been proposed to warrant further study to treat and/or prevent various types of cardiovascular diseases. Genomic studies The single nucleotide polymorphism (SNP) in the PTGER3, rs977214 A/G variant has been associated with an increase in pre-term births in two populations of European ancestry; the SNP variant -1709T>A in PTGER3 has been associated with aspirin-exacerbated respiratory disease in a Korean population; and 6 SNP variants have been associated with development of the Steven Johnson syndrome and its more severe form, toxic epidermal necrolysis, in a Japanese population. See also Eicosanoid receptor Prostaglandin E2 receptor 1 (EP1) Prostaglandin E2 receptor 2 (EP2) Prostaglandin E2 receptor 4 (EP4) References Further reading External links G protein-coupled receptors