Business and US 460 Business head straight on Campbell Avenue while US 501 joins the freeway heading southwest. Lynchburg to Buena Vista US 501 runs concurrently with US 29 and US 460 southwest along the northern slope of Candlers Mountain to a full Y interchange where US 501 heads northwest from the freeway. The U.S. Highway has an intersection with SR 128 (Mayflower Drive) and Candlers Mountain Road just east of the highway's crossing of Norfolk Southern's Danville District. SR 128 joins US 501 on Candlers Mountain Road between the intersection and the highway's cloverleaf interchange with US 29 Business (Lynchburg Expressway). US 501 exits onto the expressway while SR 128 continues west to its terminus. US 501 and US 29 Business head southwest along the freeway until the business route exits onto Wards Road to head toward Danville. US 501 curves northwest and has a cloverleaf interchange with US 460 Business (Timberlake Road), crosses Norfolk Southern's Blue Ridge District, and has a diamond interchange with Graves Mill Road. The freeway ends at US 221 (Lakeside Drive). US 501 heads north along Old Forest Road as a five-lane road with center turn lane before turning onto a two-lane segment of the Lynchburg Expressway. This segment has a partial cloverleaf interchange with Wiggington Road before ending at US 501 Business (Boonsboro Road). US 501 heads northwest on two-lane Boonsboro Road, which becomes Lee Jackson Highway when it exits the city of Lynchburg into Bedford County. The U.S. Highway curvaceously crosses Fleming Mountain and descends into the James River Gorge at Coleman Falls. US 501 follows the south bank of the river through Big Island, where the highway meets the northern end of SR 122 (Big Island Highway) and has an interchange with the Blue Ridge Parkway. North of Big Island, the U.S. Highway crosses the river and immediately intersects SR 130 (Elon Road) on the Amherst County side. The two highways have a curvaceous crossing of the spine of the Blue Ridge Mountains before descending to the town of Glasgow at the mouth of the Maury River. The two routes follow the river upstream a short distance before SR 130 (Wert Faulkner Highway) crosses the river into the town. US 501, now named Glasgow Highway, parallels the river and Norfolk Southern's Roanoke District rail line north to the city of Buena Vista, which the highway enters as Magnolia Avenue. South of