crossing eastbound PA 23 at Chestnut Street and westbound PA 23/PA 462 at Walnut Street. The two routes leave the downtown area and run through urban areas of homes and businesses. The northbound direction passes to the east of Lancaster General Hospital between East James and East Frederick streets while the southbound direction passes to the east of Clipper Magazine Stadium, home of the Lancaster Barnstormers baseball team, north of the Harrisburg Avenue/West James Street intersection. At the intersection with Liberty Street, northbound US 222/PA 272 shifts west a block onto four-lane undivided North Duke Street, a two-way road, while the one-way pair continues into Manheim Township. A block later, at McGovern Avenue, both directions of US 222/PA 272 rejoin along North Duke Street. Southbound US 222/PA 272 follows McGovern Avenue west between North Duke Street and North Prince Street, forming the border between a portion of the city of Lancaster that is home to the Lancaster station along Amtrak's Keystone Corridor railroad line to the north and Manheim Township to the south. The roadway is a three-lane road with two westbound lanes that carry southbound US 222/PA 272 and one eastbound lane. McGovern Avenue reaches an intersection with northbound PA 72 at North Queen Street, where northbound PA 72 turns west to join southbound US 222/PA 272 along the road. At North Prince Street, southbound US 222/PA 272 turn south while PA 72 becomes two-way heading north. Both directions of US 222/PA 272 continue north along four-lane undivided North Duke Street and the road reaches the Thaddeus Stevens Bridge over Amtrak's Keystone Corridor, where it becomes the border between Manheim Township to the west and Lancaster to the east. At Keller Avenue, the road name changes to Lititz Pike and it fully enters Manheim Township, running through commercial areas as a five-lane road with a center left-turn lane. Northbound US 222 and PA 272 head northeast onto Oregon Pike, with PA 272 becoming signed again, while southbound US 222 and PA 501 continue north along Lititz Pike. The two routes continue northeast as a three-lane road with a center left-turn lane and runs past businesses and a few homes before it comes to an interchange with the US 30 freeway. Here, US 222 splits from PA 272, which becomes signed again, by heading east concurrent with US 30 on an eight-lane freeway, passing near developed areas. US 222 splits