|| Lowe (4–5) || Zambrano (8–2) || ||50,020 ||30–32 |- align="center" bgcolor="#ffbbbb" | 63 || June 8 || Cubs || 3–1 || Marquis (4–3) || Penny (5–8) ||Wood (18) || 49,994|| 30–33 |- align="center" bgcolor="#bbffbb" | 64 || June 10 || @ Padres || 7–2 || Proctor (1–0)|| Hampson (0–1)|| ||26,860 ||31–33 |- align="center" bgcolor="#ffbbbb" | 65 || June 11 || @ Padres ||4–1 || Wolf (5–4)||Billingsley (4–7) || Hoffman (15)|| 29,218||31–34 |- align="center" bgcolor="#ffbbbb" | 66 || June 12 || @ Padres ||9–0 || Peavy (5–3) || Kuroda (3–6) || || 36,354||31–35 |- align="center" bgcolor="#ffbbbb" | 67 || June 13 || @ Tigers || 5–0 || Galarrage (6–2)|| Lowe (4–6) ||Dolsi (2) || 40,430|| 31–36 |- align="center" bgcolor="#ffbbbb" | 68 || June 14 || @ Tigers || 12–7 || Bonine (1–0) || Penny (5–9) || ||42,348 ||31–37 |- align="center" bgcolor="#ffbbbb" | 69 || June 15 || @ Tigers || 5–4 || Robertson (5–6) || Park (2–2) || Jones (12) || 41,189 || 31–38 |- align="center" bgcolor="#bbffbb" | 70 || June 17 || @ Reds ||3–1 || Billingsley (5–7) || Cueto (5–7) || Saito (9)|| 26,906||32–38 |- align="center" bgcolor="#bbffbb" | 71 || June 18 || @ Reds || 6–1 || Lowe (5–6)|| Arroyo (4–6)|| ||20,055 ||33–38 |- align="center" bgcolor="#bbffbb" | 72 || June 19 || @ Reds || 7–4 ||Stults (1–0) || Harang (3–10)||Saito (10) ||30,136 ||34–38 |- align="center" bgcolor="#ffbbbb" | 73 || June 20 || Indians || 6–4 (10) || Borowski (1–2) || Saito (3–3) || Kobayashi (4) || 50,667 || 34–39 |- align="center" bgcolor="#ffbbbb" | 74 || June 21 || Indians || 7–2 (11) || Kobayashi (4–3) || Wade (0–1) || || 45,036 || 34–40 |- align="center" bgcolor="#bbffbb" | 75 || June 22 || Indians || 4–3 || Billingsley (6–7) || Byrd (3–8) || Saito (11) || 39,993 || 35–40 |- align="center" bgcolor="#ffbbbb" | 76 || June 24 || White Sox || 6–1 || Buehrle (5–6) || Lowe (5–7) || || 43,900 || 35–41 |- align="center" bgcolor="bbffbb" | 77 || June 25 || White Sox || 5–0 || Stults (2–0) || Floyd (8–4) || || 40,162 || 36–41 |- align="center" bgcolor="#ffbbbb" | 78 || June 26 || White Sox || 2–0 || Danks (5–4) || Kershaw (0–2) || Jenks (17) || 37,956 || 36–42 |- align="center" bgcolor="bbffbb" | 79 || June 27 || Angels || 6–0 || Park (3–2) || Saunders (11–4) || || 50,419 || 37–42 |-