48-59 |- bgcolor="bbffbb" | 108 || July 29 || @ Athletics || 5 – 2 || Meche (9-9) || Smith (5-10) || Soria (29) || 12,182 || 49-59 |- bgcolor="bbffbb" | 109 || July 30 || @ Athletics || 4 – 3 (10) || R. Ramírez (2-1) || Street (2-4) || Soria (30) || 26,272 || 50-59 |- |- bgcolor="ffbbbb" | 110 || August 1 || White Sox || 4 – 2 || Vázquez (8-9) || Hochevar (6-9) || Jenks (22) || 21,291 || 50-60 |- bgcolor="bbffbb" | 111 || August 2 || White Sox || 9 – 7 || Davies (5-2) || Buehrle (8-10) || Soria (31) || 21,866 || 51-60 |- bgcolor="bbffbb" | 112 || August 3 || White Sox || 14 – 3 || Greinke (9-7) || Richard (0-2) || || 15,268 || 52-60 |- bgcolor="bbffbb" | 113 || August 4 || Red Sox || 4 – 3 || Meche (10-9) || Buchholz (2-7) || Soria (32) || 24,378 || 53-60 |- bgcolor="ffbbbb" | 114 || August 5 || Red Sox || 8 – 2 || Beckett (10-8) || Bannister (7-10) || || 22,069 || 53-61 |- bgcolor="ffbbbb" | 115 || August 6 || Red Sox || 8 – 2 || Wakefield (7-8) || Hochevar (6-10) || || 24,294 || 53-62 |- bgcolor="ffbbbb" | 116 || August 8 || Twins || 4 – 1 || Slowey (8-8) || Davies (5-3) || Nathan (31) || 33,653 || 53-63 |- bgcolor="ffbbbb" | 117 || August 9 || Twins || 7 – 3 || Liriano (2-3) || Greinke (9-8) || || 27,960 || 53-64 |- bgcolor="bbffbb" | 118 || August 10 || Twins || 5 – 4 (12) || Tejeda (1-2) || Breslow (0-1) || || 27,960 || 54-64 |- bgcolor="ffbbbb" | 119 || August 12 || @ White Sox || 9 – 0 || Vázquez (9-10) || Bannister (7-11) || || 31,099 || 54-65 |- bgcolor="ffbbbb" | 120 || August 13 || @ White Sox || 4 – 0 || Buehrle (10-10) || Hochevar (6-11) || || 37,838 || 54-66 |- bgcolor="ffbbbb" | 121 || August 14 || @ White Sox || 9 – 2 || Broadway (1-0) || Davies (5-4) || || 32,788 || 54-67 |- bgcolor="bbffbb" | 122 || August 15 || @ Yankees || 4 – 3 || Núñez (4-1) || Rivera (4-5) || Soria (33) || 53,067 || 55-67 |- bgcolor="ffbbbb" | 123 || August