3–4 (13) || Harper (2–2) || Bradford (1–1) || — || 10,130 || 24–28 || L2 |- style="text-align:center; style="background-color:#bbffbb;" | 53 || May 31 || @ Devil Rays || 13–9 || Venafro (2–1) || Yan (2–2) || — || 10,227 || 25–28 || W1 |- |- style="text-align:center; style="background-color:#bbffbb;" | 54 || June 1 || @ Devil Rays || 8–3 || Zito (6–2) || Kennedy (3–5) || — || 14,073 || 26–28 || W2 |- style="text-align:center; style="background-color:#bbffbb;" | 55 || June 2 || @ Devil Rays || 4–2 || Mulder (4–4) || Rupe (5–6) || Koch (11) || 10,563 || 27–28 || W3 |- style="text-align:center; style="background-color:#ffbbbb;" | 56 || June 3 || Mariners || 1–4 || García (7–4) || Harang (1–1) || Sasaki (13) || 14,188 || 27–29 || L1 |- style="text-align:center; style="background-color:#bbffbb;" | 57 || June 4 || Mariners || 3–2 (10) || Koch (3–0) || Hasegawa (3–1) || — || 13,528 || 28–29 || W1 |- style="text-align:center; style="background-color:#ffbbbb;" | 58 || June 5 || Mariners || 0–5 || Moyer (5–2) || Lidle (1–6) || — || 35,647 || 28–30 || L1 |- style="text-align:center; style="background-color:#bbffbb;" | 59 || June 6 || Mariners || 10–4 || Zito (7–2) || Baldwin (4–5) || — || 27,344 || 29–30 || W1 |- style="text-align:center; style="background-color:#bbffbb;" | 60 || June 7 || Astros || 5–3 || Mulder (5–4) || Oswalt (6–4) || Koch (12) || 17,453 || 30–30 || W2 |- style="text-align:center; style="background-color:#bbffbb;" | 61 || June 8 || Astros || 5–1 || Harang (2–1) || Reynolds (3–6) || — || 27,115 || 31–30 || W3 |- style="text-align:center; style="background-color:#bbffbb;" | 62 || June 9 || Astros || 7–6 || Koch (4–0) || Dotel (3–3) || — || 35,065 || 32–30 || W4 |- style="text-align:center; style="background-color:#bbffbb;" | 63 || June 10 || Brewers || 8–6 || Bradford (2–1) || de los Santos (1–2) || Koch (13) || 10,584 || 33–30 || W5 |- style="text-align:center; style="background-color:#bbffbb;" | 64 || June 11 || Brewers || 11–2 || Zito (8–2) || Figueroa (1–4) || — || 11,223 || 34–30 || W6 |- style="text-align:center; style="background-color:#bbffbb;" | 65 || June 12 || Brewers || 8–0 || Mulder (6–4) || Sheets (3–7) || — || 20,847 || 35–30 || W7 |- style="text-align:center; style="background-color:#bbffbb;" | 66 || June 14 || @ Giants || 3–2 || Hudson (4–6) || Schmidt (2–2) || Koch (14) || 41,457 || 36–30 || W8 |- style="text-align:center; style="background-color:#ffbbbb;" |