through the eastern shore, with U.S. 50 going generally south and U.S. 301 going generally north. The four lane divided road continues generally northeast through the rural Eastern Shore region before crossing into Delaware and becoming a freeway. Delaware US 301 in Delaware is a four-lane tolled freeway that enters the state from Maryland and heads northeast past Middletown before coming to its northern terminus at an interchange with Delaware Route 1 in Biddles Corner, south of the Senator William V. Roth Jr. Bridge over the Chesapeake & Delaware Canal in St. Georges. The new alignment opened in January 2019 and replaces the former routing that ended at U.S. Route 40 in Glasgow. History US 301 was established in 1932 as a replacement of the piece of US 17-1 north of Wilson and the whole of US 217. Thus US 301 initially ran from US 17 (now US 76) at Pee Dee, South Carolina northeast through Dillon, Lumberton, Fayetteville, Dunn, Smithfield, Wilson, Rocky Mount, and Emporia, ending at US 1 in Petersburg, Virginia. This entire route is now paralleled by Interstate 95. US 301 was at one time alternately referred to as Federal Route No. 301 early in its existence. In 1935, US 301 was extended southwest to US 15 at Summerton. This extension took it west on US 76 (formerly US 17) to Florence and south on US 52 (also formerly US 17) to Effingham. There it split to the southwest, running along what had been SC 4 via Manning to Summerton. This again runs parallel to Interstate 95. The next extension was to the north in late 1940, coinciding with the opening of the Potomac River Bridge. US 301 was extended north along US 1 from Petersburg to Richmond, then north on SR 2 to Bowling Green, and northeast on SR 207 to the bridge. In Maryland it continued along the new alignment off the bridge to Newburg, Maryland, and then replaced MD 3 all the way to US 1 in Baltimore, Maryland. In the late 1940s, US 301 was extended again, south all the way to Tampa, Florida. In South Carolina it ran along US 15 southwest to Santee, South Carolina and replaced SC 4 west to Orangeburg, South Carolina. From Orangeburg, US 301 ran southwest with US 601 to Bamberg, South Carolina, replaced SC 33 to Ulmer, South Carolina, replaced SC 508 to Allendale, South Carolina,