|| 35–28 || box |- style="text-align:center;background-color:#ffbbbb" | 64 || June 19 || @ Expos || 14–17 || Fikac (1–2) || Muñoz (0–1) || Cordero (2) || 3:28 || 18,414 || 35–29 || box |- style="text-align:center;background-color:#ffbbbb" | 65 || June 20 || @ Expos || 2–4 || Cordero (2–1) || Garland (5–4) || || 1:54 || 6,546 || 35–30 || box |- style="text-align:center;background-color:#ffbbbb" | 66 || June 21 || Indians || 1–5 || Sabathia (5–3) || Schoeneweis (5–6) || || 2:38 || 29,722 || 35–31 || box |- style="text-align:center;background-color:#bbffbb" | 67 || June 22 || Indians || 11 – 9 (10) || Takatsu (4–0) || Jimenez (1–5) || || 3:38 || 27,922 || 36–31 || box |- style="text-align:center;background-color:#ffbbbb" | 68 || June 23 || Indians || 5–9 || Lee (7–1) || Buehrle (7–2) || || 2:31 || 21,654 || 36–32 || box |- style="text-align:center;background-color:#bbffbb" | 69 || June 24 || Indians || 7–1 || Rauch (1–1) || Westbrook (6–4) || || 2:36 || 20,744 || 37–32 || box |- style="text-align:center;background-color:#ffbbbb" | 70 || June 25 || Cubs || 4–7 || Prior (2–1) || Garland (5–5) || Hawkins (10) || 2:58 || 39,596 || 37–33 || box |- style="text-align:center;background-color:#bbffbb" | 71 || June 26 || Cubs || 6–3 || Diaz (1–1) || Zambrano (8–3) || Takatsu (3) || 2:37 || 39,553 || 38–33 || box |- style="text-align:center;background-color:#bbffbb" | 72 || June 27 || Cubs || 9–4 || Loaiza (8–3) || Maddux (6–6) || || 2:48 || 38,526 || 39–33 || box |- style="text-align:center;background-color:#bbffbb" | 73 || June 29 || @ Twins || 6–2 || Buehrle (8–2) || Silva (8–5) || || 2:04 || 24,704 || 40–33 || box |- style="text-align:center;background-color:#bbffbb" | 74 || June 30 || @ Twins || 9–6 || García (5–7) || Radke (4–4) || || 2:08 || 25,433 || 41–33 || box |- style="text-align:center;background-color:#bbffbb" | 75 || July 1 || @ Twins || 2–1 || Garland (6–5) || Santana (6–5) || Marte (4) || 2:20 || 21,127 || 42–33 || box |- style="text-align:center;background-color:#ffbbbb" | 76 || July 2 || @ Cubs || 2–6 || Zambrano (9–3) || Loaiza (8–4) || || 2:44 || 39,625 || 42–34 || box |- style="text-align:center;background-color:#ffbbbb" | 77 || July 3 || @ Cubs || 2 – 4 (6) || Maddux (7–6) || Diaz (1–2) || Wuertz (1) || 1:40 || 39,528 || 42–35 || box |- style="text-align:center;background-color:#ffbbbb" | 78 || July 4 || @