Tong Ren Tang (TRT; ) is a Chinese pharmaceutical company founded in 1669, which is now the largest producer of traditional Chinese medicine (TCM). The company headquarters are in Beijing and is engaged in both manufacture and retail sales, operating drug stores predominantly in Chinese-speaking regions. Tong Ren Tang is considered one of the "Big 4" traditional Chinese medicine brands still in existence. The four companies include (listed in order of age not size): Guangyuyuan (1541 AD), Guangzhou Chen Liji (1600 AD), Beijing Tong Ren Tang (1669), and Hangzhou Hu Qing Yu Tang (1874). Tong Ren Tang and GuangYuYuan have been officially recognized as "China Time-Honored Brands" by the Ministry of Commerce of the People's Republic of China. History In 1669, the eighth year of the reign of the Kangxi Emperor in the Qing dynasty (1644-1911), Tong Ren Tang was established in Beijing by Yue Xianyang who served as a senior physician at the Qing imperial court. In 1702, the company relocated within Beijing to the address from which it has operated ever since. In 1723, Tong Ren Tang was appointed the sole supplier of herbal medicines to the imperial court by the Yongzheng Emperor and remained in that position until the collapse of the Qing dynasty in 1911. In 1924, the company Tiger bone wine was awarded at the Leipzig Trade Fair, making the product the most popular type in commerce. Modern development Like many older Chinese companies, Tong Ren Tang has struggled to adapt to market changes. In recent years, Tong Ren Tang has modernized its facilities, and changed its trade name to Tongrentang. It remains one of the oldest surviving brand names for traditional Chinese medicine, and has wide name-recognition among Chinese and Asians worldwide. It is also one of the world's largest TCM companies, with products sold in countries all over the world. Hutchison Whampoa Ltd. invested in Tong Ren Tang Technologies’ in 2000 by subscribing six million shares in the company. Page 17 of Prospectus Hutchison Whampoa Ltd., previously had two joint ventures with Tong Ren Tang. Page 6 of Prospectus In 2001, Tong Ren Tang, in collaboration with Germany-based Mirahi Biotech, diversified into skincare products. Using state-of-the-art western technologies and the vast cache of herbal medicines of Tong Ren Tang, the collaboration has come up with an impressive list of products. In 2008, the exclusive U.S. distributorship is licensed to a California corporation, Denosim