May 12 || Yankees || 7–1 || Garza (2–1) || Pettitte (3–4) || || 13,932 || 22–16 |- style="text-align:center; background:#bfb;" | 39 || May 13 || Yankees || 2–1 (11) || Howell (3–0) || Rivera (0–1) || || 16,558 || 23–16 |- style="text-align:center; background:#fbb;" | 40 || May 14 || Yankees || 2–1 || Mussina (6–3) || Shields (4–3) || Rivera (11) || 20,936 || 23–17 |- style="text-align:center; background:#bfb;" | 41 || May 15 || Yankees || 5–2 || Kazmir (2–1) || Kennedy (0–3) || Percival (10) || 19,976 || 24–17 |- style="text-align:center; background:#bfb;" | 42 || May 16 || @ Cardinals || 3–1 || Sonnanstine (6–1) || Looper (5–3) || Percival (11) || 43,136 || 25–17 |- style="text-align:center; background:#fbb;" | 43 || May 17 || @ Cardinals || 9–8 (10) || Franklin (2–1) || Wheeler (0–3) || || 43,907 || 25–18 |- style="text-align:center; background:#fbb;" | 44 || May 18 || @ Cardinals || 5–4 || Perez (1–0) || Glover (0–2) || || 46,392 || 25–19 |- style="text-align:center; background:#bfb;" | 45 || May 19 || @ Athletics || 7–6 (13) || Hammel (3–2) || Gaudin (3–3) || Percival (12) || 11,077 || 26–19 |- style="text-align:center; background:#bfb;" | 46 || May 20 || @ Athletics || 3–2 || Kazmir (3–1) || Smith (2–4) || Percival (13) || 11,272 || 27–19 |- style="text-align:center; background:#fbb;" | 47 || May 21 || @ Athletics || 9–1 || Eveland (4–3) || Sonnanstine (6–2) || || 22,712 || 27–20 |- style="text-align:center; background:#bfb;" | 48 || May 23 || Orioles || 2–0 || Garza (3–1) || Guthrie (2–5) || Percival (14) || 13,635 || 28–20 |- style="text-align:center; background:#bfb;" | 49 || May 24 || Orioles || 11–4 || Jackson (3–3) || Trachsel (2–5) || || 30,445 || 29–20 |- style="text-align:center; background:#bfb;" | 50 || May 25 || Orioles || 5–4 || Percival (1–0) || Sherrill (1–1) || || 17,762 || 30–20 |- style="text-align:center; background:#bfb;" | 51 || May 26 || Rangers || 7–3 || Kazmir (4–1) || Ponson (3–1) || || 12,174 || 31–20 |- style="text-align:center; background:#fbb;" | 52 || May 27 || Rangers || 12–6 || Padilla (7–2) || Sonnanstine (6–3) || || 10,511 || 31–21 |- style="text-align:center; background:#bfb;" | 53 || May 28 || Rangers || 5–3 || Garza (4–1) || Gabbard (1–2) || Wheeler (1) || 10,927 || 32–21 |- style="text-align:center; background:#fbb;" | 54 || May 29 || White Sox || 5–1 || Danks