diastereoisomer that has the opposite configuration at only one of the stereocenters. Le Bel-van't Hoff rule Le Bel-van't Hoff rule states that for a structure with n asymmetric carbon atoms, there is a maximum of 2n different stereoisomers possible. As an example, D-glucose is an aldohexose and has the formula C6H12O6. Four of its six carbon atoms are stereogenic, which means D-glucose is one of 24=16 possible stereoisomers. See also Descriptor (chemistry) Backbone-dependent rotamer library References Stereochemistry Isomerism Jacobus Henricus van 't Hoff