style="background-color:#ffbbbb;" | 140 || September 6 || @ Twins || 0–6 || Radke (7–4) || Lidle (8–10) || — || 27,409 || 88–52 || L1 |- style="text-align:center; style="background-color:#bbffbb;" | 141 || September 7 || @ Twins || 2–0 || Mulder (17–7) || Mays (3–6) || Koch (38) || 43,628 || 89–52 || W1 |- style="text-align:center; style="background-color:#bbffbb;" | 142 || September 8 || @ Twins || 6–0 || Zito (20–5) || Milton (13–8) || — || 20,102 || 90–52 || W2 |- style="text-align:center; style="background-color:#bbffbb;" | 143 || September 9 || @ Angels || 2–1 || Hudson (13–9) || Appier (14–10) || Koch (39) || 28,145 || 91–52 || W3 |- style="text-align:center; style="background-color:#ffbbbb;" | 144 || September 10 || @ Angels || 2–5 || Ortiz (13–9) || Lilly (4–7) || Percival (36) || 35,323 || 91–53 || L1 |- style="text-align:center; style="background-color:#ffbbbb;" | 145 || September 11 || @ Angels || 5–6 || Shields (4–3) || Tam (0–1) || Percival (37) || 34,302 || 91–54 || L2 |- style="text-align:center; style="background-color:#ffbbbb;" | 146 || September 12 || @ Angels || 6–7 || Donnelly (1–1) || Koch (9–3) || — || 31,304 || 91–55 || L3 |- style="text-align:center; style="background-color:#bbffbb;" | 147 || September 13 || Mariners || 5–0 || Zito (21–5) || Valdez (8–11) || — || 38,210 || 92–55 || W1 |- style="text-align:center; style="background-color:#bbffbb;" | 148 || September 14 || Mariners || 1–0 || Hudson (14–9) || Moyer (13–8) || — || 40,309 || 93–55 || W2 |- style="text-align:center; style="background-color:#ffbbbb;" | 149 || September 15 || Mariners || 3–6 || Piñeiro (14–6) || Harang (5–4) || Sasaki (35) || 38,783 || 93–56 || L1 |- style="text-align:center; style="background-color:#bbffbb;" | 150 || September 16 || Angels || 4–3 || Koch (10–3) || Levine (4–4) || — || 22,326 || 94–56 || W1 |- style="text-align:center; style="background-color:#ffbbbb;" | 151 || September 17 || Angels || 0–1 (10) || Weber (7–2) || Koch (10–4) || Percival (40) || 25,894 || 94–57 || L1 |- style="text-align:center; style="background-color:#bbffbb;" | 152 || September 18 || Angels || 7–4 || Zito (22–5) || Callaway (1–1) || Koch (40) || 50,730 || 95–57 || W1 |- style="text-align:center; style="background-color:#bbffbb;" | 153 || September 19 || Angels || 5–3 || Hudson (15–9) || Appier (14–11) || Koch (41) || 27,435 || 96–57 || W2 |- style="text-align:center; style="background-color:#bbffbb;" | 154 || September 20 || Rangers || 4–2 || Mecir (6–3) || Kolb (3–5) || Rincón (1) ||