|- bgcolor=#cfc | 51 || May 27 || @ Astros || 4–3 || Stechschulte || Oswalt || Isringhausen || 30,543 || 29–22 |- bgcolor=#cfc | 52 || May 28 || @ Astros || 4–1 || Morris || Reynolds || Isringhausen || 25,376 || 30–22 |- bgcolor=#fbb | 53 || May 29 || @ Astros || 5–10 || Redding || Stephenson || || 27,182 || 30–23 |- bgcolor=#fbb | 54 || May 31 || Pirates || 1–3 || Fogg || W. Williams || M. Williams || 38,148 || 30–24 |- |- bgcolor=#cfc | 55 || June 1 || Pirates || 9–4 || Kile || Arroyo || || 43,295 || 31–24 |- bgcolor=#fbb | 56 || June 2 || Pirates || 2–5 || Lowe || Morris || M. Williams || 37,243 || 31–25 |- bgcolor=#cfc | 57 || June 4 || @ Reds || 8–5 || Simontacchi || Hamilton || || 19,189 || 32–25 |- bgcolor=#bbb | || June 5 || @ Reds || colspan=6 |Postponed (Rain) Makeup date: August 27 |- bgcolor=#fbb | 58 || June 6 || @ Reds || 2–3 || Haynes || Williams || Graves || 23,102 || 32–26 |- bgcolor=#cfc | 59 || June 7 || @ Royals || 12–6|| Kile || Byrd || || 34,194 || 33–26 |- bgcolor=#cfc | 60 || June 8 || @ Royals || 11–3 || Morris || Affeldt || || 40,016 || 34–26 |- bgcolor=#fbb | 61 || June 9 || @ Royals || 2–3 || Ro. Hernandez || Timlin || || 26,905 || 34–27 |- bgcolor=#fbb | 62 || June 10 || @ Mariners || 0–10 || Moyer || B. Smith || || 45,699 || 34–28 |- bgcolor=#cfc | 63 || June 11 || @ Mariners || 7–4 || Williams || Baldwin || || 44,983 || 35–28 |- bgcolor=#fbb | 64 || June 12 || @ Mariners || 0–5 || Piñeiro || Kile || || 45,612 || 35–29 |- bgcolor=#cfc | 65 || June 14 || Royals || 3–0 || Morris || Asencio || Kline || 40,510 || 36–29 |- bgcolor=#cfc | 66 || June 15 || Royals || 5–3 || Simontacchi || Suppan || Veres || 47,453 || 37–29 |- bgcolor=#cfc | 67 || June 16 || Royals || 5–1 || Williams || May || || 47,522 || 38–29 |- bgcolor=#cfc | 68 || June 18 || Angels || 7–2 || Kile || Appier || || 39,386 || 39–29