Sosa (3–8) || || 2:49 || 22,617 || 53–50 || box |- style="text-align:center;background-color:#ffbbbb" | 104 || July 26 || Devil Rays || 6–10 || Malaska (1–0) || White (1–2) || Colomé (1) || 3:07 || 29,633 || 53–51 || box |- style="text-align:center;background-color:#bbffbb" | 105 || July 27 || Devil Rays || 9–1 || Colón (8–9) || Kennedy (3–8) || || 2:29 || 28,027 || 54–51 || box |- style="text-align:center;background-color:#bbffbb" | 106 || July 29 || @ Royals || 9–6 || Buehrle (9–10) || May (5–5) || Gordon (6) || 2:52 || 24,485 || 55–51 || box |- style="text-align:center;background-color:#bbffbb" | 107 || July 30 || @ Royals || 15–4 || Garland (8–7) || Hernández (5–4) || || 3:10 || 20,722 || 56–51 || box |- style="text-align:center;background-color:#bbffbb" | 108 || July 31 || @ Royals || 8 – 6 (11) || Schoeneweis (2–1) || Field (1–1) || || 3:35 || 21,352 || 57–51 || box |- style="text-align:center;background-color:#bbffbb" | 109 || August 1 || @ Mariners || 12–1 || Colón (9–9) || García (9–11) || || 2:52 || 39,337 || 58–51 || box |- style="text-align:center;background-color:#ffbbbb" | 110 || August 2 || @ Mariners || 0–10 || Franklin (8–9) || Wright (0–5) || || 2:22 || 45,719 || 58–52 || box |- style="text-align:center;background-color:#ffbbbb" | 111 || August 3 || @ Mariners || 2–8 || Meche (12–7) || Buehrle (9–11) || || 2:57 || 45,632 || 58–53 || box |- style="text-align:center;background-color:#ffbbbb" | 112 || August 4 || Royals || 9–13 || Hernández (6–4) || Schoeneweis (2–2) || Levine (1) || 3:26 || 43,922 || 58–54 || box |- style="text-align:center;background-color:#bbffbb" | 113 || August 5 || Royals || 5–4 || Loaiza (14–5) || Snyder (1–6) || Marte (8) || 2:58 || 38,973 || 59–54 || box |- style="text-align:center;background-color:#bbffbb" | 114 || August 6 || Royals || 4–3 || Colón (10–9) || Wilson (5–2) || Marte (9) || 2:55 || 25,348 || 60–54 || box |- style="text-align:center;background-color:#bbffbb" | 115 || August 8 || Athletics || 3–2 || Buehrle (10–11) || Mulder (15–8) || || 1:53 || 24,118 || 61–54 || box |- style="text-align:center;background-color:#ffbbbb" | 116 || August 9 || Athletics || 2–7 || Bradford (6–3) || Garland (8–8) || || 3:01 || 36,151 || 61–55 || box |- style="text-align:center;background-color:#bbffbb" | 117 || August 10 || Athletics || 5–1 || Loaiza (15–5) || Harden (3–1) || || 2:45 || 29,442 || 62–55 || box |- style="text-align:center;background-color:#ffbbbb" | 118