so-called because its two leading defenders, Arcesilaus (c. 315–240 BCE) who initiated the philosophy, and Carneades (c. 217–128 BCE), the philosophy's most famous proponent, were heads of Plato's Academy. Pyrrhonism's aims are psychological. It urges suspension of judgment (epoche) to achieve mental tranquility (ataraxia). The Academic Skeptics denied that knowledge is possible (acatalepsy). The Academic Skeptics claimed that some beliefs are more reasonable or probable than others, whereas Pyrrhonian skeptics argue that equally compelling arguments can be given for or against any disputed view. Nearly all the writings of the ancient skeptics are now lost. Most of what we know about ancient skepticism is from Sextus Empiricus, a Pyrrhonian skeptic who lived in the second or third century CE. His works contain a lucid summary of stock skeptical arguments. Ancient skepticism faded out during the late Roman Empire, particularly after Augustine (354–430 CE) attacked the skeptics in his work Against the Academics (386 CE). There was little knowledge of, or interest in, ancient skepticism in Christian Europe during the Middle Ages. Interest revived during the Renaissance and Reformation, particularly after the complete writings of Sextus Empiricus were translated into Latin in 1569 and Martin Luther's skepticism of holy orders. A number of Catholic writers, including Francisco Sanches (c. 1550–1623), Michel de Montaigne (1533–1592), Pierre Gassendi (1592–1655), and Marin Mersenne (1588–1648) deployed ancient skeptical arguments to defend moderate forms of skepticism and to argue that faith, rather than reason, must be the primary guide to truth. Similar arguments were offered later (perhaps ironically) by the Protestant thinker Pierre Bayle in his influential Historical and Critical Dictionary (1697–1702). The growing popularity of skeptical views created an intellectual crisis in seventeenth-century Europe. One major response was offered by the French philosopher and mathematician René Descartes (1596–1650). In his classic work, Meditations of First Philosophy (1641), Descartes sought to refute skepticism, but only after he had formulated the case for skepticism as powerfully as possible. Descartes argued that no matter what radical skeptical possibilities we imagine there are certain truths (e.g., that thinking is occurring, or that I exist) that are absolutely certain. Thus, the ancient skeptics were wrong to claim that knowledge is impossible. Descartes also attempted to refute skeptical doubts about the reliability of our senses, our memory, and other cognitive faculties. To do this, Descartes tried to prove that God exists and that God would not allow us to be systematically