U.S. Route 222 (US 222) is a U.S. Highway that is a spur of US 22 in the states of Maryland and Pennsylvania. It runs for from US 1 in Conowingo, Maryland, north to Interstate 78 (I-78)/Pennsylvania Route 309 (PA 309) in Dorneyville, Pennsylvania. US 222 is almost entirely in Pennsylvania, and serves as the state's principal artery between the Lancaster and Reading areas and the Lehigh Valley. US 222 heads north from US 1 in Conowingo and soon crosses from Maryland into Pennsylvania, continuing north through rural areas and passing through Quarryville and Willow Street before reaching Lancaster. The route passes through Lancaster on a one-way pair of city streets before becoming a freeway at US 30 north of the city. The US 222 freeway heads northeast, crossing US 322 in Ephrata and coming to an interchange with the Pennsylvania Turnpike (I-76). US 222 bypasses Reading to the west, where it forms a concurrency with US 422. The freeway section ends past Reading and the route continues northeast through rural areas, with a freeway bypass of Kutztown. US 222 bypasses Trexlertown on a multilane divided expressway before coming to its northern terminus at I-78/PA 309 in Dorneyville, where the road continues into Allentown as PA 222. Route description Conowingo to Lancaster US 222 begins at an intersection with US 1 in the community of Conowingo in Cecil County, Maryland. Following US 1 southwest to the Conowingo Dam across the Susquehanna River leads to the northern terminus of MD 222. From this intersection, the route heads northwest on two-lane undivided Rock Springs Road, passing through a mix of fields and woods with some homes. The road curves to the north through woodland and passes east of the community of Oakwood. US 222 turns to the northeast and runs through fields and woods with some development, passing to the southeast of the Rock Springs Generation Facility in the community of Rock Springs before it comes to the Mason–Dixon line, which marks the border between the states of Maryland and Pennsylvania. Upon crossing the Mason–Dixon line, US 222 enters Fulton Township in Lancaster County, Pennsylvania, and heads north as Robert Fulton Highway, passing between woodland to the west and farm fields to the east. The route turns to the north-northwest and runs through agricultural areas with some trees and homes, passing through the community of New Texas Lyles. The road continues through