(5–6) || Wohlers (1–3) || || 10,778 || 53–66 |-align="center" bgcolor="ffbbbb" | 120 || August 16 || @ Angels || 5–4 || Lackey (5–2) || Drese (9–9) || Percival (29) || 41,356 || 53–67 |-align="center" bgcolor="bbffbb" | 121 || August 17 || @ Angels || 9–4 || Sadler (1–0) || Washburn (15–4) || || 39,866 || 54–67 |-align="center" bgcolor="ffbbbb" | 122 || August 18 || @ Angels || 4–1 || Appier (11–9) || Sabathia (8–10) || Percival (30) || 41,059 || 54–68 |-align="center" bgcolor="ffbbbb" | 123 || August 19 || Athletics || 8–1 || Hudson (10–9) || Báez (9–10) || || 27,696 || 54–69 |-align="center" bgcolor="ffbbbb" | 124 || August 20 || Athletics || 6–3 || Harang (5–3) || Westbrook (1–2) || Koch (32) || 27,527 || 54–70 |-align="center" bgcolor="ffbbbb" | 125 || August 21 || Athletics || 6–0 || Lidle (7–9) || Rodríguez (0–1) || || 26,916 || 54–71 |-align="center" bgcolor="ffbbbb" | 126 || August 22 || Athletics || 9–3 || Mulder (15–7) || Phillips (1–2) || Bradford (2) || 27,759 || 54–72 |-align="center" bgcolor="bbffbb" | 127 || August 23 || Mariners || 4–2 || Wohlers (2–3) || Baldwin (7–10) || || 33,525 || 55–72 |-align="center" bgcolor="bbffbb" | 128 || August 24 || Mariners || 5–3 || Mulholland (2–0) || Creek (2–2) || || 38,086 || 56–72 |-align="center" bgcolor="ffbbbb" | 129 || August 25 || Mariners || 12–4 || García (14–9) || Westbrook (1–3) || || 36,402 || 56–73 |-align="center" bgcolor="bbffbb" | 130 || August 26 || Tigers || 8–2 || Rodríguez (1–1) || Sparks (8–13) || || 24,344 || 57–73 |-align="center" bgcolor="ffbbbb" | 131 || August 27 || Tigers || 8–5 || Redman (8–12) || Phillips (1–3) || Acevedo (27) || 24,375 || 57–74 |-align="center" bgcolor="bbffbb" | 132 || August 28 || Tigers || 2–1 || Sabathia (9–10) || Powell (1–4) || Báez (1) || 25,158 || 58–74 |-align="center" bgcolor="ffbbbb" | 133 || August 30 || Red Sox || 15–5 || Lowe (18–6) || Wright (0–3) || || 31,986 || 58–75 |-align="center" bgcolor="bbffbb" | 134 || August 31 || Red Sox || 8–7 || Báez (10–10) || Howry (3–4) || || 37,908 || 59–75 |- |-align="center" bgcolor="ffbbbb" | 135 || September 1 || Red Sox || 7–1 || Wakefield (8–5) || Nagy (1–4) || || 34,799 || 59–76 |-align="center" bgcolor="bbffbb" | 136 || September 2 || @ Tigers || 11–1 || Sabathia (10–10) || Powell (1–5) || ||