past years (data from Institute for Scientific Information). Smith was struck by a car and killed on December 19, 2010. Research The focus of the research undertaken by Smith's research involves investigating the pathological mechanism(s) underlying selective neuronal death in neurodegenerative diseases such as Alzheimer's disease. Further this research involves a variety of techniques including histology, state of the art molecular and cell biology and cellular and animal models of disease that are directed toward diagnostic, mechanistic, and therapeutic strategies. Current projects are directed towards 1) fundamental metabolic alterations; 2) homeostatic dysregulation of transition metals; 3) signal transduction alterations; and 4) inappropriate re-entry into the cell cycle. Smith collaborated with and co-authored works with, amongst others, Drs. Rudolph J. Castellani Jr. and George Perry. Community service Smith served on the Professional Advisory Board of the Cleveland chapter of the Alzheimer's Association and was Team Captain of a group of local researchers ("A Cure From Cleveland") that participates in the annual fund raising Memory Walk for the Alzheimer's Association. In addition, Smith donated his time as a frequent guest speaker at local caregiver groups and at a variety of community events. References External links Alzheimer Research Forum Profile Case Western Reserve University Faculty bio Discovery Medicine In Memory: Mark A. Smith Researcher ID American neuroscientists 1965 births 2010 deaths Road incident deaths in Ohio Alzheimer's disease researchers Case Western Reserve University faculty English neuroscientists Alumni of the University of Nottingham People from Geauga County, Ohio Pedestrian road incident deaths Alumni of Hatfield College, Durham