Eleutherodactylus principalis is a species of frog in the family Eleutherodactylidae. It is endemic to eastern Cuba and found in the upland regions of Holguín and Guantánamo Provinces. Its natural habitats are mesic, closed forests at elevations of above sea level. It is an arboreal species that is moderately common within suitable habitat. It is threatened by habitat loss caused by mining and agriculture. It occurs in the Alejandro de Humboldt National Park, but habitat loss is also occurring in the park. References principalis Endemic fauna of Cuba Amphibians of Cuba Amphibians described in 1997 Taxa named by Stephen Blair Hedges Taxonomy articles created by Polbot