through agricultural areas and crosses into Maxatawny Township, where it comes to a southbound exit and northbound entrance at Crystal Cave Road that provides access to Crystal Cave and the community of Virginville. From here, the route heads through more rural land before it passes through a section of Kutztown and runs near residential areas and farmland north of the Kutztown University of Pennsylvania campus. US 222 crosses back into Maxatawny Township and curves east, passing over the Sacony Creek and coming to a partial cloverleaf interchange with the southern terminus of PA 737 that provides access to Kutztown. The freeway crosses back into Kutztown and passes near homes before it reenters Maxatawny Township and the Kutztown Bypass ends at a southbound exit and northbound entrance with Kutztown Road that serves the borough. From here, US 222 becomes two-lane undivided Kutztown Road and runs east-northeast through farmland before heading past businesses near the Long Lane intersection. The route gains a center left-turn lane and passes through the residential community of Monterey before it continues through agricultural areas. Farther east, the road heads into the community of Maxatawny, where it is lined with homes and a few businesses. US 222 enters Upper Macungie Township in Lehigh County, which is in the Lehigh Valley, and becomes two-lane undivided Hamilton Boulevard, passing through farmland with some businesses and coming to a roundabout with the southern terminus of PA 863, Schantz Road, and Farmington Road. The route gains a center left-turn lane and continues east through farm fields with some homes and businesses, heading to the south of an office park. Residential and commercial development along the road increases as it passes to the north of the community of Breinigsville. A bit further east, US 222 diverges from Hamilton Boulevard at a northbound exit and southbound entrance onto a four-lane divided expressway called the Frederick J. Jaindl Jr. Memorial Highway, immediately reaching a partial interchange with the PA 100 bypass of the community of Trexlertown. Here, Hamilton Boulevard continues east into Trexlertown, northbound US 222 merges with northbound PA 100, and southbound US 222 splits from southbound PA 100. All other connections between PA 100 and US 222 are provided by Hamilton Boulevard and Weilers Road. US 222 and PA 100 continue north concurrent along the expressway, passing near homes and intersecting Grim Road/Cetronia Road at-grade. The road curves northeast and runs between warehouses