episode "Take Out", Charlie and Millie attend a black tie reception for CalSci fundraising and bond. Soon after, Charlie is asked by Millie to meet with Macmillan Pharmaceuticals, which according to Amita has a reputation for exploiting third-world countries. Amita serves as his conscience in this matter, and he goes to see Dr. Finch about it. With "Pythagorean wit," he dazzles Macmillan and is to serve as a mathematical consultant for the pharmaco-kinetic modelling project, only under the provision that CalSci will administer the trials and monitor the drug at every step, all computational analyses are conducted by Charlie and his team, and 5% of the gross will go to third-world AIDS organizations chosen by Professors Eppes and Ramanujan . In "Democracy", as part of his duties, he recruits the young fantasy baseball and sabermetrics fanatic Oswald Kittner (Jay Baruchel), who shows great promise, to attend CalSci. When Larry announces his leave of absence to board the International Space Station (in the episode "Brutus"), Charlie is shocked and upset. He is in denial about Larry's ambitions and he thinks reason of the risks involved will assert itself firmly in Larry's mind. He reasons that apparently Larry wouldn't do such a thing. Larry remands his few prized possessions to him, and he is grateful for the gesture. When he tells him his concerns, Larry is angered. Amita says to Larry, "[Charlie] has never dreamt of something he couldn't reach, so he has no idea what it is like to want something he is not able to get. So how could he understand how much [Larry] you would give up when this chance comes along?" Larry understands and decides to ignore Charlie's protestations. Though neither apologize, they are on good terms. Charlie says to Amita that he does not know what he would do without him, as he peruses through Larry's precious items that were bestowed upon him. In "Killer Chat", he says that he was glad that Larry's dream could come true, but feels conflicted about being relieved when he discovers that Larry might have been scrapped from the mission when NASA learned of his eccentric indulgences such as sleeping in the campus steam tunnels. However, Charlie agrees with Megan in wanting to help Larry and personally vouches for him. Eppes' words and affiliation with the NSA gets him back on the mission, thus, repaying a debt as Larry helped launch