of ME/CFS symptoms that always follows physical activity and often follows cognitive activity". Orthostatic intolerance (OI) occurs in CFS. OI includes exercise intolerance as one of the main symptoms. It also includes fatigue, nausea, headaches, cognitive problems and visual disturbances as other less major symptoms. Post-concussion syndrome (PCS) Exercise intolerance is present in those with PCS however their intolerance to exercise may reduce over time. Individuals with postconcussion syndrome may also experience a level of exercise intolerance, however there is little known comparatively about exercise intolerance in PCS patients. Heart conditions Angina pectoris Heart failure: Exercise intolerance is a primary symptom of chronic diastolic heart failure. Cardiac arrhythmia Aortic valve insufficiency Pulmonary artery hypertension: PAH has the following symptoms; dyspnea and fatigue, these systems consequently contribute to exercise intolerance. Asymptomatic atrial septal defects; In the heart the right ventricular (RV) can have a volume overload which ultimately produces a pressure overload in the RV resulting in exercise intolerance as the RV is no longer able to control high pressure associated with exercise. Chronic heart failure Musculoskeletal disorders Spinal muscular atrophy: symptoms include exercise intolerance, cognitive impairment and fatigue. Rhabdomyolysis: a condition in which muscle degrades, releasing intracellular muscle content into the blood as reflected by elevated blood levels of creatine kinase. Exercise tolerance is significantly compromised. Mutations Mitochondrial complex III: Currently it is suggested that there are 27 different mutations identified in cytochrome b (mitochondrial complex III is one of those mutations). This mutation can often lead to skeletal muscle weakness and as a result exercise intolerance. A complex of Coenzyme Q10: Skeletal muscle respiratory chain defect (electron transport chain [ETC]): This can result in severe exercise intolerance which is manifested by the following symptoms of Skeletal muscle respiratory chain defect; muscle fatigue and lactic acidosis. Exercise tolerance reflects the combined capacity of components in the oxygen cascade to supply adequate oxygen for ATP resynthesis. In individuals with diseases such as cancer, certain therapies can affect one or more components of this cascade and therefore reduce the body's ability to utilise or deliver oxygen, leading to temporary exercise intolerance. Riboflavin-responsive exercise intolerance caused by mutations of the SLC25A32 gene Glycogen storage disease type V, caused by mutations of the gene encoding myophosphorylase. Cytochrome b mutations Cytochrome b mutations can frequently cause isolated exercise intolerance and myopathy and in some cases multisystem disorders. The mitochondrial respiratory chain complex III catalyses electron