2012, and the CyberKnife S7 System in 2020. Clinical application The system is used to treat most types of intracranial tumors with SRS and notably paved the way for the use of SBRT anywhere in the body. SRS is commonly used in the treatment of brain metastases as well as other intracranial indications, with the advantage of delivering high doses to the tumor while minimizing dose to surrounding organs at risk. SBRT requires precise image-guided delivery and is now commonly used in localized prostate cancer patients, demonstrating encouraging control rates. SBRT is also widely utilized in the treatment of patients with inoperable lung cancer or those that may refuse surgery.The CyberKnife System plays a crucial role in the treatment of local recurrence as it allows very precise re-irradiation in areas close to critical structures. Oligometastases represent a limited number of metastatic sites that can benefit from radiation therapy to achieve long-term disease control. These metastatic sites are amenable to direct treatment approaches to control disease effectively. Several studies have shown the benefit of the CyberKnife System and effective oligometastatic SBRT in breast and gynecological cancers. Clinical Citations Brain Metastases Borzillo V, Di Franco R, Giannarelli D, Cammarota F, Scipilliti E, D'Ippolito E, Petito A, Serra M, Falivene S, Grimaldi AM, Simeone E, Festino L, Vanella V, Trojaniello C, Vitale MG, Madonna G, Ascierto PA, Muto P. Ipilimumab and Stereotactic Radiosurgery with CyberKnife® System in Melanoma Brain Metastases: A Retrospective Monoinstitutional Experience. Cancers (Basel). 2021 Apr 13;13(8):1857. doi: 10.3390/cancers13081857. PMID: 33924595; PMCID: PMC8068853. Martinage G, Geffrelot J, Stefan D, Bogart E, Rault E, Reyns N, Emery E, Makhloufi-Martinage S, Mouttet-Audouard R, Basson L, Mirabel X, Lartigau E, Pasquier D. Efficacy and Tolerance of Post-operative Hypo-Fractionated Stereotactic Radiotherapy in a Large Series of Patients With Brain Metastases. Front Oncol. 2019 Mar 28;9:184. doi: 10.3389/fonc.2019.00184. PMID: 30984617; PMCID: PMC6448411. Trigeminal Neuralgia Conti A, Acker G, Pontoriero A, Hardt J, Kluge A, Cacciola A, Iatì G, Kufeld M, Budach V, Vajkoczy P, Beltramo G, Pergolizzi S, Bergantin A, Loebel F, Parisi S, Senger C, Romanelli P. Factors affecting outcome in frameless non-isocentric stereotactic radiosurgery for trigeminal neuralgia: a multicentric cohort study. Radiat Oncol. 2020 May 22;15(1):115. doi: 10.1186/s13014-020-01535-1. PMID: 32443978; PMCID: PMC7243318. Romanelli P, Conti A, Redaelli I, Martinotti AS, Bergantin A, Bianchi LC, Beltramo G. Cyberknife Radiosurgery for Trigeminal Neuralgia. Cureus. 2019 Oct 28;11(10):e6014. doi: 10.7759/cureus.6014. PMID: 31815078; PMCID: PMC6881081. Arteriovenous Malformations Kelly