|| 18-22 |-align="center" bgcolor="#ffbbbb" | 41 || May 22 || @ Devil Rays || 6 – 3 || Waechter (2-4) || Westbrook (3-2) || Sosa (1) || 12,008 || 18-23 |-align="center" bgcolor="#ffbbbb" | 42 || May 23 || @ Devil Rays || 5 – 4 (10) || Harper (1-0) || Riske (0-2) || || 10,555 || 18-24 |-align="center" bgcolor="#ffbbbb" | 43 || May 25 || Mariners || 5 – 4 (12) || Myers (2-1) || Jiménez (0-3) || Guardado (7) || 15,349 || 18-25 |-align="center" bgcolor="#ffbbbb" | 44 || May 26 || Mariners || 7 – 3 || Moyer (3-2) || Sabathia (2-3) || Guardado (8) || 16,007 || 18-26 |-align="center" bgcolor="#bbffbb" | 45 || May 27 || Mariners || 9 – 5 || Westbrook (4-2) || Meche (1-5) || || 17,272 || 19-26 |-align="center" bgcolor="#bbffbb" | 46 || May 28 || Athletics || 1 – 0 || Jiménez (1-3) || Mecir (0-4) || || 19,257 || 20-26 |-align="center" bgcolor="#bbffbb" | 47 || May 29 || Athletics || 8 – 6 || Riske (1-2) || Rhodes (1-2) || Jiménez (1) || 26,441 || 21-26 |-align="center" bgcolor="#bbffbb" | 48 || May 30 || Athletics || 4 – 3 || White (2-0) || Rhodes (1-3) || || 24,005 || 22-26 |- |-align="center" bgcolor="#ffbbbb" | 49 || June 1 || Rangers || 6 – 5 (12) || Ramirez (3-2) || White (2-1) || Cordero (17) || 17,136 || 22-27 |-align="center" bgcolor="#ffbbbb" | 50 || June 2 || Rangers || 5 – 3 || Almanzar (5-0) || Betancourt (2-4) || Cordero (18) || 18,098 || 22-28 |-align="center" bgcolor="#ffbbbb" | 51 || June 3 || @ Angels || 5 – 2 || Escobar (4-2) || Lee (5-1) || || 39,353 || 22-29 |-align="center" bgcolor="#bbffbb" | 52 || June 4 || @ Angels || 9 – 6 || Riske (2-2) || Rodríguez (1-1) || Jiménez (2) || 43,590 || 23-29 |-align="center" bgcolor="#bbffbb" | 53 || June 5 || @ Angels || 3 – 2 || White (3-1) || Lackey (3-7) || Jiménez (3) || 43,514 || 24-29 |-align="center" bgcolor="#bbffbb" | 54 || June 6 || @ Angels || 7 – 0 || Sabathia (3-3) || Colón (4-4) || || 43,337 || 25-29 |-align="center" bgcolor="#ffbbbb" | 55 || June 8 || Marlins || 7 – 5 || Bump (1-3) || Jiménez (1-4) || Benítez (23) || 21,252 || 25-30 |-align="center" bgcolor="#bbffbb" | 56 || June 9 ||