Athletics || 4 – 6 (12) || Duchscherer (3–1) || Cotts (0–3) || || 3:06 || 14,344 || 29–21 || box |- style="text-align:center;background-color:#ffbbbb" | 51 || June 2 || @ Athletics || 2 – 3 (10) || Rhodes (2–3) || Adkins (2–2) || || 2:50 || 33,111 || 29–22 || box |- style="text-align:center;background-color:#bbffbb" | 52 || June 4 || @ Mariners || 4–2 || Garland (5–2) || García (3–4) || Koch (8) || 2:36 || 36,340 || 30–22 || box |- style="text-align:center;background-color:#ffbbbb" | 53 || June 5 || @ Mariners || 2–4 || Franklin (3–4) || Schoeneweis (5–3) || Guardado (10) || 2:58 || 40,050 || 30–23 || box |- style="text-align:center;background-color:#ffbbbb" | 54 || June 6 || @ Mariners || 4–5 || Hasegawa (2–3) || Koch (1–1) || || 3:13 || 36,462 || 30–24 || box |- style="text-align:center;background-color:#bbffbb" | 55 || June 8 || Phillies || 14–11 || Buehrle (6–1) || Telemaco (0–2) || Politte (1) || 2:57 || 33,114 || 31–24 || box |- style="text-align:center;background-color:#ffbbbb" | 56 || June 9 || Phillies || 10–13 || Milton (8–1) || Garland (5–3) || || 3:24 || 17,570 || 31–25 || box |- style="text-align:center;background-color:#bbbbbb" | – || June 10 || Phillies ||colspan=8| Postponed (rain), rescheduled for August 30 |- style="text-align:center;background-color:#ffbbbb" | 57 || June 11 || Braves || 4–6 || Wright (5–5) || Schoeneweis (5–4) || || 2:33 || 23,217 || 31–26 || box |- style="text-align:center;background-color:#bbffbb" | 58 || June 12 || Braves || 10–8 || Loaiza (7–3) || Thomson (5–4) || Takatsu (1) || 2:52 || 34,719 || 32–26 || box |- style="text-align:center;background-color:#bbffbb" | 59 || June 13 || Braves || 10–3 || Buehrle (7–1) || Smith (0–3) || || 2:18 || 32,589 || 33–26 || box |- style="text-align:center;background-color:#bbffbb" | 60 || June 15 || @ Marlins || 7 – 5 (10) || Marte (2–2) || Borland (1–1) || Takatsu (2) || 3:10 || 15,345 || 34–26 || box |- style="text-align:center;background-color:#ffbbbb" | 61 || June 16 || @ Marlins || 0–4 || Pavano (7–2) || Schoeneweis (5–5) || || 2:10 || 14,310 || 34–27 || box |- style="text-align:center;background-color:#ffbbbb" | 62 || June 17 || @ Marlins || 1 – 2 (11) || Benítez (2–0) || Politte (0–2) || || 3:11 || 17,857 || 34–28 || box |- style="text-align:center;background-color:#bbffbb" | 63 || June 18 || @ Expos || 11–7 || Cotts (1–3) || Ayala (0–6) || Marte (3) || 3:02 || 4,576