|| September 17 || Red Sox || 10–3 || Balfour (5–2) || Wakefield (9–11) || || 36,048 || 90–60 |- style="text-align:center; background:#fbb;" | 151 || September 18 || Twins || 11–8 || Guardado (4–4) || Wheeler (5–6) || Nathan (37) || 17,296 || 90–61 |- style="text-align:center; background:#bfb;" | 152 || September 19 || Twins || 11–1 || Jackson (12–11) || Blackburn (11–10) || || 28,306 || 91–61 |- style="text-align:center; background:#bfb;" | 153 || September 20 || Twins || 7–2 || Kazmir (12–7) || Slowey (12–11) || || 36,048 || 92–61 |- style="text-align:center; background:#fbb;" | 154 || September 21 || Twins || 4–1 || Liriano (6–3) || Sonnanstine (13–8) || Nathan (38) || 36,048 || 92–62 |- style="text-align:center; background:#bfb;" | 155 || September 22 || @ Orioles || 4–2 || Balfour (6–2) || Cherry (0–3) || Wheeler (12) || 12,489 || 93–62 |- style="text-align:center; background:#bfb;" | 156 || September 23 || @ Orioles || 5–2 || Shields (14–8) || Olson (9–10) || Wheeler (13) || 15,215 || 94–62 |- style="text-align:center; background:#bfb;" | 157 || September 23 || @ Orioles || 7–5 || Niemann (2–1) || Walker (1–3) || Howell (3) || 15,215 || 95–62 |- style="text-align:center; background:#bfb;" | 158 || September 24 || @ Orioles || 11–6 || Jackson (13–11) || Burres (7–10) || Miller (2) || 13,632 || 96–62 |- style="text-align:center; background:#fbb;" | 159 || September 25 || @ Tigers || 7–5 || Galarraga (13–6) || Kazmir (12–8) || Rodney (11) || 36,259 || 96–63 |- style="text-align:center; background:#fbb;" | 160 || September 26 || @ Tigers || 6–4 || Verlander (11–17) || Sonnanstine (13–9) || Rodney (12) || 39,617 || 96–64 |- style="text-align:center; background:#fbb;" | 161 || September 27 || @ Tigers || 4–3 || López (4–1) || Niemann (2–2) || Rodney (13) || 40,756 || 96–65 |- style="text-align:center; background:#bfb;" | 162 || September 28 || @ Tigers || 8–7 (11) || Jackson (14–11) || Lambert (1–2) || Hammel (2) || 40,373 || 97–65 |- Postseason |- style="text-align:center; background:#bfb;" | 1 || October 2 || White Sox || 6–4 || Shields (1–0) || Vázquez (0–1) || Wheeler (1) || Tropicana Field 35,041 || 1–0 |- style="text-align:center; background:#bfb;" | 2 || October 3 || White Sox || 6–2 || Kazmir (1–0) || Buehrle (0–1) || || Tropicana Field 35,257 || 2–0 |- style="text-align:center; background:#fbb;" | 3 || October 5 || @ White Sox || 5–3 || Danks (1–0) || Garza (0–1)