| 5 || April 5 || Tigers || 7–0 || Buehrle (1–1) || Maroth (0–2) || || 2:16 || 16,972 || 2–3 || box |- style="text-align:center;background-color:#bbffbb" | 6 || April 6 || Tigers || 10–2 || Marte (1–0) || Germán (0–1) || || 2:59 || 14,514 || 3–3 || box |- style="text-align:center;background-color:#bbbbbb" | – || April 7 || @ Indians || colspan=8 | Postponed (rain) Rescheduled for June 2 |- style="text-align:center;background-color:#bbffbb" | 7 || April 8 || @ Indians || 5 – 3 (10) || Koch (1–0) || Paronto (0–1) || || 3:07 || 42,301 || 4–3 || box |- style="text-align:center;background-color:#ffbbbb" | 8 || April 9 || @ Indians || 2–5 || Anderson (2–0) || Garland (0–1) || Báez (3) || 2:25 || 14,841 || 4–4 || box |- style="text-align:center;background-color:#bbffbb" | 9 || April 10 || @ Indians || 7–2 || Buehrle (2–1) || Davis (0–2) || || 2:25 || 15,916 || 5–4 || box |- style="text-align:center;background-color:#bbffbb" | 10 || April 11 || @ Tigers || 5–0 || Loaiza (2–0) || Bernero (0–2) || || 2:10 || 12,577 || 6–4 || box |- style="text-align:center;background-color:#ffbbbb" | 11 || April 12 || @ Tigers || 3–4 || Cornejo (1–1) || Stewart (0–1) || Anderson (1) || 3:03 || 12,985 || 6–5 || box |- style="text-align:center;background-color:#bbffbb" | 12 || April 13 || @ Tigers || 3–2 || Colón (1–0) || Knotts (0–1) || Koch (2) || 2:27 || 12,808 || 7–5 || box |- style="text-align:center;background-color:#ffbbbb" | 13 || April 15 || Royals || 5–8 || López (2–0) || Koch (1–1) || MacDougal (7) || 3:01 || 20,591 || 7–6 || box |- style="text-align:center;background-color:#bbffbb" | 14 || April 16 || Royals || 4–3 || Gordon (1–1) || Grimsley (0–1) || || 2:32 || 9,882 || 8–6 || box |- style="text-align:center;background-color:#bbffbb" | 15 || April 17 || Royals || 8–2 || Loaiza (3–0) || George (2–1) || || 2:42 || 10,716 || 9–6 || box |- style="text-align:center;background-color:#bbffbb" | 16 || April 18 || Indians || 5–3 || Colón (2–0) || Traber (0–1) || || 2:25 || 13,015 || 10–6 || box |- style="text-align:center;background-color:#bbffbb" | 17 || April 19 || Indians || 12–3 || Stewart (1–1) || Anderson (2–2) || || 2:33 || 18,907 || 11–6 || box |- style="text-align:center;background-color:#ffbbbb" | 18 || April 20 || Indians || 4–7 || Davis (2–2) || Buehrle (2–2) || || 2:19 || 14,975 || 11–7 || box |- style="text-align:center;background-color:#ffbbbb"