|-align="center" bgcolor="#bbffbb" | 11 || April 16 || Tigers || 10 – 3 || Sabathia (1-0) || Cornejo (1-1) || || 18,507 || 4-7 |-align="center" bgcolor="#ffbbbb" | 12 || April 17 || Tigers || 6 – 1 || Maroth (2-0) || Davis (0-1) || || 18,955 || 4-8 |-align="center" bgcolor="#bbffbb" | 13 || April 18 || Tigers || 9 – 7 || Lee (2-0) || Bonderman (1-1) || Riske (1) || 19,240 || 5-8 |-align="center" bgcolor="#ffbbbb" | 14 || April 19 || Tigers || 10 – 4 || Levine (1-0) || Betancourt (0-2) || || 13,650 || 5-9 |-align="center" bgcolor="#ffbbbb" | 15 || April 20 || Royals || 15 – 5 || Anderson (1-0) || Durbin (1-2) || || 13,563 || 5-10 |-align="center" bgcolor="#bbbbbb" | -- || April 21 || Royals || colspan=6|Postponed (rain) Rescheduled for July 24 |-align="center" bgcolor="#bbffbb" | 16 || April 22 || Royals || 5 – 4 || Betancourt (1-2) || Grimsley (1-1) || Riske (2) || 15,720 || 6-10 |-align="center" bgcolor="#ffbbbb" | 17 || April 23 || @ Tigers || 17 – 3 || Bonderman (2-1) || Davis (0-2) || || 22,008 || 6-11 |-align="center" bgcolor="#ffbbbb" | 18 || April 24 || @ Tigers || 5 – 2 || Urbina (1-0) || Stewart (0-1) || || 20,913 || 6-12 |-align="center" bgcolor="#bbffbb" | 19 || April 25 || @ Tigers || 3 – 2 || Westbrook (1-1) || Johnson (1-4) || ||17,253 || 7-12 |-align="center" bgcolor="#bbffbb" | 20 || April 27 || @ White Sox || 11 – 7 (10) || Betancourt (2-2) || Adkins (2-1) || || 14,572 || 8-12 |-align="center" bgcolor="#ffbbbb" | 21 || April 28 || @ White Sox || 9 – 8 || Jackson (1-0) || Betancourt (2-3) || || 12,189 || 8-13 |-align="center" bgcolor="#bbffbb" | 22 || April 30 || Orioles || 11 – 2 || Lee (3-0) || Ponson (2-2) || || 18,782 || 9-13 |- |-align="center" bgcolor="#bbffbb" | 23 || May 1 || Orioles || 3 – 2(13) || Durbin (2-2) || DeJean (0-2) || || 17,275 || 10-13 |-align="center" bgcolor="#bbbbbb" | -- || May 2 || Orioles || colspan=6|Postponed (rain) Rescheduled for June 14 |-align="center" bgcolor="#bbffbb" | 24 || May 3 || Red Sox || 2 – 1 || Westbrook (2-1) || Schilling (3-2) || Betancourt (1) || 16,285 || 11-13 |-align="center" bgcolor="#bbffbb" | 25 || May 4 || Red Sox || 7 – 6 || Davis (1-2)