residues. If these resides are mutated membrane targeting is reduced or lost. The rat CSP forms a complex with Sgt (SGTA) and Hsc70 (HSPA8) located on the synaptic vesicle surface. This complex functions as an ATP-dependent chaperone that reactivates denatured substrates. Furthermore, the Csp/Sgt/Hsc70 complex appears to be important for maintenance of normal synapses. Its expression may be increased with the use of lithium. Quercetin promotes formation of stable CSPα-CSPα dimers. Cysteine-string protein increases the calcium sensitivity of neurotransmitter exocytosis. Interactions DNAJC5 has been shown to interact with the cystic fibrosis transmembrane conductance regulator. Clinical significance Mutations in this gene may cause neuronal ceroid lipofuscinosis. References Further reading External links GeneReviews/NCBI/NIH/UW entry on Neuronal Ceroid-Lipofuscinosis Heat shock proteins Co-chaperones