in risk assessments. Contraindications The drug is contraindicated in subjects with known hypersensitivity to the active ingredient or to any of the inactive ingredients contained in the pharmaceutical formulation. It is also contraindicated in women who are pregnant and breastfeeding. Therapeutic doses Calcium dobesilate is administered orally at a daily dose of 0.5–2 g (equivalent to 1-4 tablets). It can also be administered rectally in the case of hemorrhoidal disease. References Sulfonates Calcium compounds