San Diego ( , ; ) is a city on the Pacific Ocean coast of Southern California located immediately adjacent to the Mexico–United States border. With a 2020 population of 1,386,932, it is the eighth most populous city in the United States and the seat of San Diego County, the fifth most populous county in the United States, with 3,286,069 estimated residents as of 2021. The city is known for its mild year-round Mediterranean climate, natural deep-water harbor, extensive beaches and parks, long association with the United States Navy, and recent emergence as a healthcare and biotechnology development center. San Diego is the second largest city in the state of California after Los Angeles. Historically home to the Kumeyaay Native Americans, San Diego has been referred to as the Birthplace of California, since it was the first site visited and settled by Europeans on what is now the U.S. west coast. Upon landing in San Diego Bay in 1542, Juan Rodríguez Cabrillo claimed the area for Spain, forming the basis for the settlement of Alta California 200 years later. The Presidio and Mission San Diego de Alcalá, founded in 1769, formed the first European settlement in what is now California. In 1821, San Diego became part of the newly declared Mexican Empire, which reformed as the First Mexican Republic two years later. California became part of the U.S. in 1848 following the Mexican–American War and was admitted to the union as a state in 1850. San Diego's main economic engines are military and defense-related activities, tourism, international trade, research, and manufacturing. The city is the economic center of the San Diego–Tijuana conurbation, the second-most populous transborder metropolitan area in the Western Hemisphere (after Detroit–Windsor), home to an estimated 4,922,723 people as of 2012. The primary border crossing between San Diego and Tijuana, the San Ysidro Port of Entry, is the busiest international land border crossing in the world outside of Asia (fourth-busiest overall). The city's airport, San Diego International Airport, is the busiest single-runway airport in the world. History Pre-colonial period What has been referred to as the San Dieguito complex was established in the area at least 9,000 years ago. The Kumeyaay may have culturally evolved from this complex or migrated into the area around 1000 C.E. Archaeologist Malcolm Rogers hypothesized that the early cultures of San Diego were separate from the Kumeyaay, yet this claim is disputed, with