US 421 intersects and merges with I-74 west, through the Shelbyville area en route to Indianapolis. Originally, US 421 followed Southeastern Avenue into downtown Indianapolis, where it merged with US 40 (Washington Street) to West Street, then turned north, following West Street, Northwestern Avenue (later MLK Street), and Michigan Road up to the northwest side of the city. US 421 went past the Pyramids, an Indianapolis landmark. North of Indianapolis, US 421 continues to the north-northwest, providing a direct highway link between Indianapolis and Michigan City. US 421 ends at its junction with US 20 on the south side of Michigan City. Originally, the highway's end was a few miles north at the junction with US 12 near the shores of Lake Michigan. History North Carolina US 421 mainly followed the same route between Clinton and Wilmington. However, there are several old alignments from Clinton to the Tennessee state line. US 421 bypasses Clinton, old alignment uses local streets. Between Dunn and Sanford, uses an old alignment, fully connected. Between Goldston and Greensboro, uses several old alignments but not fully connected. Between Greensboro and Wilkesboro, uses multiple old alignments of different alignments. In *addition, they are no longer connected consistently. US 421 bypasses Wilkesboro, with a special US Business route. Between Deep Gap and Boone, uses a new alignment. Between Vilas and the Tennessee state line, uses an old alignment. Future US 421 is projected to be upgraded to a freeway in Indiana from Greensburg to Versailles. US 421 freeway will go near, or pass through Napoleon and Osgood. Major intersections North Carolina Parking area in Federal Point in Wilmington in Wilmington. The highways travel concurrently to Eagle Island. on Eagle Island. US 17/US 421 travels concurrently to west of Wrightsboro. US 74/US 421 travels concurrently to southwest of Hightsville. west of Wrightsboro south-southeast of Clinton. The highways travel concurrently to Clinton. in Spivey's Corner in Dunn in Dunn in Lillington. The highways travel concurrently through Lillington. in Sanford in Siler City in Greensboro. The highways travel concurrently to south-southwest of Greensboro. south of Greensboro. I-73/US 421 travels concurrently to Greensboro. south-southwest of Greensboro in Greensboro. I-40/US 421 travels concurrently to west of Greensboro. in Winston-Salem. The highways travel concurrently through Winston-Salem. in Winston-Salem in Winston-Salem in Yadkinville in Brooks Crossroads west-northwest of Hamptonville north-northeast of Deep Gap. The highways travel concurrently to Boone. in Boone. The highways travel concurrently