|| 62–48 || L1 |- style="text-align:center; style="background-color:#bbffbb;" | 111 || August 3 || Tigers || 8–4 || Hudson (8–9) || Lima (2–5) || — || 29,648 || 63–48 || W1 |- style="text-align:center; style="background-color:#bbffbb;" | 112 || August 4 || Tigers || 4–0 || Lidle (4–9) || Maroth (3–4) || — || 24,546 || 64–48 || W2 |- style="text-align:center; style="background-color:#bbffbb;" | 113 || August 6 || @ Red Sox || 9–1 || Mulder (13–6) || Wakefield (5–4) || — || 34,059 || 65–48 || W3 |- style="text-align:center; style="background-color:#bbffbb;" | 114 || August 7 || @ Red Sox || 3–2 || Harang (4–2) || Burkett (10–5) || Koch (28) || 33,325 || 66–48 || W4 |- style="text-align:center; style="background-color:#ffbbbb;" | 115 || August 8 || @ Red Sox || 2–4 || Lowe (16–5) || Zito (15–5) || Urbina (26) || 33,855 || 66–49 || L1 |- style="text-align:center; style="background-color:#bbffbb;" | 116 || August 9 || @ Yankees || 3–2 (16) || Bowie (2–0) || Hitchcock (1–1) || — || 54,316 || 67–49 || W1 |- style="text-align:center; style="background-color:#bbffbb;" | 117 || August 10 || @ Yankees || 8–0 || Lidle (5–9) || Wells (12–6) || — || 54,439 || 68–49 || W2 |- style="text-align:center; style="background-color:#ffbbbb;" | 118 || August 11 || @ Yankees || 5–8 || Mussina (14–6) || Mulder (13–7) || — || 54,703 || 68–50 || L1 |- style="text-align:center; style="background-color:#ffbbbb;" | 119 || August 12 || Blue Jays || 1–2 || Loaiza (5–6) || Harang (4–3) || Escobar (24) || 14,178 || 68–51 || L2 |- style="text-align:center; style="background-color:#bbffbb;" | 120 || August 13 || Blue Jays || 5–4 || Zito (16–5) || Carpenter (4–5) || Koch (29) || 17,466 || 69–51 || W1 |- style="text-align:center; style="background-color:#bbffbb;" | 121 || August 14 || Blue Jays || 4–2 || Hudson (9–9) || Walker (5–3) || Koch (30) || 40,528 || 70–51 || W2 |- style="text-align:center; style="background-color:#bbffbb;" | 122 || August 16 || White Sox || 1–0 || Lidle (6–9) || Buehrle (15–9) || Koch (31) || 22,622 || 71–51 || W3 |- style="text-align:center; style="background-color:#bbffbb;" | 123 || August 17 || White Sox || 9–2 || Mulder (14–7) || Garland (8–9) || — || 40,658 || 72–51 || W4 |- style="text-align:center; style="background-color:#bbffbb;" | 124 || August 18 || White Sox || 7–4 || Zito (17–5) || Wright (8–11) || — || 31,489 || 73–51 || W5 |- style="text-align:center; style="background-color:#bbffbb;" | 125 || August 19 || @