13,188 || 64-83 |-align="center" bgcolor="#bbffbb" | 148 || September 12 || Twins || 4 – 3 || Sabathia (13-8) || Rogers (11-8) || Riske (7) || 20,679 || 65-83 |-align="center" bgcolor="#ffbbbb" | 149 || September 13 || Twins || 2 – 0 || Lohse (13-11) || Stanford (0-2) || Guardado (35) || 20,440 || 65-84 |-align="center" bgcolor="#ffbbbb" | 150 || September 14 || Twins || 5 – 3 || Rincón (5-6) || Báez (2-9) || Guardado (36) || 19,452 || 65-85 |-align="center" bgcolor="#ffbbbb" | 151 || September 15 || Twins || 13 – 6 || Santana (11-3) || Davis (8-11) || || 16,967 || 65-86 |-align="center" bgcolor="#ffbbbb" | 152 || September 16 || Royals || 12 – 8 || May (9-7) || Traber (6-9) || || 16,145 || 65-87 |-align="center" bgcolor="#bbffbb" | 153 || September 17 || Royals || 9 – 1 || Westbrook (7-9) || Abbott (1-2) || || 16,363 || 66-87 |-align="center" bgcolor="#ffbbbb" | 154 || September 18 || Royals || 3 – 2 || Lima (8-1) || Sabathia (13-9) || Leskanic (2) || 17,275 || 66-88 |-align="center" bgcolor="#ffbbbb" | 155 || September 19 || Red Sox || 2 – 0 || Burkett (11-8) || Stanford (0-3) || Embree (1) || 20,374 || 66-89 |-align="center" bgcolor="#bbffbb" | 156 || September 20 || Red Sox || 13 – 4 || Lee (1-0) || Lowe (16-7) || || 23,242 || 67-89 |-align="center" bgcolor="#ffbbbb" | 157 || September 21 || Red Sox || 2 – 0 || Martínez (14-4) || Lee (3-2) || Kim (15) || 27,655 || 67-90 |-align="center" bgcolor="#ffbbbb" | 158 || September 23 || @ Twins || 4 – 1 || Rogers (13-8) || Westbrook (7-10) || Guardado (40) || 33,650 || 67-91 |-align="center" bgcolor="#ffbbbb" | 159 || September 24 || @ Twins || 3 – 2 || Orosco (1-0) || Betancourt (2-2) || Guardado (41) || 32,986 || 67-92 |-align="center" bgcolor="#bbffbb" | 160 || September 26 || @ Blue Jays || 2 – 1 || Stanford (1-3) || Lidle (12-15) || Riske (8) || 13,861 || 68-92 |-align="center" bgcolor="#ffbbbb" | 161 || September 27 || @ Blue Jays || 5 – 4 || Halladay (22-7) || Mulholland (3-4) || || 21,504 || 68-93 |-align="center" bgcolor="#ffbbbb" | 162 || September 28 || @ Blue Jays || 6 – 2 || Towers (8-1) || Lee (3-3) || || 22,014 || 68-94 |- Player stats Batting Starters by position Note: