months, 4 months, 6 months, 15–18 months and then 4–6 years old. Possible side events that are associated with the diphtheria vaccine include "mild fever, fussiness, drowsiness or tenderness at the injection site". Although it is rare, the DTaP vaccine may cause an allergic reaction that causes hives or a rash to breakout within minutes of administering the vaccine. Genetics The genome of C. diphtheriae consists of a single circular chromosome of 2.5 Mbp, with no plasmids. Its genome shows an extreme compositional bias, being noticeably higher in G+C near the origin than at the terminus. The Corynebacterium diphtheriae genome is a single circular chromosome that has no plasmids. These chromosomes have a high G+C content which is what contributes to their high genetic diversity. The high content of guanine and cytosine is not constant across the entire genome of the bacteria. There is a terminus of replication around the ~740kb region that causes a decrease in the G+C content. In other bacteria, it is often seen that the G+C content gets smaller near the terminus, but C. diphtheriae is a considerably strongly genome that has this occurrence. Chromosomal replication is one of the ways this happens within this genome. Notes References See also Cutaneous diphtheria Diphtheria vaccine External links CoryneRegNet—Database of Corynebacterial Transcription Factors and Regulatory Networks'' Corynebacterium diphtheriae genome Type strain of Corynebacterium diphtheriae at BacDive - the Bacterial Diversity Metadatabase Corynebacterium Gram-positive bacteria Diphtheria Bacteria described in 1886 1884 in biology