influence or predict the incidence of outcome or disease”. Biomarker has to be quantifiable up-to certain level in biological process in well-being. One specific example of biomarker is blood cholesterol that is commonly acquainted with us reliable for coronary heart disease; another biomarker is PSA (Prostate-Specific Antigen) and has been contributing to prostate cancer. There are a lot of biomarkers are considering as being cancer: Hepatitis C virus ribonucleic acid (HCV-RNA), International Normalized Ratio (INR), Prothrombin Time (PT), Monoclonal Protein (M protein), Cancer Antigen-125 (CA-125), Human Immunodeficiency Virus -Ribonucleic Acid (HIV RNA), B-type Natriuretic Peptide (BNP).27and Lymphoma cell (Ramos cell lines and Jurkat cell lines) a form of cancer. Other common biomarkers are breast cancer, Ovarian cancer, Colorectal cancer, Lung cancer and brain tumor. This disease-causing verdict agent is the biomarker is existing extremely trace amount especially initial state of the disease. Therefore, identifying or getting images of biomarker is tricky and, in few circumstances, uncertain by NMR tech. Hence, we must use the contrasting agent to enhance the images at least to visualize level to Physicians. As molecules of biomarker is less abundant in vivo system. The NMR or MRI experiment provides a very small signal even in some cases, the analyzer can miss the signal peak in data due to the lack in abundance of biomarkers. Therefore, to make sure, to reach the true conclusion about the existence of trouble-causing biomarkers, we need to enhance the probe (contrasting mechanisms) to get the clear peak at the most visible level of peak height as well as the position of the peak in data. If it is possible to gather the acceptable and clearly interpretable data from NMR or MRI experiment by using the contrasting agent, then experts can take a right initial step to recover the patients who already have been suffering from cancer. Among the various technique to get the enhanced data in MRI experiment, SEOP is one of them. Researchers in SEOP are interested to use the 129Xe. Because 129Xe has a number of favorable facts in NMR Tech. for working as a contrasting agent even over the other novel gases: Inert xenon does not show chemical reaction like other metals and non-metals because Xenon's electronic configuration is fully occupied as well as it is not radioactive also. To get the solid, liquid state from naturally occurring gaseous state is easy going (figure-8). The solid and liquid