April 8 || @ Tigers || 4 – 3 || Riske (1-0) || Urbina (0-1) || Wickman (1) || 23,294 || 2-2 |-align="center" bgcolor="#ffbbbb" | 5 || April 9 || @ Tigers || 11 – 1 || Ledezma (1-0) || Westbrook (0-2) || || 26,037 || 2-3 |-align="center" bgcolor="#bbffbb" | 6 || April 10 || @ Tigers || 7 – 6 || Davis (1-0) || Bonderman (0-1) || Wickman (2) || 25,758 || 3-3 |-align="center" bgcolor="#ffbbbb" | 7 || April 11 || White Sox || 2 – 1 || García (1-0) || Millwood (0-1) || Takatsu (3) || 42,461 || 3-4 |-align="center" bgcolor="#ffbbbb" | 8 || April 13 || White Sox || 5 – 4 (10) || Vizcaíno (1-1) || Howry (0-1) || Hermanson (1) || 14,410 || 3-5 |-align="center" bgcolor="#bbffbb" | 9 || April 14 || White Sox || 8 – 6 || Betancourt (1-0) || Hernández (1-1) || Wickman (3) || 12,470 || 4-5 |-align="center" bgcolor="#ffbbbb" | 10 || April 15 || Twins || 3 – 2 || Santana (3-0) || Westbrook (0-3) || Nathan (3) || 15,360 || 4-6 |-align="center" bgcolor="#ffbbbb" | 11 || April 16 || Twins || 6 – 4 || Gassner (1-0) || Millwood (0-2) || Nathan (4) || 18,699 || 4-7 |-align="center" bgcolor="#bbffbb" | 12 || April 17 || Twins || 2 – 1 || Howry (1-1) || Romero (0-1) || Wickman (4) || 19,021 || 5-7 |-align="center" bgcolor="#bbffbb" | 13 || April 18 || @ Royals || 5 – 1 || Lee (1-0) || Greinke (0-1) || || 11,115 || 6-7 |-align="center" bgcolor="#ffbbbb" | 14 || April 19 || @ Royals || 6 – 5 || MacDougal (1-0) || Rhodes (1-1) || || 11,884 || 6-8 |-align="center" bgcolor="#ffbbbb" | 15 || April 20 || @ Angels || 2- 0 || Colón (3-1) || Westbrook (0-4) || Rodríguez (3) || 42,531 || 6-9 |-align="center" bgcolor="#ffbbbb" | 16 || April 21 || @ Angels || 6 – 5 (10) || Rodríguez (1-0) || Davis (1-1) || || 39,673 || 6-10 |-align="center" bgcolor="#bbffbb" | 17 || April 22 || @ Mariners || 6 – 1 || Sabathia (1-0) || Meche (1-1) || || 43,207 || 7-10 |-align="center" bgcolor="#bbffbb" | 18 || April 23 || @ Mariners || 5 – 2 || Lee (2-0) || Sele (1-2) || Wickman (5) || 33,564 || 8-10 |-align="center" bgcolor="#ffbbbb" | 19 || April 24 || @ Mariners || 9