|- bgcolor=#fbb | 32 || May 7 || @ Reds || 2–4 || Graves || Simontacchi || Williamson || 20,849 || 17–15 |- bgcolor=#fbb | 33 || May 8 || @ Reds || 6–8 || Sullivan || Crudale || Williamson || 30,567 || 17–16 |- bgcolor=#cfc | 34 || May 9 || @ Cubs || 6–3 || Morris || Zambrano || Fassero || 38,531 || 18–16 |- bgcolor=#fbb || 35 || May 10 || @ Cubs || 2–3 || Remlinger || Eldred || || 38,106 || 18–17 |- bgcolor=#fbb | 36 || May 13 || Reds || 2–7 || Wilson || Simontacchi || || 34,276 || 18–18 |- bgcolor=#fbb | 37 || May 14 || Reds || 0–4 || Graves || Morris || || 31,731 || 18–19 |- bgcolor=#cfc | 38 || May 15 || Reds || 6–3 || Stephenson || Riedling || Eldred || 37,904 || 19–19 |- bgcolor=#cfc |39 || May 16 || Cubs || 7–4 || W. Williams || Clement || Eldred || 42,589 || 20–19 |- bgcolor=#fbb | 40 || May 17 || Cubs || 1–2 || Remlinger || Kline || Borowski || 45,385 || 20–20 |- bgcolor=#cfc |41 || May 18 || Cubs || 6–3 || Hermanson || Cruz || Eldred || 45,773 || 21–20 |- bgcolor=#cfc | 42 || May 19 || Cubs || 2–0 || Morris || Zambrano || || 46,734 || 22–20 |- bgcolor=#fbb | 43 || May 20 || @ Astros || 2–3 || Miller || Stephenson || Wagner || 23,623 || 22–21 |- bgcolor=#cfc | 44 || May 21 || @ Astros || 7–4 || W. Williams || Munro || Eldred || 22,441 || 23–21 |- bgcolor=#fbb | 45 || May 22 || @ Astros || 2–5 || Robertson || Tomko || Wagner || 23,866 || 23–22 |- bgcolor=#cfc | 46 || May 23 || @ Pirates || 10–8 || Eldred || Meadows || Fassero || 18,660 || 24–22 |- bgcolor=#cfc | 47 || May 24 || @ Pirates || 6–0 || Morris || Suppan || || 35,733 || 25–22 |- bgcolor=#fbb | 48 || May 25 || @ Pirates || 7–8 || Boehringer || Hermanson || M. Williams || 25,983 || 25–23 |- bgcolor=#cfc | 49 || May 26 || Astros || 10–5 || W. Williams || Munro || || 35,600 || 26–23 |- bgcolor=#fbb | 50 || May 27 || Astros || 4–7 || Robertson || Tomko ||