polymerase holoenzyme in the stationary phase, high abundant 6S RNA is discovered to influence gene transcription, resulting in bacterial response regulation to challenges such as hunger. 6S RNA in E. coli abundantly increases throughout in log and early stationary phase. So, the increase level of 6S RNA regulate alterations in gene expression are expected to aid adaptation to environmental challenges such as nutritional scarcity and high cell density. 6S RNA role in bacterial virulence has been identified that includes L. pneumophila and Salmonella enterica serovar Typhimurium specifically where pathogenesis is linked to replication and stress resistance. References External links Non-coding RNA