Eastern and South-Eastern Asia. China has 50% of HCC cases globally, and more than 80% of total cases occur in sub-Saharan Africa or in East-Asia due to hepatitis B virus. In these high disease burden areas, evidence indicates the majority of the HBC and HCV infections occur via perinatal transmission (also called mother-to-child transmission). However, it is important to note that the risk factors for HCC varies by geographic region. For example, in China chronic HBV infection and aflatoxin are the largest risk factors; whereas, in Mongolia it is a combination of HBV and HCV co-infection and high levels of alcohol use that are driving the high levels of HCC. In terms of intrahepatic cholangiocarcinoma, we currently do not have sufficient epidemiological data because it is a rare cancer. According to the United States National Cancer Institute, the incidence of cholangiocarcinoma is not known. Cholangiocarcinoma also has a significant geographical distribution, with Thailand showing the highest rates worldwide due to the presence of liver fluke. In the United States there were 42,810 new cases of liver and intrahepatic bile duct cancer in 2020, which represents 2.4% of all new cancer cases in the United States. There are about 89.950 people who have liver and intrahepatic liver cancer in the United States. In terms of mortality, the 5-year survival rate for liver and intrahepatic bile duct cancers in the United States is 19.6%. In the United States there is an estimated 1% chance of getting liver cancer across the lifespan, which makes this cancer relatively rare. Despite the low number of cases, it is one of the top causes of cancer deaths. References External links EASL Guideline Liver cancer information from Cancer Research UK Digestive system neoplasia C Hepatology Wikipedia medicine articles ready to translate