highway becomes concurrent with US 1 (Main Street) on the western edge of the town of Lexington. After US 1 splits southeast to head to the center of town, US 378 continues on Columbia Avenue, then has a brief concurrency with SC 6 along Lake Drive. The U.S. Highway exits the town along Sunset Boulevard. US 378 has a partial cloverleaf interchange with I-20 and a single-point urban interchange with I-26 before entering the city of West Columbia. The highway meets the northern ends of SC 35 (12th Street) and SC 12 Connector (9th Street), which provides access to westbound SC 12. East of the connector route, US 378 becomes a four-lane undivided highway. The highway has a partial interchange with SC 12 (Jarvis Klapman Boulevard) that only allows access to and from Columbia. US 378 meets US 1 (Meeting Street) and the northern end of SC 2 (State Street) just before the two U.S. Highways cross the Congaree River on the four-lane Gervais Street Bridge into Richland County and the city of Columbia. The highways follow four-lane divided Gervais Street past EdVenture and the South Carolina State Museum and intersect Huger Street, which carries US 21, US 176, and US 321. US 378 and US 1 cross over Norfolk Southern Railway's W Line and pass through the Congaree Vista neighborhood. At the intersection with SC 48 (Assembly Street), the highways pass between the South Carolina State House and Capitol Center. US 378 begins its long concurrency with US 76 when the latter highway turns onto Gervais Street from Bull Street. The three U.S. Highways cross over Norfolk Southern's Columbia District rail line before reaching Millwood Avenue, where US 1 turns north and US 378 and US 76 turn south. Gervais Street continues east as an unnumbered street several blocks through a residential area before reaching its eastern terminus. US 378 and US 76 follow Millwood Avenue, a four-lane street with center turn lane, southeast to an oblique intersection with Devine Street. Devine Street carries US 21 Connector and US 76 Connector west through Five Points and the University of South Carolina campus. The U.S. Highways continue east along Devine Street to their intersection with SC 16 (Beltline Boulevard), where the road expands to six lanes. A short distance to the east, US 378 and US 76 have an intersection with SC 760 (Fort Jackson Boulevard), which heads east toward