and typhus decimated the pre-Columbian population. Disease killed between 50% and 95% of the indigenous population. The Spanish colonisation of the Americas started with the colonisation of the Caribbean. It was followed by the conquest of powerful pre-Columbian polities in Central Mexico and the Pacific Coast of South America. Miscegenation was the rule between the native and the Spanish cultures and people. An expedition sponsored by the Spanish crown completed the first voyage around the world in human history, the Magellan-Elcano circumnavigation. The tornaviaje or return route from the Philippines to Mexico made possible the Manila galleon trading route. The Spanish encountered Islam in Southeast Asia and in order to incorporate the Philippines, Spanish expeditions organised from newly Christianised Mexico had invaded the Philippine territories of the Sultanate of Brunei. The Spanish considered the war with the Muslims of Brunei and the Philippines, a repeat of the Reconquista. A centralisation of royal power ensued in the Early Modern Period at the expense of local nobility, and the word España, whose root is the ancient name Hispania, began to be commonly used to designate the whole of the two kingdoms. With their wide-ranging political, legal, religious and military reforms, the Hispanic Monarchy emerged as a world power. The unification of the crowns of Aragon and Castile by the marriage of their sovereigns laid the basis for modern Spain and the Spanish Empire, although each kingdom of Spain remained a separate country socially, politically, legally, and in currency and language. Two big revolts broke out during the early reign of the Habsburg emperor, Charles V: the Revolt of the Comuneros in the Crown of Castile and Revolt of the Brotherhoods in the Crown of Aragon. Habsburg Spain was one of the leading world powers throughout the 16th century and most of the 17th century, a position reinforced by trade and wealth from colonial possessions and became the world's leading maritime power. It reached its apogee during the reigns of the first two Spanish Habsburgs—Charles V/I (1516–1556) and Philip II (1556–1598). This period saw the Italian Wars, the Schmalkaldic War, the Dutch Revolt, the War of the Portuguese Succession, clashes with the Ottomans, intervention in the French Wars of Religion and the Anglo-Spanish War. Through exploration and conquest or royal marriage alliances and inheritance, the Spanish Empire expanded across vast areas in the Americas, the Indo-Pacific, Africa as well as the European continent