|| 3:23 || 20,715 || 16–17 || box |- style="text-align:center;background-color:#ffbbbb" | 34 || May 8 || @ Athletics || 5–8 || Halama (2–2) || Garland (2–3) || Foulke (9) || 3:00 || 12,329 || 16–18 || box |- style="text-align:center;background-color:#ffbbbb" | 35 || May 9 || @ Mariners || 3–6 || Franklin (3–2) || Wright (0–1) || Nelson (3) || 2:43 || 38,749 || 16–19 || box |- style="text-align:center;background-color:#bbffbb" | 36 || May 10 || @ Mariners || 4–3 || Colón (3–3) || Meche (4–2) || Marte (4) || 2:34 || 43,123 || 17–19 || box |- style="text-align:center;background-color:#ffbbbb" | 37 || May 11 || @ Mariners || 2–7 || Moyer (5–2) || Buehrle (2–6) || || 2:40 || 45,383 || 17–20 || box |- style="text-align:center;background-color:#bbffbb" | 38 || May 13 || Orioles || 1–0 || Loaiza (7–1) || Daal (2–5) || Koch (4) || 2:27 || 14,397 || 18–20 || box |- style="text-align:center;background-color:#bbffbb" | 39 || May 14 || Orioles || 5–1 || Gordon (2–2) || Helling (2–4) || || 2:30 || 12,078 || 19–20 || box |- style="text-align:center;background-color:#bbffbb" | 40 || May 15 || Orioles || 8–2 || Colón (4–3) || Ponson (4–3) || || 2:49 || 11,886 || 20–20 || box |- style="text-align:center;background-color:#ffbbbb" | 41 || May 16 || @ Twins || 3–18 || Radke (5–3) || Buehrle (2–7) || || 2:55 || 22,233 || 20–21 || box |- style="text-align:center;background-color:#ffbbbb" | 42 || May 17 || @ Twins || 1–3 || Mays (4–3) || Garland (2–4) || Guardado (9) || 2:20 || 23,209 || 20–22 || box |- style="text-align:center;background-color:#ffbbbb" | 43 || May 18 || @ Twins || 2–3 || Hawkins (3–0) || Gordon (2–3) || Guardado (10) || 2:48 || 25,055 || 20–23 || box |- style="text-align:center;background-color:#ffbbbb" | 44 || May 19 || Blue Jays || 2–12 || Lidle (7–2) || Wright (0–2) || || 2:52 || 19,628 || 20–24 || box |- style="text-align:center;background-color:#bbffbb" | 45 || May 20 || Blue Jays || 4–1 || Colón (5–3) || Davis (1–3) || || 3:01 || 12,857 || 21–24 || box |- style="text-align:center;background-color:#bbffbb" | 46 || May 21 || Blue Jays || 6–5 || Marte (2–0) || Politte (1–3) || Koch (5) || 2:53 || 13,076 || 22–24 || box |- style="text-align:center;background-color:#ffbbbb" | 47 || May 23 || Tigers || 2–3 || Maroth (1–9) || Gordon (2–4) || Spurling (2) || 2:25 || 15,069 || 22–25 || box |- style="text-align:center;background-color:#ffbbbb"