building (now known as the Crile Building) designed by architect Cesar Pelli. In September 2014, the Cleveland Clinic opened the center for Functional Medicine, directed by Mark Hyman. Research and education The Cleveland Clinic Lerner Research Institute (LRI) conducts biomedical research in a 480,000-square-foot building that opened in 1999, following a $16 million donation from Al and Norma Lerner in 1997, the largest single charitable donation made to the Cleveland Clinic up until that point. LRI hosts graduate student research through joint PhD programs in conjunction with nearby universities, including Case Western Reserve University, Cleveland State University (including an NIH-funded PhD program for minority and underrepresented students in science, technology, engineering, and mathematics), Kent State University and the University of Akron. In 2002, the Lerners eclipsed their previous gift and made a $100 million donation to establish the Cleveland Clinic Lerner College of Medicine (CCLCM) within Case Western Reserve University School of Medicine, opening in 2004. Physician researcher Eric Topol played an important role in securing the donation from the Lerner family. Topol served as Provost and Chief Academic Officer at CCLCM until 2006, when his position was eliminated amid controversy regarding his criticism of Vioxx and disagreements with other Cleveland Clinic leaders, including then-CEO Toby Cosgrove. CCLCM is a five-year medical school program affiliated with the Case Western Reserve University School of Medicine with 32 students per class, each receiving a scholarship for full tuition and fees. While traditional MD-granting medical schools in the U.S. are four-year programs, the extra year in the program is dedicated to a year of research. The curriculum is notable for its lack of class rank, pre-clinical or clinical grading, or end-of-course examinations. In 2019, Cleveland Clinic and Case Western opened the Samson Pavilion Health Education Campus on the campus of the Cleveland Clinic, a $515 million building project, amid a multi-million dollar joint fundraising campaign between CWRU and the Cleveland Clinic. The campus houses students Case Western Reserve School of Medicine (CCLCM and traditional MD programs), Frances Payne Bolton School of Nursing and Case School of Dental Medicine, all of which—with the exception of CCLCM—had previously held classes on the campus of CWRU and University Hospitals Cleveland Medical Center. The move, announced in 2013, was a major contributing factor for University Hospitals to shift its name from University Hospitals Case Medical Center to University Hospitals Cleveland Medical Center in 2016, as well as