for his senior season in January 2009. He was projected as a first-round draft choice in the 2010 NFL Draft and was listed as the No. 1 running back of the 2010 class by ESPN. Buffalo Bills Spiller was selected 9th overall in the 2010 NFL Draft by the Buffalo Bills. He was the highest drafted Clemson player since Banks McFadden (1940 NFL Draft) and Gaines Adams (2007 NFL Draft), both of whom went fourth overall. On August 6, 2010 Spiller signed a five-year /$25 million deal ($20.8M guaranteed). 2010 season On August 19, 2010, Spiller rushed 31 yards for his first NFL touchdown in week two of the preseason at the Rogers Centre in Toronto, Ontario, Canada against the Indianapolis Colts. Spiller finished the 2010 preseason with 26 carries for 122 yards (4.69 average per carry) and three touchdowns. He also caught three passes for 35 yards. Spiller was named the #1 running back on Buffalo's final depth chart, ahead of the recently injured Marshawn Lynch and Fred Jackson. Lynch was later traded to the Seattle Seahawks. On September 12, 2010, Spiller played in his first career NFL game in a home loss against the Miami Dolphins. Spiller was named Special Teams player of the week for September 26, 2010 for a 95-yard touchdown return against the New England Patriots. Spiller also had a touchdown off a pass by Ryan Fitzpatrick. However, his rookie season was marked with disappointment as he scored no rushing touchdowns and accumulated fewer yards than running backs taken after him in the draft, including Ryan Mathews, Jahvid Best, and Toby Gerhart. For his rookie year in 2010, Spiller produced 283 rushing yards, 157 receiving yards, and 1189 return yards on 56 kickoff and punt return opportunities in 14 games (1 start). 2011 season In 2011, it was announced that Spiller would trade numbers with Leodis McKelvin, receiving the number 28 in exchange for the number 21. Spiller wore number 28 at Clemson. Heading into Week 12, Spiller hadn't gotten as much action as the Bills were planning on because of the Pro Bowl caliber season that Fred Jackson was having, but Jackson was then placed on injured reserve, meaning Spiller would finally get his opportunity and become the Bills' starting running back for the rest of the season. In a Week 16 home game against the Denver Broncos on December 24, 2011, Spiller had