(4–7) || — || 2:42 || 32,729 || 81–61 || L1 |-style="background:#fcc;" | 143 || September 14 || 3:05p.m. CDT || @ Padres || L 2–3 || Lefferts (9–7) || Scott (16–10) || — || 2:35 || 13,279 || 81–62 || L2 |-style="background:#cfc;" | 144 || September 16 || 6:35p.m. CDT || @ Reds || W 6–1 || Knepper (16–11) || Gullickson (13–11) || Andersen (1) || 2:34 || 16,927 || 82–62 || W1 |-style="background:#cfc;" | 145 || September 17 || 6:35p.m. CDT || @ Reds || W 6–1 || Darwin (9–9) || Welsh (6–7) || — || 2:26 || 15,195 || 83–62 || W2 |-style="background:#cfc;" | 146 || September 18 || 11:35a.m. CDT || @ Reds || W 5–3 || Keough (4–3) || Browning (13–13) || López (6) || 2:16 || 11,825 || 84–62 || W3 |-style="background:#cfc;" | 147 || September 19 || 7:35p.m. CDT || Padres || W 5–4 || Kerfeld (11–2) || LaPoint (4–9) || Smith (31) || 2:47 || 23,805 || 85–62 || W4 |-style="background:#cfc;" | 148 || September 20 || 7:35p.m. CDT || Padres || W 10–6 || Scott (17–10) || Hayward (0–1) || — || 2:33 || 36,878 || 86–62 || W5 |-style="background:#fcc;" | 149 || September 21 || 2:05p.m. CDT || Padres || L 0–5 || Jones (1–0) || Knepper (16–12) || — || 2:24 || 23,385 || 86–63 || L1 |-style="background:#fcc;" | 150 || September 22 || 7:35p.m. CDT || Dodgers || L 2–9 || Valenzuela (20–10) || Darwin (9–10) || — || 2:35 || 27,641 || 86–64 || L2 |-style="background:#cfc;" | 151 || September 23 || 7:35p.m. CDT || Dodgers || W 4–0 || Deshaies (10–5) || Powell (2–7) || — || 2:44 || 27,734 || 87–64 || W1 |-style="background:#cfc;" | 152 || September 24 || 7:35p.m. CDT || Giants || W 6–0 || Ryan (11–8) || LaCoss (10–13) || — || 2:39 || 37,611 || 88–64 || W2 |-style="background:#cfc;" | 153 || September 25 || 3:35p.m. CDT || Giants || W 2–0 || Scott (18–10) || Berenguer (2–3) || — || 2:24 || 32,808 || 89–64 || W3 |-style="background:#fcc;" | 154 || September 26 || 6:40p.m. CDT || @ Braves || L 4–5 || Alexander (11–10) || Keough (4–4) || Smith (1) || 2:15 || 6,754 || 89–65 || L1 |-style="background:#cfc;" | 155 || September 27 || 1:20p.m. CDT || @ Braves || W 4–0 || Darwin (10–10) || Palmer