Substance may refer to: Matter, anything that has mass and takes up space Chemistry Chemical substance, a material with a definite chemical composition Drug substance Substance abuse, drug-related healthcare and social policy diagnosis or label Substance dependence, drug-related healthcare and social policy diagnosis or label Arts, entertainment, and media Music Substance (Blank & Jones album), 2002 Substance (Joy Division album), 1988 Substance 1987, a New Order album "Substance", a song by Haste the Day on the album That They May Know You "Substance" (song), a 2022 song by Demi Lovato Other media SubStance, an interdisciplinary journal on literature published by the University of Wisconsin Press Metal Gear Solid 2: Substance, an update of the video game Metal Gear Solid 2: Sons of Liberty Religion and philosophy Dravya, a term used in Jainism to refer a substance Ousia, term for substance in ancient Greek philosophy and Christian theology Substance theory, an ontological theory positing that a substance is distinct from its properties See also Substance control (disambiguation) Substantial (rapper)