Reichert (1–3) || Sabathia (3–4) || || 24,279 || 17–19 |-align="center" bgcolor="bbbbbb" | -- || May 11 || @ Royals ||colspan=6|Postponed (rain) |-align="center" bgcolor="ffbbbb" | 37 || May 12 || @ Royals || 4–1 || Byrd (6–2) || Finley (2–4) || Hernández (3) || 10,820 || 17–20 |-align="center" bgcolor="bbffbb" | 38 || May 14 || Orioles || 6–5 || Shuey (2–0) || Julio (2–2) || || 30,447 || 18–20 |-align="center" bgcolor="bbffbb" | 39 || May 15 || Orioles || 3–1 || Colón (5–3) || Bauer (1–1) || Wickman (8) || 26,315 || 19–20 |-align="center" bgcolor="ffbbbb" | 40 || May 17 || Royals || 6–2 || Byrd (7–2) || Finley (2–5) || || 32,593 || 19–21 |-align="center" bgcolor="ffbbbb" | 41 || May 18 || Royals || 4–2 || Reichert (2–4) || Wickman (0–1) || Hernández (4) || 29,388 || 19–22 |-align="center" bgcolor="bbffbb" | 42 || May 18 || Royals || 4–1 || Drese (4–3) || May (0–1) || Wickman (9) || 32,110 || 20–22 |-align="center" bgcolor="ffbbbb" | 43 || May 19 || Royals || 5–4 || Grimsley (2–2) || Wickman (0–2) || Hernández (5) || 31,105 || 20–23 |-align="center" bgcolor="ffbbbb" | 44 || May 20 || @ Tigers || 4–3 || Santana (3–0) || Rincón (0–2) || Walker (1) || 12,851 || 20–24 |-align="center" bgcolor="ffbbbb" | 45 || May 21 || @ Tigers || 5–1 || Redman (1–5) || Nagy (0–1) || || 14,442 || 20–25 |-align="center" bgcolor="ffbbbb" | 46 || May 22 || @ Tigers || 2–0 || Weaver (4–5) || Finley (2–6) || || 14,396 || 20–26 |-align="center" bgcolor="bbffbb" | 47 || May 24 || @ Blue Jays || 5–2 || Drese (5–3) || Miller (3–2) || Wickman (10) || 16,385 || 21–26 |-align="center" bgcolor="bbffbb" | 48 || May 25 || @ Blue Jays || 3–0 || Sabathia (4–4) || Loaiza (2–1) || Wickman (11) || 21,589 || 22–26 |-align="center" bgcolor="bbffbb" | 49 || May 26 || @ Blue Jays || 3–1 || Colón (6–3) || Prokopec (2–7) || || 22,380 || 23–26 |-align="center" bgcolor="ffbbbb" | 50 || May 27 || Tigers || 4–1 || Redman (2–5) || Báez (4–4) || || 40,652 || 23–27 |-align="center" bgcolor="bbffbb" | 51 || May 28 || Tigers || 4–2 || Finley (3–6) || Weaver (4–6) || Wickman (12) || 25,028 || 24–27 |-align="center" bgcolor="ffbbbb" | 52 || May 29 || Tigers || 9–5 || Sparks (3–5) || Riske (0–2) || Acevedo (7)