bearing to the induced stress, Paris and Erdogan's crack growth model, and stochastic defect-propagation model are other examples of micro-level models. Since measurements of critical damage properties (such as stress or strain of a mechanical component) are rarely available, sensed system parameters have to be used to infer the stress/strain values. Micro-level models need to account in the uncertainty management the assumptions and simplifications, which may pose significant limitations of that approach. Macro-level models are the mathematical model at system level, which defines the relationship among system input variables, system state variables, and system measures variables/outputs where the model is often a somewhat simplified representation of the system, for example a lumped parameter model. The trade-off is increased coverage with possibly reducing accuracy of a particular degradation mode. Where this trade-off is permissible, faster prototyping may be the result. However, where systems are complex (e.g., a gas turbine engine), even a macro-level model may be a rather time-consuming and labor-intensive process. As a result, macro-level models may not be available in detail for all subsystems. The resulting simplifications need to be accounted for by the uncertainty management. Hybrid approaches Hybrid approaches attempt to leverage the strength from both data-driven approaches as well as model-based approaches. In reality, it is rare that the fielded approaches are completely either purely data-driven or purely model-based. More often than not, model-based approaches include some aspects of data-driven approaches and data-driven approaches glean available information from models. An example for the former would be where model parameters are tuned using field data. An example for the latter is when the set-point, bias, or normalization factor for a data-driven approach is given by models. Hybrid approaches can be categorized broadly into two categories, 1) Pre-estimate fusion and 2.) Post-estimate fusion. Pre-estimate fusion of models and data The motivation for pre-estimate aggregation may be that no ground truth data are available. This may occur in situations where diagnostics does a good job in detecting faults that are resolved (through maintenance) before system failure occurs. Therefore, there are hardly any run-to-failure data. However, there is incentive to know better when a system would fail to better leverage the remaining useful life while at the same time avoiding unscheduled maintenance (unscheduled maintenance is typically more costly than scheduled maintenance and results in system downtime). Garga et al. describe conceptually a pre-estimate aggregation hybrid approach where domain knowledge is used