three novel mutations in the RMRP gene, suggesting a link to the RMRP gene, but research is ongoing to better ascertain the cause of OS. At the moment there exists only one treatment for OS which is bone marrow transplantation. If no treatment is performed OS is rather fatal resulting in death in infancy. Patients with OS are immunodeficient meaning their immune system is compromised and cannot properly fight infections resulting in serious secondary illnesses. References External links Ribozymes RNA splicing