Rangers || 3-2 || Blanton (2-2) || Wilson (1-1) || Duchscherer (1) || 23,802 || 9-11 |- style="background-color:#ffbbbb" | 21 || April 25 || @ Rangers || 5-6 || Cordero (3-2) || Gaudin (0-1) || – || 25,492 || 9-12 |- style="background-color:#bbffbb" | 22 || April 26 || @ Rangers || 6-4 (10) || Duchscherer (2-1) || Wilson (1-2) || Kennedy (1) || 23,756 || 10-12 |- style="background-color:#bbffbb" | 23 || April 28 || @ Royals || 5-3 || Haren (1-2) || Mays (0-3) || Saarloos (1) || 12,203 || 11-12 |- style="background-color:#bbbbbb" | --- || April 29|| @ Royals || colspan=5|Postponed (rain) || 11-12 |- style="background-color:#bbffbb" | 24 || April 30 || @ Royals || 13-6 || Blanton (3-2) || Hudson (0-3) || – || 15,224 || 12-12 |- style="background-color:#bbffbb" | 25 || May 1 || @ Angels || 1-0 || Zito (2-2) || Carrasco (0-2)|| Duchscherer (2) || 41,721 || 13-12 |- style="background-color:#bbffbb" | 26 || May 2 || @ Angels || 10-3 || Halsey (1-0) || Lackey (3-2)|| – || 35,943 || 14-12 |- style="background-color:#ffbbbb" | 27 || May 3 || Indians || 3-14 || Byrd (4-2) || Haren (1-3) || – || 18,248 || 14-13 |- style="background-color:#bbffbb" | 28 || May 4 || Indians || 12-4 || Saarloos (1-0) || Johnson (2-2) || Gaudin (1) || 14,695 || 15-13 |- style="background-color:#ffbbbb" | 29 || May 5 || Devil Rays || 1-3 || Kazmir (4-2) || Blanton (3-3) || Walker (2) || 12,552 || 15-14 |- style="background-color:#bbffbb" | 30 || May 6 || Devil Rays || 3-2 || Kennedy (2-0) || Orvella (1-3) || – || 25,080 || 16-14 |- style="background-color:#ffbbbb" | 31 || May 7 || Devil Rays || 2-3 || Hendrickson (2-2) || Halsey (1-1) || Walker (3) || 22,837 || 16-15 |- style="background-color:#bbffbb" | 32 || May 9 || @ Blue Jays || 6-5 || Haren (2-3) || Towers (0-7) || Street (5) || 36,269 || 17-15 |- style="background-color:#ffbbbb" | 33 || May 10 || @ Blue Jays || 7-9 || Rosario (1-0) || Blanton (3-4) || Ryan (8) || 19,269 || 17-16 |- style="background-color:#ffbbbb" | 34 || May 11 || @ Blue Jays || 3-8 || Lilly (4-2) || Saarloos (1-1) || – || 23,974 || 17-17 |- style="background-color:#ffbbbb" | 35 || May 12 || @ Yankees || 0-2 || Wang (3-1) || Zito (2-3) || Rivera (7) || 47,497 || 17-18 |-