The CyberKnife System is a radiation therapy device manufactured by Accuray Incorporated. The CyberKnife System is the only radiation delivery system in the world that features a linear accelerator (linac) directly mounted on a robot to deliver high-energy x-rays or photons used in radiation therapy and combines real-time artificial intelligence (AI)-driven target tracking and treatment delivery. The platform is designed to deliver precise stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT) for the treatment of benign tumors, malignant tumors, neurologic disorders and other medical conditions. The CyberKnife System combines a robotic arm that can autonomously move a compact linear accelerator with an option of fixed collimators, IrisTM Variable Aperture Collimator and InCiseTM MLC. The CyberKnife System incorporates an image guidance system that creates images from two orthogonal diagnostic X-ray sources/detectors mounted in the room. During treatment, the patient’s X-ray images are compared in real-time with digitally reconstructed radiographs, and the robot’s position is adjusted according to the findings from comparing those images. Synchrony Technology The CyberKnife System uses real-time target tracking with dynamic delivery technology called Synchrony. Using external markers in conjunction with diagnostic x-ray images, Synchrony helps guide the robotic arm to shift the radiation beam in real-time such that the beam always remains aligned with the target. This design is intended to enable the CyberKnife System to deliver high-dose radiation with sub-millimeter precision and accuracy, minimizing damage to surrounding healthy tissue without the need for invasive fixation devices. History The system was invented by John R. Adler, a Stanford University professor of neurosurgery and radiation oncology, and Peter and Russell Schonberg of Schonberg Research Corporation. The CyberKnife System was developed to address limitations of a radiosurgery delivery system that required a rigid frame to be bolted to the patients' head, from imaging through to treatment. Wearing this head frame limited the use of the system to single treatments within the brain or base of the skull. The first CyberKnife system was installed at Stanford University in 1991. The device was approved by the FDA for the treatment of intracranial tumors in 1999 and for the treatment of tumors anywhere in the body in 2001. Since the original design, Accuray Incorporated released several CyberKnife System models, with significant features and clinical improvements over the years: the CyberKnife G3 System in 2005, the CyberKnife G4 System in 2007, the CyberKnife VSI System in 2009, the CyberKnife M6 System in