human body including the heart, thyroid, stomach, skin, urogenital, immune system, and more. TAS2R14 extra-oral function In the respiratory system, several TAS2R subtypes: TAS2R4, TAS2R16, TAS2R14 and TAS2R38, were found to play important roles in innate immune nitric oxide production (NO). T2R14 causes inhibition of IgE-dependent mast cells. Associations between single nucleotide polymorphisms in TAS214 gene and male infertility were observed. See also Taste receptor References Further reading Human taste receptors