12 || @ Red Sox || 4–7 || Suppan (12–9) || Wright (1–6) || Kim (13) || 3:14 || 34,890 || 78–69 || box |- style="text-align:center;background-color:#bbffbb" | 148 || September 13 || @ Red Sox || 3–1 || Colón (14–12) || Wakefield (10–7) || || 2:21 || 34,414 || 79–69 || box |- style="text-align:center;background-color:#bbffbb" | 149 || September 14 || @ Red Sox || 7–2 || Buehrle (13–13) || Burkett (10–8) || Marte (11) || 2:36 || 34,174 || 80–69 || box |- style="text-align:center;background-color:#ffbbbb" | 150 || September 16 || @ Twins || 2–5 || Radke (13–10) || Loaiza (19–8) || || 2:51 || 32,921 || 80–70 || box |- style="text-align:center;background-color:#ffbbbb" | 151 || September 17 || @ Twins || 2–4 || Rogers (12–8) || Garland (11–12) || Guardado (37) || 2:39 || 40,304 || 80–71 || box |- style="text-align:center;background-color:#ffbbbb" | 152 || September 18 || @ Twins || 3–5 || Lohse (14–11) || Colón (14–13) || Guardado (38) || 2:55 || 39,948 || 80–72 || box |- style="text-align:center;background-color:#bbffbb" | 153 || September 19 || Royals || 8–5 || Buehrle (14–13) || Carrasco (6–5) || Gordon (12) || 2:21 || 32,812 || 81–72 || box |- style="text-align:center;background-color:#ffbbbb" | 154 || September 20 || Royals || 1–7 || Anderson (13–11) || Loaiza (19–9) || || 2:36 || 37,367 || 81–73 || box |- style="text-align:center;background-color:#ffbbbb" | 155 || September 21 || Royals || 4–10 || May (10–7) || Garland (11–13) || || 2:31 || 31,539 || 81–74 || box |- style="text-align:center;background-color:#bbffbb" | 156 || September 22 || Yankees || 6 – 3 (10) || Gordon (7–6) || White (5–1) || || 3:21 || 39,627 || 82–74 || box |- style="text-align:center;background-color:#ffbbbb" | 157 || September 23 || Yankees || 0–7 || Contreras (7–2) || Buehrle (14–14) || || 2:48 || 31,305 || 82–75 || box |- style="text-align:center;background-color:#bbffbb" | 158 || September 24 || Yankees || 9–4 || Loaiza (20–9) || Mussina (17–8) || || 2:45 || 26,019 || 83–75 || box |- style="text-align:center;background-color:#ffbbbb" | 159 || September 25 || @ Royals || 3–7 || Anderson (14–11) || Wright (1–7) || || 2:06 || 16,438 || 83–76 || box |- style="text-align:center;background-color:#bbffbb" | 160 || September 26 || @ Royals || 11–2 || Garland (12–13) || May (10–8) || || 2:22 || 36,598 || 84–76 || box |- style="text-align:center;background-color:#bbffbb" | 161 || September 27 || @ Royals || 19–3 || Colón (15–13) || Wright (1–2)