the phosphatidylinositol (PIP2) pathway. The nonselective cation Transient Receptor Potential channel TRPM5 has been shown to correlate with both umami and sweet taste. Also, the phospholipase PLCβ2 was shown to similarly correlate with umami and sweet taste. This suggests that activation of the G-protein pathway and subsequent activation of PLC β2 and the TRPM5 channel in these taste cells functions to activate the cell. Location and innervation TAS1R2+3 expressing cells are found in circumvallate papillae and foliate papillae near the back of the tongue and palate taste receptor cells in the roof of the mouth. These cells are shown to synapse upon the chorda tympani and glossopharyngeal nerves to send their signals to the brain. TAS1R and TAS2R (bitter) channels are not expressed together in taste buds. See also Taste receptor TAS1R1 TAS1R3 References Further reading External links TAS1R2 Gene TASTE RECEPTOR TYPE 1, MEMBER 2; TAS1R2 Human taste receptors