West Virginia; I-68, I-70, and US 40 in Hancock during its streak across Maryland; and US 30 in McConnellsburg and US 22 and US 322 in Lewistown during its route through Pennsylvania. Powhatan to Culpeper US 522 begins at a four-legged intersection with US 60 (Anderson Highway) on the western edge of the unincorporated village of Powhatan, the county seat of Powhatan County. The roadway continues on the south side of the intersection as SR 1002 (Emmanuel Church Road), which passes the eponymous church before it connects with SR 13. US 522 heads north as Maidens Road, which heads through the community of Jefferson, the site of the historic home Elmington. North of Michaux, the highway meets the east end of SR 313 (Beaumont Road), which leads to the Beaumont Learning Center, before it crosses the William Walthall Michaux Bridge over the James River into Goochland County. US 522 crosses over CSX's James River Subdivision rail line and joins SR 6 (River Road) at Maidens. The two highways meet the east end of SR 329, which leads to the Virginia Correctional Center for Women, opposite the historic home Brightly. US 522 and SR 6 continue through Goochland, where the highways pass the Goochland County Court Square. The highways meet the west end of SR 396 (Dickenson Road), which leads to the Goochland campus of J. Sargeant Reynolds Community College, before the two highways diverge at the north end of the county seat. US 522 continues north on Sandy Hook Road, which passes through the eponymous hamlet before entering Louisa County at the village of Gum Spring. There, the U.S. Highway intersects US 250 (Broad Street Road) and has a diamond interchange with I-64. US 522 continues on Cross County Road, which passes through Shelfar and Orchid and crosses the South Anna River at Southanna. The route continues through Apple Grove to Cuckoo, where the highway joins US 33 (Jefferson Highway) in front of the eponymous historic estate. After a brief concurrency with US 33, US 522 splits north onto Pendleton Road through Pendleton, where the highway parallels CSX's Piedmont Subdivision rail line into the town of Mineral, where the route follows Mineral Avenue and passes through its namesake historic district. At the intersection of Mineral Avenue and First Street, US 522 meets SR 208 and SR 22, the latter of which has its eastern terminus at the intersection. SR 208