syncytial virus (RSV) for high-risk newborns. This was considered a breakthrough, as the clinical trial was proven to reduce infant hospitalizations by 41% and length of hospital stays by 53%. After two years the product demand began to exceed the supply of plasma and Synagis, the first humanized monoclonal antibody was approved in its place. Monoclonal antibodies became advantageous due to their decreased variability in quality, a decreased risk of bloodborne diseases, and increased potency. This enabled a large expansion of the usages of antiserum and opened the door for the treatment of autoimmune diseases. The past 30 years have seen the transformation of how chronic and autoimmune diseases (e. g. cancer, ulcerative colitis) are treated, with 30 drugs—28 of which for chronic conditions—with monoclonal antibodies being approved. Monoclonal antibodies are currently being researched to treat viral diseases without vaccines, such as HIV, SARS, and MERS. Modern use For a more complete list of monoclonal antibodies visit list of therapeutic monoclonal antibodies. Monoclonal antibodies are used to treat both acute and chronic conditions. Acute conditions may include, but are not limited to Ebola virus, envenomation (e. g. snake bites), and anthrax infection. Chronic conditions may include, but are not limited to rheumatoid arthritis, ulcerative colitis, and lupus. There are four main types of monoclonal antibodies. They are murine, chimeric, humanized, and human. Murine monoclonal antibodies are identified with the suffix "-omab". They originate from a murine animal and can trigger allergic reactions in humans. An example of a murine monoclonal antibody is Blinatumomab, which is used to treat acute lymphoblastic leukemia. Chimeric monoclonal antibodies are identified with the suffix "-ximab". They originate partially from a murine animal and partially from a human. An example of a chimeric monoclonal antibody is Infliximab, which is used to treat Crohn disease. Humanized monoclonal antibodies are identified with the suffix "-zumab". They mostly originate from a human but differ in the component that attaches to its target. An example of a humanized monoclonal antibody is Crizanlizumab, which treats sickle cell disease. Human monoclonal antibodies are identified with the suffix "-umab". They originate from a human. An example of a human monoclonal antibody is Ustekinumab, which treats psoriasis. During the early stages of the COVID-19 pandemic, reliable treatment options had not yet been found or approved. In reaction, convalescent blood plasma was considered as a possibility and is used as a treatment option at least