a new superheavy element factory (SHE-factory) with improved detectors and the ability to work on a smaller scale, but even so, continuing beyond element 120 and perhaps 121 would be a great challenge. It is possible that the age of fusion–evaporation reactions to produce new superheavy elements is coming to an end due to the increasingly short half-lives to spontaneous fission and the looming proton drip line, so that new techniques such as nuclear transfer reactions (for example, firing uranium nuclei at each other and letting them exchange protons, potentially producing products with around 120 protons) would be required to reach the superactinides. Because the cross sections of these fusion-evaporation reactions increase with the asymmetry of the reaction, titanium would be a better projectile than chromium for the synthesis of element 121, though this necessitates an einsteinium target. This poses severe challenges due to the significant heating and damage of the target due to the high radioactivity of einsteinium-254, but it would nonetheless probably be the most promising approach. It would require working on a smaller scale due to the lower amount of 254Es that can be produced. This small-scale work could in the near future only be carried out in Dubna's SHE-factory. The isotopes 299Ubu, 300Ubu, and 301Ubu, that could be produced in the reaction between 254Es and 50Ti via the 3n and 4n channels, are expected to be the only reachable unbiunium isotopes with half-lives long enough for detection. The cross sections would nevertheless push the limits of what can currently be detected. For example, in a 2016 publication, the cross section of the aforementioned reaction between 254Es and 50Ti was predicted to be arond 7 fb in the 4n channel, four times lower than the lowest measured cross section for a successful reaction. A 2021 calculation gives similarly low theoretical cross sections of 10 fb for the 3n channel and 0.6 fb for the 4n channel of this reaction, along with cross sections on the order of 1–10 fb for the reactions 249Bk+54Cr, 252Es+50Ti, and 258Md+48Ca. However, 252Es and 258Md cannot currently be synthesized in sufficient quantities to form target material. Should the synthesis of unbiunium isotopes in such a reaction be successful, the resulting nuclei would decay through isotopes of ununennium that could be produced by cross-bombardments in the 248Cm+51V or 249Bk+50Ti reactions, down through known isotopes of tennessine and moscovium synthesized in the 249Bk+48Ca and