route in Maryland. US 340 contains several segments that are part of the National Highway System. The U.S. highway is part of the main system from Virginia State Route 7 (SR 7) near Berryville to its northern terminus in Frederick. US 340 is a National Highway System principal arterial from I-64 to its eastern junction with US 250 in Waynesboro, along its US 211 concurrency near Luray, and from US 522 to I-66 in Front Royal. The U.S. Highway's other junctions with highways part of the National Highway System include US 33 in Elkton, West Virginia Route 9 (WV 9) in Charles Town, and Maryland Route 180 (MD 180) in Knoxville as part of an intermodal connection to Brunswick station. Greenville to Elkton US 340 begins at an intersection with US 11 (Lee Highway) on the northern edge of Greenville and just east of US 11's interchange with I-64 and I-81 in southern Augusta County. The U.S. Highway heads northeast as two-lane Stuarts Draft Highway, which crosses several branches of Christians Creek and then Christians Creek itself. US 340 expands to a five-lane road with center turn lane west of the village of Stuarts Draft. The highway passes the historic Harper House then expands to divided highway. US 340 passes through the hamlet of Ladd before leaving Augusta County and entering the independent city of Waynesboro at its partial cloverleaf interchange with I-64. The highway follows Rosser Avenue northeast, crosses Pratts Run, and reduces to two lanes as the route approaches the west end of downtown, where the route meets US 250. Both highways must turn off to stay on the route: US 250 heads west on Main Street and, via the north leg of the four-legged intersection, east on four-lane Broad Street, and US 340 turns east onto two-lane Main Street. US 340 meets the eastern end of SR 254 (Poplar Avenue) and passes by Waynesboro High School, the Fishburne Military School, and the historic Plumb House and Coiner-Quesenbery House in the Waynesboro Downtown Historic District. The U.S. Highway crosses the South River and intersects US 250 at the east end of Broad Street. The two highways run concurrently east along four-lane Main Street and under Norfolk Southern Railway's Roanoke District rail line to Delphine Avenue, onto which US 340 turns north. The five-lane street with center turn lane passes through the Basic City portion of Waynesboro, where the