Miller (1) || Angel Stadium of Anaheim || 42,986 || 45–47 || W1 |- bgcolor="#bbffbb" | 93 || July 20 || @ Angels || 14–5 || Westbrook (7–5) || Washburn (10–5) || || Angel Stadium of Anaheim || 40,000 || 46–47 || W2 |- |- bgcolor="#ffbbbb" | 136 || September 3 || Angels || 5–10 || Escobar (9–9) || Elarton (3–4) || || Jacobs Field || 20,994 || 67–69 || L3 |- bgcolor="#ffbbbb" | 137 || September 4 || Angels || 1–6 || Washburn (11–5) || Davis (2–7) || || Jacobs Field || 23,786 || 67–70 || L4 |- bgcolor="#ffbbbb" | 138 || September 5 || Angels || 1–2 || Lackey (12–11) || Westbrook (12–7) || Rodríguez (11) || Jacobs Field || 26,208 || 67–71 || L5 |- |- style="text-align:center;" | Legend: = Win = Loss = PostponementBold = Indians team member |-align="center" bgcolor="#ffbbbb" | 1 || April 5 || @ Twins || 7 – 4 (11) || Rincón (1-0) || Durbin (0-1) || || 49,584 || 0-1 |-align="center" bgcolor="#ffbbbb" | 2 || April 6 || @ Twins || 7 – 6 (15) || Roa (1-0) || Westbrook (0-1) || || 19,832 || 0-2 |-align="center" bgcolor="#bbffbb" | 3 || April 7 || @ Twins || 11 – 4 || Durbin (1-1) || Lohse (0-1) || || 20,313 || 1-2 |-align="center" bgcolor="#bbffbb" | 4 || April 8 || @ Royals || 6 – 1 || D'Amico (1-0) || Affeldt (0-1) || || 14,671 || 2-2 |-align="center" bgcolor="#ffbbbb" | 5 || April 9 || @ Royals || 3 – 1 || Grimsley (1-0) || Cressend (0-1) || Leskanic (1) || 28,535 || 2-3 |-align="center" bgcolor="#ffbbbb" | 6 || April 10 || @ Royals || 7 – 6 (10) || Sullivan (1-0) || Betancourt (0-1) || || 21,889 || 2-4 |-align="center" bgcolor="#ffbbbb" | 7 || April 11 || @ Royals || 5 – 3 || Sullivan (2-0) || Jiménez (0-1) || Leskanic (2) || 16,933 || 2-5 |-align="center" bgcolor="#bbffbb" | 8 || April 12 || Twins || 6 – 3 || Lee (1-0) || Lohse (0-2) || || 42,424 || 3-5 |-align="center" bgcolor="#ffbbbb" | 9 || April 14 || Twins || 10 – 6 || Silva (1-0) || D'Amico (1-1) || Rincón (1) || 14,237 || 3-6 |-align="center" bgcolor="#ffbbbb" | 10 || April 15 || Twins || 3 – 0 || Radke (2-0) || Stanford (0-1) || Nathan (1) || 15,105 || 3-7