|| Westbrook (0-2) || MacDougal (6) || 17,931 || 3-6 |-align="center" bgcolor="#ffbbbb" | 10 || April 12 || Royals || 5 – 2 || George (2-0) || Sabathia (0-2) || Carrasco (1) || 18,168 || 3-7 |-align="center" bgcolor="#bbffbb" | 11 || April 13 || Royals || 6 – 1 || Rodríguez (2-0) || May (0-1) || || 19,335 || 4-7 |-align="center" bgcolor="#ffbbbb" | 12 || April 14 || Royals || 12 – 4 || Affeldt (2-0) || Anderson (2-1) || || 15,875 || 4-8 |-align="center" bgcolor="#bbffbb" | 13 || April 15 || Orioles || 8 – 3 || Davis (1-2) || Daal (0-2) || || 17,015 || 5-8 |-align="center" bgcolor="#ffbbbb" | 14 || April 16 || Orioles || 4 – 3 || Groom (1-0) || Báez (0-1) || Julio (2) || 15,674 || 5-9 |-align="center" bgcolor="#ffbbbb" | 15 || April 17 || Orioles || 6 – 4 (12) || Roberts (1-1) || Paronto (0-2) || Julio (3) || 17,368 || 5-10 |-align="center" bgcolor="#ffbbbb" | 16 || April 18 || @ White Sox || 5 – 3 || Colón (2-0) || Traber (0-1) || || 13,015 || 5-11 |-align="center" bgcolor="#ffbbbb" | 17 || April 19 || @ White Sox || 12 – 3 || Stewart (1-1) || Anderson (2-2) || || 18,907 || 5-12 |-align="center" bgcolor="#bbffbb" | 18 || April 20 || @ White Sox || 7 – 4 || Davis (2-2) || Buehrle (2-2) || || 14,975 || 6-12 |-align="center" bgcolor="#bbffbb" | 19 || April 21 || @ White Sox || 9 – 2 || Westbrook (1-2) || Garland (0-2) || || 15,424 || 7-12 |-align="center" bgcolor="#ffbbbb" | 20 || April 22 || @ Mariners || 8 – 5 || Carrara (1-0) || Báez (0-2) || || 25,231 || 7-13 |-align="center" bgcolor="#ffbbbb" | 21 || April 23 || @ Mariners || 4 – 0 || Meche (2-1) || Rodríguez (2-1) || || 26,036 || 7-14 |-align="center" bgcolor="#ffbbbb" | 22 || April 24 || @ Mariners || 4 – 2 || Moyer (3-1) || Traber (0-2) || Nelson (1) || 26,263 || 7-15 |-align="center" bgcolor="#ffbbbb" | 23 || April 25 || @ Athletics || 5 – 2 || Lilly (2-0) || Davis (2-3) || Foulke (5) || 11,178 || 7-16 |-align="center" bgcolor="#ffbbbb" | 24 || April 26 || @ Athletics || 6 – 3 || Bradford (2-2) || Mulholland (0-1) || Foulke (6) || 36,346 || 7-17 |-align="center" bgcolor="#ffbbbb" | 25