U.S. Route 278 (US 278) is a parallel route of US 78. It currently runs for from Hilton Head Island, South Carolina, to Wickes, Arkansas at US 71/US 59, passing through five states in the process. Landmarks along its route include the Department of Energy's Savannah River Site in South Carolina and the Tennessee-Tombigbee Waterway in eastern Mississippi. There are several universities located along the highway including Georgia State University, the University of Mississippi, and the University of Arkansas at Monticello. Route description Arkansas US 278 begins at an intersection with US 59/US 71 in the town of Wickes in southwestern Arkansas. From Wickes, US 278 continues eastward near Gillham Lake to an overlap with US 70 through Dierks. Continuing south, US 278 overlaps Highway 26 for at Center Point. Further south the route continues into Nashville. The route overlaps US 371 and later Highway 27 upon entering Nashville. Entering Hempstead County, the highway winds through rural areas to Ozan and Washington, before meeting US 278 Business (US 278B) outside Hope. The highway crosses over Interstate 30 (I-30) shortly after entering the city limits and overlaps Highway 29 and Highway 32. US 278/AR 29/AR 32 intersect US 67 in east Hope. South of this junction AR 29 splits and US 278/AR 32 continues southeast. Further along this route, AR 32 turns southeast to Willisville and US 278 runs toward Camden. The route intersects Highway 53 in rural Nevada County, overlaps US 371 in Rosston, and has a junction with Highway 57 upon entering Ouachita County. In Camden, US 278 intersects Highway 24 before it meets US 278B and US 79B prior to overlapping US 79. US 278 breaks from US 79 near Harrell Field shortly before entering East Camden. US 278 continues into Calhoun County and Hampton and a junction with US 371. The east edge of town brings an intersection with Highway 274 as US 278 continues to Harrell and Highway 160 before entering Bradley County. Aside from Banks, where US 278 has a junction with Highway 275, the route runs through rural country until Warren, where US 278 almost entirely bypasses the city to the south while US 278B runs downtown, including a brief overlap with US 63B. US 278 has an intersection with US 63/AR 8 along the southern edge of Warren before serving as the eastern terminus for US 278B. Further east the highway intersects Highway