(1–0) || Leskanic (0–1) || || 3:27 || 11,765 || 5–3 || box |- style="text-align:center;background-color:#bbffbb" | 9 || April 15 || Royals || 6 – 5 (10) || Marte (1–1) || Carrasco (1–1) || || 2:36 || 15,150 || 6–3 || box |- style="text-align:center;background-color:#ffbbbb" | 10 || April 16 || @ Devil Rays || 0–3 || Abbott (1–1) || Wright (0–2) || Báez (1) || 2:14 || 12,108 || 6–4 || box |- style="text-align:center;background-color:#bbffbb" | 11 || April 17 || @ Devil Rays || 4–1 || Schoeneweis (1–1) || Zambrano (3–1) || Marte (1) || 2:39 || 14,302 || 7–4 || box |- style="text-align:center;background-color:#bbffbb" | 12 || April 18 || @ Devil Rays || 5–0 || Loaiza (3–0) || González (0–3) || || 2:12 || 12,072 || 8–4 || box |- style="text-align:center;background-color:#ffbbbb" | 13 || April 20 || Yankees || 8–11 || Quantrill (2–0) || Buehrle (1–1) || Rivera (4) || 3:01 || 32,034 || 8–5 || box |- style="text-align:center;background-color:#ffbbbb" | 14 || April 21 || Yankees || 1–3 || Vázquez (2–1) || Garland (1–1) || Rivera (5) || 2:32 || 26,154 || 8–6 || box |- style="text-align:center;background-color:#bbffbb" | 15 || April 22 || Yankees || 4–3 || Schoeneweis (2–1) || Mussina (1–4) || Marte (2) || 2:27 || 34,030 || 9–6 || box |- style="text-align:center;background-color:#bbffbb" | 16 || April 23 || Devil Rays || 3 – 2 (10) || Koch (1–0) || Báez (1–1) || || 3:00 || 12,049 || 10–6 || box |- style="text-align:center;background-color:#ffbbbb" | 17 || April 24 || Devil Rays || 1–4 || Waechter (1–0) || Wright (0–3) || Báez (2) || 2:44 || 17,062 || 10–7 || box |- style="text-align:center;background-color:#bbffbb" | 18 || April 25 || Devil Rays || 6–5 || Adkins (2–0) || Miller (0–1) || || 2:43 || 17,497 || 11–7 || box |- style="text-align:center;background-color:#ffbbbb" | 19 || April 27 || Indians || 7 – 11 (10) || Betancourt (2–2) || Adkins (2–1) || || 3:53 || 14,572 || 11–8 || box |- style="text-align:center;background-color:#bbffbb" | 20 || April 28 || Indians || 9–8 || Jackson (1–0) || Betancourt (2–3) || || 2:55 || 12,189 || 12–8 || box |- style="text-align:center;background-color:#bbffbb" | 21 || April 29 || Blue Jays || 6–4 || Loaiza (3–0) || Nakamura (0–1) || Koch (2) || 2:47 || 11,210 || 13–8 || box |- style="text-align:center;background-color:#bbbbbb" | – || April 30 || Blue Jays ||colspan=8| Postponed (rain), rescheduled for May