| 19 || April 21 || Indians || 2–9 || Westbrook (1–2) || Garland (0–2) || || 2:39 || 15,424 || 11–8 || box |- style="text-align:center;background-color:#bbffbb" | 20 || April 22 || @ Orioles || 3–1 || Loaiza (4–0) || Ponson (1–2) || Koch (3) || 2:08 || 18,676 || 12–8 || box |- style="text-align:center;background-color:#ffbbbb" | 21 || April 23 || @ Orioles || 1–7 || Johnson (3–0) || Colón (2–1) || || 2:48 || 19,908 || 12–9 || box |- style="text-align:center;background-color:#ffbbbb" | 22 || April 24 || @ Orioles || 4–5 || Roberts (2–1) || Gordon (1–2) || Julio (6) || 2:46 || 23,731 || 12–10 || box |- style="text-align:center;background-color:#ffbbbb" | 23 || April 25 || Twins || 1–6 || Mays (3–2) || Buehrle (2–3) || || 2:22 || 14,285 || 12–11 || box |- style="text-align:center;background-color:#bbffbb" | 24 || April 26 || Twins || 7–4 || Garland (1–2) || Lohse (2–3) || || 2:48 || 25,381 || 13–11 || box |- style="text-align:center;background-color:#bbffbb" | 25 || April 27 || Twins || 3–1 || Loaiza (5–0) || Reed (1–4) || Marte (1) || 2:00 || 22,714 || 14–11 || box |- style="text-align:center;background-color:#ffbbbb" | 26 || April 29 || Athletics || 2–3 || Zito (4–2) || Colón (2–2) || Foulke (7) || 2:30 || 13,936 || 14–12 || box |- style="text-align:center;background-color:#ffbbbb" | 27 || April 30 || Athletics || 1–4 || Mulder (4–1) || Buehrle (2–4) || || 1:54 || 11,084 || 14–13 || box |- style="text-align:center;background-color:#bbffbb" | 28 || May 1 || Athletics || 7–5 || Garland (2–2) || Halama (1–2) || Marte (2) || 2:57 || 10,639 || 15–13 || box |- style="text-align:center;background-color:#ffbbbb" | 29 || May 2 || Mariners || 2–9 || Franklin (2–2) || Loaiza (5–1) || || 2:39 || 13,355 || 15–14 || box |- style="text-align:center;background-color:#ffbbbb" | 30 || May 3 || Mariners || 2–12 || García (3–3) || Stewart (1–2) || || 3:16 || 25,837 || 15–15 || box |- style="text-align:center;background-color:#ffbbbb" | 31 || May 4 || Mariners || 1 – 5 (6) || Meche (4–1) || Colón (2–3) || || 1:21 || 15,413 || 15–16 || box |- style="text-align:center;background-color:#ffbbbb" | 32 || May 6 || @ Athletics || 0–6 || Mulder (5–1) || Buehrle (2–5) || || 1:49 || 10,695 || 15–17 || box |- style="text-align:center;background-color:#bbffbb" | 33 || May 7 || @ Athletics || 8–4 || Loaiza (6–1) || Lilly (2–2) || Marte (3)