genetic deletion of EP1 receptor produce either beneficial or deleterious effects in rodent models of neurological disorders such as ischemic stroke, epileptic seizure, surgically induced brain injury and traumatic brain injury. Clinical studies EP1 receptor antagonists have been studied clinically primarily to treat hyperalgesia. Numerous EP antagonists have been developed including SC51332, GW-848687X, a benzofuran-containing drug that have had some efficacy in treating various hyperalgesic syndromes in animal models. None have as yet been reported to be useful in humans. See also Prostaglandin receptors Prostanoid receptors Prostaglandin E2 receptor 2 (EP2) Prostaglandin E2 receptor 3 (EP3) Prostaglandin E2 receptor 4 (EP4) Eicosanoid receptor References Further reading External links G protein-coupled receptors