Puffer may refer to: Clyde puffer, a type of cargo ship used in the Clyde estuary and off the west coast of Scotland Puffer, a type of circuit breaker Inhaler, a medical device used for delivering medication into the body via the lungs Puffer machine, used to detect explosives Puffer train, a class of patterns in automata such as Conway's Game of Life Pufferfish, a type of fish in family Tetraodontidae which can inflate itself as a defence mechanism Puffer (surname), a surname Supercharger for a motor car engine USS Puffer, two submarine vessels of the United States Navy Puffer, name for a particular type of German Wheellock pistol, usually from Nuremberg or Augsburg Puffer jacket, a type of jacket "Puffer", a song by indie rock/noise pop band Speedy Ortiz from Foil Deer Puffer (TV service), online streaming service