In enzymology, a cortisol O-acetyltransferase () is an enzyme that catalyzes the chemical reaction acetyl-CoA + cortisol CoA + cortisol 21-acetate Thus, the two substrates of this enzyme are acetyl-CoA and cortisol, whereas its two products are CoA and cortisol 21-acetate. This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:cortisol O-acetyltransferase. Other names in common use include cortisol acetyltransferase, corticosteroid acetyltransferase, and corticosteroid-21-O-acetyltransferase. References EC 2.3.1 Enzymes of unknown structure