of the most important publications in medicine and was used until the 18th century. By the eleventh century, most of Europe had become Christian, and in 1088, the University of Bologna emerged as the first university in Europe. As such, demand for Latin translation of ancient and scientific texts grew, a major contributor to the Renaissance of the 12th century. Renaissance scholasticism in western Europe flourished, with experiments done by observing, describing, and classifying subjects in nature. In the 13rd century, medical teachers and students at Bologna began opening human bodies, leading to the first anatomy textbook based on human dissection by Mondino de Luzzi. Renaissance New developments in optics played a role in the inception of the Renaissance, both by challenging long-held metaphysical ideas on perception, as well as by contributing to the improvement and development of technology such as the camera obscura and the telescope. At the start of the Renaissance, Roger Bacon, Vitello, and John Peckham each built up a scholastic ontology upon a causal chain beginning with sensation, perception, and finally apperception of the individual and universal forms of Aristotle. A model of vision later known as perspectivism was exploited and studied by the artists of the Renaissance. This theory uses only three of Aristotle's four causes: formal, material, and final. In the sixteenth century, Nicolaus Copernicus formulated a heliocentric model of the Solar System, stating that the planets revolve around the Sun, instead of the geocentric model where the planets and the Sun revolve around the Earth. This was based on a theorem that the orbital periods of the planets are longer as their orbs are farther from the center of motion, which he found not to agree with Ptolemy's model. Johannes Kepler and others challenged the notion that the only function of the eye is perception, and shifted the main focus in optics from the eye to the propagation of light. Kepler is best known, however, for improving Copernicus' heliocentric model through the discovery of Kepler's laws of planetary motion. Kepler did not reject Aristotelian metaphysics and described his work as a search for the Harmony of the Spheres. Galileo had made significant contributions to astronomy, physics and engineering. However, he became persecuted after Pope Urban VIII sentenced him for writing about the heliocentric model. The printing press was widely used to publish scholarly arguments, including some that disagreed widely with contemporary ideas of