State Route 157 (SR 157) is a state highway in the northern and northwestern parts of the U.S. state of Alabama. The southern terminus of the highway is at an intersection with U.S. Route 278 (US 278) approximately east of Cullman, where it continues as County Road 719.The northern terminus of the highway is at the Tennessee state line northwest of Florence. SR 157 continues as Tennessee State Route 227 (SR 227) once it crosses into Tennessee. Route description State Route 157 begins at a 4-way stop with US 278. South of the 4-way stop, the road continues as Cullman County Road 719. Throughout North Cullman, AL-157 is oriented in an east-to-west trajectory, passing by a large Buick/GMC dealership at its junction with U.S. 31, then past several restaurants, and ultimately reaching I-65. In northern Cullman County, the route makes a gradual curve north. The county line with Morgan County is marked in the middle of a steep downgrade/upgrade known as Battleground Mountain for the nearby town of Battleground. After this descent/ascent, the route winds its way to Danville, where it junctions with CR-55 and CR-41 (Danville Road). It crosses the line into Lawrence County and shortly junctions with SR-36, which leads to Hartselle and Wren. Eventually, the route reaches Moulton, where it serves as the main north-to-south thoroughfare for the east district of Moulton, which contains most of its restaurants and shops. It eventually junctions with Alabama State Route 24/Corridor V and Alabama State Route 33. Past this point, the route passes through Hatton and Alabama State Route 101. It eventually reaches the Colbert County line and thence junctions with Alabama State Route 20. The concurrent routes reach Muscle Shoals, where the route turns north in a concurrency with Alabama State Route 133, losing Alabama State Route 20. Past this point, the route crosses the Tennessee River and the Lauderdale County line. The route passes through Florence on a freeway directly through town, intersecting with U.S. 72 and U.S. 43, also losing Alabama State Route 133 and gaining Alabama State Route 17 before and at this specific interchange respectively. On the north side of town, the route re-engages in a concurrency with S.R. 133 and now S.R. 17. After a short concurrency, the route drops S.R. 17 and continues west with S.R. 133. Eventually, it turns off of the concurrency and heads north, crossing the Tennessee state line directly