De Witt is part of the Great River Road in Arkansas. The designation follows AR 1 north from De Witt and US 65 south of Dermott. History US 165 was established in 1926 on a route extending from Iowa, Louisiana to McGehee, Arkansas. A proposed extension north to Corning, Arkansas in 1946 was deferred. The route was extended to its current North Little Rock terminus in 1982. The Louisiana portion was generally aligned with the existing State Route 24 south of Alexandria and State Route 14 north of Alexandria. Both had been designated in 1921 and remained co-signed with US 165 until the 1955 Louisiana Highway renumbering. US 165 replaced Arkansas Highway 11 in much of Arkansas County, Arkansas. Highway 11 was the main route through the area since its designation in the original 1926 state highway system. Some of this original pavement has been preserved by the National Register of Historic Places as Old AR 11 – Kauffman Road. Major intersections Special routes Alexandria business route U.S. Highway 165 Business (officially U.S. Highway 165-Z) is a business route of U.S. Highway 165 in and near Alexandria, Louisiana, United States. It once ran along Masonic Drive in Alexandria, but has since been truncated by other routes. It currently begins at an intersection with US 71/US 165, running concurrently with LA 1. LA 1/US 165 BUS meet, and run concurrently with, LA 28 BUS before LA 1/LA 28 split from US 165 BUS. US 165 Business then travels along Jackson Street, which is the same as its former alignment. It then crosses the Red River along the Gillis Long Bridge before meeting LA 3100. US 165 Business travels north while meeting LA 180, a former segment of the Jefferson Highway auto trail, and crossing the Pineville Expressway before ending at an intersection with its parent route. Alexandria bypass route US 165 Bypass was the original designation for the current route of US 165 through Alexandria and Pineville. Until 1961, when it was moved to the bypass, US 165 was routed along the current business route. Monroe business route Business US 165 starts a few miles south of Monroe and also becomes Jackson and Ouachita streets, going through downtown Monroe and passing by Saint Francis Medical Center and the Monroe Civic Center. It follows US 80 at Louisville Avenue, and is signed along Louisville Avenue to its terminus at US 165 (Sterlington