Gillecomgain", Gruoch Macduff's first husband, to the fateful letter in the first act of Shakespeare's tragedy. Alex Kingston starred as Lady Macbeth opposite Kenneth Branagh in his and Rob Ashford's adaption of Macbeth. The play was first performed at the Manchester Festival in 2013 and then transferred to New York for a limited engagement in 2014. Marion Cotillard played the character in Justin Kurzel's 2015 film adaptation opposite Michael Fassbender as Macbeth. Frances McDormand played the character in The Tragedy of Macbeth opposite Denzel Washington as Macbeth directed by her husband Joel Coen, the first film directed without his brother Ethan Coen. In popular culture During former United States President Bill Clinton's 1992 campaign for the American presidency, Daniel Wattenberg's August 1992 The American Spectator article "The Lady Macbeth of Little Rock", and some twenty other articles in major publications drew comparisons between his wife and Lady Macbeth, questioning Hillary Clinton's ideological and ethical record in comparison to Shakespeare's famous character and suggesting parallels. The Simpsons twentieth episode of its twentieth season, "Four Great Women and a Manicure" is loosely based on Macbeth. In the third act of the episode, Marge embodies Lady Macbeth, an ambitious wife who is frustrated by everything around her. She not only has to clean the costumes worn by other actors, but is also frustrated over the fact that Homer doesn't have any interest in auditioning for lead roles and would rather play a tree. She convinces him to kill Sideshow Mel and he does to assume the lead role of Macbeth. When Marge learns that no one cares for Homer's lack of acting skills over Hibbert's and those with no lines, she forces him to kill off everyone else until he's the only actor left. The angry spirits visit her that night and she tries to pin the blame on Homer. They refuse to believe Marge and point out that they knew he was a victim himself in her devious ambitions. The angry spirits get their revenge on her by killing her in a fright induced heart attack. Even though Homer gives Marge's ghost a promising performance, he eventually frustrates her more by killing himself so he doesn't have to audition for more Shakespearean plays. This forces Marge to learn her lesson the hard way when she must spend eternity with a lazy and happy Homer. In 2008, Three Rivers Press published Lady Macbeth