(1–3) || Parque (0–1) || Koch (5) || 10,129 || 13–10 || W2 |- style="text-align:center; style="background-color:#bbffbb;" | 24 || April 27 || White Sox || 16–1 || Fyhrie (1–1) || Buehrle (4–2) || — || 26,111 || 14–10 || W3 |- style="text-align:center; style="background-color:#bbffbb;" | 25 || April 28 || White Sox || 10–0 || Hudson (3–2) || Ritchie (2–2) || — || 20,365 || 15–10 || W4 |- style="text-align:center; style="background-color:#ffbbbb;" | 26 || April 30 || @ Yankees || 2–8 || Wells (4–0) || Zito (1–2) || — || 32,888 || 15–11 || L1 |- |- style="text-align:center; style="background-color:#bbffbb;" | 27 || May 1 || @ Yankees || 4–1 || Hiljus (3–1) || Mussina (3–2) || Koch (6) || 31,006 || 16–11 || W1 |- style="text-align:center; style="background-color:#ffbbbb;" | 28 || May 2 || @ Yankees || 2–9 || Clemens (4–2) || Lidle (1–4) || — || 30,463 || 16–12 || L1 |- style="text-align:center; style="background-color:#ffbbbb;" | 29 || May 3 || @ White Sox || 1–6 || Buehrle (5–2) || Fyhrie (1–2) || — || 15,746 || 16–13 || L2 |- style="text-align:center; style="background-color:#ffbbbb;" | 30 || May 4 || @ White Sox || 2–10 || Ritchie (3–2) || Hudson (3–3) || — || 27,511 || 16–14 || L3 |- style="text-align:center; style="background-color:#bbffbb;" | 31 || May 5 || @ White Sox || 3–2 || Zito (2–2) || Wright (3–3) || Koch (7) || 27,275 || 17–14 || W1 |- style="text-align:center; style="background-color:#ffbbbb;" | 32 || May 7 || Red Sox || 7–9 || Arrojo (2–0) || Mecir (1–1) || Urbina (12) || 19,715 || 17–15 || L1 |- style="text-align:center; style="background-color:#ffbbbb;" | 33 || May 8 || Red Sox || 6–12 || Burkett (3–0) || Hiljus (3–2) || — || 40,155 || 17–16 || L2 |- style="text-align:center; style="background-color:#ffbbbb;" | 34 || May 9 || Red Sox || 1–5 || Lowe (5–1) || Hudson (3–4) || — || 18,477 || 17–17 || L3 |- style="text-align:center; style="background-color:#ffbbbb;" | 35 || May 10 || Blue Jays || 2–6 || Prokopec (2–4) || Mulder (2–2) || — || 10,824 || 17–18 || L4 |- style="text-align:center; style="background-color:#bbffbb;" | 36 || May 11 || Blue Jays || 7–4 || Zito (3–2) || Miller (2–1) || — || 21,115 || 18–18 || W1 |- style="text-align:center; style="background-color:#ffbbbb;" | 37 || May 12 || Blue Jays || 4–11 || Halladay (3–1) || Lidle (1–5) || Walker (1) || 19,519 || 18–19 || L1 |-