nearby microglia or astrocytes. CMKLR1, GPR32, FPR2, and NMDA receptors have been proposed to be the receptors through which SPMs may operate to down-regulate TRPs and thereby pain perception. Ligand examples Agonists 4-Oxo-2-nonenal Allicin Allyl isothiocyanate ASP-7663 Cannabidiol Cannabichromene Gingerol Icilin Polygodial Propofol Hepoxilins A3 and B3 12S-Hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid 4,5-Epoxyeicosatrienoic acid Cinnamaldehyde PF-4840154 2-Arachidonoylglycerol Anandamide N-Arachidonoyl dopamine Palmitoylethanolamide Cannabidiolic acid Cannabidivarin Cannabigerol Cannabigerolic acid Cannabigerovarin Tetrahydrocannabivarin Tetrahydrocannabivarin acid Gating Modifiers WaTx Antagonists HC-030031 GRC17536 A-967079 ALGX-2513 ALGX-2541 ALGX-2563 ALGX-2561 ALGX-2542 References External links Membrane proteins Ion channels