Greisinger (1–2) || Loaiza (4–3) || Nathan (12) || 2:12 || 32,360 || 19–16 || box |- style="text-align:center;background-color:#bbffbb" | 36 || May 16 || Twins || 11–0 || Buehrle (3–1) || Silva (5–1) || || 2:34 || 26,348 || 20–16 || box |- style="text-align:center;background-color:#ffbbbb" | 37 || May 17 || @ Indians || 2–7 || Lee (5–0) || Diaz (0–1) || || 2:46 || 15,617 || 20–17 || box |- style="text-align:center;background-color:#bbffbb" | 38 || May 18 || @ Indians || 4–2 || Garland (3–2) || Durbin (3–4) || Koch (7) || 2:18 || 15,298 || 21–17 || box |- style="text-align:center;background-color:#bbffbb" | 39 || May 19 || @ Indians || 15–3 || Schoeneweis (4–1) || Davis (1–3) || || 3:04 || 17,205 || 22–17 || box |- style="text-align:center;background-color:#bbffbb" | 40 || May 20 || @ Twins || 10–3 || Loaiza (5–3) || Greisinger (1–3) || || 2:32 || 17,640 || 23–17 || box |- style="text-align:center;background-color:#bbffbb" | 41 || May 21 || @ Twins || 8–2 || Buehrle (4–1) || Silva (5–2) || || 2:20 || 30,116 || 24–17 || box |- style="text-align:center;background-color:#ffbbbb" | 42 || May 22 || @ Twins || 1–9 || Radke (4–2) || Cotts (0–2) || || 2:39 || 27,413 || 24–18 || box |- style="text-align:center;background-color:#bbffbb" | 43 || May 23 || @ Twins || 17–7 || Garland (4–2) || Santana (2–2) || || 3:06 || 22,859 || 25–18 || box |- style="text-align:center;background-color:#ffbbbb" | 44 || May 25 || Rangers || 4–7 || Rogers (7–2) || Schoeneweis (4–2) || Cordero (15) || 3:14 || 22,359 || 25–19 || box |- style="text-align:center;background-color:#bbffbb" | 45 || May 26 || Rangers || 4–0 || Loaiza (6–3) || Benoit (2–2) || || 2:28 || 18,185 || 26–19 || box |- style="text-align:center;background-color:#bbffbb" | 46 || May 27 || Rangers || 9–0 || Buehrle (5–1) || Drese (2–2) || || 2:14 || 14,428 || 27–19 || box |- style="text-align:center;background-color:#bbffbb" | 47 || May 28 || Angels || 4–3 || Takatsu (3–0) || Ortiz (1–4) || || 3:11 || 21,163 || 28–19 || box |- style="text-align:center;background-color:#ffbbbb" | 48 || May 29 || Angels || 1–5 || Sele (4–0) || Rauch (0–1) || || 2:51 || 25,050 || 28–20 || box |- style="text-align:center;background-color:#bbffbb" | 49 || May 30 || Angels || 11–2 || Schoeneweis (5–2) || Lackey (3–6) || || 2:30 || 14,344 || 29–20 || box |- style="text-align:center;background-color:#ffbbbb" | 50 || June 1 || @