G protein pathway suppressor 2 is a protein that in humans is encoded by the GPS2 gene. Function This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. Interactions GPS2 (gene) has been shown to interact with: C21orf7, Cyclin A1, EP300, HDAC3, NCOR1, P53, and TBL1X. References Further reading