12–16–3–2 || 29 || |- align="center" bgcolor="#ffbbbb" |34 || December 26 || Columbus Blue Jackets || 2–4 || Detroit Red Wings || 12–17–3–2 || 29 || |- align="center" bgcolor="#ffbbbb" |35 || December 28 || St. Louis Blues || 6–1 || Columbus Blue Jackets || 12–18–3–2 || 29 || |- align="center" bgcolor="#ffbbbb" |36 || December 29 || Columbus Blue Jackets || 2–5 || St. Louis Blues || 12–19–3–2 || 29 || |- align="center" bgcolor="#bbffbb" |37 || December 31 || Pittsburgh Penguins || 2–5 || Columbus Blue Jackets || 13–19–3–2 || 31 || |- |- align="center" |38 || January 3 || Columbus Blue Jackets || 2–2 || Washington Capitals || 13–19–4–2 || 32 || |- align="center" bgcolor="#bbffbb" |39 || January 4 || Phoenix Coyotes ||