|| Jenks (1) || U.S. Cellular Field 40,142 || 2–1 |- style="text-align:center; background:#bfb;" | 4 || October 6 || @ White Sox || 6–2 || Sonnanstine (1–0) || Floyd (0–1) || || U.S. Cellular Field 40,453 || 3–1 |- |- style="text-align:center; background:#fbb;" | 1 || October 10 || Red Sox || 2–0 || Matsuzaka (1–0) || Shields (0–1) || Papelbon (1) || Tropicana Field 35,001 || 0–1 |- style="text-align:center; background:#bfb;" | 2 || October 11 || Red Sox || 9–8 (11) || Price (1–0) || Timlin (0–1) || || Tropicana Field 34,904 || 1–1 |- style="text-align:center; background:#bfb;" | 3 || October 13 || @ Red Sox || 9–1 || Garza (1–0) || Lester (0–1) || || Fenway Park 38,301 || 2–1 |- style="text-align:center; background:#bfb;" | 4 || October 14 || @ Red Sox || 13–4 || Sonnanstine (1–0) || Wakefield (0–1) || || Fenway Park 38,133 || 3–1 |- style="text-align:center; background:#fbb;" | 5 || October 16 || @ Red Sox || 8–7 || Masterson (1–0) || Howell (0–1) || || Fenway Park 38,437 || 3–2 |- style="text-align:center; background:#fbb;" | 6 || October 18 || Red Sox || 4–2 || Beckett (1–0) || Shields (0–2) || Papelbon (2) || Tropicana Field 40,947 || 3–3 |- style="text-align:center; background:#bfb;" | 7 || October 19 || Red Sox || 3–1 || Garza (2–0) || Lester (0–2) || Price (1)|| Tropicana Field 40,473|| 4–3 |- |- style="text-align:center; background:#fbb;" | 1 || October 22 || Phillies || 3–2 || Hamels (1–0) || Kazmir (0–1) || Lidge (1) || Tropicana Field40,783 || 0–1 |- style="text-align:center; background:#bfb;" | 2 || October 23 || Phillies || 4–2 || Shields (1–0) || Myers (0–1) || || Tropicana Field40,843 || 1–1 |- style="text-align:center; background:#fbb;" | 3 || October 25 || @ Phillies || 5–4 || Romero (1–0) || Howell (0–1) || || Citizens Bank Park45,900 || 1–2 |- style="text-align:center; background:#fbb;" | 4 || October 26 || @ Phillies || 10–2 || Blanton (1–0) || Sonnanstine (0–1) || || Citizens Bank Park45,903 || 1–3 |- style="text-align:center; background:#fbb;" | 5 || October 27 & 29 || @ Phillies || 4–3 || Romero (2–0) || Howell (0–2) || Lidge (2) || Citizens Bank Park45,940 || 1–4 |- Player stats Batting Note: G = Games played; AB = At bats; R = Runs scored; H = Hits; 2B = Doubles; 3B = Triples; HR = Home runs; RBI = Runs batted in; AVG = Batting