bgcolor="ffbbbb" | 16 || April 17 || @ Angels || 5 – 3 || Garland (2-2) || Tomko (1-2) || Rodríguez (6) || 40,021 || 9-7 |- bgcolor="ffbbbb" | 17 || April 18 || @ Athletics || 13 – 2 || Gaudin (1-1) || Bannister (3-1) || || 12,528 || 9-8 |- bgcolor="ffbbbb" | 18 || April 19 || @ Athletics || 6 – 5 || Devine (2-0) || Peralta (0-1) || Street (5) || 20,390 || 9-9 |- bgcolor="ffbbbb" | 19 || April 20 || @ Athletics || 7 – 1 || Eveland (2-1) || Hochevar (0-1) || || 18,645 || 9-10 |- bgcolor="ffbbbb" | 20 || April 22 || Indians || 15 – 1 || Sabathia (1-3) || Meche (1-3) || || 16,165 || 9-11 |- bgcolor=#bbbbbb | N/A || April 23 || Indians ||colspan=6|Postponed (rain) Rescheduled for April 24 |- bgcolor="ffbbbb" | 21 || rowspan="2" |April 24 || rowspan="2" |Indians(doubleheader) || 9 – 6 || Carmona (3-1) || Tomko (1-3) || Betancourt (1) || rowspan="2"|11,637 || 9-12 |- bgcolor="ffbbbb" | 22 || 2 – 0 || Lee (4-0) || Bannister (3-2) || || 9-13 |- bgcolor="#bbffbb" | 23 || April 25 || Blue Jays || 8 – 4 || Núñez (2-0) || Burnett (2-2) || || 22,561 || 10-13 |- bgcolor="#bbffbb" | 24 || April 26 || Blue Jays || 2 – 1 || Hochevar (1-1) || Marcum (2-2) || Soria (6) || 24,078 || 11-13 |- bgcolor="ffbbbb" | 25 || April 27 || Blue Jays || 5 – 2 || Litsch (3-1) || Meche (1-4) || Carlson (1) || 13,998 || 11-14 |- bgcolor="#bbffbb" | 26 || April 29 || @ Rangers || 9 – 5 || Mahay (1-0) || Jennings (0-5) || || 16,472 || 12-14 |- bgcolor="ffbbbb" | 27 || April 30 || @ Rangers || 11 – 9 || Millwood (2-2) || Bannister (3-2) || || 17,705 || 12-15 |- |- bgcolor="ffbbbb" | 28 || May 1 || @ Rangers || 2 – 1 || Ponson (1-0) || Greinke (3-1) || Wilson (6) || 14,563 || 12-16 |- bgcolor="#bbbbbb" | N/A || May 2 || @ Indians || colspan=6|Postponed (rain) Rescheduled for September 13 |- bgcolor="#bbffbb" | 29 || May 3 || @ Indians || 4 – 2 || Hochevar (2-1) || Sabathia (1-5) || Soria (7) || 27,272 || 13-16 |- bgcolor="#bbffbb" | 30 || May 4 || @ Indians || 2