U.S. Route 601 (US 601) is a north–south United States highway that runs for from U.S. Route 321, near Tarboro, South Carolina, to U.S. Route 52, in Mount Airy, North Carolina. In North Carolina, it is one of the main north-south corridors connecting the cities of Salisbury, Mocksville, and Mount Airy. Route description South Carolina US 601 begins at US 321 near Tarboro, SC and intersects with such highways as US 278 in Hampton. Beginning in Bamberg US 601 has an overlap with US 301, then intersects US 78. Within the vicinity of Orangeburg, the overlap with US 301 ends at US 21, then it encounters Interstate 26 at Exit 145. In the vicinity of Lugoff, US 601 encounters Interstate 20 at exit 92 near then begins another short overlap with US 1 which last until Camden where that concurrency is replaced by US 521 which last slightly longer than the previous one, ending in Kershaw. The route joins SC 9 three miles west of Pageland, then leaves SC 9 when it arrives in downtown Pageland before eventually crossing the North Carolina border. North Carolina After crossing the north–South Carolina border, US 601 intersects with such highways as US 74 in Monroe, which it shares a short concurrency with until the interchange with the northern terminus of NC 207. Just as it leaves the city limits, it runs past the site of a future interchange with the Monroe Bypass. Traveling north along what is now known as "Concord Highway" it encounters another intersection with the NC 24/NC 27 overlap in Midland and later an interchange with NC 49 south of Concord. Also in Concord, it joins US 29 which it overlaps until Interstate 85 at Exit 58 and runs along the interstate until it reaches Salisbury, at exit 75, then joins a brief concurrency with US 70. In Mocksville, the road has a short concurrency with US 64 beginning at the western terminus of US 158, and after leaving that overlap encounters Interstate 40 at exit 170. Further north it has an interchange with US 421 in Yadkinville, Interstate 74 at exit 11 near White Plains, and finally terminates at US 52 in Mount Airy. History Established in 1927 as an original US Highway; the original routing was from US 1, in Cheraw, to US 17/US 76, in Florence. In 1932, US 601 was extended north into North Carolina, replacing