|| April 27 || @ Athletics || 4 – 3 || Rincón (2-1) || Báez (0-3) || || 26,414 || 7-18 |-align="center" bgcolor="#ffbbbb" | 26 || April 29 || Angels || 10 – 1 || Ortiz (4-2) || Rodríguez (2-2) || || 16,667 || 7-19 |-align="center" bgcolor="#ffbbbb" | 27 || April 30 || Angels || 6 – 2 || Washburn (2-3) || Anderson (2-3) || || 15,761 || 7-20 |- |-align="center" bgcolor="#bbffbb" | 28 || May 2 || Rangers || 6 – 5 || Elder (1-0) || Cordero (1-3) || Báez (4) || 19,823 || 8-20 |-align="center" bgcolor="#ffbbbb" | 29 || May 3 || Rangers || 6 – 5 || Powell (1-0) || Santiago (0-1) || Urbina (9) || 23,030 || 8-21 |-align="center" bgcolor="#bbffbb" | 30 || May 4 || Rangers || 3 – 1 || Sabathia (1-2) || Thomson (2-3) || Báez (5) || 20,866 || 9-21 |-align="center" bgcolor="#ffbbbb" | 31 || May 6 || @ Angels || 6 – 1 || Washburn (3-3) || Rodríguez (2-3) || || 25,043 || 9-22 |-align="center" bgcolor="#ffbbbb" | 32 || May 7 || @ Angels || 6 – 5 || Shields (2-1) || Elder (1-1) || Percival (4) || 24,063 || 9-23 |-align="center" bgcolor="#ffbbbb" | 33 || May 8 || @ Angels || 7 – 1 || Appier (2-2) || Davis (2-4) || || 27,957 || 9-24 |-align="center" bgcolor="#bbffbb" | 34 || May 9 || @ Rangers || 9 – 5 || Westbrook (2-2) || Thomson (2-4) || || 25,106 || 10-24 |-align="center" bgcolor="#bbffbb" | 35 || May 10 || @ Rangers || 6 – 4 || Sabathia (2-2) || Benes (0-1) || Báez (6) || 43,484 || 11-24 |-align="center" bgcolor="#ffbbbb" | 36 || May 11 || @ Rangers || 17 – 10 || Benoit (1-0) || Rodríguez (2-4) || || 23,407 || 11-25 |-align="center" bgcolor="#ffbbbb" | 37 || May 13 || Mariners || 8 – 3 || Piñeiro (3-3) || Anderson (2-4) || || 16,721 || 11-26 |-align="center" bgcolor="#bbffbb" | 38 || May 14 || Mariners || 7 – 2 || Davis (3-4) || García (3-5) || || 17,324 || 12-26 |-align="center" bgcolor="#ffbbbb" | 39 || May 15 || Mariners || 9 – 1 || Carrara (2-0) || Westbrook (2-3) || || 17,889 || 12-27 |-align="center" bgcolor="#bbffbb" | 40 || May 16 || Athletics || 3 – 2 || Traber (1-2) || Mulder (6-2) || Báez (7) || 22,357 || 13-27