18,722 || 60–76 |-align="center" bgcolor="ffbbbb" | 137 || September 3 || @ Tigers || 4–0 || Van Hekken (1–0) || Mulholland (2–1) || || 11,635 || 60–77 |-align="center" bgcolor="bbffbb" | 138 || September 4 || @ Tigers || 9–3 || Wright (1–3) || Maroth (5–7) || || 12,715 || 61–77 |-align="center" bgcolor="bbffbb" | 139 || September 5 || @ White Sox || 11–6 || Rodríguez (2–1) || Glover (7–7) || || 12,667 || 62–77 |-align="center" bgcolor="bbffbb" | 140 || September 6 || @ White Sox || 9–7 || Burba (1–0) || Buehrle (17–10) || Báez (2) || 17,131 || 63–77 |-align="center" bgcolor="bbffbb" | 141 || September 7 || @ White Sox || 4–2 || Sabathia (11–10) || Garland (10–11) || Wohlers (7) || 16,622 || 64–77 |-align="center" bgcolor="ffbbbb" | 142 || September 8 || @ White Sox || 7–6 || Osuna (8–2) || Báez (10–11) || || 15,067 || 64–78 |-align="center" bgcolor="ffbbbb" | 143 || September 9 || Blue Jays || 11–9 || Bowles (1–1) || Sadler (1–1) || Escobar (30) || 28,567 || 64–79 |-align="center" bgcolor="ffbbbb" | 144 || September 10 || Blue Jays || 5–4 || Bowles (2–1) || Wohlers (2–4) || Escobar (31) || 24,312 || 64–80 |-align="center" bgcolor="ffbbbb" | 145 || September 11 || Blue Jays || 6–5 (11) || Cassidy (1–4) || Elder (0–1) || Kershner (1) || 26,609 || 64–81 |-align="center" bgcolor="bbffbb" | 146 || September 12 || Twins || 5–4 || Riggan (2–1) || Mays (3–7) || Báez (3) || 28,649 || 65–81 |-align="center" bgcolor="bbffbb" | 147 || September 13 || Twins || 12–5 || Mulholland (3–1) || Milton (13–9) || || 30,421 || 66–81 |-align="center" bgcolor="ffbbbb" | 148 || September 14 || Twins || 3–2 || Reed (15–7) || Sadler (1–2) || Guardado (41) || 32,330 || 66–82 |-align="center" bgcolor="ffbbbb" | 149 || September 15 || Twins || 5–0 || Lohse (13–8) || Lee (0–1) || || 28,061 || 66–83 |-align="center" bgcolor="ffbbbb" | 150 || September 16 || @ Red Sox || 6–1 || Martínez (19–4) || Rodríguez (2–2) || || 30,023 || 66–84 |-align="center" bgcolor="bbffbb" | 151 || September 16 || @ Red Sox || 7–1 || Tallet (1–0) || Castillo (5–15) || || 31,203 || 67–84 |-align="center" bgcolor="ffbbbb" | 152 || September 17 || @ Red Sox || 4–2 || Wakefield (11–5) || Sabathia (11–11) || Urbina (36) || 31,760 || 67–85 |-align="center" bgcolor="bbffbb" | 153 || September 18 ||