SPE may refer to: Science and technology A monomer used to make polysulfobetaines, or occasionally the resulting polymer itself Serum protein electrophoresis Solar particle event,generating very high energy protons Solid phase extraction, from a mixture Solid-phase epitaxy, from amorphous to crystalline The Sound Pattern of English, a 1968 book by Noam Chomsky and Morris Halle SpE, abbreviation for Sporadic E propagation Spe (planet), 14 Andromedae b Stanford prison experiment, in psychology Synchronous payload envelope, in synchronous optical networking Computer science Synergistic Processing Element in the Cell microprocessor Signal-Processing Engine, for example in the PowerPC e500 Single-Pair Ethernet Organizations Sauber Petronas Engineering, car engine manufacturer Societas Privata Europaea, a Europe-wide type of limited company Sony Pictures Entertainment, a US company SPE, later Luminus (company) Special Police Establishment, later Central Bureau of Investigation, India Special purpose entity, for a specific purpose Professional societies Society for Photographic Education Society of Petroleum Engineers SPE Certified Petroleum Professional, a designation Society of Plastics Engineers Society of Professional Engineers UK Other US supervisory patent examiner SPE Certified, a food standard Société Parisienne d'Édition (S.P.É.), a French publisher See also Spes (disambiguation)