thereby pain perception. 2-Aminoethoxydiphenyl borate (2-APB) is a mixed agonist-antagonist of the TRPV3 receptor, acting as an antagonist at low concentrations but showing agonist activity when used in larger amounts. Drofenine also acts as a TRPV3 agonist in addition to its other actions. Conversely, icilin has been shown to act as a TRPV3 antagonist, as well as a TRPM8 agonist. Forsythoside B acts as a TRPV3 inhibitor among other actions. Farnesyl pyrophosphate is an endogenous agonist of TRPV3, while incensole acetate from frankincense also acts as an agonist at TRPV3. TRPV3-74a is a selective TRPV3 antagonist. Ligands Agonists Cannabidiol Tetrahydrocannabivarin Cannabigerolic acid Cannabigerovarin See also TRPV Endocannabinoid system Endocannabinoidome References Further reading External links Ion channels