facilities for containers, bulk cargo, and refrigerated and frozen storage, so that it can handle the import and export of many commodities. In 2009 the Port of San Diego handled 1,137,054 short tons of total trade; foreign trade accounted for 956,637 short tons while domestic trade amounted to 180,417 short tons. Historically tuna fishing and canning was one of San Diego's major industries, although the American tuna fishing fleet is no longer based in San Diego. Seafood company Bumble Bee Foods is headquartered in San Diego and Chicken of the Sea was until 2018. Companies San Diego hosts several major producers of wireless cellular technology. Qualcomm was founded and is headquartered in San Diego, and is one of the largest private-sector employers in San Diego. Other wireless industry manufacturers headquartered here include Nokia, LG Electronics, Kyocera International, Cricket Communications and Novatel Wireless. San Diego also has the U.S. headquarters for the Slovakian security company ESET. San Diego has been designated as an iHub Innovation Center for potential collaboration between wireless and the life sciences. The University of California, San Diego and other research institutions have helped to fuel the growth of biotechnology. In 2013, San Diego had the second-largest biotech cluster in the United States, below the Boston area and above the San Francisco Bay Area. There are more than 400 biotechnology companies in the area. In particular, the La Jolla and nearby Sorrento Valley areas are home to offices and research facilities for numerous biotechnology companies. Major biotechnology companies like Illumina and Neurocrine Biosciences are headquartered in San Diego, while many other biotech and pharmaceutical companies have offices or research facilities in San Diego. San Diego is also home to more than 140 contract research organizations (CROs) that provide contract services for pharmaceutical and biotechnology companies. Top employers According to the city's 2022 Annual Comprehensive Financial Report, the top employers in the city are: Real estate San Diego has high real estate prices. San Diego home prices peaked in 2005, and then declined along with the national trend. As of December 2010, prices were down 36 percent from the peak, median price of homes having declined by more than $200,000 between 2005 and 2010. As of May 2015, the median price of a house was $520,000. In November 2018 the median home price was $558,000. The San Diego metropolitan area had one of the worst housing affordability rankings of