But now I'm back fit and highly motivated to achieve with Leverkusen both my personal goals as well as the club's." On 3 November 2014, Leverkusen announced that Papadopoulos had been ruled out for the remainder of 2014 with a shoulder injury. The centre-back suffered the injury in the final training session ahead of his side's UEFA Champions League away match with Zenit Saint Petersburg; he underwent surgery. "That's just bitter for Papa," Leverkusen coach Roger Schmidt told reporters ahead of Leverkusen's trip to Russia. Following his injury, the club announced that Papadopoulos underwent successful surgery on the following Monday in Herne. On 8 March 2015, Papadopoulos scored his first Bundesliga goal for Bayer Leverkusen against SC Paderborn. His injury misery continued after, on 25 April 2015, he dislocated his right shoulder in a league match away against 1. FC Köln. Leverkusen officials reported that Papadopoulos would return to the training after three months. Bayer Leverkusen On 7 June 2015, Bayer Leverkusen opted to make Papadopoulos' loan from Schalke 04 permanent on a €6.5 million transfer fee, with the player signing a five-year contract. On 29 September 2015, Papadopoulos scored his first goal in the 2015–16 season in the first half of a Champions League encounter against Barcelona: Hakan Çalhanoğlu, swung in a corner that hit right underneath Barça goalkeeper Marc-André ter Stegen's crossbar; Papadopoulos headed in the rebound from close range. Papadopoulos suffered a lot of injuries during the season facing a tear in a joint capsule that kept him two weeks out of training, as well as a right calf tendon in the 0–0 Europa League draw with Villarreal that kept him out of the club until the end of the season. Loan to RB Leipzig On 31 August 2016, Papadopoulos joined RB Leipzig on a €1.5 million season-long loan deal, linking up once again with Leipzig's director of sport Ralf Rangnick, who was his coach when they won the DFB Pokal together with Schalke in 2011. On 21 September 2016, he made his debut with the club as a substitute in a 1–1 Bundesliga match against Borussia Mönchengladbach. On 24 November 2016, Papadopoulos underwent a successful routine surgery to overcome a chronic knee problem. and started a rehabilitation program, with his return to action estimated at three weeks. Hamburger SV On 13 January 2017, after a frustrating first half of the campaign with RB Leipzig and due