|| 30,165 || 2-1 |- style="background-color:#ffbbbb" | 4 || April 6 || @ Mariners || 2-6 || Meche (1-0) || Loaiza (0-1) || Putz (1) || 22,701 || 2-2 |- style="background-color:#bbffbb" | 5 || April 7 || @ Mariners || 5-0 || Blanton (1-0) || Hernández (0-1) || – || 30,612 || 3-2 |- style="background-color:#bbffbb" | 6 || April 8 || @ Mariners || 3-0 || Zito (1-1) || Moyer (0-1) || Street (1) || 37,904 || 4-2 |- style="background-color:#bbffbb" | 7 || April 9 || @ Mariners || 6-4 || Harden (1-0) || Piñeiro (1-1) || Street (2) || 27,139 || 5-2 |- style="background-color:#ffbbbb" | 8 || April 11 || @ Twins || 6-7 || Radke (2-0) || Haren (0-1) || Nathan (1) || 48,911 || 5-3 |- style="background-color:#ffbbbb" | 9 || April 12 || @ Twins || 5-6 || Silva (1-1) || Loaiza (0-2) || Nathan (2) || 22,603 || 5-4 |- style="background-color:#ffbbbb" | 10 || April 13 || @ Twins || 2-8 || Lohse (1-1) || Blanton (1-1) || – || 13,520 || 5-5 |- style="background-color:#ffbbbb" | 11 || April 14 || Rangers || 3-6 || Millwood (1-2) || Zito (1-2) || – || 14,049 || 5-6 |- style="background-color:#bbffbb" | 12 || April 15 || Rangers || 5-4 || Harden (2-0) || Padilla (2-1) || Street (3) || 16,186 || 6-6 |- style="background-color:#ffbbbb" | 13 || April 16 || Rangers || 3-5 || Cordero (1-1) || Street (1-1) || – || 21,256 || 6-7 |- style="background-color:#bbffbb" | 14 || April 18 || Tigers || 4-3 || Duchscherer (1-0) || Verlander (1-2) || Street (4) || 16,857 || 7-7 |- style="background-color:#ffbbbb" | 15 || April 19 || Tigers || 4-11 || Rogers (3-1) || Blanton (1-2) || – || 18,309 || 7-8 |- style="background-color:#ffbbbb" | 16 || April 20 || Tigers || 3-4 || Rodney (1-0) || Duchscherer (1-1) || – || 15,489 || 7-9 |- style="background-color:#bbffbb" | 17 || April 21 || Angels || 5-3 || Harden (3-0) || Romero (1-2) || Calero (1) || 19,874 || 8-9 |- style="background-color:#ffbbbb" | 18 || April 22 || Angels || 4-5 || Weaver (1-2) || Haren (0-2) || F. Rodríguez (6) || 22,670 || 8-10 |- style="background-color:#ffbbbb" | 19 || April 23 || Angels || 3-4 || Escobar (3-1) || Loaiza (0-3) || F. Rodríguez (7) || 27,104 || 8-11 |- style="background-color:#bbffbb" | 20 || April 24 || @