| 103 || July 28 || Tigers || 9–6 || DePaula (1–0) || Acevedo (1–5) || || 35,076 || 45–58 |-align="center" bgcolor="bbffbb" | 104 || July 29 || @ Athletics || 8–6 || Mulholland (1–0) || Magnante (0–2) || Wohlers (1) || 18,297 || 46–58 |-align="center" bgcolor="bbffbb" | 105 || July 30 || @ Athletics || 5–4 || Drese (9–8) || Lidle (3–9) || Wohlers (2) || 14,737 || 47–58 |-align="center" bgcolor="ffbbbb" | 106 || July 31 || @ Athletics || 6–4 || Mulder (12–6) || Westbrook (0–1) || Koch (26) || 47,574 || 47–59 |- |-align="center" bgcolor="ffbbbb" | 107 || August 1 || @ Mariners || 10–6 || Nelson (2–2) || DePaula (1–1) || || 45,590 || 47–60 |-align="center" bgcolor="ffbbbb" | 108 || August 2 || @ Mariners || 3–1 || Moyer (11–4) || Báez (8–8) || Sasaki (29) || 45,995 || 47–61 |-align="center" bgcolor="ffbbbb" | 109 || August 3 || @ Mariners || 12–4 || García (12–7) || Wright (0–2) || || 46,219 || 47–62 |-align="center" bgcolor="bbffbb" | 110 || August 4 || @ Mariners || 10–8 || Westbrook (1–1) || Sasaki (2–5) || Wohlers (3) || 46,120 || 48–62 |-align="center" bgcolor="bbffbb" | 111 || August 6 || Devil Rays || 4–2 || Nagy (1–2) || Sosa (1–5) || Wohlers (4) || 35,302 || 49–62 |-align="center" bgcolor="bbffbb" | 112 || August 7 || Devil Rays || 6–2 || Sabathia (7–9) || Sturtze (1–12) || || 37,888 || 50–62 |-align="center" bgcolor="ffbbbb" | 113 || August 8 || Devil Rays || 4–2 || Wilson (5–7) || Báez (8–9) || Yan (15) || 29,973 || 50–63 |-align="center" bgcolor="ffbbbb" | 114 || August 9 || Rangers || 3–2 || Rogers (12–6) || Wohlers (1–2) || Cordero (4) || 41,019 || 50–64 |-align="center" bgcolor="bbffbb" | 115 || August 10 || Rangers || 4–3 || Wickman (1–3) || Kolb (2–1) || || 37,753 || 51–64 |-align="center" bgcolor="ffbbbb" | 116 || August 11 || Rangers || 11–5 || Myette (1–4) || Nagy (1–3) || || 36,789 || 51–65 |-align="center" bgcolor="bbffbb" | 117 || August 13 || @ Devil Rays || 9–5 || Sabathia (8–9) || Sturtze (1–13) || Wohlers (5) || 11,779 || 52–65 |-align="center" bgcolor="bbffbb" | 118 || August 14 || @ Devil Rays || 6–4 || Báez (9–9) || Wilson (5–8) || Wohlers (6) || 10,455 || 53–65 |-align="center" bgcolor="ffbbbb" | 119 || August 15 || @ Devil Rays || 4–3 || Harper