Destroy All Humans! is an open world action-adventure video game franchise that is designed as a parody of Cold War-era alien invasion films. Destroy All Humans! and Destroy All Humans! 2 was released for the PlayStation 2 and Xbox; Destroy All Humans! Big Willy Unleashed was released for the Wii; and Destroy All Humans! Path of the Furon was released for the Xbox 360 and PlayStation 3. A remake of the original game and its sequel were developed by Black Forest Games and were released in 2020 and 2022, respectively. The two main protagonists of the series are voiced by J. Grant Albrecht and Richard Steven Horvitz, with the exception of the game Big Willy Unleashed, in which actors Sean Donnellan and Darryl Kurylo portray the characters. The musical score for the series is performed by composer Garry Schyman. Setting The games take place mostly on Earth where the Furon Cryptosporidium, also known as Crypto, is tasked by his superiors to gather Furon DNA locked inside human brain stems in order to save his race from cloning themselves to extinction. In Destroy All Humans!, Crypto's objectives also include investigating what happened to his previous clone. Destroy All Humans! 2 features Crypto hunting for revenge, after the KGB try to assassinate him and successfully destroy the mothership and his mission officer, Orthopox-13 (Pox), as well as exterminating the Furons' enemy from the Martian War, the Blisk. Destroy All Humans! Big Willy Unleashed involves Crypto protecting Pox's new fast food chain using a giant robot mech disguised as the restaurant's mascot, called "Big Willy". Destroy All Humans! Path of the Furon is available on Xbox 360 (and PlayStation 3 only in Australia and Europe), and involves Crypto seeking enlightenment to help him stop a conspiracy that threatens the Furon empire. Destroy All Humans! takes place in 1959; Destroy All Humans! 2 takes place in 1969; Destroy All Humans! Big Willy Unleashed takes place in 1975; Destroy All Humans! Path of the Furon takes place in 1979. Games Destroy All Humans! (2005) During the year 1959, Cryptosporidium 137 first arrived on the Earth to investigate the planet and search for his predecessor clone, Cryptosporidium 136, who disappeared in 1947 after Orthopox 13 sent him to Earth on a similar mission. Pox sends Crypto on a mission to harvest human brain stems (which contain a small amount of pure Furon DNA due to an