style="background-color:#ffbbbb" | 36 || May 13 || @ Yankees || 3-4 || Wright (1-2) || Halsey (1-2) || Farnsworth (1) || 53,907 || 17-19 |- style="background-color:#bbffbb" | 37 || May 14 || @ Yankees || 6-1 || Haren (3-3) || Johnson (5-4) || – || 52,587 || 18-19 |- style="background-color:#bbffbb" | 38 || May 16 || Mariners || 12-6 || Blanton (4-4) || Hernández (3-5) || – || 16,397 || 19-19 |- style="background-color:#bbffbb" | 39 || May 17 || Mariners || 7-2 || Zito (3-3) || Moyer (1-4) || – || 19,208 || 20-19 |- style="background-color:#bbffbb" | 40 || May 18 || Mariners || 6-3 || Saarloos (2-1) || Piñeiro (4-4) || Street (6) || 18,136 || 21-19 |- style="background-color:#bbffbb" | 41 || May 19 || Giants || 1-0 || Haren (4-3) || Lowry (1-1) || Street (7) || 35,077 || 22-19 |- style="background-color:#ffbbbb" | 42 || May 20 || Giants || 2-4 (10) || Benítez (3-0) || Calero (0-1) || – || 35,077 || 22-20 |- style="background-color:#ffbbbb" | 43 || May 21 || Giants || 0-6 || Cain (2-5) || Blanton (4-5) || – || 35,077 || 22-21 |- style="background-color:#ffbbbb" | 44 || May 22 || @ White Sox || 4-5 (10) || Jenks (2-1) || Flores (0-1) || – || 39,354 || 22-22 |- style="background-color:#ffbbbb" | 45 || May 23 || @ White Sox || 3-9 || Vázquez (5-3) || Saarloos (2-2) || – || 38,860 || 22-23 |- style="background-color:#ffbbbb" | 46 || May 24 || @ White Sox || 2-3 || Buehrle (6-2) || Haren (4-4) || Jenks (13) || 38,434 || 22-24 |- style="background-color:#ffbbbb" | 47 || May 25 || @ Rangers || 7-8 || Otsuka (1-1) || Street (1-2) || – || 22,006 || 22-25 |- style="background-color:#ffbbbb" | 48 || May 26 || @ Rangers || 3-5 || Cordero (4-3) || Gaudin (0-2) || Otsuka (7) || 27,791 || 22-26 |- style="background-color:#bbffbb" | 49 || May 27 || @ Rangers || 6-3 || Zito (4-3) || Loe (3-5) || Street (8) || 41,226 || 23-26 |- style="background-color:#ffbbbb" | 50 || May 28 || @ Rangers || 3-4 || Padilla (5-3) || Saarloos (2-3) || Otsuka (8) || 38,905 || 23-27 |- style="background-color:#ffbbbb" | 51 || May 29 || Royals || 4-6 || Etherton (1-0) || Haren (4-5) || Burgos (6) || 28,040 || 23-28 |- style="background-color:#ffbbbb" | 52 || May 30 || Royals || 7-8