– 0 || Meche (2-4) || Laffey (0-2) || Soria (8) || 27,836 || 14-16 |- bgcolor="ffbbbb" | 31 || May 5 || Angels || 4 – 0 || Santana (6-0) || R. Ramírez (0-1) || || 12,157 || 14-17 |- bgcolor="ffbbbb" | 32 || May 6 || Angels || 5 – 3 || Oliver (2-1) || Bannister (3-4) || Rodríguez (14) || 11,354 || 14-18 |- bgcolor="#bbffbb" | 33 || May 7 || Angels || 9 – 4 || Greinke (4-1) || Weaver (2-5) || || 11,084 || 15-18 |- bgcolor="ffbbbb" | 34 || May 8 || Orioles || 4 – 1 || Cabrera (3-1) || Hochevar (2-2) || || 11,781 || 15-19 |- bgcolor="ffbbbb" | 35 || May 9 || Orioles || 7 – 4 || Trachsel (2-4) || Meche (2-4) || Sherrill (12) || 21,873 || 15-20 |- bgcolor="ffbbbb" | 36 || May 10 || Orioles || 6 – 5 || Olson (1-0) || Tomko (1-4) || Sherrill (13) || 15,808 || 15-21 |- bgcolor="#bbffbb" | 37 || May 11 || Orioles || 4 – 0 || Bannister (4-4) || Burres (3-4) || || 18,635 || 16-21 |- bgcolor="#bbffbb" | 38 || May 13 || Tigers || 3 – 2 || Núñez (3-0) || Cruceta (0-1) || Soria (9) || 11,703 || 17-21 |- bgcolor="bbffbb" | 39 || May 14 || Tigers || 2 – 0 || Hochevar (3-2) || Verlander (1-7) || Soria (10) || 14,053 || 18-21 |- bgcolor="bbffbb" | 40 || May 15 || Tigers || 8 – 4 || Meche (3-5) || Rogers (3-4) || || 34,734 || 19-21 |- bgcolor="bbffbb" | 41 || May 16 || @ Marlins || 7 – 6 || Tomko (2-4) || Miller (3-3) || Soria (11) || 14,825 || 20-21 |- bgcolor="ffbbbb" | 42 || May 17 || @ Marlins || 7 – 3|| Kensing (3-0) || Bannister (4-5) || || 16,214 || 20-22 |- bgcolor="bbffbb" | 43 || May 18 || @ Marlins || 9 – 3 || Greinke (5-1) || Badenhop (1-3) || || 10,617 || 21-22 |- bgcolor="ffbbbb" | 44 || May 19 || @ Red Sox || 7 – 0 || Lester (3-2) || Hochevar (3-3) || || 37,746 || 21-23 |- bgcolor="ffbbbb" | 45 || May 20 || @ Red Sox || 2 – 1 || Masterson (1-0) || Meche (3-6) || Papelbon (13) || 37,486 || 21-24 |- bgcolor="ffbbbb" | 46