bgcolor="#ffbbbb" | 61 || June 8 || @ Diamondbacks || 3–13 || Webb (3–1) || Rodríguez (3–7) || || Bank One Ballpark || 42,956 || 24–37 || L2 |- |- bgcolor="#ffbbbb" | 115 || August 8 || Angels || 2–5 || Washburn (9–11) || Davis (7–9) || || Jacobs Field || 26,175 || 47–68 || L1 |- bgcolor="#bbffbb" | 116 || August 9 || Angels || 3–2 (13) || Cressend (1–0) || Weber (2–1) || || Jacobs Field || 26,391 || 48–68 || W1 |- bgcolor="#bbffbb" | 117 || August 9 || Angels || 3–2 || Boyd (3–1) || Shields (2–3) || Báez (25) || Jacobs Field || 20,116 || 49–68 || W2 |- bgcolor="#bbffbb" | 118 || August 10 || Angels || 3–1 || Sabathia (10–7) || Lackey (7–11) || Betancourt (1) || Jacobs Field || 23,576 || 50–68 || W3 |- |- style="text-align:center;" | Legend: = Win = Loss = PostponementBold = Indians team member |-align="center" bgcolor="#ffbbbb" | 1 || March 31 || @ Orioles || 6 – 5 (13) || Ryan (1-0) || Westbrook (0-1) || || 46,257 || 0-1 |-align="center" bgcolor="#bbffbb" | 2 || April 2 || @ Orioles || 4 – 2 || Rodríguez (1-0) || Daal (0-1) || Báez (1) || 27,658 || 1-1 |-align="center" bgcolor="#bbffbb" | 3 || April 3 || @ Orioles || 3 – 0 || Anderson (1-0) || Helling (0-1) || Báez (2) || 18,470 || 2-1 |-align="center" bgcolor="#ffbbbb" | 4 || April 4 || @ Royals || 5 – 1 || George (1-0) || Davis (0-1) || || 15,241 || 2-2 |-align="center" bgcolor="#ffbbbb" | 5 || April 5 || @ Royals || 3 – 1 || Hernández (2-0) || Sabathia (0-1) || MacDougal (3) || 19,912 || 2-3 |-align="center" bgcolor="#bbbbbb" | -- || April 6 || @ Royals || colspan=6|Postponed (rain) Rescheduled for June 30 |-align="center" bgcolor="#ffbbbb" | 6 || April 8 || White Sox || 5 – 3 (10) || Koch (1-0) || Paronto (0-1) || || 42,301 || 2-4 |-align="center" bgcolor="#bbffbb" | 7 || April 9 || White Sox || 5 – 2 || Anderson (2-0) || Garland (0-1) || Báez (3) || 14,841 || 3-4 |-align="center" bgcolor="#ffbbbb" | 8 || April 10 || White Sox || 7 – 2 || Buehrle (2-1) || Davis (0-2) || || 15,916 || 3-5 |-align="center" bgcolor="#ffbbbb" | 9 || April 11 || Royals || 1 – 0 || Hernández (3-0)