Gubicza (2–4) || Groom || 15,987 || 10–20 |- bgcolor="ccffcc" | 31 || May 5 || Athletics || 2–0 || Haney (1–4) || Prieto || — || 16,589 || 11–20 |- bgcolor="ccffcc" | 32 || May 6 || @ Angels || 9–4 || Belcher (3–1) || Leftwich || Pichardo (1) || 14,447 || 12–20 |- bgcolor="ccffcc" | 33 || May 7 || @ Angels || 5–3 || Valera (1–1) || Abbott || Montgomery (8) || 14,657 || 13–20 |- bgcolor="ccffcc" | 34 || May 8 || @ Angels || 3–1 (14) || Pichardo (2–3) || Eichhorn || — || 16,210 || 14–20 |- bgcolor="ccffcc" | 35 || May 9 || @ Angels || 8–2 || Gubicza (3–4) || Grimsley || — || 15,302 || 15–20 |- bgcolor="ccffcc" | 36 || May 10 || @ Mariners || 14–10 || Valera (2–1) || Davis || — || 24,231 || 16–20 |- bgcolor="ffbbbb" | 37 || May 11 || @ Mariners || 1–11 || Wolcott || Belcher (3–2) || Carmona || 43,297 || 16–21 |- bgcolor="ffbbbb" | 38 || May 12 || @ Mariners || 5–8 || Johnson || Linton (0–1) || Charlton || 27,470 || 16–22 |- bgcolor="ffbbbb" | 39 || May 13 || @ Rangers || 6–7 || Cook || Montgomery (0–2) || Henneman || 22,981 || 16–23 |- bgcolor="ffbbbb" | 40 || May 14 || @ Rangers || 0–10 || Hill || Gubicza (3–5) || — || 28,999 || 16–24 |- bgcolor="ccffcc" | 41 || May 15 || @ Rangers || 3–1 || Haney (2–4) || Pavlik || Montgomery (9) || 26,881 || 17–24 |- bgcolor="ccffcc" | 42 || May 17 || Blue Jays || 4–2 || Belcher (4–2) || Guzman || Montgomery (10) || 20,079 || 18–24 |- bgcolor="ffbbbb" | 43 || May 18 || Blue Jays || 2–6 || Viola || Appier (3–4) || — || 18,116 || 18–25 |- bgcolor="ffbbbb" | 44 || May 19 || Blue Jays || 2–3 || Hanson || Gubicza (3–6) || Timlin || 15,039 || 18–26 |- bgcolor="ccffcc" | 45 || May 20 || Blue Jays || 5–4 || Haney (3–4) || Hentgen || Montgomery (11) || 14,303 || 19–26 |- bgcolor="ccffcc" | 46 || May 21 || @ Tigers || 7–1 || Linton (1–1) || Williams || Valera (1) || 24,372 || 20–26 |- bgcolor="ccffcc" | 47 || May 22 || @ Tigers || 6–4 || Belcher (5–2) || Farrell ||