Brook vs. Senchenko at the Sheffield Arena in October 2013, Yafai defeateds Spanish boxer Santiago Bustos via points (59-55) after 6 rounds. Two months later in December, although being docked a point for a low blow, Yafai defeated British boxer Ashley Lane (4-3-2, 1 KO) via fourth-round TKO. Super Flyweight On 21 May 2014 Yafai fought at the First Direct Arena in Leeds for the vacant Commonwealth super flyweight title against Nigerian contender and former titleholder Yaqub Kareem (13-3-1, 8 KOs). With 30 seconds remaining in round 3, Yafai knocked down Kareem with a body shot to claim the vacant title. For the first time in his career, in September 2014, Yafai fought at the Wembley Arena in London live on Sky Sports. His opponent was 34 year old Nicaragua Herald Molina (17-8-3, 7 KOs) for the vacant IBF Inter-Continental super flyweight title. Yafai knocked Molina down once in round 1, before finishing the fight off in round 2 via KO. Yafai defended the title two months later at 3Arena in Dublin, Ireland against 38 year old Everth Briceno (35-9-2, 26 KOs). Briceno was knocked down in round five and twice in round eight. Briceno also lost one point in round six for low blows. The fight went the full 12 rounds as Yafai retained the title via unanimous decision (119-106, 118–105,120-104). This was Yafai's 13th straight win since turning professional in 2012. In March 2015, Yafai went the 8 round distance with 20 year old Cristofer Rosales in a non-title bout at the Sheffield Arena. Two months later, he knocked out 35 year old veteran Isaac Quaye (27-10-1, 18 KOs) in just one round following a left hook. In September 2015, Yafai fought 20 year old Nicaraguan boxer Aron Juarez (6-2-1) at the First Direct Arena. Yafai knocked Juarez down twice in round one following two left hooks to the body. It was announced that Yafai would have a chance to claim the vacant BBBofC British super flyweight title on 17 October 2015 against Jason Cunningham (17-2, 6 KOs) at the Barclaycard Arena in Birmingham, live on Sky Sports 1. Despite a height disadvantage, Yafai outclassed Cunningham from the opening bell winning a clear unanimous decision (119-108, 120–107, 120-107). The highlights of the fight came in round 5 when Yafai connected with a double left hook, staggering Cunningham and then knocked him down in round 6. After the fight