| Athletics(doubleheader) || 5 – 4 (10) || Soria (2-3) || Devine (4-1) || || rowspan="2"| 12,791 || 59-79 |-bgcolor="bbffbb" | 139 || 9 – 6 || Davies (6-6) || Meyer (0-4) || R. Ramírez (1) || 60-79 |- bgcolor="ffbbbb" | 140 || September 5 || Indians || 9 – 3 || Mujica (2-1) || Duckworth (2-1) || || 21,107 || 60-80 |- bgcolor="bbffbb" | 141 || September 6 || Indians || 3 – 1 || Meche (11-10) || Jackson (0-2) || Soria (35) || 18,795 || 61-80 |- bgcolor="ffbbbb" | 142 || September 7 || Indians || 3 – 1 || Lee (21-2) || Greinke (10-10) || Lewis (8) || 15,023 || 61-81 |- bgcolor="ffbbbb" | 143 || September 9 || @ Twins || 7 – 2 || Blackburn (10-8) || Bannister (7-15) || || 17,015 || 61-82 |- bgcolor="ffbbbb" | 144 || September 10 || @ Twins || 7 – 1 || Slowey (12-9) || Davies (6-7) || || 20,421 || 61-83 |- bgcolor="bbffbb" | 145 || September 11 || @ Twins || 3 – 2 (10) || R. Ramírez (3-2) || Guerrier (6-8) || Soria (36) || 20,138 || 62-83 |- bgcolor="ffbbbb" | 146 || September 12 || @ Indians || 12 – 5 || Lee (22-2) || Meche (11-11) || || 32,843 || 62-84 |- bgcolor="bbffbb" | 147 || rowspan="2" |September 13 || rowspan="2" | @ Indians(doubleheader) || 8 – 3 || Greinke (11-10) || Carmona (8-7) || || rowspan="2"| 25,783 || 63-84 |- bgcolor="bbffbb" | 148 || 8 – 4 || Tejeda (2-2) || Bullington (0-1) || Soria (37) || 64-84 |- bgcolor="bbffbb" | 149 || September 14 || @ Indians || 13 – 3 || Bannister (8-15) || Mujica (2-2) || || 29,530 || 65-84 |- bgcolor="bbffbb" | 150 || September 15 || Mariners || 3 – 0 || Davies (7-7) || Silva (4-15) || Soria (38) || 10,307 || 66-84 |- bgcolor="bbffbb" | 151 || September 16 || Mariners || 6 – 3 || Duckworth (3-1) || Morrow (2-4) || Soria (39) || 19,135 || 67-84 |- bgcolor="bbffbb" | 152 || September 17 || Mariners || 5 – 2 || Meche (12-11) || Corcoran (5-2) || Soria (40) || 13,382 || 68-84 |- bgcolor="bbffbb" | 153 || September 18 || Mariners || 12 – 0 || Greinke (12-10) || Feierabend (1-4) || || 14,144 || 69-84 |- bgcolor="ffbbbb" | 154 || September 19