ADP-ribosylation factor-like protein 2 is a protein that in humans is encoded by the ARL2 gene. Function The ADP-ribosylation factor (ARF) genes are small GTP-binding proteins of the RAS superfamily. ARL2 is a member of a functionally distinct group of ARF-like genes. In photoreceptors, ARL2 participates in the trafficking of lipidated membrane-associated proteins. There is an evidence that increased activity of ARL2 protein is strongly correlated with increased mitochondria fusion, while loss of ARL2 activity results in a decreased rate of fusion. Interactions ARL2 has been shown to interact with Protein unc-119 homolog, TBCD and PDE6D. References External links Further reading