conversion of K2PtCl4 to K2PtI4, as originally described by Dhara. Reaction with ammonia forms PtI2(NH3)2 which is isolated as a yellow compound. When silver nitrate in water is added insoluble silver iodide precipitates and [Pt(OH2)2(NH3)2](NO3)2 remains in solution. Addition of potassium chloride will form the final product which precipitates In the triiodo intermediate the addition of the second ammonia ligand is governed by the trans effect. A one-pot synthesis of cisplatin from K2PtCl4 has been developed. It relies on the slow release of ammonia from ammonium acetate. See also Carboplatin Dicycloplatin References Further reading External links IARC Monograph: "Cisplatin" Ammine complexes Bioinorganic chemistry Cancer treatments Chloro complexes Coordination complexes IARC Group 2A carcinogens Medicinal inorganic chemistry Metal-containing drugs Nephrotoxins Platinum complexes Platinum-based antineoplastic agents Platinum(II) compounds World Health Organization essential medicines Wikipedia medicine articles ready to translate