(0–1) || || 41,302 || 3–3 |- style="text-align:center; background:#fbb;" | 7 || April 8 || Mariners || 6–5 || Bédard (1–0) || Glover (0–1) || Rowland-Smith (1) || 36,048 || 3–4 |- style="text-align:center; background:#fbb;" | 8 || April 9 || Mariners || 7–1 || Washburn (1–1) || Sonnanstine (1–1) || || 12,106 || 3–5 |- style="text-align:center; background:#bfb;" | 9 || April 10 || Mariners || 7–0 || Jackson (2–0) || Batista (0–2) || || 11,898 || 4–5 |- style="text-align:center; background:#bfb;" | 10 || April 11 || Orioles || 10–5 || Reyes (1–1) || Sarfate (2–1) || || 12,146 || 5–5 |- style="text-align:center; background:#fbb;" | 11 || April 12 || Orioles || 3–2 || Bradford (1–1) || Wheeler (0–1) || Sherrill (5) || 19,295 || 5–6 |- style="text-align:center; background:#bfb;" | 12 || April 13 || Orioles || 6–2 || Niemann (1–0) || Burres (1–1) || || 16,748 || 6–6 |- style="text-align:center; background:#fbb;" | 13 || April 14 || Yankees || 8–7 || Bruney (1–0) || Reyes (1–2) || Rivera (4) || 18,872 || 6–7 |- style="text-align:center; background:#fbb;" | 14 || April 15 || Yankees || 5–3 || Pettitte (2–1) || Jackson (2–1) || Rivera (5) || 20,923 || 6–8 |- style="text-align:center; background:#fbb;" | 15 || April 16 || @ Twins || 6–5 || Rincón (1–0) || Wheeler (0–2) || Nathan (5) || 20,209 || 6–9 |- style="text-align:center; background:#bfb;" | 16 || April 17 || @ Twins || 7–3 || Hammel (1–1) || Bonser (1–3) || Howell (1) || 14,781 || 7–9 |- style="text-align:center; background:#fbb;" | 17 || April 18 || White Sox || 9–2 || Vázquez (3–1) || Niemann (1–1) || || 12,379 || 7–10 |- style="text-align:center; background:#bfb;" | 18 || April 19 || White Sox || 5–0 || Sonnanstine (2–1) || Buehrle (1–2) || || 17,613 || 8–10 |- style="text-align:center; background:#fbb;" | 19 || April 20 || White Sox || 6–0 || Danks (2–1) || Jackson (2–2) || || 17,212 || 8–11 |- style="text-align:center; background:#bfb;" | 20 || April 22 || Blue Jays* || 6–4 || Shields (2–1) || Litsch (2–1) || Percival (2) || 8,269 || 9–11 |- style="text-align:center; background:#bfb;" | 21 || April 23 || Blue Jays* || 5–3 || Hammel (2–1) || Halladay (2–3) || Percival (3) || 8,989 || 10–11 |- style="text-align:center; background:#bfb;" | 22 || April 24 || Blue Jays* || 5–3 || Sonnanstine (3–1) || McGowan (1–2) || Percival (4) || 9,540 || 11–11