back to original statements of Newton, "Nature is pleased with simplicity", Dalton, "rule of greatest simplicity," and Einstein, "Nature is the realization of the simplest conceivable mathematical ideas." In 1974 Rustum Roy and Olaf Müller noted simplexity in the structure of ternary compounds: By dealing with approximately ten ternary structural groupings we can cover the most important structures of science and technology specific to the non-metallics world. It is a remarkable instance of nature's 'simplexity'. In 2003, simplexity has been defined by Philippe Compain in the context of an article on the future of synthetic chemistry as follows: "Simplexity may be defined as the combination of simplicity and complexity within the context of a dynamic relationship between means and ends.";Philippe Compain et al. "Looking forward: a glance into the future of organic chemistry" New J. Chem., 2006, 30, pages 823-831. The quest for simplicity constitutes indeed the basis for all future challenges of chemical synthesis including diversity, selectivity and green chemistry. Due to the almost infinity of molecules that could in theory be synthesized, the focus of synthetic research has been shifted gradually from target-oriented synthesis to diversity-oriented synthesis (divergent synthesis). A scientific approach based on the power of the molecular construction game and guided by an ideal for simplicity, has a high potential for discovery. The creative combination of synthetic methodologies, mixing simplicity and maximization of structural complexity, is indeed expected to be a powerful tool to produce unprecedented molecular structures with beneficial properties for mankind. Interdisciplinary Simplexity became the topic of formal discussion at the Hamburg Trend Day in Germany. Among the formal contributors were Peter Wippermann, Dr. Norbert Bolz, David Bosshart, Designer Ora Ito, Markus Shepherd, Susane Tide Frater. Simplexity: Why Simple Things Become Complex (and How Complex Things Can Be Made Simple) by Jeffrey Kluger details many ways in which simplexity theory can be applied to multiple disciplines. Kluger offers a look at simplexity at work in economics, sports, linguistics, technology, medicine, and dozens of human behaviors. Simplexity also provides insight into how readers can improve their lives by understanding the interplay of complexity and simplicity. Finance Simplexity has been used by Jens Nordvig to describe the particular aim of his analytics firm Exante Data."Maybe the best word for what we are trying to achieve is simplexity. A research product that draws on a very complex analytical foundation, but is presented in a very simple and