defeated in the first round by qualifier and eventual champion, Clara Tauson. At the Dubai Championships, she lost in a three-set first round battle to Coco Gauff after saving multiple match points and having match points of her own. Competing as the top seed at the St. Petersburg Ladies Trophy, she reached the quarterfinals where she was defeated by compatriot and eventual finalist, Margarita Gasparyan. Seeded 30th in Miami, she lost in the third round to fifth seed Elina Svitolina. At the Porsche Tennis Grand Prix, Alexandrova made it to the quarterfinals in a WTA clay tournament for the first time in her career where she was defeated by second seed Simona Halep. In Madrid, she lost in the first round to 12th seed Victoria Azarenka. At the Italian Open, she was defeated in the third round by Jessica Pegula. Seeded third at the Internationaux de Strasbourg, she reached the quarterfinals where she lost to fifth seed and eventual champion, Barbora Krejčíková. Seeded 32nd at the French Open, she beat seven-time Grand Slam champion Venus Williams in the first round. She was defeated in the second round by eventual champion Krejčíková. Alexandrova played only one grass-court tournament to prepare for Wimbledon. At the German Open, she stunned second seed Elina Svitolina in the second round for her second top 10 win of the year. She lost in the quarterfinals to fifth seed and eventual finalist, Belinda Bencic. Seeded 32nd at Wimbledon, she was shocked by qualifier María Camila Osorio Serrano in the second round. Representing Russia at the Summer Olympics, Alexandrova lost in the second round to Nadia Podoroska after upsetting Elise Mertens in the first round. Alexandrova lost in the opening rounds of the Western & Southern Open and the Tennis in the Land events to Jennifer Brady and Irina-Camelia Begu respectively. She ended a three-match losing streak at the US Open, defeating former Grand Slam finalist Sara Errani in the first round with 42 winners. However, she was stunned by lucky loser Kamilla Rakhimova in the second round. She lost to Tauson for the second time in 2021 at the Luxembourg Open before she retired in the final qualifying round of the Ostrava Open. After recuperating for more than a month, Alexandrova returned for the Kremlin Cup. She took the first set against top-10 player Ons Jabeur in the first round before her opponent was forced to retire.