U.S. Route 221 (US 221) is a spur of U.S. Route 21. It travels from Perry, Florida, at US 19/US 98/US 27 Alternate to Lynchburg, Virginia, at US 29 Business (Lynchburg Expressway). It travels through the states of Florida, Georgia, South Carolina, North Carolina, and Virginia. It travels through the cities of Valdosta, Georgia; Spartanburg, South Carolina; Marion, North Carolina; Roanoke, Virginia; and Lynchburg, Virginia. Throughout western North Carolina, from the Virginia state line to the Blue Ridge Parkway, US 221 is a challenging drive, and can be described as one climb after another. In some places, the route skirts around large foothills. Route description Florida U.S. Route 221 originates just south of the city of Perry, with its southern terminus intersecting with the cosigned U.S. Route 19 U.S. Route 98 and U.S. Route 27 Alternate, taking hidden SR 55 with it away from US 19. It continues through the city of Perry and intersects Interstate 10 and U.S. Route 90 in rural Madison County before crossing into Georgia. Georgia U.S. Route 221 runs through the cities of Quitman, Valdosta, Lakeland, Pearson, and Douglas in southern Georgia. In Quitman, it joins U.S. Route 84 (cosigned Georgia State Route 38) to Valdosta. From Valdosta to Douglas, it joins with Georgia State Route 31. It also joins with Georgia State Route 135 and State Route 56. From Pearson to Douglas, it joins with U.S. Route 441 as a four-lane highway, which was completed in 2000. In Douglas, U.S. Route 221 runs as the eastern part of Bowens Mill Rd. and will be widened in the future. It passes through Hazelhurst, Mount Vernon and Soperton before crossing Interstate 16, then later joins up with U.S. Route 1 and Georgia State Route 4 after passing through Louisville. After going through Wrens, it splits off to the north, cosigned with Georgia State Route 47 and passes through Harlem before crossing Interstate 20 /Georgia State Route 402 approximately 20 miles west of Augusta. Shortly before crossing into South Carolina, Georgia State Route 150 merges with Route 221 at the Pollards Corner intersection as Georgia 47 turns away. The passage into South Carolina takes place on top of the J. Strom Thurmond Dam, which forms the southern shore of J. Strom Thurmond Lake. South Carolina U.S. Route 221 enters South Carolina in rural McCormick County at the southeastern edge of Lake Strom Thurmond. It continues north and