|| September 19 || Royals || 8 – 3 || Denney (1-1) || Bautista (0-3) || || 16,745 || 72-77 |-align="center" bgcolor="#ffbbbb" | 150 || September 20 || @ Tigers || 3 – 1 || Maroth (11-11) || Elarton (3-5) || Yan (5) || 13,820 || 72-78 |-align="center" bgcolor="#bbffbb" | 151 || September 21 || @ Tigers || 8 – 7 || Howry (3-1) || Yan (3-5) || Wickman (10) || 11,351 || 73-78 |-align="center" bgcolor="#bbffbb" | 152 || September 22 || @ Tigers || 7 – 6 || Westbrook (13-9) || Ledezma (4-3) || || 16,360 || 74-78 |-align="center" bgcolor="#bbffbb" | 153 || September 23 || Twins || 9 – 7 || Lee (12-8) || Durbin (0-1) || Betancourt (4) || 18,053 || 75-78 |-align="center" bgcolor="#ffbbbb" | 154 || September 24 || Twins || 8 – 2 || Santana (20-6) || Denney (1-2) || || 16,253 || 75-79 |-align="center" bgcolor="#bbffbb" | 155 || September 25 || Twins || 5 – 3 || Howry (4-1) || Romero (7-3) || Wickman (11) || 23,541 || 76-79 |-align="center" bgcolor="#ffbbbb" | 156 || September 26 || Twins || 6 – 2 || Silva (14-8) || Cruceta (0-1) || || 22,091 || 76-80 |-align="center" bgcolor="#bbffbb" | 157 || September 27 || @ Royals || 6 – 1 || Westbrook (14-9) || Cerda (1-3) || || 11,544 || 77-80 |-align="center" bgcolor="#bbffbb" | 158 || September 28 || @ Royals || 5 – 1 || Lee (13-8) || May (9-19) || || 11,847 || 78-80 |-align="center" bgcolor="#bbffbb" | 159 || September 29 || @ Royals || 5 – 2 || Bartosh (1-0) || Wood (3-8) || Wickman (12) || 11,193 || 79-80 |- |-align="center" bgcolor="#ffbbbb" | 160 || October 1 || @ Twins || 4 – 3 || Crain (3-0) || Howry (4-2) || Nathan (44) || 25,322 || 79-81 |-align="center" bgcolor="#ffbbbb" | 161 || October 2 || @ Twins || 6 – 5 (12) || Lohse (9-12) || Riske (7-3) || || 32,268 || 79-82 |-align="center" bgcolor="#bbffbb" | 162 || October 3 || @ Twins || 5 – 2 || Lee (14-8) || Lohse (9-13) || Wickman (13) || 28,624 || 80-82 |- Player stats Batting Note: G = Games played; AB = At bats; R = Runs scored; H = Hits; 2B = Doubles; 3B = Triples; HR = Home runs; RBI = Runs batted in; AVG = Batting average; SB = Stolen bases