The Russian then defeated Anhelina Kalinina in straight sets to reach her first quarterfinal since June. She then sealed a huge upset over world No. 2, Aryna Sabalenka, in straight sets before earning her third top 10 win of the tournament over Maria Sakkari when the Greek was forced to retire down 1–4 in the opening set. Leading 6–4, 4–0 in the final set against Anett Kontaveit, she was unable to close out the victory and eventually lost in three sets. Alexandrova was part of the Russia team that won the inaugural Billie Jean King Cup Finals in Prague. She lost the only match she competed in the week against Clara Burel, but Russia was still able to defeat France 2–1 in that tie and win the title at the end of the week. 2022: Top 20 debut, two WTA titles Alexandrova started her season at 2022 Adelaide International 1. She lost in the first round to Leylah Fernandez which is followed by a second round exit to Garbiñe Muguruza in Sydney. Unseeded at the Australian Open, she lost to Bernarda Pera in the first round. After defeating Camila Giorgi, she was defeated by Maria Sakkari in the second round of St. Petersburg. Alexandrova suffered early exits in both Indian Wells and Miami losing to Simona Halep and Victoria Azarenka, respectively in the second rounds. Alexandrova eventually turned her underwhelming season around and reached the semifinals of the Charleston Open, defeating Allie Kiick, Zheng Qinwen, Karolina Pliskova and Magda Linette in route. She lost to the eventual champion Belinda Bencic, in straight sets. Following a second-round exit in Stuttgart to Anett Kontaveit, she reached her first WTA 1000 semifinals in Madrid from qualies cruising past Ostapenko and Anisimova in route. She lost to the eventual champion Ons Jabeur in the semifinal. However, it was followed by a second round appearance in Rome to Maria Sakkari. Seeded 30th in the French Open, she lost to Irina-Camelia Begu in the second round. She won her second WTA Tour title at the Rosmalen Open cruising past Dayana Yastremska, Anhelina Kalinina, Caty McNally, Veronika Kudermetova and Aryna Sabalenka dropping only one set. Following a second round loss to Daria Kasatkina in Berlin, she suffered a wrist injury and took a break. She suffered some early exits after returning from injury, losing in the second rounds of Cincinnati and Cleveland. Seeded 28th in the US