The 22nd Indiana Volunteer Infantry Regiment was an infantry regiment that served in the Union Army during the American Civil War. On October 8, 1862, at the Battle of Perryville, Kentucky, the regiment suffered 65.3% casualties, one of the highest percentages of casualties suffered by any American Civil War regiment in a single engagement. Service Attached to Army of the West and Department of Missouri September 1861 to January 1862. 1st Brigade, 3rd Division, Army of Southwest Missouri, to May 1862. 1st Brigade, 4th Division, Army of the Mississippi, to September 1862. 30th Brigade, 9th Division, Army of the Ohio, September 1862. 30th Brigade, 9th Division, III Corps, Army of the Ohio, to November 1862. 1st Brigade, 1st Division, Right Wing, XIV Corps, Army of the Cumberland, to January 1863. 1st Brigade, 1st Division, XX Corps, Army of the Cumberland, to October 1863. 2nd Brigade, 1st Division, IV Corps, Army of the Cumberland, October 1863. 1st Brigade, 2nd Division, IV Corps, to April 1864. 3rd Brigade, 2nd Division, XIV Corps, to July 1865. Detailed Service The 22nd Indiana Volunteer Infantry was organized at Madison, Indiana, and mustered in at Indianapolis, Indiana, on August 15, 1861. Moved to St. Louis, Missouri, August 17. March to relief of Colonel Mulligan at Lexington, Missouri, September. Action at Glasgow, Missouri, September 19. Fremont's advance on Springfield, Missouri, September 22-October 15. Pope's Expedition to Milford, Missouri, December 15–19, 1861. Action at Milford (or Shawnee) Mound on Blackwater Creek and capture of 1,300 prisoners on December 18. Duty at Otterville, Missouri, in January, 1862. Advanace on Springfield, Missouri, January 24-February 14. Pursuit of Sterling Price to Cassville, Arkansas. Battle of Pea Ridge, Arkansas, March 6–8. March to Batesville, Arkansas, April 5-May 3. Moved to Cape Girardeau, Missouri, thence to Corinth, Mississippi, May 20–28. Siege of Corinth, Mississippi, May 28–30. Pursuit to Booneville May 31-June 6. Duty at Jacinto and other points in Northern Mississippi till August 17. March to Louisville, Kentucky, August 17-September 26. Pursuit of Braxton Bragg into Kentucky October 1–15. Battle of Perryville, Kentucky, October 8. Lancaster October 14. March to Nashville, Tennessee, October 16-November 28. Scout to Harpeth Shoals November 26–30. At Nashville till December 26. Wilson's Creek Pike December 25. Advance on Murfreesboro December 26–30. Nolensville December 26–27. Battle of Stones River December 30–31, 1862, and January 1–3, 1863. Duty at Murfreesboro till June. Operations on Edgeville Pike near Munfreesboro, June 4.