|-style="background:#fbb" |14 || April 17 || Astros || 2–7 || Hernández || Haynes || — || 14,527 || 7–7 || || L3 |-style="background:#cfc" |15 || April 18 || Astros || 5–4 || White || Cruz || — || 15,848 || 8–7 || || W1 |-style="background:#fbb" |16 || April 19 || at Cubs || 2–5 || Clement || Hamilton || Alfonseca || 33,949 || 8–8 || || L1 |-style="background:#cfc" |17 || April 20 || at Cubs || 6–1 || Dessens || Wood || — || 36,476 || 9–8 || || W1 |-style="background:#cfc" |18 || April 21 || at Cubs || 5–3 || Rijo || Cruz || Graves || 29,458 || 10–8 || || W2 |-style="background:#cfc" |19 || April 23 || Rockies || 3–2 || Haynes || Jennings || Graves || 14,518 || 11–8 || || W3 |-style="background:#cfc" |20 || April 24 || Rockies || 4–3 || Williamson || Jiménez || — || 13,004 || 12–8 || || W4 |-style="background:#cfc" |21 || April 25 || Rockies || 4–3 || Sullivan || White || Graves || 14,416 || 13–8 || || W5 |-style="background:#cfc" |22 || April 26 || Giants || 4–3 || Sullivan || Rodríguez || Graves || 28,341 || 14–8 || || W6 |-style="background:#cfc" |23 || April 27 || Giants || 8–4 || Rijo || Jensen || — || 22,616 || 15–8 || || W7 |-style="background:#fbb" |24 || April 28 || Giants || 4–5 || Rueter || Haynes || Nen || 23,426 || 15–9 || || L1 |-style="background:#cfc" |25 || April 30 || at Dodgers || 3–1 || Reitsma || Brown || Graves || 25, 178 || 16–9 || || W1 |-style = |-style="background:#cfc" |26 || May 1 || at Los Angeles Dodgers || 4–0 || Hamilton || Nomo || || 23,346 || 17–9 || || W2 |-style="background:#fbb" |27 || May 2 || at Los Angeles Dodgers || 2–3 || Carrara || Pineda || || 27,224 || 17–10 || L1 |-style="background:#fbb" |28 || May 3 || at San Francisco Giants || 1–6 || Rueter || Rijo || || 39,845 || 17–11 || || L2 |-style="background:#fbb" |29 || May 4 || at San Francisco Giants || 0–3 || Jensen || Haynes || Nen || 40,959 || 17–12 || || L3 |-style="background:#fbb" |30 || May 5 || at San Francisco Giants || 5–6 || Nen || Pineda || || 41,263 || 17–13 || || L4 |-style="background:#cfc" |31 || May 6 || Milwaukee Brewers ||