ointment. In 2008 the FDA announced its intention to take action against these products because it had received reports of serious adverse events in patients using products containing papain. Reports included hypersensitivity (allergic) reactions that lead to hypotension (low blood pressure) and tachycardia (rapid heart rate). In addition, people allergic to latex can also be allergic to papaya, the source of papain, implying that people with latex sensitivity may be at increased risk of suffering an adverse reaction to a topical papain drug product. FDA recommended that people with concerns about using topical papain preparations contact their health care provider about discontinuing use. Human cysteine proteases from papain family See also Bromelain References External links The MEROPS online database for peptidases and their inhibitors: C01.001 drugdigest- info on papin Papain Applications, Inhibitors and Substrates Data sheet-Papain from BIOZYM Papain on Proteopedia (wiki with more protein specific info) EC 3.4.22 Proteases Hydrolases Food additives Dietary supplements Articles containing video clips