– 1 || Moyer (4-0) || Elarton (0-1) || || 32,889 || 8-11 |-align="center" bgcolor="#bbbbbb" | -- || April 26 || Tigers || colspan=6|Postponed (rain) Rescheduled for July 4 |-align="center" bgcolor="#ffbbbb" | 20 || April 27 || Tigers || 10 – 3 || Bonderman (3-2) || Westbrook (0-5) || || 12,162 || 8-12 |-align="center" bgcolor="#ffbbbb" | 21 || April 28 || Tigers || 3 – 2 || Maroth (2-1) || Millwood (0-3) || Percival (2) || 13,809 || 8-13 |-align="center" bgcolor="#bbffbb" | 22 || April 29 || Royals || 6 – 0 || Sabathia (2-0) || Greinke (0-2) || || 16,666 || 9-13 |-align="center" bgcolor="#ffbbbb" | 23 || April 30 || Royals || 8 – 1 || Bautista (2-1) || Lee (2-1) || || 15,771 || 9-14 |- |-align="center" bgcolor="#ffbbbb" | 24 || May 1 || Royals || 6 – 5 || Wood (1-2) || Betancourt (1-1) || Burgos (1) || 17,672 || 9-15 |-align="center" bgcolor="#bbffbb" | 25 || May 3 || @ Twins || 4 – 2 || Westbrook (1-5) || Mays (1-1) || Wickman (6) || 16,919 || 10-15 |-align="center" bgcolor="#bbffbb" | 26 || May 4 || @ Twins || 5 – 4 || Howry (2-1) || Romero (0-2) || Wickman (7) || 19,856 || 11-15 |-align="center" bgcolor="#ffbbbb" | 27 || May 5 || @ Twins || 9 – 0 || Radke (3-3) || Sabathia (2-1) || || 18,265 || 11-16 |-align="center" bgcolor="#bbffbb" | 28 || May 6 || @ Rangers || 8 – 6 || Lee (3-1) || Astacio (1-4) || Wickman (8) || 30,742 || 12-16 |-align="center" bgcolor="#ffbbbb" | 29 || May 7 || @ Rangers || 6 – 1 || Drese (3-3) || Elarton (0-2) || || 36,311 || 12-17 |-align="center" bgcolor="#ffbbbb" | 30 || May 8 || @ Rangers || 7 – 2 || Rogers (3-2) || Westbrook (1-6) || Cordero (10) || 23,203 || 12-18 |-align="center" bgcolor="#bbffbb" | 31 || May 9 || @ Angels || 3 – 0 || Millwood (1-3) || Lackey (3-2) || Wickman (9) || 36,763 || 13-18 |-align="center" bgcolor="#ffbbbb" | 32 || May 10 || @ Angels || 5 – 4 || Byrd (3-3) || Sabathia (2-2) || Rodríguez (9) || 38,320 || 13-19 |-align="center" bgcolor="#bbffbb" | 33 || May 11 || @ Angels || 9 – 3 || Lee (4-1) || Escobar (1-2) || || 35,508 || 14-19 |-align="center" bgcolor="#bbffbb" | 34 || May 13 || Blue