5 || Mariners || 6–2 || Diaz (2–4) || Moyer (6–10) || Marte (5) || 2:30 || 30,409 || 68–67 || box |- style="text-align:center;background-color:#bbffbb" | 136 || September 6 || @ Rangers || 7 – 4 (10) || Grilli (1–1) || Park (3–5) || || 2:50 || 31,251 || 69–67 || box |- style="text-align:center;background-color:#ffbbbb" | 137 || September 7 || @ Rangers || 3–10 || Rogers (16–7) || Contreras (12–8) || || 2:37 || 20,004 || 69–68 || box |- style="text-align:center;background-color:#bbffbb" | 138 || September 8 || @ Rangers || 5–2 || García (11–10) || Wasdin (2–4) || Takatsu (17) || 2:48 || 21,836 || 70–68 || box |- style="text-align:center;background-color:#bbffbb" | 139 || September 9 || @ Rangers || 7–3 || Buehrle (14–8) || Young (1–2) || || 2:24 || 19,384 || 71–68 || box |- style="text-align:center;background-color:#ffbbbb" | 140 || September 10 || @ Angels || 5–7 || Rodríguez (3–1) || Bajenaru (0–1) || Percival (28) || 3:03 || 42,431 || 71–69 || box |- style="text-align:center;background-color:#bbffbb" | 141 || September 11 || @ Angels || 13–6 || Grilli (2–1) || Sele (8–3) || || 2:57 || 42,568 || 72–69 || box |- style="text-align:center;background-color:#ffbbbb" | 142 || September 12 || @ Angels || 0–11 || Colón (15–11) || Contreras (12–9) || || 2:39 || 41,932 || 72–70 || box |- style="text-align:center;background-color:#ffbbbb" | 143 || September 14 || @ Twins || 2–10 || Santana (18–6) || García (11–11) || || 2:32 || 22,145 || 72–71 || box |- style="text-align:center;background-color:#ffbbbb" | 144 || September 15 || @ Twins || 1–6 || Silva (12–8) || Buehrle (14–9) || || 2:12 || 20,612 || 72–72 || box |- style="text-align:center;background-color:#ffbbbb" | 145 || September 16 || @ Twins || 1–10 || Lohse (8–11) || Garland (10–11) || || 2:21 || 20,052 || 72–73 || box |- style="text-align:center;background-color:#ffbbbb" | 146 || September 17 || @ Tigers || 10 – 11 (10) || Yan (3–4) || Takatsu (6–4) || Ennis (1) || 3:21 || 23,132 || 72–74 || box |- style="text-align:center;background-color:#bbffbb" | 147 || September 18 || @ Tigers || 9 – 8 (12) || Marte (5–5) || Levine (3–4) || || 4:05 || 23,533 || 73–74 || box |- style="text-align:center;background-color:#bbffbb" | 148 || September 19 || @ Tigers || 6–1 || García (12–11) || Bonderman (10–12) || || 2:44 || 19,269 || 74–74 || box |- style="text-align:center;background-color:#ffbbbb" | 149 || September 20 || Twins || 2–8 ||