US 25. US 301 enters Georgia from Florida concurrent with US 1/US 23, also designated as SR 4/SR 15, on a bridge over the St. Marys River. In Folkston, SR 23/SR 121 join. US 1/US 23/SR 4/SR 15/SR 121 split to the northwest at a junction north of Folkston, leaving only US 301 and SR 23 to head north across US 82/SR 520 at Nahunta to Jesup. At Jesup, US 301 crosses US 341/SR 27, where US 25 turns from US 341 onto US 301, and then merges with US 84/SR 38. The combined routes (US 25/US 84/US 301/SR 23/SR 38) cross the Altamaha River to the junction with SR 57 in Ludowici. There US 84 and SR 38 continue northeast, while US 25/US 301/SR 23 turn northwest with SR 57. SR 23 and SR 57 split off to the northwest at Glennville. SR 73 begins there, taking US 25 and US 301 north from Glenville across US 280/SR 30 at Claxton and I-16/SR 404 to Statesboro. US 25 and US 301 meet US 80/SR 26 and SR 67 in Statesboro. SR 67 joins south of the US 80/SR 26 crossing and then turns west with US 80/SR 26, as does US 25; US 25 and SR 67 split from US 80/SR 26 about to the west. US 301 and SR 73 continue north from Statesboro through Sylvania to the Savannah River and the border with South Carolina. South Carolina US 301 enters South Carolina over the Savannah River southwest of Allendale. Concurrencies include U.S. 321 in and around Ulmer, U.S. 601 between Bamberg and Orangeburg, then I-95/U.S. 15 Santee, at Exit 97 before all three move across Lake Marion. The U.S. 15-301 multiplex leaves I-95 at Exit 102, running in close proximity to I-95, but U.S. 15 breaks away at Summerton. Other concurrencies include U.S. 521 in Manning, U.S. 52 between Effingham and just south of Florence, U.S. 76 eastbound from east of Florence until Pee Dee, and finally joins U.S. 501 in Latta, where they both approach the South of the Border roadside attraction complex at the interchange with I-95 on the North Carolina-South Carolina border. North Carolina US 301-501 enters North Carolina at the interchange with I-95 where it passes the South of the Border roadside attraction complex, then closely parallels by I-95 throughout North Carolina. Concurrencies include US 501 between Latta (South Carolina) and Rowland, I-95