The Allen Institute is a non-profit, bioscience research institute located in Seattle. It was founded by billionaire philanthropist Paul G. Allen in 2003. The Allen Institute conducts large-scale basic science research studying the brain, cells and immune system in effort to accelerate science and disease research. The organization practices open science, in that they make all their data and resources publicly available for researchers to access. Scientific Focus The Allen Institute's research is focused on neuroscience, through the Allen Institute for Brain Science, founded in 2003; cell biology, through the Allen Institute for Cell Science, founded in 2014; broad areas of bioscience and medical research, through The Paul G. Allen Frontiers Group, founded in 2016; and human immunology, through the Allen Institute for Immunology, founded in 2018. The Paul G. Allen Frontiers Group recommends research funding to scientific investigators outside the Allen Institute, while the other three divisions conduct research in-house. Allen Institute for Brain Science The Allen Institute for Brain Science launched with an initial single scientific project, the Allen Mouse Brain Atlas, which aimed to map gene expression across the entire mouse brain. The publication describing that project, published in 2007, has been cited more than 1,800 times. The Allen Institute for Brain Science has since generated several other large-scale neuroscience projects, focusing on both the mouse and human brains in health and disease. Its most recent open-source projects focus on defining brain cell types in the healthy mouse and human brains through multimodal characterization of neurons and other brain cells, including their connectivity, electrophysiology, morphology and transcriptomic profiles; and on the cellular level of activity in the mouse visual cortex through the Allen Brain Observatory. In 2020, the National Institutes of Health awarded $40.5 million to launch a new research center headquartered at the Allen Institute focused on brain cell types in Alzheimer's disease. Allen Institute for Cell Science The Allen Institute for Cell Science was modeled on the Allen Institute for Brain Science and was launched to capture a global view of human cells, developing gene-edited, fluorescently tagged human induced pluripotent stem cells that form the backbone of an openly available library of digital microscopy images and computational models to predict cellular organization. The tagged cell lines are available for others in the scientific community to use, and have been used in research on kidney disease and cardiomyocyte function, among others. Ongoing projects at the institute