(3–1) || Buehrle (4–1) || Wickman (6) || 24,519 || 12–7 |-align="center" bgcolor="ffbbbb" | 20 || April 23 || White Sox || 5–1 || Ritchie (2–1) || Colón (3–2) || || 25,284 || 12–8 |-align="center" bgcolor="ffbbbb" | 21 || April 24 || White Sox || 9–2 || Wright (2–2) || Sabathia (2–2) || || 25,935 || 12–9 |-align="center" bgcolor="ffbbbb" | 22 || April 25 || White Sox || 6–3 || Garland (3–1) || Drese (2–2) || Foulke (6) || 29,046 || 12–10 |-align="center" bgcolor="#bbffbb" | 23 || April 26 || @ Rangers || 7–4 || Finley (2–2) || Davis (2–2) || || 33,243 || 13–10 |-align="center" bgcolor="ffbbbb" | 24 || April 27 || @ Rangers || 4–2 || Bell (1–0) || Báez (3–2) || Irabu (4) || 43,353 || 13–11 |-align="center" bgcolor="ffbbbb" | 25 || April 28 || @ Rangers || 2–1 || Valdez (2–3) || Colón (3–3) || Irabu (5) || 24,118 || 13–12 |-align="center" bgcolor="ffbbbb" | 26 || April 30 || Angels || 21–2 || Ortiz (2–3) || Sabathia (2–3) || || 24,286 || 13–13 |- |-align="center" bgcolor="ffbbbb" | 27 || May 1 || Angels || 7–2 || Washburn (3–2) || Drese (2–3) || || 23,536 || 13–14 |-align="center" bgcolor="ffbbbb" | 28 || May 2 || Angels || 8–0 || Appier (3–1) || Finley (2–3) || || 26,068 || 13–15 |-align="center" bgcolor="ffbbbb" | 29 || May 3 || Rangers || 4–2 || Davis (3–2) || Báez (3–3) || Irabu (7) || 32,846 || 13–16 |-align="center" bgcolor="bbffbb" | 30 || May 4 || Rangers || 3–0 || Colón (4–3) || Valdez (2–4) || Wickman (7) || 33,788 || 14–16 |-align="center" bgcolor="bbffbb" | 31 || May 5 || Rangers || 9–2 || Sabathia (3–3) || Rogers (3–1) || || 31,990 || 15–16 |-align="center" bgcolor="bbffbb" | 32 || May 6 || @ Orioles || 9–4 || Drese (3–3) || Groom (1–1) || || 24,976 || 16–16 |-align="center" bgcolor="ffbbbb" | 33 || May 7 || @ Orioles || 4–3 (10) || Julio (2–0) || Wohlers (0–1) || || 26,455 || 16–17 |-align="center" bgcolor="bbffbb" | 34 || May 8 || @ Orioles || 6–2 || Báez (4–3) || Erickson (3–3) || || 29,361 || 17–17 |-align="center" bgcolor="ffbbbb" | 35 || May 9 || @ Royals || 5–3 || Suppan (3–4) || Rincón (0–1) || Hernández (2) || 12,555 || 17–18 |-align="center" bgcolor="ffbbbb" | 36 || May 10 || @ Royals || 9–0 ||