222 in Perryville north to MD 276 in Woodlawn. US 222 Truck continued north on MD 276 from Woodlawn north to US 1 west of Rising Sun. The truck route then headed west on US 1 to US 222 in Conowingo. US 222 Truck was downgraded to MD 222 Truck when US 222 became MD 222 between Perryville and Conowingo. Reading business loop U.S. Route 222 Business (US 222 Bus.) is a business route of US 222 located in Reading, Pennsylvania. The southern terminus is at US 222 in Cumru Township. Its northern terminus is at US 222 in Ontelaunee Township. The route begins at the US 222 freeway and heads through the southwestern suburbs of Reading as Lancaster Avenue, intersecting PA 724 in Shillington. US 222 Bus. continues into Reading on Lancaster Avenue and intersects the northern termini of PA 625 and PA 10 before reaching an interchange with the US 422 freeway. The business route crosses the Schuylkill River and becomes Bingaman Street. US 222 Bus. turns north on 5th Street and intersects US 422 Bus. in downtown Reading and the southern terminus of PA 61 to the north of downtown. The route interchanges with the PA 12 freeway and continues north through suburban Muhlenberg Township as 5th Street Highway. US 222 Bus. reaches Temple and continues northeast to its northern terminus as Allentown Pike. US 222 Bus. is the only auxiliary route of US 222 in Pennsylvania. With the creation of the U.S. Highway System in 1926, the road between Reading and Lancaster was designated US 222 while the road between Reading and Allentown was part of US 22, which ran along what was designated the William Penn Highway in 1916 and PA 3 in 1924. In the late 1920s, US 222 briefly ran concurrent with PA 41 and PA 240 at different times. PA 42 originally ran north–south through Reading starting in 1927. By 1930, the concurrent state route designations were removed from US 222 and US 22. US 222 entered Reading along with PA 73 along Lancaster Avenue and Bingaman Street before turning north on 9th Street along with PA 83 to end at US 22 and US 422 at Penn Street. US 22 continued north on 9th Street out of Reading and continued along Kutztown Road through Temple toward Allentown. US 120 began at US 222 at Bingaman Street and headed north on 4th