|| Wickman (33) || 8,648 || 70-56 |-align="center" bgcolor="#ffbbbb" | 127 || August 24 || @ Devil Rays || 13 – 3 || McClung (5-7) || Elarton (7-7) || || 11,261 || 70-57 |-align="center" bgcolor="#bbffbb" | 128 || August 25 || @ Devil Rays || 12 – 4 || Lee (14-4) || Kazmir (7-9) || || 9,172 || 71-57 |-align="center" bgcolor="#bbffbb" | 129 || August 26 || @ Blue Jays || 9 – 3 || Sabathia (11-9) || McGowan (1-2) || || 24,649 || 72-57 |-align="center" bgcolor="#ffbbbb" | 130 || August 27 || @ Blue Jays || 2 – 1 || Downs (2-3) || Millwood (7-11) || Batista (24) || 27,630 || 72-58 |-align="center" bgcolor="#bbffbb" | 131 || August 28 || @ Blue Jays || 4 – 1 || Westbrook (13-13) || Towers (10-10) || Wickman (34) || 31,785 || 73-58 |-align="center" bgcolor="#bbffbb" | 132 || August 29 || Tigers || 10 – 8 || Cabrera (2-0) || Bonderman (14-11) || Wickman (35) || 22,713 || 74-58 |-align="center" bgcolor="#bbbbbb" | --- || August 30 || Tigers || colspan=6|Postponed (rain) Rescheduled for September 8 |-align="center" bgcolor="#ffbbbb" | 133 || August 31 || Tigers || 4 – 3 || Maroth (12-12) || Betancourt (2-3) || Rodney (7) || 22,091 || 74-59 |- |-align="center" bgcolor="#bbffbb" | 134 || September 2 || @ Twins || 6 – 1 || Sabathia (12-9) || Radke (9-11) || || 16,119 || 75-59 |-align="center" bgcolor="#ffbbbb" | 135 || September 3 || @ Twins || 3 – 2 || Nathan (7-3) || Howry (6-3) || || 21,757 || 75-60 |-align="center" bgcolor="#ffbbbb" | 136 || September 4 || @ Twins || 7 – 5 || Crain (10-4) || Westbrook (13-14) || Nathan (35) || 21,717 || 75-61 |-align="center" bgcolor="#bbffbb" | 137 || September 5 || @ Tigers || 2 – 0 || Elarton (8-7) || Maroth (12-13) || Wickman (36) || 26,150 || 76-61 |-align="center" bgcolor="#bbffbb" | 138 || September 6 || @ Tigers || 6 – 1 || Lee (15-4) || Johnson (7-12) || || 15,308 || 77-61 |-align="center" bgcolor="#bbffbb" | 139 || September 7 || @ Tigers || 4 – 1 || Sabathia (13-9) || Colón (1-1) || || 13,193 || 78-61 |-align="center" bgcolor="#bbffbb" | 140 || September 8 || Tigers || 4 – 2 || Betancourt (3-3) || Robertson (6-13) || Wickman (37) || 20,363 || 79-61 |-align="center" bgcolor="#bbffbb" | 141 || September 9 || Twins ||