of the internal colonic wall seen on colonoscopy. This abnormal pigmentation is known as melanosis coli. Interactions Senna glycosides can increase digoxin toxicity in patients taking digoxin by reducing serum potassium levels, thereby enhancing the effects of digoxin. Mechanism of action The breakdown products of senna act directly as irritants on the colonic wall to induce fluid secretion and colonic motility. Pharmacology They are anthraquinone derivatives and dimeric glycosides. Society and culture Formulations Senna is an over-the-counter medication available in multiple formulations, including oral formations (liquid, tablet, granular) and rectal suppositories. Senna products are manufactured by multiple generic drug makers and sold under various brand names. Kayam churna is a traditional Indian laxative that contains senna leaves. Brand names Ex-Lax, Geri-kot, Perdiem Overnight Relief, Senexon, Pursennid, Senna Smooth, Senna-Gen, Senna-GRX, Senna-Lax, Senna-Tabs, Senna-Time, SennaCon, Senno, Senokot. References External links Anthraquinone glycosides Laxatives World Health Organization essential medicines Wikipedia medicine articles ready to translate