largely prevent and, if needed, reverse symptoms of AMS:"In comparison with previous studies,4,5 this report may suggest that acclimatization, as well as AMS symptom relief, can be safely accelerated. Based on previous data, it was expected that the majority of our group would experience severe AMS. All 26 trekkers had symptoms of AMS to some extent, but even without prophylaxis, none had severe AMS. Even though we discourage (very) rapid ascent because of potentially lethal risks, we consider these outcomes of potentially great relevance for the prevention and treatment of AMS, as well as for rescue teams needing to ascend fast with little time for acclimatization. Further research is warranted to expand or revise our understanding of the physiology and treatment of these conditions."In 2015, a proof-of-principle study titled The Role of Outcome Expectancies for a Training Program Consisting of Meditation, Breathing Exercises, and Cold Exposure on the Response to Endotoxin Administration, demonstrated that the WHM can attenuate the inflammatory response, "through practicing techniques that are relatively easy to learn within a short time frame", but "It remains to be determined whether the results of this study using an acute model of inflammation in healthy volunteers can be extrapolated to patients with chronic autoimmune diseases." In 2018, the RMIT University in Melbourne, Australia, conducted a survey asking people around the world what impact the Wim Hof method had on their lives. More than 3,200 people responded. In 2019, a proof of concept trial titled Battling Arthritis-An add-on training program involving breathing exercises, cold exposure, and meditation attenuates inflammation and disease activity in axial spondyloarthritis, concluded that: "There was a significant decrease in ESR levels and ASDAS-CRP upon the add-on training program in the intervention group. These findings warrant full-scale randomised controlled trials of this novel therapeutic approach in patients with inflammatory conditions." In 2020, an article titled Involvement of lactate and pyruvate in the anti-inflammatory effects exerted by voluntary activation of the sympathetic nervous system, concluded that: "Practicing the breathing exercises acquired during the training program results in enhanced activity of the Cori cycle, and next to the previously established relationship between epinephrine and IL-10 induction, the current data indicate a role of lactate and pyruvate in the enhanced production of this key anti-inflammatory mediator and in the overall anti-inflammatory phenotype observed in trained subjects." A 2021 pilot study on fifteen sprinters concluded that the WHM caused side effects and