an increment of the ATAT1 enzyme. For others, an inhibitor of this enzyme is needed to reach the correct level of acetylation. Neurological disorders Pathologically, tubulin acetylation might be connected to several neurological disorders, such as: Charcot-Marie-Tooth disease or distal hereditary motor neuropathy Joubert syndrome, which affects the cerebellum It is although thought to play an important role in Parkinson's disease Amyotrophic lateral sclerosis or Lou Gehrid's disease Moreover, acetylation by ATAT1 could also be implicated in Alzheimer's disease Epilepsy Axon injury However it is still being investigated if these disorders are directly caused by an abnormality level of acetylation done by ATAT1. Nevertheless, it seems that the only associated disease which can be stated that is caused by a decrease of acetylation caused by ATAT1 is axon injury Cancer An increase of tubulin acetylation done by ATAT1 may play an important role in: Head and neck squamous cell carcinoma Breast cancer. ATAT1 together with other enzymes with opposite functions like histone deacetylase 6, carry out processes of acetylation and deacetylation and the balance of these two processes contributes to establish the regulation of invasive properties of tumor cells, particularly breast ones. Pancreatic cancer Neurofibromatosis type 2 Inflammation and immunity It has been also slightly demonstrated that an increase of acetylation done by α-tubulin N-acetyltransferase could ease the entrance of virus in the cell. References Further reading See also Tubulin Acetylation Protein Isoform Post-translational modification Microtubules Clathrin EC 2.3.1 Enzymes of unknown structure