Melanin-concentrating hormone receptor 1, also known as MCH1, is one of the melanin-concentrating hormone receptors found in all mammals. The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. Function MCH1 is thought to have a number of functions including in the regulation of appetite, and in stress, anxiety and depression. Selective ligands Agonists Melanin concentrating hormone (MCH) S-36057 - modified MCH 6-13 fragment substituted with 3-iodotyrosine at N-terminus via dioxyoctanoyl linker, used as 125I radioligand for mapping MCH1 in vivo. LK-184 (Procter & Gamble) is one pick Antagonists ATC-0065 ATC-0175 GW-803,430 NGD-4715 SNAP-7941 SNAP-94847 T-226,296 See also Melanin-concentrating hormone receptor References Further reading External links G protein-coupled receptors Human proteins