|| 4–2 || Morris || Heilman || Isringhausen || 32,949 || 24–13 |- bgcolor=#ffbbbb | 38 || May 17 || @ Phillies || 5–7 || Lidle || Suppan || Wagner || 32,103 || 24–14 |- bgcolor=#ccffcc | 39 || May 18 || @ Phillies || 8–4 || Carpenter || Lieber || || 29,130 || 25–14 |- bgcolor=#ffbbbb | 40 || May 19 || @ Phillies || 4–7 || Myers || Marquis || || 38,229 || 25–15 |- bgcolor=#ccffcc | 41 || May 20 || @ Royals || 7–6 || Mulder || Greinke || Isringhausen || 31,513 || 26–15 |- bgcolor=#ccffcc | 42 || May 21 || @ Royals || 6–5 || Morris || Cerda || Isringhausen || 39,781 || 27–15 |- bgcolor=#ffbbbb | 43 || May 22 || @ Royals || 2–9 || Jensen || Suppan || || 29,269 || 27–16 |- bgcolor=#ccffcc | 44 || May 23 || Pirates || 4–2 || Carpenter || D. Williams || Isringhausen || 33,073 || 28–16 |- bgcolor=#ccffcc | 45 || May 24 || Pirates || 2–1 || Reyes || Mesa || || 36,285 || 29–16 |- bgcolor=#ccffcc | 46 || May 25 || Pirates || 11–5 || Mulder || Redman || || 34,895 || 30–16 |- bgcolor=#ccffcc | 47 || May 27 || Nationals || 6–3 || Morris || Armas || Isringhausen || 47,383 || 31–16 |- bgcolor=#ccffcc | 48 || May 28 || Nationals || 3–1 || Suppan || Loaiza || Isringhausen || 49,123 || 32–16 |- bgcolor=#ffbbbb | 49 || May 29 || Nationals || 2–3 || L. Hernandez || Carpenter || Cordero || 47,012 || 32–17 |- bgcolor=#ccffcc | 50 || May 30 || @ Rockies || 5–4 || Marquis || Witasick || Isringhausen || 34,239 || 33–17 |- bgcolor=#ffbbbb | 51 || May 31 || @ Rockies || 1–2 || Jennings || Mulder || Fuentes || 23,519 || 33–18 |- |- bgcolor=#ccffcc | 52 || June 1 || @ Rockies || 8–6 || Morris || Neal || Isringhausen || 22,266 || 34–18 |- bgcolor=#ffbbbb | 53 || June 2 || @ Rockies || 7–8 || Fuentes || Isringhausen || || 21,381 || 34–19 |- bgcolor=#ccffcc | 54 || June 3 || @ Astros || 2–0 || Carpenter || Pettitte || Tavárez || 34,092 || 35–19 |- bgcolor=#ccffcc | 55 || June 4 || @ Astros || 11–9 || Marquis || Rodriguez || Isringhausen || 39,288 || 36–19 |-