|| Westbrook (12-6) || Vázquez (13-8) || || 51,777 || 67-66 |- |-align="center" bgcolor="#ffbbbb" | 134 || September 1 || @ Yankees || 5 – 3 || Hernández (6-0) || Sabathia (10-9) || Rivera (46) || 41,448 || 67-67 |-align="center" bgcolor="#ffbbbb" | 135 || September 2 || @ Yankees || 9 – 1 || Lieber (10-8) || Lee (10-7) || || 37,963 || 67-68 |-align="center" bgcolor="#ffbbbb" | 136 || September 3 || Angels || 10 – 5 || Escobar (9-9) || Elarton (3-4) || || 20,994 || 67-69 |-align="center" bgcolor="#ffbbbb" | 137 || September 4 || Angels || 6 – 1 || Washburn (11-5) || Davis (2-7) || || 23,786 || 67-70 |-align="center" bgcolor="#ffbbbb" | 138 || September 5 || Angels || 2 – 1 || Lackey (12-11) || Westbrook (12-7) || Rodríguez (11) || 26,208 || 67-71 |-align="center" bgcolor="#bbffbb" | 139 || September 6 || @ Mariners || 5 – 0 || Sabathia (11-9) || Meche (4-6) || || 33,084 || 68-71 |-align="center" bgcolor="#bbffbb" | 140 || September 8 || @ Mariners || 9 – 5 || Lee (11-7) || Baek (1-2) || || 28,764 || 69-71 |-align="center" bgcolor="#bbffbb" | 141 || September 10 || @ Athletics || 4 – 3 (12) || White (5-5) || Duchscherer (5-6) || Wickman (8) || 24,154 || 70-71 |-align="center" bgcolor="#ffbbbb" | 142 || September 11 || @ Athletics || 5 – 4 || Rincón (1-0) || Howry (1-1) || Dotel (19) || 30,436 || 70-72 |-align="center" bgcolor="#ffbbbb" | 143 || September 12 || @ Athletics || 1 – 0 || Zito (11-10) || Westbrook (12-8) || Dotel (20) || 29,107 || 70-73 |-align="center" bgcolor="#ffbbbb" | 144 || September 14 || Tigers || 11 – 3 || Bonderman (10-11) || Denney (0-1) || || 16,489 || 70-74 |-align="center" bgcolor="#bbffbb" | 145 || September 15 || Tigers || 5 – 3 || Howry (2-1) || Yan (2-4) || Wickman (9) || 15,411 || 71-74 |-align="center" bgcolor="#ffbbbb" | 146 || September 16 || Tigers || 6 – 4 || Walker (3-4) || Sabathia (11-10) || Yan (4) || 15,943 || 71-75 |-align="center" bgcolor="#ffbbbb" | 147 || September 17 || Royals || 6 – 4 || Wood (3-7) || Westbrook (12-9) || Affeldt (11) || 14,347 || 71-76 |-align="center" bgcolor="#ffbbbb" | 148 || September 18 || Royals || 7 – 1 || Gobble (8-8) || Lee (11-8) || || 17,848 || 71-77 |-align="center" bgcolor="#bbffbb" | 149