|- style="text-align:center; background:#bfb;" | 23 || April 25 || Red Sox || 5–4 (11) || Dohmann (1–0) || Timlin (2–2) || || 30,290 || 12–11 |- style="text-align:center; background:#bfb;" | 24 || April 26 || Red Sox || 2–1 || Dohmann (2–0) || Buchholz (1–2) || Percival (5) || 36,048 || 13–11 |- style="text-align:center; background:#bfb;" | 25 || April 27 || Red Sox || 3–0 || Shields (3–1) || Beckett (2–2) || || 32,363 || 14–11 |- style="text-align:center; background:#fbb;" | 26 || April 29 || @ Orioles || 7–4 || Olson (1–0) || Hammel (2–2) || Sherrill (10) || 11,588 || 14–12 |- style="text-align:center; background:#bfb;" | 27 || April 30 || @ Orioles || 8–1 || Sonnanstine (4–1) || Albers (2–1) || || 11,944 || 15–12 |- | colspan=9| * Played at Disney's Wide World of Sports in Orlando, Florida |- |- style="text-align:center; background:#bfb;" | 28 || May 1 || @ Orioles || 4–2 || Garza (1–0) || Burres (3–2) || Percival (6) || 16,456 || 16–12 |- style="text-align:center; background:#fbb;" | 29 || May 2 || @ Red Sox || 7–3 || Buchholz (2–2) || Jackson (2–3) || || 37,541 || 16–13 |- style="text-align:center; background:#fbb;" | 30 || May 3 || @ Red Sox || 12–4 || Beckett (3–2) || Shields (3–2) || || 37,700 || 16–14 |- style="text-align:center; background:#fbb;" | 31 || May 4 || @ Red Sox || 7–3 || Lester (2–2) || Kazmir (0–1) || Papelbon (9) || 37,091 || 16–15 |- style="text-align:center; background:#bfb;" | 32 || May 6 || @ Blue Jays || 5–4 || Sonnanstine (5–1) || Burnett (3–3) || Percival (7) || 30,397 || 17–15 |- style="text-align:center; background:#fbb;" | 33 || May 7 || @ Blue Jays || 6–2 || Marcum (4–2) || Garza (1–1) || || 19,276 || 17–16 |- style="text-align:center; background:#bfb;" | 34 || May 8 || @ Blue Jays || 8–3 (13) || Howell (1–0) || Camp (0–1) || || 21,118 || 18–16 |- style="text-align:center; background:#bfb;" | 35 || May 9 || Angels || 2–0 || Shields (4–2) || Speier (0–2) || || 12,039 || 19–16 |- style="text-align:center; background:#bfb;" | 36 || May 10 || Angels || 2–0 || Kazmir (1–1) || Saunders (6–1) || Percival (8) || 25,512 || 20–16 |- style="text-align:center; background:#bfb;" | 37 || May 11 || Angels || 8–5 || Howell (2–0) || Speier (0–3) || Percival (9) || 13,010 || 21–16 |- style="text-align:center; background:#bfb;" | 38 ||