| 40 || May 24 || 12:20p.m. CDT || @ Cubs || L 3–4 || Frazier (2–3) || Smith (0–2) || Smith (6) || 2:50 || 33,355 || 22–18 || L2 |-style="background:#cfc;" | 41 || May 25 || 1:20p.m. CDT || @ Cubs || W 3–1 || Kerfeld (4–1) || Smith (0–2) || Smith (11) || 3:02 || 36,000 || 23–18 || W1 |-style="background:#cfc;" | 42 || May 26 || 5:35p.m. CDT || @ Cardinals || W 4–1 || Deshaies (1–1) || Forsch (3–3) || DiPino (2) || 2:43 || 20,099 || 24–18 || W2 |-style="background:#cfc;" | 43 || May 27 || 7:35p.m. CDT || @ Cardinals || W 5–4 || Smith (1–2) || Dayley (0–3) || — || 2:48 || 20,146 || 25–18 || W3 |-style="background:#cfc;" | 44 || May 28 || 12:35p.m. CDT || @ Cardinals || W 4–3 || Kerfeld (5–1) || Worrell (3–3) || — || 3:18 || 17,582 || 26–18 || W4 |-style="background:#fcc;" | 45 || May 30 || 7:35p.m. CDT || Expos || L 0–1 || Smith (4–4) || Scott (4–4) || Reardon (12) || 2:14 || 13,854 || 26–19 || L1 |-style="background:#cfc;" | 46 || May 31 || 7:35p.m. CDT || Expos || W 4–3 || DiPino (1–1) || Burke (2–1) || Smith (12) || 2:30 || 25,831 || 27–19 || W1 |- |-style="background:#cfc;" | 47 || June 1 || 2:05p.m. CDT || Expos || W 8–4 || Knepper (9–2) || Hesketh (3–4) || — || 2:38 || 13,325 || 28–19 || W2 |-style="background:#fcc;" | 48 || June 2 || 7:35p.m. CDT || Cardinals || L 2–9 || Tudor (5–3) || Madden (1–2) || — || 2:45 || 11,669 || 28–20 || L1 |-style="background:#fcc;" | 49 || June 3 || 7:35p.m. CDT || Cardinals || L 1–3 || Mathews (1–0) || Deshaies (1–2) || Worrell (8) || 2:20 || 6,430 || 28–21 || L2 |-style="background:#cfc;" | 50 || June 4 || 7:35p.m. CDT || Cardinals || W 4–2 || Scott (5–4) || Burris (2–2) || Smith (13) || 2:33 || 11,396 || 29–21 || W1 |-style="background:#fcc;" | 51 || June 5 || 9:35p.m. CDT || @ Dodgers || L 0–1 || Honeycutt (3–3) || Hernández (0–1) || Howell (3) || 2:25 || 32,545 || 29–22 || L1 |-style="background:#fcc;" | 52 || June 6 || 9:35p.m. CDT || @ Dodgers || L 2–3 || Howell (2–2) || Knepper (9–3) || — || 2:52 ||