|| Williams (2-4) || Duchscherer (7) || 31,179 || 78-56 |- style="background-color:#ffbbbb" | 135 || September 2 || Orioles || 5-6 || Loewen (5-4) || Haren (12-11) || Ray (31) || 24,383 || 78-57 |- style="background-color:#bbffbb" | 136 || September 3 || Orioles || 10-1 || Loaiza (9-7) || Penn (0-1) || – || 26,280 || 79-57 |- style="background-color:#ffbbbb" | 137 || September 4 || Rangers || 1-8 || Tejeda (4-3) || Zito (15-9) || – || 23,949 || 79-58 |- style="background-color:#ffbbbb" | 138 || September 5 || Rangers || 4-5 || Eaton (5-4) || Saarloos (7-7) || Otsuka (31) || 27,225 || 79-59 |- style="background-color:#bbffbb" | 139 || September 6 || Rangers || 9-6 || Blanton (15-10) || Rupe (0-1) || Duchscherer (8) || 17,838 || 80-59 |- style="background-color:#bbffbb" | 140 || September 8 || @ Devil Rays || 8-6 || Haren (13-11) || Shields (6-7) || Street (30) || 12,821 || 81-59 |- style="background-color:#ffbbbb" | 141 || September 9 || @ Devil Rays || 6-9 || Miceli (1-1) || Loaiza (9-8) || McClung (6) || 22,016 || 81-60 |- style="background-color:#bbffbb" | 142 || September 10 || @ Devil Rays || 9-7 || Kennedy (4-0) || Camp (7-3) || Street (31) || 16,791 || 82-60 |- style="background-color:#ffbbbb" | 143 || September 11 || @ Twins || 4-9 || Silva (9-13) || Blanton (15-11) || Nathan (31) || 15,728 || 82-61 |- style="background-color:#ffbbbb" | 144 || September 12 || @ Twins || 5-7 || Reyes (5-0) || Kennedy (4-1) || Nathan (32) || 20,991 || 82-62 |- style="background-color:#bbffbb" | 145 || September 13 || @ Twins || 1-0 || Haren (14-11) || Garza (1-5) || Street (32) || 18,902 || 83-62 |- style="background-color:#bbffbb" | 146 || September 15 || White Sox || 4-2 || Loaiza (10-8) || Garland (17-5) || Street (33) || 26,809 || 84-62 |- style="background-color:#bbffbb" | 147 || September 16 || White Sox || 7-4 || Zito (16-9) || Thornton (5-3) || Street (34) || 32,169 || 85-62 |- style="background-color:#bbffbb" | 148 || September 17 || White Sox || 5-4 || Blanton (16-11) || Contreras (13-8) || Duchscherer (9) || 28,806 || 86-62 |- style="background-color:#ffbbbb" | 149 || September 18 || Indians || 2-7 || Westbrook (13-10) || Haren (14-12) || – || 17,352 || 86-63 |- style="background-color:#bbffbb" | 150 || September 19 || Indians || 7-3 || Gaudin (2-2) || Lee (12-11) || – || 15,866