March 2007, a fracas broke out between players of the two teams. Burdisso suffered a broken nose from a punch in the face from Valencia defender David Navarro. As punishment for his part in the brawl, Burdisso was handed a six-match ban from all European club competitions, with an additional two match suspension. Navarro was sentenced to a seven-month ban from domestic, European and international matches. The match at Mestalla Stadium ended in a goalless draw which sent Inter out of competition on away goal rule. Burdisso eventually returned to duty on 12 March 2008 in the second leg of the Champions League match against Liverpool, but was sent off in the 60th minute after receiving his second yellow card of the game. With Inter, he played left and right back and central defender as a key member of the squad in three different competitions. Burdisso left the club in August 2009 after playing 139 matches and scoring 8 goals in all competitions, winning 9 trophies in the process. Roma On 22 August 2009, Burdisso was signed by Roma on loan, which offered him €3.04 million (gross) salary per year. He played the opening match of the league on 23 August. He scored his first goal for Roma on 20 December 2009, opening the scoring in a 2–0 win over Parma. Burdisso was then signed by Roma permanently on 28 August 2010 for an €8 million transfer fee. He signed a four-year contract, in which he would earn €3.8 million (pre-tax) his first year, increasing to €4.5 million pre-tax in the next three years. He scored his fifth goal—first in the 2011–12 Serie A—for Roma against Milan on 29 October. Roma lost that game 3–2. On 15 November 2011, he suffered a serious injury to his left knee which will force him out of action for six months. In 2007, Burdisso expressed his desire to finish his career at Boca Juniors. In 2012–13 season under Zdeněk Zeman, Burdisso was relegated to the bench. He played only eight matches in the first part of the season, scoring the opener in a 4–2 win over Milan. Prospects in the starting XI remained dismal after the arrival of new manager Rudi Garcia, typically serving as third-choice centre-back behind starters Mehdi Benatia and Leandro Castán. Genoa On 23 January 2014, Burdisso signed with Genoa. He played for Genoa for four seasons, making 113 appearances.