no significant effect on dopamine receptors (unlike LSD) and only affects the noradrenergic system at very high dosages. Psilocin's half-life ranges from 1 to 3 hours. Behavioral and non-behavioral effects Its physiological effects are similar to a sympathetic arousal state. Specific effects observed after ingestion can include but are not limited to tachycardia, dilated pupils, restlessness or arousal, euphoria, open and closed eye visuals (common at medium to high doses), synesthesia (e.g. hearing colours and seeing sounds), increased body temperature, headache, sweating and chills, and nausea. Psilocin acts as a 5-HT2A, 5-HT2C, and 5-HT1A receptor agonist or partial agonist. Such receptors are claimed to significantly regulate visuals, decision making, mood, decreased blood pressure, and heart rate. There is virtually no direct lethality associated with psilocin. There is virtually no withdrawal syndrome when chronic use of this drug is ceased. There is cross tolerance among psilocin, mescaline, LSD, and other 5-HT2A, 5-HT2C, and 5-HT1A agonists due to down-regulation of these receptors. Legal status The United Nations Convention on Psychotropic Substances (adopted in 1971) requires its members to prohibit psilocybin, and parties to the treaty are required to restrict the use of the drug to medical and scientific research under strictly controlled conditions. Australia Psilocin is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard (October 2015). A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities. Russia Psilocin and psilocybin are banned in Russia as narcotic drugs with a criminal penalty for possession of at least 50 mg. See also O-4310 O-Acetylpsilocin Indole Metocin Miprocin Psilocybin Psychoactive drug Tryptamine References External links 4-HO-DMT entry in TiHKAL Dimethylamino compounds Entheogens Hydroxyarenes Mycotoxins Psilocybin Psychedelic drugs Psychedelic tryptamines Serotonin receptor agonists Tryptamine alkaloids