|| August 14 || Mariners || 5-4 || Kennedy (3-0) || Soriano (1-2) || Duchscherer (3) || 21,859 || 66-52 |- style="background-color:#bbffbb" | 119 || August 15 || Mariners || 11-2 || Saarloos (5-6) || Piñeiro (7-11) || – || 23,726 || 67-52 |- style="background-color:#bbffbb" | 120 || August 16 || Mariners || 4-0 || Haren (11-9) || Meche (9-8) || – || 34,077 || 68-52 |- style="background-color:#ffbbbb" | 121 || August 18|| @ Royals || 1-7 || Hudson (6-4) || Blanton (13-10) || – || n/a || 68-53 |- style="background-color:#ffbbbb" | 122 || August 18 || @ Royals || 3-5 || Burgos (3-5) || Street (4-4) || Nelson (2) || 23,952 || 68-54 |- style="background-color:#bbffbb" | 123 || August 19 || @ Royals || 7-2 || Zito (13-8) || Redman (7-8) || – || 30,810 || 69-54 |- style="background-color:#bbffbb" | 124 || August 20 || @ Royals || 6-4 || Saarloos (6-6) || Hernández (3-8) || – || 16,592 || 70-54 |- style="background-color:#bbffbb" | 125 || August 21 || @ Blue Jays || 12-10 || Haren (12-9) || League (0-1) || Duchscherer (4) || 28,280 || 71-54 |- style="background-color:#ffbbbb" | 126 || August 22 || @ Blue Jays || 3-4 || Burnett (6-5) || Halsey (3-4) || Ryan (28) || 30,071 || 71-55 |- style="background-color:#bbffbb" | 127 || August 23 || @ Blue Jays || 6-0 || Loaiza (7-7) || Chacín (6-3) || – || 32,516 || 72-55 |- style="background-color:#bbffbb" | 128 || August 25 || @ Rangers || 9-3 || Zito (14-8) || Vólquez (1-3) || – || 31,178 || 73-55 |- style="background-color:#bbffbb" | 129 || August 26 || @ Rangers || 5-3 || Blanton (14-10) || Eaton (3-4) || Duchscherer (5) || 37,752 || 74-55 |- style="background-color:#ffbbbb" | 130 || August 27 || @ Rangers || 0-3 || Padilla (13-8) || Haren (12-10) || Otsuka (28) || 25,708 || 74-56 |- style="background-color:#bbffbb" | 131 || August 28 || Red Sox || 9-0 || Loaiza (8-7) || Gabbard (0-3) || – || 30,159 || 75-56 |- style="background-color:#bbffbb" | 132 || August 29 || Red Sox || 2-1 || Saarloos (7-6) || Beckett (14-9) || Duchscherer (6) || 30,517 || 76-56 |- style="background-color:#bbffbb" | 133 || August 30 || Red Sox || 7-2 || Zito (15-8) || Schilling (14-7) || – || 31,073 || 77-56 |- style="background-color:#bbffbb" | 134 || September 1 || Orioles || 5-4 || Halsey (4-4)