(4–4) || Jackson (3–4) || || 12,636 || 32–22 |- style="text-align:center; background:#bfb;" | 55 || May 30 || White Sox || 2–1 || Wheeler (1–3) || Linebrink (2–1) || || 14,679 || 33–22 |- style="text-align:center; background:#bfb;" | 56 || May 31 || White Sox || 2–0 || Kazmir (5–1) || Vázquez (5–4) || Balfour (1) || 36,048 || 34–22 |- |- style="text-align:center; background:#bfb;" | 57 || June 1 || White Sox || 4–3 (10) || Howell (4–0) || Thornton (1–1) || || 24,720 || 35–22 |- style="text-align:center; background:#fbb;" | 58 || June 3 || @ Red Sox || 7–4 || Masterson (2–0) || Garza (4–2) || Papelbon (17) || 37,823 || 35–23 |- style="text-align:center; background:#fbb;" | 59 || June 4 || @ Red Sox || 5–1 || Beckett (6–4) || Jackson (3–5) || || 37,474 || 35–24 |- style="text-align:center; background:#fbb;" | 60 || June 5 || @ Red Sox || 7–1 || Lester (4–3) || Shields (4–4) || || 37,639 || 35–25 |- style="text-align:center; background:#bfb;" | 61 || June 6 || @ Rangers || 12–4 || Kazmir (6–1) || Padilla (7–3) || || 21,783 || 36–25 |- style="text-align:center; background:#bfb;" | 62 || June 7 || @ Rangers || 5–4 || Howell (5–0) || Benoit (3–2) || Wheeler (2) || 28,788 || 37–25 |- style="text-align:center; background:#fbb;" | 63 || June 8 || @ Rangers || 6–3 || Mathis (2–1) || Garza (4–3) || || 20,258 || 37–26 |- style="text-align:center; background:#bfb;" | 64 || June 9 || @ Angels || 13–4 || Jackson (4–5) || Saunders (9–3) || || 42,019 || 38–26 |- style="text-align:center; background:#fbb;" | 65 || June 10 || @ Angels || 6–1 || Weaver (6–6) || Shields (4–5) || || 37,610 || 38–27 |- style="text-align:center; background:#fbb;" | 66 || June 11 || @ Angels || 4–2 || Lackey (6–6) || Kazmir (6–2) || Rodríguez (27) || 36,622 || 38–28 |- style="text-align:center; background:#bfb;" | 67 || June 13 || Marlins || 7–3 || Sonnanstine (7–3) || Tucker (1–1) || || 19,312 || 39–28 |- style="text-align:center; background:#bfb;" | 68 || June 14 || Marlins || 4–1 || Garza (5–3) || Hendrickson (7–5) || Percival (15) || 31,195 || 40–28 |- style="text-align:center; background:#fbb;" | 69 || June 15 || Marlins || 9–3 || Nolasco (7–4) || Jackson (4–6) || || 28,886 || 40–29 |- style="text-align:center; background:#bfb;" | 70 || June 17 || Cubs || 3–2 || Balfour (1–0) || Cotts (0–1) ||