chamber underneath the Sistine Chapel, where they are met by a hologram of Minerva, a member of the Precursor race known as the Isu that created humanity and the Pieces of Eden. Minerva addresses Desmond by name, knowing that he is reliving Ezio's memories, and talks about a cataclysm that wiped out most of her race thousands of years ago, and which is set to occur again by the end of that year, if Desmond does not prevent it. Desmond is then pulled from the Animus as Abstergo discovers the Assassins' hideout. As the team escapes to a new hideout, Desmond re-enters the Animus, knowing Ezio and perhaps Subject 16 may have the answers they seek. Assassin's Creed: Brotherhood In Assassin's Creed: Brotherhood, Desmond, Lucy, Shaun, and Rebecca arrive at Monteriggioni, where they set up a safe house in the Villa Auditore's sanctuary. Desmond re-enters the Animus 2.0 to continue reliving Ezio's memories and discover what he did with the Apple of Eden he had obtained, hoping to use the artifact to defeat the Templars and stop the cataclysm Minerva warned him about. After learning Ezio hid the Apple under the Colosseum once he retrieved it from the Templars and used it to end their reign in Italy, Desmond and the other Assassins head there to retrieve it. Desmond takes the Apple, but through it another Isu named Juno takes control of his body and forces him to stab Lucy, saying that she would have betrayed him if he allowed her to accompany him any further. Desmond then falls into a coma and is placed back into the Animus by two unknown Assassins in a bid to preserve his consciousness. Assassin's Creed: Revelations In Assassin's Creed: Revelations, Desmond awakens within the Black Room, a safe mode area for the Animus. In the Black Room's Animus Island, he meets the digital construct of Subject 16, Clay Kaczmarek, who tells Desmond that he must find a "Synch Nexus", a memory that links him with Altaïr and Ezio, so that the Animus can reintegrate his shattered subconscious and awaken him from his coma. While in this state, Desmond can hear conversations between Shaun, Rebecca, and his father, William Miles, who are concerned about his state, and access five memory sequences, known as "Desmond's Journey", that detail his own life prior to his abduction by Abstergo. In these sequences, Desmond reminisces of his time