U.S. Route 322 (US 322) is a long, east–west United States Highway, traversing Ohio, Pennsylvania, and New Jersey. The road is a spur of US 22 and one of the original highways from 1926. A portion of it at one time was concurrent with the Lakes-to-Sea Highway. Route description |- |OH |62 |99 |- |PA |370 |595 |- |NJ |62 |99 |} Ohio US 322 begins at the intersection of Superior Avenue and East Roadway at Public Square in Downtown Cleveland, just northeast of the junction of U.S. Routes US 6, US 42, and State Route 3 (Superior Avenue) with US 422 and State Route 8, State Route 14, State Route 43, and State Route 87 (Ontario Street). East of Public Square, the route runs eastward through midtown Cleveland conjoined with US 6 along Superior Avenue. Northwest of Cleveland State University, US 322 turns south onto 13th Street and runs eastward (as Chester Avenue) through Playhouse Square. Exiting the commercial district, US 322 interchanges Interstate 90, at exit 173. In University Circle, US 322 is briefly concurrent with U.S. Route 20 (Euclid Avenue). The overlap terminates at the eastern edge of University Circle, where US 322 splits off to the south by southwest, becoming Mayfield Road as it enters Little Italy, and through the eastern suburbs of Cleveland Heights, South Euclid, Lyndhurst, Mayfield Heights, and Gates Mills, continuing on as Mayfield until the Geauga County/Ashtabula County line. In Geauga County, US 322 passes through suburban Chester Township and into Ohio's second largest Amish community, which includes the rural townships of Claridon, Huntsburg, Windsor Township and the west side of Orwell Township. In Ashtabula County, US 322 crosses through Windsor Township, Orwell Township, the village of Orwell, Colebrook Township, Wayne Township and Williamsfield Township before crossing the Ohio-Pennsylvania state line south of Pymatuning Reservoir. Pennsylvania US 322 enters Pennsylvania from Ohio in West Shenango Township. From this point, the road continues east, forming a concurrency with U.S. Route 6 between Conneaut Lake and Meadville, interchanging with Interstate 79 and intersecting U.S. Route 19 in Meadville. In Franklin, the route crosses U.S. Route 62. Continuing east, US 322 interchanges with Interstate 80 near Clarion before meeting U.S. Route 119 and U.S. Route 219 south of DuBois. US 322 heads southeast as a surface road before merging onto the Interstate 99/U.S. Route 220 freeway in Port Matilda, following that east to State College.