from US 30 at a trumpet interchange and heads north onto a four-lane freeway. The route curves northeast and runs through a mix of farmland and residential and commercial development. The freeway comes to a northbound exit and entrance with Butter Road, which provides access to PA 272 via Jake Landis Road, and a southbound exit and entrance with PA 272. Past this interchange, US 222 continues through a mix of farm fields and woodland, passing through a corner of Warwick Township before crossing the Cocalico Creek into West Earl Township. The route passes near farmland before heading near homes and businesses, reaching a partial cloverleaf interchange with PA 772 north of the community of Brownstown. Past here, the freeway runs northeast through agricultural areas. Farther along, US 222 curves to the north and comes to a diverging diamond interchange with US 322 southeast of the borough of Ephrata, at which point it crosses into Ephrata Township. The route passes near businesses at the interchange before it turns northeast and runs through wooded areas with some nearby residential development and farm fields. The freeway heads into East Cocalico Township and runs through more woodland before it passes to the southeast of the community of Reamstown. US 222 passes through farmland and comes to a diamond interchange with Colonel Howard Boulevard, which heads west to provide access to PA 272 and east to provide access to the Pennsylvania Turnpike (I-76). Following this, the route passes over the Pennsylvania Turnpike and crosses into Brecknock Township, running through a mix of farm fields and woods with some nearby residential and commercial development as it passes to the southeast of the borough of Adamstown. The US 222 freeway enters Brecknock Township in Berks County and continues north, passing a northbound weigh station before coming to a partial cloverleaf interchange serving the northern terminus of PA 272 and the western terminus of PA 568. Past this interchange, the route crosses into Spring Township and runs through wooded areas with some fields and homes, curving to the northeast and reaching a diamond interchange at Mohns Hill Road to the west of the community of Gouglersville. Here, the freeway crosses into Cumru Township and runs north-northeast through more rural areas, coming to a diamond interchange that connects to Grings Hill Road west of the borough of Mohnton. Reading to Allentown A short distance later, US 222 comes