Indians || 8–1 || Hudson (10–9) || Báez (9–10) || — || 27,696 || 74–51 || W6 |- style="text-align:center; style="background-color:#bbffbb;" | 126 || August 20 || @ Indians || 6–3 || Harang (5–3) || Westbrook (1–2) || Koch (32) || 27,527 || 75–51 || W7 |- style="text-align:center; style="background-color:#bbffbb;" | 127 || August 21 || @ Indians || 6–0 || Lidle (7–9) || Rodríguez (0–1) || — || 26,916 || 76–51 || W8 |- style="text-align:center; style="background-color:#bbffbb;" | 128 || August 22 || @ Indians || 9–3 || Mulder (15–7) || Phillips (1–2) || Bradford (2) || 27,759 || 77–51 || W9 |- style="text-align:center; style="background-color:#bbffbb;" | 129 || August 23 || @ Tigers || 9–1 || Zito (18–5) || Powell (1–3) || — || 21,807 || 78–51 || W10 |- style="text-align:center; style="background-color:#bbffbb;" | 130 || August 24 || @ Tigers || 12–3 || Hudson (11–9) || Lima (4–6) || — || 19,045 || 79–51 || W11 |- style="text-align:center; style="background-color:#bbffbb;" | 131 || August 25 || @ Tigers || 10–7 || Mecir (4–3) || Walker (1–1) || Koch (33) || 24,346 || 80–51 || W12 |- style="text-align:center; style="background-color:#bbffbb;" | 132 || August 26 || @ Royals || 6–3 || Lidle (8–9) || May (3–9) || Koch (34) || 11,096 || 81–51 || W13 |- style="text-align:center; style="background-color:#bbffbb;" | 133 || August 27 || @ Royals || 6–4 || Mulder (16–7) || Hernández (3–3) || Koch (35) || 13,077 || 82–51 || W14 |- style="text-align:center; style="background-color:#bbffbb;" | 134 || August 28 || @ Royals || 7–1 || Zito (19–5) || Sedlacek (3–4) || — || 15,952 || 83–51 || W15 |- style="text-align:center; style="background-color:#bbffbb;" | 135 || August 30 || Twins || 4–2 || Hudson (12–9) || Radke (6–4) || Koch (36) || 25,221 || 84–51 || W16 |- style="text-align:center; style="background-color:#bbffbb;" | 136 || August 31 || Twins || 6–3 || Mecir (5–3) || Romero (8–2) || Koch (37) || 42,841 || 85–51 || W17 |- |- style="text-align:center; style="background-color:#bbffbb;" | 137 || September 1 || Twins || 7–5 || Koch (7–2) || Guardado (1–3) || — || 37,676 || 86–51 || W18 |- style="text-align:center; style="background-color:#bbffbb;" | 138 || September 2 || Royals || 7–6 || Koch (8–2) || Grimsley (3–5) || — || 26,325 || 87–51 || W19 |- style="text-align:center; style="background-color:#bbffbb;" | 139 || September 4 || Royals || 12–11 || Koch (9–2) || Grimsley (3–6) || — || 55,528 || 88–51 || W20 |- style="text-align:center;