First Databank (FDB) is a major provider of drug and medical device databases that help inform healthcare professionals to make decisions. FDB partners with information system developers to deliver useful medication- and medical device-related information to clinicians, business associates, and patients. FDB is part of Hearst and the Hearst Health network. History First Databank was founded in 1977 as a company that published a quarterly magazine of drug prices. They were bought by Hearst Corporation in 1980. First Databank then evolved to become a provider of clinical and descriptive drug knowledge that is integrated into healthcare information systems globally. FDB has its headquarters in San Francisco, California, and has other offices in Indianapolis, Indiana, Exeter, England, Dubai, UAE and Hyderabad, India. The firm's drug databases support pharmacy dispensing, formulary management, drug pricing analysis, claims processing, computerized physician order entry (CPOE), electronic health records (EHR), electronic medical records (EMR), electronic prescribing (e-Prescribing), electronic medication administration records (EMAR), population health and telemedicine/telehealth. Beginning in 2011, First Databank's set of National Drug Codes (NDCs) have been integrated into RxNorm's standard clinical drug vocabulary that includes all medications available on the US market. RxNorm is produced and maintained by the United States National Library of Medicine (NLM). In 2017, FDB acquired Polygot Systems, which simplifies drug information for patients and translates that information into 21 languages. In 2018, FDB partnered with PetIQ to release the first veterinary medication database to provide information on pet medications structured for integration into pharmacy systems. Beginning in 2020, FDB partnered with Amazon and its Alexa devices to provide drug information and answer medication questions. During the COVID-19 pandemic, FDB posted drug data (regarding remdesivir, chloroquine, and hydroxychloroquine) and medical device-related coronavirus information to its website. In August 2021, the company announced a partnership with RxRevu to provide integrated decision support tools to improve patient access to care, delivering patient-specific pharmacy benefit information to EHR workflows via direct connections with pharmacy benefit managers. The technology displays accurate, real-time data at the point of prescribing, allowing physicians to find affordable alternatives for medications specific to a patient's health needs and insurance benefits. FDB will offer RxRevu's prescription cost and coverage solution to current and future hospital, health system, and EHR clients. Operations FDB MedKnowledge (formerly National Drug Data File Plus) First Databank's MedKnowledge provides prices, descriptions, and collateral clinical information on drugs approved by the US Food and Drug Administration