Sporting News 2010 All-Pro Team and AP's Second All-Pro team. He was 3rd in the league with 52 quarterback pressures, behind only Chris Long and Julius Peppers. On May 5, 2012 Wake signed a four-year contract extension with the Dolphins reported to be worth a total of $49 million, $20 million of which was guaranteed. After being moved from outside linebacker to defensive end for the 2012 season, Wake had arguably his best season in the NFL. He totaled 53 tackles and 15 sacks, including 4.5 sacks in one game against the Arizona Cardinals. That season, Wake was named a starter for the Pro Bowl for the second time and, together with Randy Starks, became the first of two Dolphins to make the Pro Bowl at two different positions. He was also named a First-team All-Pro by both the AP and the PFWA for the first time in his career. Wake earned AFC Defensive Player of the Week honors for his performance against the Cincinnati Bengals in Week 9 of the 2013 season, racking up five tackles, three sacks, two tackles for loss, two quarterback hits and a safety in the Dolphins’ 22–20 overtime victory. Wake sacked Bengals quarterback Andy Dalton in overtime for a safety to end the game, giving the Dolphins a 22–20 victory. It was only the third game in NFL history to end with an overtime safety. He ended the season with 8.5 sacks and another Pro Bowl selection. After an unproductive start to the 2015 season, in which the Dolphins were 1-3 and Wake had one tackle, head coach Joe Philbin was fired and replaced with tight ends coach Dan Campbell. Wake returned to his dominant form, recording six sacks and four forced fumbles in a two-week span, which were both wins against the Titans and Texans. In a game against the Patriots, Wake notched his seventh sack, which put him in second place on the NFL leaderboard, but he was also injured and carried off the field on a later play. On October 30, 2015, NFL Insider Ian Rapoport reported, due to an Achilles injury, that Wake was out for the rest of the 2015 NFL season. Wake had a bounce-back season in 2016 after the Achilles injury in 2015. On December 17, 2016, Wake got his first career interception by picking off Jets quarterback Bryce Petty. He finished the season with 11.5 sacks,