histocompatibility complex (MHC) region is a complex of tightly linked genes all acting in the immune system, but has no claim to be a supergene, even though the component genes very likely have epistatic effects and are in strong disequilibrium due in part to selection. References Reading Berdan EL, Flatt T, Kozak GM, Lotterhos KE, Wielstra B. 2022 Genomic architecture of supergenes: connecting form and function. Phil. Trans. R. Soc. B 377: 20210192 External links www.cbc.yale.edu/old/cce/papers/HomNat/homnat.html - evolution of modularity Genes