used in the treatment of metabolic disorders, like metabolic syndrome. It has control of skeletal muscle metabolism and energy that can be beneficial in treatment options. Rev-Erbβ gene contributes to the downstream regulation of clock output genes by generating specific KO mutants. It is still unknown all of the functions Rev-Erbβ has in the core circadian clock and exactly how it differs from Rev-Erbα. References Further reading External links Intracellular receptors Transcription factors