278 in western Alabama was formerly routed through Haleyville via current SR 195 and SR 129. In 2014, Alabama relocated US 278 in Cullman. Major intersections Arkansas in Wickes north-northeast of Dierks. The highways travel concurrently to Dierks. west of Nashville. The highways travel concurrently to Nashville. in Hope in Hope in Rosston. The highways travel concurrently through Rosston. in Camden. The highways travel concurrently to west-northwest of East Camden. in Hampton in Warren east of Warren in Monticello west of Monticello northwest of McGehee. The highways will travel concurrently to Clarksdale, Mississippi. in McGehee. US 65/US 278 travels concurrently to south-southeast of Lake Village. US 165/US 278 travels concurrently to Dermott. in Lake Village. The highways travel concurrently to east of Leland, Mississippi. Mississippi east of Leland. US 61/US 278 travels concurrently to Clarksdale. in Clarksdale. The highways travel concurrently through Clarksdale. in Clarksdale in Batesville in Batesville on the Verona–Tupelo city line. The highways travel concurrently to north-northwest of New Wren. Alabama in Guin. The highways travel concurrently to Hamilton. in Hamilton in Cullman in Cullman south-southwest of Summit northwest of Attalla. The highways travel concurrently to Gadsden. in Attalla. The highways travel concurrently through Attalla. in Attalla in Gadsden Georgia in Cedartown. The highways travel concurrently through Cedartown. in Lithia Springs. The highways travel concurrently to Druid Hills. in Atlanta in Atlanta. The highways travel concurrently through Atlanta. in Atlanta. US 29/US 278 travels concurrently to Druid Hills. in Atlanta. The highways travel concurrently to Druid Hills. in Belvedere Park southeast of Lithonia. The highways travel concurrently to Covington. south of Social Circle in Madison. The highways travel concurrently to northeast of Madison. in Barnett southeast of Thomson. The highways travel concurrently to Clearwater, South Carolina. in Harlem in Augusta in Augusta. The highways travel concurrently to Clearwater, South Carolina. in Augusta. The highways travel concurrently to North Augusta, South Carolina. South Carolina in North Augusta in Allendale. The highways travel concurrently through Allendale. in Fairfax in Hampton. The highways travel concurrently through Hampton. in Ridgeland. The highways travel concurrently to Hardeeville. in Hilton Head Island. See also U.S. Route 78 Special routes of U.S. Route 278 References External links U.S. Route 278 in South Carolina (Mapmikey's South Carolina Highways Page) Endpoints of U.S. Highway 278 United States Numbered Highway System U.S. Highways in Mississippi