alveoli, tissue plasminogen activator (tPA) in vascular smooth muscle cells and for anti-proliferative factor (APF) in bladder epithelial cells of patients with interstitial cystitis disorder. Diseases More recently, CLIMP-63 has been related to different types of cancer prognosis. Upregulation of CLIMP-63 is observed in cholangio-cellular and hepatocellular carcinoma and it correlates with lymph node metastasis appearance. References Further reading External links