claimed to significantly predict all ten personality disorder symptoms and outperform the Minnesota Multiphasic Personality Inventory (MMPI) in the prediction of borderline, avoidant, and dependent personality disorder symptoms. However, most predictions related to an increase in Neuroticism and a decrease in Agreeableness, and therefore did not differentiate between the disorders very well. Common mental disorders Converging evidence from several nationally representative studies has established three classes of mental disorders which are especially common in the general population: Depressive disorders (e.g., major depressive disorder (MDD), dysthymic disorder), anxiety disorders (e.g., generalized anxiety disorder (GAD), post-traumatic stress disorder (PTSD), panic disorder, agoraphobia, specific phobia, and social phobia), and substance use disorders (SUDs). The Five Factor personality profiles of users of different drugs may be different. For example, the typical profile for heroin users is , whereas for ecstasy users the high level of N is not expected but E is higher: . These common mental disorders (CMDs) have been empirically linked to the Big Five personality traits, neuroticism in particular. Numerous studies have found that having high scores of neuroticism significantly increases one's risk for developing a common mental disorder. A large-scale meta-analysis (n > 75,000) examining the relationship between all of the Big Five personality traits and common mental disorders found that low conscientiousness yielded consistently strong effects for each common mental disorder examined (i.e., MDD, dysthymic disorder, GAD, PTSD, panic disorder, agoraphobia, social phobia, specific phobia, and SUD). This finding parallels research on physical health, which has established that conscientiousness is the strongest personality predictor of reduced mortality, and is highly negatively correlated with making poor health choices. In regards to the other personality domains, the meta-analysis found that all common mental disorders examined were defined by high neuroticism, most exhibited low extraversion, only SUD was linked to agreeableness (negatively), and no disorders were associated with Openness. A meta-analysis of 59 longitudinal studies showed that high neuroticism predicted the development of anxiety, depression, substance abuse, psychosis, schizophrenia, and non-specific mental distress, also after adjustment for baseline symptoms and psychiatric history. The personality-psychopathology models Five major models have been posed to explain the nature of the relationship between personality and mental illness. There is currently no single "best model", as each of them has received at least some empirical support. It is also important to note that these models are not mutually exclusive – more than one may be operating for