|| Red Sox || 7–6 (10) || Mohler (3–0) || Slocumb || — || 8,282 || 24–27 |- bgcolor="ffbbbb" | 52 || May 31 || Yankees || 1–4 || Key || Johns (4–6) || Wetteland || 13,279 || 24–28 |- |- bgcolor="ffbbbb" | 53 || June 1 || Yankees || 3–6 || Pettitte || Chouinard (0–2) || Wetteland || 21,354 || 24–29 |- bgcolor="ffbbbb" | 54 || June 2 || Yankees || 4–11 || Rogers || Wojciechowski (5–2) || Wetteland || 26,331 || 24–30 |- bgcolor="ccffcc" | 55 || June 3 || Royals || 2–1 || Wasdin (2–0) || Appier || Taylor (4) || 6,465 || 25–30 |- bgcolor="ccffcc" | 56 || June 4 || Royals || 8–3 || Wengert (2–2) || Gubicza || — || 11,524 || 26–30 |- bgcolor="ffbbbb" | 57 || June 5 || Royals || 2–5 || Haney || Johns (4–7) || Montgomery || 8,113 || 26–31 |- bgcolor="ccffcc" | 58 || June 7 || @ Twins || 6–4 || Reyes (4–8) || Radke || Corsi (2) || 14,999 || 27–31 |- bgcolor="ffbbbb" | 59 || June 8 || @ Twins || 2–4 || Robertson || Wojciechowski (5–3) || Guardado || — || 27–32 |- bgcolor="ccffcc" | 60 || June 8 || @ Twins || 13–7 || Wasdin (3–0) || Mahomes || — || 22,164 || 28–32 |- bgcolor="ffbbbb" | 61 || June 9 || @ Twins || 3–5 || Rodriguez || Wengert (2–3) || — || 13,291 || 28–33 |- bgcolor="ffbbbb" | 62 || June 10 || @ Indians || 4–5 || Nagy || Johns (4–8) || Mesa || 42,167 || 28–34 |- bgcolor="ffbbbb" | 63 || June 11 || @ Indians || 5–6 (13) || Ogea || Reyes (4–9) || — || 42,249 || 28–35 |- bgcolor="ccffcc" | 64 || June 12 || @ Indians || 9–6 || Montgomery (1–0) || McDowell || Mohler (5) || 40,673 || 29–35 |- bgcolor="ffbbbb" | 65 || June 13 || @ Brewers || 3–16 || Karl || Wojciechowski (5–4) || — || 12,439 || 29–36 |- bgcolor="ffbbbb" | 66 || June 14 || @ Brewers || 2–6 || Bones || Wasdin (3–1) || — || 14,404 || 29–37 |- bgcolor="ffbbbb" | 67 || June 15 || @ Brewers || 9–12 || Givens || Wengert (2–4) || Garcia || 21,064 || 29–38 |- bgcolor="ccffcc" | 68 || June 16 || @ Brewers || 10–9 || Taylor (2–1) ||