|| Mariners || 0–8 || Bosio || Gross (3–3) || — || 27,272 || 16–10 |- |- bgcolor="ccffcc" | 27 || May 1 || Mariners || 5–4 || Russell (1–0) || Jackson || Henneman (6) || 31,775 || 17–10 |- bgcolor="ffbbbb" | 28 || May 2 || @ Tigers || 2–5 || Lira || Witt (3–2) || Williams || 7,416 || 17–11 |- bgcolor="ccffcc" | 29 || May 3 || @ Tigers || 11–0 || Hill (4–2) || Keagle || — || 9,079 || 18–11 |- bgcolor="ccffcc" | 30 || May 4 || @ Tigers || 3–1 || Pavlik (4–0) || Gohr || — || 10,734 || 19–11 |- bgcolor="ccffcc" | 31 || May 5 || @ Tigers || 3–2 || Gross (4–3) || Lima || Henneman (7) || 12,337 || 20–11 |- bgcolor="ccffcc" | 32 || May 7 || Blue Jays || 5–1 || Oliver (2–0) || Guzman || — || 23,005 || 21–11 |- bgcolor="ccffcc" | 33 || May 8 || Blue Jays || 4–2 || Witt (4–2) || Hanson || Henneman (8) || 20,694 || 22–11 |- bgcolor="ffbbbb" | 34 || May 9 || Blue Jays || 2–5 || Quantrill || Hill (4–3) || Timlin || 34,451 || 22–12 |- bgcolor="ccffcc" | 35 || May 10 || Tigers || 6–2 || Pavlik (5–0) || Lima || Henneman (9) || 31,426 || 23–12 |- bgcolor="ccffcc" | 36 || May 11 || Tigers || 11–7 || Gross (5–3) || Aldred || — || 42,732 || 24–12 |- bgcolor="ffbbbb" | 37 || May 12 || Tigers || 3–5 || Lira || Oliver (2–1) || Myers || 35,677 || 24–13 |- bgcolor="ccffcc" | 38 || May 13 || Royals || 7–6 || Cook (2–0) || Montgomery || Henneman (10) || 22,981 || 25–13 |- bgcolor="ccffcc" | 39 || May 14 || Royals || 10–0 || Hill (5–3) || Gubicza || — || 28,999 || 26–13 |- bgcolor="ffbbbb" | 40 || May 15 || Royals || 1–3 || Haney || Pavlik (5–1) || Montgomery || 26,881 || 26–14 |- bgcolor="ffbbbb" | 41 || May 17 || @ Indians || 10–12 || Embree || Heredia (1–3) || Mesa || 41,225 || 26–15 |- bgcolor="ccffcc" | 42 || May 18 || @ Indians || 6–3 || Oliver (3–1) || Anderson || Henneman (11) || 40,973 || 27–15 |- bgcolor="ffbbbb" | 43 || May 19 || @ Indians || 5–8 || Nagy || Witt (4–3)