down by beta-amyloid. Rabies NCAM has been identified as one of the target proteins for the rabies virus, allowing entry into the cell. Anti-NCAM therapy NCAM has been used as a target molecule for experimental antibody-based immunotherapy. Successful radio-immunolocalisation of metastases was demonstrated after giving injections of NCAM-binding 123J-UJ13a or 131J-UJ13a radio-immunoconjugates to children with neuroblastoma. Patients with small cell lung cancer were treated with the anti-NCAM immunotoxin huN901-DM1 in two different clinical studies, revealing acceptable toxicity and signs of clinical response. References External links Cell adhesion proteins CD56