|| 2:59 || 38,884 || 70–62 || box |- style="text-align:center;background-color:#bbffbb" | 133 || August 27 || @ Yankees || 11–2 || Colón (12–11) || Wells (12–5) || || 3:09 || 40,654 || 71–62 || box |- style="text-align:center;background-color:#ffbbbb" | 134 || August 28 || @ Yankees || 5–7 || Mussina (15–7) || Cotts (1–1) || Rivera (29) || 3:11 || 40,569 || 71–63 || box |- style="text-align:center;background-color:#ffbbbb" | 135 || August 29 || @ Tigers || 4–8 || Robertson (1–0) || Buehrle (11–13) || || 2:44 || 15,828 || 71–64 || box |- style="text-align:center;background-color:#bbffbb" | 136 || August 30 || @ Tigers || 5–2 || Garland (10–10) || Maroth (6–19) || || 2:44 || 15,786 || 72–64 || box |- style="text-align:center;background-color:#bbffbb" | 137 || August 31 || @ Tigers || 6–1 || Loaiza (18–6) || Cornejo (6–14) || || 2:28 || 15,873 || 73–64 || box |- style="text-align:center;background-color:#ffbbbb" | 138 || September 2 || Red Sox || 1–2 || Burkett (10–7) || Colón (12–12) || Kim (12) || 2:41 || 23,943 || 73–65 || box |- style="text-align:center;background-color:#ffbbbb" | 139 || September 3 || Red Sox || 4 – 5 (10) || Kim (8–9) || Gordon (6–6) || || 3:14 || 20,082 || 73–66 || box |- style="text-align:center;background-color:#bbffbb" | 140 || September 5 || Indians || 5–3 || Garland (11–10) || Traber (6–8) || Gordon (9) || 2:50 || 27,196 || 74–66 || box |- style="text-align:center;background-color:#bbffbb" | 141 || September 6 || Indians || 8–5 || Loaiza (19–6) || Cressend (2–1) || Gordon (10) || 2:49 || 24,796 || 75–66 || box |- style="text-align:center;background-color:#bbffbb" | 142 || September 7 || Indians || 7–3 || Schoeneweis (3–2) || Báez (1–8) || || 2:56 || 19,999 || 76–66 || box |- style="text-align:center;background-color:#bbffbb" | 143 || September 8 || Twins || 5–2 || Colón (13–12) || Lohse (12–11) || || 2:42 || 32,807 || 77–66 || box |- style="text-align:center;background-color:#bbffbb" | 144 || September 9 || Twins || 8–6 || Buehrle (12–13) || Pulido (0–1) || Gordon (11) || 3:18 || 27,623 || 78–66 || box |- style="text-align:center;background-color:#ffbbbb" | 145 || September 10 || Twins || 1–4 || Santana (10–3) || Garland (11–11) || Guardado (34) || 2:54 || 22,188 || 78–67 || box |- style="text-align:center;background-color:#ffbbbb" | 146 || September 11 || Twins || 2–5 || Radke (12–10) || Loaiza (19–7) || || 2:30 || 20,541 || 78–68 || box |- style="text-align:center;background-color:#ffbbbb" | 147 || September