Republic of Venice held a monopoly on spice trade with the Middle East, using this position to dominate the neighboring Italian maritime republics and city-states. The trade made the region rich. It has been estimated that around 1,000 tons of pepper and 1,000 tons of other common spices were imported into Western Europe each year during the Late Middle Ages. The value of these goods was the equivalent of a yearly supply of grain for 1.5 million people. The most exclusive was saffron, used as much for its vivid yellow-red color as for its flavor. Spices that have now fallen into obscurity in European cuisine include grains of paradise, a relative of cardamom which mostly replaced pepper in late medieval north French cooking, long pepper, mace, spikenard, galangal, and cubeb. Early modern period Spain and Portugal were interested in seeking new routes to trade in spices and other valuable products from Asia. The control of trade routes and the spice-producing regions were the main reasons that Portuguese navigator Vasco da Gama sailed to India in 1499.[8] When da Gama discovered the pepper market in India, he was able to secure peppers for a much cheaper price than the ones demanded by Venice. At around the same time, Christopher Columbus returned from the New World. He described to investors the new spices available there. Another source of competition in the spice trade during the 15th and 16th centuries was the Ragusans from the maritime republic of Dubrovnik in southern Croatia. The military prowess of Afonso de Albuquerque (1453–1515) allowed the Portuguese to take control of the sea routes to India. In 1506, he took the island of Socotra in the mouth of the Red Sea and, in 1507, Ormuz in the Persian Gulf. Since becoming the viceroy of the Indies, he took Goa in India in 1510, and Malacca on the Malay peninsula in 1511. The Portuguese could now trade directly with Siam, China, and the Maluku Islands. With the discovery of the New World came new spices, including allspice, chili peppers, vanilla, and chocolate. This development kept the spice trade, with America as a latecomer with its new seasonings, profitable well into the 19th century. Function Spices are primarily used as food flavoring or to create variety. They are also used to perfume cosmetics and incense. At various periods, many spices have been believed to have medicinal value. Finally, since