vs. Winner S4 Match F2: Winner S2 vs. Winner S3 Finals: Winner F1 vs. Winner F2 Round of 16 The first legs were played on 26–28 April, and the second legs were played on 3–5 May 2016. |} Match A Atlético Nacional won 4–2 on aggregate and advanced to the quarterfinals (Match S1). Match B UNAM won 2–1 on aggregate and advanced to the quarterfinals (Match S2). Match C Tied 2–2 on aggregate, Nacional won on away goals and advanced to the quarterfinals (Match S3). Match D Atlético Mineiro won 2–1 on aggregate and advanced to the quarterfinals (Match S4). Match E São Paulo won 5–3 on aggregate and advanced to the quarterfinals (Match S4). Match F Boca Juniors won 5–2 on aggregate and advanced to the quarterfinals (Match S3). Match G Independiente del Valle won 2–1 on aggregate and advanced to the quarterfinals (Match S2). Match H Rosario Central won 4–0 on aggregate and advanced to the quarterfinals (Match S1). Quarterfinals The first legs were played on 11–12 and 17 May, and the second legs were played on 18–19 and 24 May 2016. |} Match S1 Atlético Nacional won 3–2 on aggregate and advanced to the semifinals (Match F1). Match S2 Tied 3–3 on aggregate, Independiente del Valle won on penalties and advanced to the semifinals (Match F2). Match S3 Tied 2–2 on aggregate, Boca Juniors won on penalties and advanced to the semifinals (Match F2). Match S4 Tied 2–2 on aggregate, São Paulo won on away goals and advanced to the semifinals (Match F1). Semifinals The first legs were played on 6–7 July, and the second legs were played on 13–14 July 2016. |} Match F1 Atlético Nacional won 4–1 on aggregate and advanced to the finals. Match F2 Independiente del Valle won 5–3 on aggregate and advanced to the finals. Finals The first leg was played on 20 July, and the second leg was played on 27 July 2016. |} Atlético Nacional won 2–1 on aggregate. References External links Copa Libertadores 2016, CONMEBOL.com 3