1 |- style="text-align:center;background-color:#bbffbb" | 22 || May 1 || Blue Jays || 4 – 3 (10) || Takatsu (1–0) || Speier (1–3) || || 2:45 || N/A || 14–8 || box |- style="text-align:center;background-color:#ffbbbb" | 23 || May 1 || Blue Jays || 6–10 || Lilly (2–2) || Wright (0–4) || || 3:23 || 22,072 || 14–9 || box |- style="text-align:center;background-color:#bbffbb" | 24 || May 2 || Blue Jays || 3–2 || Garland (2–1) || Batista (0–3) || Koch (3) || 2:17 || 15,550 || 15–9 || box |- style="text-align:center;background-color:#bbffbb" | 25 || May 3 || @ Orioles || 5–4 || Schoeneweis (3–1) || DeJean (0–3) || Koch (4) || 3:10 || 18,849 || 16–9 || box |- style="text-align:center;background-color:#ffbbbb" | 26 || May 4 || @ Orioles || 3–10 || López (2–1) || Loaiza (4–1) || || 2:52 || 21,488 || 16–10 || box |- style="text-align:center;background-color:#bbffbb" | 27 || May 5 || @ Orioles || 6–5 || Takatsu (2–0) || Ryan (1–1) || Koch (5) || 3:01 || 20,978 || 17–10 || box |- style="text-align:center;background-color:#ffbbbb" | 28 || May 7 || @ Blue Jays || 4–5 || Adams (3–1) || Politte (0–1) || || 2:44 || 15,661 || 17–11 || box |- style="text-align:center;background-color:#ffbbbb" | 29 || May 8 || @ Blue Jays || 2–4 || Frasor (1–1) || Cotts (0–1) || Adams (1) || 2:20 || 18,368 || 17–12 || box |- style="text-align:center;background-color:#ffbbbb" | 30 || May 9 || @ Blue Jays || 2–5 || Miller (1–0) || Loaiza (4–2) || Ligtenberg (1) || 2:11 || 17,546 || 17–13 || box |- style="text-align:center;background-color:#bbffbb" | 31 || May 11 || Orioles || 15–0 || Buehrle (2–1) || Ponson (2–3) || || 2:20 || 20,400 || 18–13 || box |- style="text-align:center;background-color:#bbbbbb" | – || May 12 || Orioles || colspan=8 | Postponed (rain) Rescheduled for May 13 |- style="text-align:center;background-color:#ffbbbb" | 32 || May 13 || Orioles || 0–1 || Cabrera (1–0) || Garland (2–2) || Julio (6) || 2:27 || N/A || 18–14 || box |- style="text-align:center;background-color:#bbffbb" | 33 || May 13 || Orioles || 6–5 || Jackson (2–0) || Bédard (0–1) || Koch (6) || 2:30 || 18,324 || 19–14 || box |- style="text-align:center;background-color:#ffbbbb" | 34 || May 14 || Twins || 2–3 || Rincón (5–2) || Marte (1–2) || Nathan (11) || 3:06 || 15,962 || 19–15 || box |- style="text-align:center;background-color:#ffbbbb" | 35 || May 15 || Twins || 1–4 ||