— || 20,158 || 6–2 || W3 |- style="text-align:center; style="background-color:#ffbbbb;" | 9 || April 10 || @ Rangers || 2–4 || Burba (1–0) || Lidle (0–2) || Rocker (1) || 21,384 || 6–3 || L1 |- style="text-align:center; style="background-color:#ffbbbb;" | 10 || April 11 || @ Rangers || 0–7 || Davis (2–0) || Mulder (2–1) || — || 21,903 || 6–4 || L2 |- style="text-align:center; style="background-color:#bbffbb;" | 11 || April 12 || @ Angels || 5–1 || Hudson (2–0) || Ortiz (1–1) || — || 31,815 || 7–4 || W1 |- style="text-align:center; style="background-color:#bbffbb;" | 12 || April 13 || @ Angels || 7–2 || Hiljus (1–1) || Washburn (0–2) || — || 33,554 || 8–4 || W2 |- style="text-align:center; style="background-color:#ffbbbb;" | 13 || April 14 || @ Angels || 1–4 || Appier (1–1) || Zito (0–1) || Levine (3) || 32,881 || 8–5 || L1 |- style="text-align:center; style="background-color:#ffbbbb;" | 14 || April 16 || Mariners || 2–6 (7) || Piñeiro (1–0) || Lidle (0–3) || — || 13,022 || 8–6 || L2 |- style="text-align:center; style="background-color:#ffbbbb;" | 15 || April 17 || Mariners || 4–7 || Moyer (2–1) || Hudson (2–1) || Sasaki (4) || 31,260 || 8–7 || L3 |- style="text-align:center; style="background-color:#bbffbb;" | 16 || April 18 || Angels || 4–2 || Hiljus (2–1) || Ortiz (1–2) || Koch (3) || 9,145 || 9–7 || W1 |- style="text-align:center; style="background-color:#ffbbbb;" | 17 || April 19 || Angels || 7–9 || Washburn (1–2) || Fyhrie (0–1) || Percival (2) || 12,468 || 9–8 || L1 |- style="text-align:center; style="background-color:#bbffbb;" | 18 || April 20 || Angels || 8–7 || Bradford (1–0) || Levine (1–1) || Koch (4) || 20,253 || 10–8 || W1 |- style="text-align:center; style="background-color:#bbffbb;" | 19 || April 21 || Angels || 6–5 || Venafro (1–0) || Percival (0–1) || — || 20,088 || 11–8 || W2 |- style="text-align:center; style="background-color:#ffbbbb;" | 20 || April 23 || Yankees || 1–2 || Hernández (3–1) || Hudson (2–2) || Rivera (6) || 40,360 || 11–9 || L1 |- style="text-align:center; style="background-color:#ffbbbb;" | 21 || April 24 || Yankees || 5–8 || Stanton (1–0) || Magnante (0–1) || Rivera (7) || 54,513 || 11–10 || L2 |- style="text-align:center; style="background-color:#bbffbb;" | 22 || April 25 || Yankees || 6–2 || Zito (1–1) || Mussina (3–1) || — || 31,870 || 12–10 || W1 |- style="text-align:center; style="background-color:#bbffbb;" | 23 || April 26 || White Sox || 6–4 || Lidle