As with the hero, the majority of the villains' powers originate with scientific accidents or the misuse of scientific technology, and many have animal-themed costumes or powers. The most notable Spider-Man villains are listed down below in the ordering of their original chronological appearance: Indicates a group. Unlike most superheroes, Spider-Man does not have a single villain with whom he has come into conflict the most. Instead, he is often regarded as having three archenemies, and it can be debated as to which one is the worst: Doctor Octopus (a.k.a. Doc Ock) is a highly intelligent mad scientist who utilizes four mechanical appendages for both movement and combat. He has been described as Spider-Man's greatest enemy, and the man Peter Parker might have become if he had not been raised with a sense of responsibility. Doc Ock is infamous for defeating him the first time in battle and for almost marrying Peter's Aunt May. He is also the core leader of the Sinister Six, and at one point adopted the "Master Planner" alias. ("If This Be My Destiny...!") Later depictions revealed him in Peter Parker's body where he was the titular character for a while. The Norman Osborn version of the Green Goblin is most commonly regarded as Spider-Man's arch-enemy. While Norman is usually portrayed as an amoral industrialist and the head of the Oscorp scientific corporation, the Goblin is a psychopathic alternate personality, born after Norman's exposore to some unstable chemicals that also increased his strength and agility. The Goblin is a Halloween-themed villain, dressing up like an actual goblin and utilizing a large arsenal of high tech weapons, including a glider and pumpkin-shaped explosives. Unlike most villains, who only aim to kill Spider-Man, the Goblin also targeted his loved ones and showed no remorse in killing them as long as it caused pain to Spider-Man, therefore making him not only Spider-Man's worst enemy, but also Peter Parker's. His most infamous feat is killing Spider-Man's girlfriend in what became one of the most famous Spider-Man stories of all time and helped end the Silver Age of Comic Books and begin the Bronze Age of Comic Books. While the Goblin was killed in the same story, he returned in the 1990s to plague Spider-Man once again, committing more heinous acts (such as being involved in the murder of Aunt May). He also came into conflict with other heroes, such as