Davis (1–1) || Billingsley (0–1) || || 28,973 || 4–4 |- align="center" bgcolor="#ffbbbb" | 9 || April 9 || @ Diamondbacks || 4–3 || Owings (2–0) || Kuroda (0–1) || Lyon (1) || 23,331 || 4–5 |- align="center" bgcolor="#ffbbbb" | 10 || April 11 || Padres || 7–5 || Peavy (3–0) || Penny (1–2) || Hoffman (3) || 54,052 || 4–6 |- align="center" bgcolor="#bbffbb" | 11 || April 12 || Padres || 11–1 || Lowe (1–0) || Young (1–1) || || 54,955 || 5–6 |- align="center" bgcolor="#ffbbbb" | 12 || April 13 || Padres || 1–0 || Maddux (2–0) || Billingsley (0–2) || Hoffman (4) || 47,357 || 5–7 |- align="center" bgcolor="#ffbbbb" | 13 || April 14 || Pirates || 6–4 || Yates (2–0) || Saito (1–1) || Capps (4) || 37,334 || 5–8 |- align="center" bgcolor="#bbffbb" | 14 || April 15 || Pirates || 11–2 || Loaiza (1–2) || Morris (0–2) || || 37,896 || 6–8 |- align="center" bgcolor="#bbffbb" | 15 || April 16 || Pirates || 8–1 || Penny (2–2) || Maholm (0–2) || || 53,629 || 7–8 |- align="center" bgcolor="#ffbbbb" | 16 || April 18 || @ Braves || 6–1 || Ohman (1–0) || Lowe (1–1) || || 38,250 || 7–9 |- align="center" bgcolor="#ffbbbb" | 17 || April 19 || @ Braves || 4–1 || James (1–1) ||Billingsley (0–3)|| Acosta (1)|| 40,451|| 7–10 |- align="center" bgcolor="#ffbbbb" | 18 || April 20 || @ Braves || 6–1 || Jurrjens (2–2)||Kuroda (1–2) || ||36,772 ||7–11 |- align="center" bgcolor="#bbffbb" | 19 || April 21 || @ Reds || 9–3 || Penny (3–2) || Belisle (0–1) ||Park (1) || 14,446|| 8–11 |- align="center" bgcolor="#ffbbbb" | 20 || April 22 || @ Reds || 8–1 || Vólquez (3–0) || Kuo (0–1)|| || 14,763||8–12 |- align="center" bgcolor="#bbffbb" | 21 || April 23 || Diamondbacks || 8–3 ||Lowe (2–1)|| Haren (3–1) ||Saito (2) || 42,590||9–12 |- align="center" bgcolor="#ffbbbb" | 22 || April 24 || Diamondbacks || 6–4 ||González (1–1)||Billingsley (0–4) ||Lyon (6) ||38,350 ||9–13 |- align="center" bgcolor="#bbffbb" | 23 || April 25 || Rockies || 8–7 (13) || Park (1–0)|| Buchholz (1–2)|| ||53,205 || 10–13 |- align="center" bgcolor="#bbffbb" | 24 || April 26 || Rockies || 11–3 ||Penny (4–2)||Redman (2–2) || ||50,469 || 11–13 |- align="center" bgcolor="#bbffbb" | 25 || April 27 || Rockies || 3–2 (10) || Beimel (1–0)||Corpas (0–2) || || 50,670||12–13 |- align="center" bgcolor="#bbffbb" | 26 || April 29 || @