4 – 2 || Westbrook (14-14) || Santana (13-7) || Wickman (38) || 26,078 || 80-61 |-align="center" bgcolor="#bbffbb" | 142 || September 10 || Twins || 7 – 5 || Elarton (9-7) || Baker (1-2) || Wickman (39) || 32,123 || 81-61 |-align="center" bgcolor="#bbffbb" | 143 || September 11 || Twins || 12 – 4 || Lee (16-4) || Silva (9-8) || || 38,564 || 82-61 |-align="center" bgcolor="#ffbbbb" | 144 || September 12 || Athletics || 2 – 0 || Haren (13-10) || Sabathia (13-10) || Street (21) || 20,282 || 82-62 |-align="center" bgcolor="#bbffbb" | 145 || September 13 || Athletics || 5 – 2 || Millwood (8-11) || Duchscherer (6-4) || Wickman (40) || 21,564 || 83-62 |-align="center" bgcolor="#bbffbb" | 146 || September 14 || Athletics || 6 – 4 || Westbrook (15-14) || Zito (13-12) || Wickman (41) || 21,920 || 84-62 |-align="center" bgcolor="#bbffbb" | 147 || September 16 || Royals || 3 – 1 || Elarton (10-7) || Gobble (1-1) || Wickman (42) || 21,975 || 85-62 |-align="center" bgcolor="#bbffbb" | 148 || September 17 || Royals || 5 – 4 || Lee (17-4) || Hernández (8-12) || Wickman (43) || 32,392 || 86-62 |-align="center" bgcolor="#bbffbb" | 149 || September 18 || Royals || 11 – 0 || Sabathia (14-10) || Lima (5-16) || || 22,654 || 87-62 |-align="center" bgcolor="#bbffbb" | 150 || September 19 || @ White Sox || 7 – 5 || Betancourt (4-3) || Marte (3-4) || Wickman (44) || 35,748 || 88-62 |-align="center" bgcolor="#ffbbbb" | 151 || September 20 || @ White Sox || 7 – 6 (10) || Hermanson (2-4) || Riske (3-4) || || 26,147 || 88-63 |-align="center" bgcolor="#bbffbb" | 152 || September 21 || @ White Sox || 8 – 0 || Elarton (11-7) || Garland (17-10) || || 36,543 || 89-63 |-align="center" bgcolor="#bbffbb" | 153 || September 22 || @ Royals || 11 – 6 || Lee (18-4) || Sisco (2-4) || Betancourt (1) || 10,028 || 90-63 |-align="center" bgcolor="#bbffbb" | 154 || September 23 || @ Royals || 7 – 6 || Howry (7-3) || MacDougal (4-6) || Wickman (45) || 12,519 || 91-63 |-align="center" bgcolor="#bbffbb" | 155 || September 24 || @ Royals || 11 – 4 || Millwood (9-11) || Wood (5-8) || || 17,358 || 92-63 |-align="center" bgcolor="#ffbbbb" | 156 || September 25 || @ Royals || 5 – 4 || MacDougal (5-6) || Howry (7-4)