into West Lampeter Township. The road heads north through farmland and bends northwest to reach an intersection with PA 741. Here, PA 741 becomes concurrent with US 222 and the two routes curve to the west-southwest, passing between farm fields to the north and residential and commercial development to the south and heading into the community of Willow Street. Here, the road comes to an intersection with PA 272, which is split into a one-way pair at this point. At this point, US 222 splits from PA 741 by turning north to join PA 272 along Willow Street Pike, a one-way pair which carries two lanes in each direction. PA 272 becomes unsigned along the US 222 concurrency. Both directions of Willow Street Pike rejoin and it continues north as a two-lane undivided road past commercial development before it runs through wooded residential areas, passing through Hollinger. US 222/PA 272 crosses Mill Creek and heads through the community of Lyndon. The road briefly gains a center left-turn lane as it continues through wooded areas of development and passes to the west of a golf course. US 222/PA 272 splits into a one-way pair, with two lanes in each direction, and crosses the Conestoga River into Lancaster Township. Lancaster to Reading After crossing the Conestoga River, northbound US 222/PA 272 becomes Highland Avenue and southbound US 222/PA 272 is called South Prince Street. The southbound direction intersects PA 324 in the community of Engleside before the two routes continue into the city of Lancaster, heading into urban residential and commercial areas. A short distance after entering Lancaster, northbound US 222/PA 272 intersects the end of one-way northbound PA 324 and heads onto South Queen Street. The two routes continues past urban rowhomes along South Queen Street northbound and South Prince Street southbound, with South Queen Street passing to the west of Woodward Hill Cemetery. Northbound US 222/PA 272 splits from South Queen Street by heading northeast onto Church Street, which carries three lanes of one-way traffic, while northbound PA 72 starts along South Queen Street. Just south of downtown Lancaster, the northbound direction of the route turns north onto South Lime Street, which carries two lanes of one-way traffic. US 222/PA 272 heads into the commercial downtown of Lancaster and crosses eastbound PA 462 at King Street. Past this, the route becomes North Lime Street northbound and North Prince Street southbound,