confirmed that the entire complex is a dimer containing two of each subunit. Further imaging reveals the overall architecture of the Fanconi Anemia core complex centres on FANCB protein. Meiosis FANCB mutant mice are infertile and exhibit primordial germ cell defects during embryogenesis. The germ cells and testicular size are severely compromised in FANCB mutant mice. FANCB protein is essential for spermatogenesis and likely has a role in the activation of the Fanconi anemia DNA repair pathway during meiosis. References External links Human proteins