4–1 || Colón (6–5) || Ashby (0–4) || || 2:19 || 44,122 || 27–34 || box |- style="text-align:center;background-color:#bbffbb" | 62 || June 8 || @ Dodgers || 10–3 || Loaiza (9–2) || Pérez (4–4) || || 2:41 || 52,637 || 28–34 || box |- style="text-align:center;background-color:#bbffbb" | 63 || June 10 || Giants || 5–3 || Garland (4–5) || Nathan (6–3) || || 2:51 || 23,837 || 29–34 || box |- style="text-align:center;background-color:#ffbbbb" | 64 || June 11 || Giants || 4–11 || Foppert (4–5) || Buehrle (2–10) || || 2:59 || 19,114 || 29–35 || box |- style="text-align:center;background-color:#ffbbbb" | 65 || June 12 || Giants || 4–8 || Nathan (7–3) || Colón (6–6) || || 2:40 || 22,827 || 29–36 || box |- style="text-align:center;background-color:#bbffbb" | 66 || June 13 || Padres || 5–3 || Gordon (3–5) || Linebrink (1–2) || Koch (7) || 2:51 || 14,162 || 30–36 || box |- style="text-align:center;background-color:#bbffbb" | 67 || June 14 || Padres || 6–5 || Gordon (4–5) || Witasick (0–1) || Koch (8) || 2:51 || 27,287 || 31–36 || box |- style="text-align:center;background-color:#ffbbbb" | 68 || June 15 || Padres || 0–1 || Pérez (2–3) || Garland (4–6) || Beck (1) || 2:38 || 26,491 || 31–37 || box |- style="text-align:center;background-color:#bbffbb" | 69 || June 16 || Red Sox || 4–2 || Buehrle (3–10) || Rupe (1–1) || Gordon (1) || 2:06 || 30,779 || 32–37 || box |- style="text-align:center;background-color:#ffbbbb" | 70 || June 17 || Red Sox || 4–7 || Burkett (5–3) || Colón (6–7) || Lyon (8) || 2:53 || 19,887 || 32–38 || box |- style="text-align:center;background-color:#bbffbb" | 71 || June 18 || Red Sox || 3–1 || Loaiza (10–2) || Wakefield (5–3) || Koch (9) || 2:22 || 18,708 || 33–38 || box |- style="text-align:center;background-color:#ffbbbb" | 72 || June 19 || Red Sox || 3 – 4 (10) || Lyon (3–3) || Koch (2–3) || || 3:15 || 17,225 || 33–39 || box |- style="text-align:center;background-color:#bbffbb" | 73 || June 20 || @ Cubs || 12–3 || Garland (5–6) || Estes (6–6) || || 3:13 || 39,080 || 34–39 || box |- style="text-align:center;background-color:#bbffbb" | 74 || June 21 || @ Cubs || 7–6 || Buehrle (4–10) || Clement (5–7) || Koch (10) || 3:13 || 38,938 || 35–39 || box |- style="text-align:center;background-color:#ffbbbb" | 75 || June 22 || @ Cubs || 1–2 || Zambrano (6–6) || Marte (2–1) || Borowski (15) ||