|| 3:10 || 37,303 || 60–60 || box |- style="text-align:center;background-color:#ffbbbb" | 121 || August 22 || Red Sox || 5–6 || Leskanic (2–5) || Marte (4–5) || Foulke (22) || 3:05 || 34,355 || 60–61 || box |- style="text-align:center;background-color:#ffbbbb" | 122 || August 23 || @ Tigers || 0–7 || Bonderman (7–10) || Contreras (11–6) || || 2:26 || 25,220 || 60–62 || box |- style="text-align:center;background-color:#bbffbb" | 123 || August 24 || @ Tigers || 9–5 || Garland (9–9) || Ledezma (3–1) || || 2:36 || 24,584 || 61–62 || box |- style="text-align:center;background-color:#ffbbbb" | 124 || August 25 || @ Tigers || 4–5 || Robertson (11–7) || Buehrle (11–8) || || 2:29 || 23,254 || 61–63 || box |- style="text-align:center;background-color:#bbffbb" | 125 || August 26 || @ Indians || 14–9 || Cotts (2–3) || Durbin (5–6) || || 3:20 || 30,049 || 62–63 || box |- style="text-align:center;background-color:#ffbbbb" | 126 || August 27 || @ Indians || 3–6 || Sabathia (10–8) || Grilli (0–1) || Wickman (7) || 2:34 || 30,527 || 62–64 || box |- style="text-align:center;background-color:#bbffbb" | 127 || August 28 || @ Indians || 5–3 || Contreras (12–6) || Lee (10–6) || Takatsu (13) || 2:40 || 37,374 || 63–64 || box |- style="text-align:center;background-color:#ffbbbb" | 128 || August 29 || @ Indians || 0–9 || Elarton (3–9) || Garland (9–10) || || 1:56 || 32,834 || 63–65 || box |- style="text-align:center;background-color:#bbffbb" | 129 || August 30 || Phillies || 9–8 || Buehrle (12–8) || Hernández (2–5) || Takatsu (14) || 2:47 || 5,747 || 64–65 || box |- style="text-align:center;background-color:#ffbbbb" | 130 || August 31 || Athletics || 2–7 || Harden (9–5) || Diaz (1–4) || || 2:31 || 18,841 || 64–66 || box |- style="text-align:center;background-color:#bbffbb" | 131 || September 1 || Athletics || 5–4 || Takatsu (6–3) || Duchscherer (5–5) || || 2:36 || 21,564 || 65–66 || box |- style="text-align:center;background-color:#ffbbbb" | 132 || September 2 || Athletics || 2–4 || Redman (10–10) || Contreras (12–7) || Dotel (31) || 2:55 || 17,579 || 65–67 || box |- style="text-align:center;background-color:#bbffbb" | 133 || September 3 || Mariners || 7–5 || Garland (10–10) || Madritsch (3–2) || Takatsu (15) || 2:50 || 21,716 || 66–67 || box |- style="text-align:center;background-color:#bbffbb" | 134 || September 4 || Mariners || 8–7 || Buehrle (13–8) || Franklin (3–14) || Takatsu (16) || 2:44 || 24,191 || 67–67 || box |- style="text-align:center;background-color:#bbffbb" | 135 || September