nails, skin flaking, and other biological wastes in missions exceeding one week in length. Other environmental considerations such as radiation, gravity, noise, vibration, and lighting also factor into human physiological response in outer space, though not with the more immediate effect that the metabolic parameters have. Atmosphere Outer space life-support systems maintain atmospheres composed, at a minimum, of oxygen, water vapor and carbon dioxide. The partial pressure of each component gas adds to the overall barometric pressure. However, the elimination of diluent gases substantially increases fire risks, especially in ground operations when for structural reasons the total cabin pressure must exceed the external atmospheric pressure; see Apollo 1. Furthermore, oxygen toxicity becomes a factor at high oxygen concentrations. For this reason, most modern crewed spacecraft use conventional air (nitrogen/oxygen) atmospheres and use pure oxygen only in pressure suits during extravehicular activity where acceptable suit flexibility mandates the lowest inflation pressure possible. Water Water is consumed by crew members for drinking, cleaning activities, EVA thermal control, and emergency uses. It must be stored, used, and reclaimed (from waste water) efficiently since no on-site sources currently exist for the environments reached in the course of human space exploration. Future lunar missions may utilize water sourced from polar ices; Mars missions may utilize water from the atmosphere or ice deposits. Food All space missions to date have used supplied food. Life-support systems could include a plant cultivation system which allows food to be grown within buildings or vessels. This would also regenerate water and oxygen. However, no such system has flown in outer space as yet. Such a system could be designed so that it reuses most (otherwise lost) nutrients. This is done, for example, by composting toilets which reintegrate waste material (excrement) back into the system, allowing the nutrients to be taken up by the food crops. The food coming from the crops is then consumed again by the system's users and the cycle continues. The logistics and area requirements involved however have been prohibitive in implementing such a system to date. Gravity Depending on the length of the mission, astronauts may need artificial gravity to reduce the effects of space adaptation syndrome, body fluid redistribution, and loss of bone and muscle mass. Two methods of generating artificial weight in outer space exist. Linear acceleration If a spacecraft's engines could produce thrust continuously on the outbound trip with a thrust level equal