her wedding, Bianca wore a bodice "with eighty pieces of the jeweler's art pinned thereon, with each piece consisting of one ruby and four pearls". Maximilian's claim to overlordship of Milan angered Anne of France, regent for her brother King Charles VIII of France, and brought about French intervention in Italy, thus inaugurating the lengthy Italian Wars. The union was unhappy: shortly after the consummation of the marriage, Maximilian complained that Bianca may have been more beautiful than his first wife, Duchess Mary of Burgundy, but was not as wise. It was impossible for the young bride to win the affection of her husband, who considered her too uneducated, talkative, naive, wasteful with money, and careless. She very much liked her stepchildren Philip the Handsome and Margaret, but, as was remarked by Hermann Wiesflecker, Bianca Maria remained "all her life a child who played while sitting on the floor" and was criticized for forgetting the dignity of her position as Maximilian's wife. According to Daniel Unterholzner, although there was early rumours of pregnancies, Bianca apparently could not become pregnant (the time she shared with Maximilian was already little, due to his busy schedule, and decreased more and more). The reasons for this were not certain, although she seemed to be angry with her doctor Battista Baldironi for this problem —however, according to Italian biographer and journalist Daniela Pizzagalli, Bianca in fact became pregnant soon after her wedding, but she had a miscarriage three months later on her way to Flanders in June 1494; if this event really took place, it probably impaired Bianca's hability to conceive again. Maximilian had always concentrated on the children of his first marriage in terms of succession politics from the beginning, despite this policy being very risky as he had only one male child, Philip (after whose early death in 1506, he would concentrate on Charles and Ferdinand, his grandsons). Her childlessness made Bianca lose one of her important areas of responsibility as the female head of their family. Although the marriage was a failure even in the beginning, at this point Maximilian was eager to show his subjects in the Low Countries that he had a new wife. It was also the period in which Philip turned 16 and had fully taken charge of the government. Thus various events were staged to celebrate these facts. After 1500, Maximilian lost all interest in Bianca. She