Runa. The first mutant that Kyosuke faces in the premiere episode "The Crest of the Devil." Kyoya fights Kyosuke (now in his mutant form) but is eventually defeated when Kyosuke kills him with the Lightning Breaker. The CEO and head of the Kirihara Corporation, and one of the series' antagonists. She is killed by the Alien, who is later revealed to be five-year-old Runa herself. In Nurse Witch Komugi, she appears as a director of the company; her return unknown. The man who aligns himself with Kyosuke and Komugi against the Kirihara Corporation. It is later revealed that Shiro is Yui's younger brother. Kyosuke's good friend and savior, who was soon kidnapped by the Kirihara Corporation to be experimented on to search for Runa Tokisaka. She was the very first Flicker to be created. She is restored to life when all of the Flickers leave Runa. She was the first SoulAnubis, before all the Flickers were absorbed into Runa. A nurse girl who betrayed the Hospital to help Kyosuke after she realizes that she has fallen for him. She is the main protagonist in the mini spin-off, Nurse Witch Komugi. One of the main antagonists who is the late Tsubaki's husband, and the father of Kyosuke and Runa. He is also a mutant, with the ability to turn into the mutant SoulCrusher. He battles his son in the fifth episode, and reveals the truth about the Hospital and the Beta Applicon virus to Kyosuke. He ends up being destroyed by his own son in their second (and last) battle. She is the wife of Richard Vincent and mother of fraternal twins Kyosuke and Runa. She was one of the Tokisaka Clan who used the extraterrestrial substance of the Beta Applicon to further their research in eradicating disease and the evolution of humankind. She was the first to be saved after her father, Daigo Tokisaka, had injected the alien anti-virus into her system. Five years later, she and her daughter were pursued by the members of the Kirihara Corporation. Knowing that she could no longer protect Runa, she had stabbed her in the chest in order for Runa to develop her inherent mutant abilities. The circumstances of her demise is unknown, though Runa had unconsciously created a Flicker that took on her appearance and memories. This motherly flicker appeared to Kyosuke in the seventh episode, "The Last of a Woman". The