and SR 22 head north and west on Mineral Avenue toward the county seat of Louisa; US 522 and SR 208 turn east onto First Street, intersect the rail line at grade, and turn north onto Louisa Avenue. US 522 and SR 208 follow Zachary Taylor Highway away from Mineral. North of Contrary Creek, the two routes diverge at Wares Crossroads. SR 208 splits east onto New Bridge Road toward Spotsylvania Courthouse, and US 522 continues northwest along the presidential-named highway. The U.S. Highway crosses the mainstem of Lake Anna, the North Anna River, to cross the western corner of Spotsylvania County. US 522 crosses Pamunkey Creek as it enters Orange County. After leaving the Lake Anna area, the U.S. Highway heads straight north to Unionville, where the route intersects SR 20 (Constitution Highway). US 522 crosses Mill Run and Mountain Run and follows Raccoon Branch as the route curves northwest and crosses the Rapidan River into Culpeper County. At Winston, US 522 curves northeast and joins Rapidan Road on a tangent and begins to parallel Norfolk Southern Railway's Washington District rail line. The U.S. Highway veers away from the rail line, crosses Sumerduck Creek, and expands to a four-lane divided highway as passes the National Audio-Visual Conservation Center and approaches Germanna Highway, which carries SR 3, southeast of Culpeper. Culpeper to Front Royal US 522 and SR 3 head northwest along four-lane divided Germanna Highway. The highways meet US 15 and US 29 (James Madison Highway) at a diamond interchange and enter the town of Culpeper, where the divided highway narrows to a two-lane road and crosses over the Norfolk Southern rail line. SR 3 has its western terminus at Orange Road, which heads south carrying US 15 Bus.; US 15 Bus. joins US 522 on Germanna Highway west one block to US 29 Bus., where US 522 and US 15 Bus. turn north and join US 29 Bus. on Main Street. The three highways pass by the historic Burgandine House, at Main Street's oblique intersection with Orange Road, and to the west of the South East Street Historic District, which contains the Hill Mansion and Culpeper National Cemetery. The U.S. Highway and the two business routes continue through the Culpeper Historic District, where they pass the Pitts Theatre, the A. P. Hill Boyhood Home, and the Lord Culpeper Hotel and pass to the west of the Culpeper railroad