where SR 99 separates from US 412 at an interchange with US 43/SR 6, where US 412 follows that highway while SR 99 continues into town concurrent with US 412 Bus. They go east along Hampshire Pike to an intersection and become concurrent with SR 50 (Williamsport Pike), before continuing east through a couple of neighborhoods before coming to an intersection with James Campbell Boulevard, where SR 50 splits off and goes southeast. US 412 Bus/SR 99 continue east through several neighborhoods, where they have an intersection with SR 243 (Trotwood Avenue) before entering downtown and coming to an intersection and turning north to become concurrent with US 31/SR 7 (North Garden Street). They continue north through downtown to an intersection with North James Campbell Boulevard, where SR 7 splits off and goes north. They then cross a bridge over the Duck River to leave downtown and widen to a 4-lane divided highway, where it passes through a major business district before coming to another intersection with US 43/US 412/SR 6, where US 412 Bus ends, US 43/SR 6 turn north on US 31, and SR 99 turns right to become concurrent as they turns and go through another business district. US 412/SR 99 then narrows to 2-lanes and continues east to leave the city, though it is still within the city limits, and go through farmland to eventually come to an interchange with I-65 (Exit 46), where US 412 ends and SR 99 becomes signed as a primary highway as it leaves Columbia and continues east. The highway passes through farmland and has short concurrency with US 431/SR 106 before crossing into Marshall County. Marshall County SR 99 continues east through farmland, where it has an intersection with SR 272, to come to an intersection with US 31A/SR 11, where it turns secondary and becomes concurrent with that highway shortly before having an intersection SR 270. The highway then continues north past several homes and businesses before passing straight through downtown Chapel Hill, after which SR 99 splits off from US 31A/SR 11 and goes east, leaving Chapel Hill. The highway then curves northeastward and crosses into Rutherford County shortly afterwards. Rutherford County SR 99 continues northeast to enter Eagleville at a Y-Intersection with US 41A/SR 16, which it becomes concurrent with for a short distance splitting off and going east on a new bypass of downtown and becoming