41 yrs. Although, the age of initiation of dialysis is earlier with one risk allele this effect is only seen in those with the G1 variant. In a study, ~96% of patients with two risk alleles started dialysis before the age of 75 compared to 94% for G1 heterozygotes, and 84% for those with no risk alleles. Kidneys from donors containing two APOL1 variants experience allograft failure more rapidly than donors with 0 or 1 variants. Kidney recipients who have copies of the APOL1 risk variants, but do not receive kidneys from donors with the risk variants do not have decreased survival rates of the donated kidneys. These observations together suggest that the genotype of the donor only affects allograft survival. References External links Further reading Proteins