Jays || 6 – 4 || Davis (2-1) || Lilly (1-4) || Wickman (10) || 19,637 || 15-19 |-align="center" bgcolor="#bbffbb" | 35 || May 14 || Blue Jays || 3 – 2 || Rhodes (2-1) || Frasor (1-3) || Wickman (11) || 22,525 || 16-19 |-align="center" bgcolor="#ffbbbb" | 36 || May 15 || Blue Jays || 5 – 2 || Halladay (6-2) || Sabathia (2-3) || || 23,446 || 16-20 |-align="center" bgcolor="#ffbbbb" | 37 || May 16 || Angels || 3 – 1 || Byrd (4-3) || Lee (4-2) || Shields (3) || 13,729 || 16-21 |-align="center" bgcolor="#bbffbb" | 38 || May 17 || Angels || 13 – 5 || Elarton (1-2) || Santana (0-1) || || 15,033 || 17-21 |-align="center" bgcolor="#ffbbbb" | 39 || May 18 || Angels || 2 – 1 || Colón (5-3) || Westbrook (1-7) || Shields (4) || 19,030 || 17-22 |-align="center" bgcolor="#ffbbbb" | 40 || May 20 || @ Reds || 2 – 1 || Harang (3-2) || Millwood (1-4) || Graves (10) || 25,412 || 17-23 |-align="center" bgcolor="#bbffbb" | 41 || May 21 || @ Reds || 5 -3 || Sabathia (3-3) || Ramírez (0-2) || Wickman (12) || 31,083 || 18-23 |-align="center" bgcolor="#bbffbb" | 42 || May 22 || @ Reds || 9 – 2 || Lee (5-2) || Ortiz (1-3) || || 21,862 || 19-23 |-align="center" bgcolor="#bbffbb" | 43 || May 23 || Twins || 2 – 1 || Rhodes (3-1) || Lohse (3-3) || Wickman (13) || 13,257 || 20-23 |-align="center" bgcolor="#ffbbbb" | 44 || May 24 || Twins || 6 – 3 (11) || Crain (4-0) || Riske (1-1) || Nathan (13) || 15,884 || 20-24 |-align="center" bgcolor="#bbffbb" | 45 || May 25 || Twins || 3 – 2 (10) || Howry (3-1) || Rincón (2-2) || || 15,794 || 21-24 |-align="center" bgcolor="#ffbbbb" | 46 || May 26 || Twins || 5 – 4 (11) || Crain (5-0) || Riske (1-2) || Nathan (14) || 19,161 || 21-25 |-align="center" bgcolor="#bbffbb" | 47 || May 27 || Athletics || 4 – 1 || Lee (6-2) || Zito (1-6) || Riske (1) || 19,711 || 22-25 |-align="center" bgcolor="#bbffbb" | 48 || May 28 || Athletics || 6 – 3 || Elarton (2-2) || Saarloos (1-4) || Howry (1) || 33,646 || 23-25 |-align="center" bgcolor="#bbffbb" | 49 || May 29 || Athletics || 6 – 2 || Westbrook (2-7) || Etherton (1-1)