U.S. Route 176 (US 176) is a spur of US 76 in the U.S. states of North Carolina and South Carolina. The U.S. Highway runs from US 25 Business and North Carolina Highway 225 (NC 225) in Hendersonville, North Carolina, east to US 52 in Goose Creek, South Carolina. US 176 serves the transition region between the Blue Ridge Mountains and Foothills of Western North Carolina and the Upstate, Midlands, and Lowcountry regions of South Carolina. The highway passes through and connects Spartanburg, one of two major cities in the Upstate, and Columbia, the South Carolina state capital and central city of the Midlands. US 176 parallels and serves as a secondary highway to Interstate 26 (I-26) except for between Spartanburg and Columbia, where the U.S. Highway deviates from the I-26 corridor to serve Union. Route description US 176 spans in North Carolina and runs in South Carolina. The U.S. Highway is a part of the National Highway System in four locations in South Carolina. US 176 is part of the national system from I-85 Business near Spartanburg to South Carolina Highway 295 (SC 295) near Pacolet, during which the U.S. Highway is concurrent with either I-585 or SC 9. The highway's second stretch of National Highway System is along its concurrency with SC 72 around Whitmire. US 176 is also part of the system along its concurrencies with US 21, US 76, and US 321 on Elmwood Street and Huger Street north of SC 12 in Columbia. The highway's final section in which it is included in the National Highway System is during its concurrency with US 21 and US 321 from I-26 in Cayce to where US 321 splits from US 176 and US 21 south of Cayce. Hendersonville to Spartanburg US 176 begins at the southern end of Main Street in the city of Hendersonville. Main Street heads north into the downtown area as US 25 Business; the road also continues south as NC 225 (Greenville Highway). US 176 and US 25 Bus. head east concurrently along Spartanburg Highway, a four-lane highway with a center turn lane that heads through a commercial area and crosses over Norfolk Southern Railway's W Line. The highway leaves Hendersonville and heads southeast through the town of East Flat Rock. US 25 Bus. reaches its southern terminus at US 176's diamond interchange with US 25. US 176 reduces to two lanes and