Holmes in series 6 of CBC's Victorian drama Murdoch Mysteries and would later reprise his role in series 7. After a cameo in Showtime's The Borgias, Gower appeared as Lord Strange in several episodes of the BBC's mini-series The White Queen. In 2014, Gower was featured in Jon Stewart's film directorial debut, Rosewater, as Jimmy the Avid Editor. That same year, he appeared in series 2 of the BBC's drama The Village as Gilbert Hankin and in series 2 of ITV's crime drama Endeavour as Nicholas Myers. The next year (2015) Gower was cast in the role of Caligula in NBC's drama A.D. The Bible Continues and he played Mark, an ambitious young banker, in the Emmy awarded three-part BBC series Capital, based on John Lanchester's novel of the same name later that year. In 2016, Gower made his West End debut as Winston Smith in a theatrical adaptation of George Orwell's 1984, a dystopian look at life today, at the Playhouse Theatre in London. He also appeared as Prince Charles Stuart in series 2 and 3 of the Starz historical dramatic series Outlander, based upon Diana Gabaldon's best-selling book series. Returning to the dystopian roots he explored in 1984, Gower played Rob in series four of the award-winning Netflix drama Black Mirror. The episode, entitled "Crocodile", was helmed by Australian director John Hillcoat and centres on the idea of a device that can access personal memories. It was announced in December 2017 that Gower will portray Ezra Spurnrose, the young heir of a wealthy family, in Amazon's eight-episode fantasy-noir drama Carnival Row. The series from executive producers Travis Beacham and Rene Echevarria was released on Amazon Prime on 30 August 2019. Ahead of its premiere, the series was renewed for a second season by Amazon Prime in July 2019. Andrew Gower is set to reprise his role as Ezra Spurnrose. Another upcoming project for Andrew Gower is Running Naked, a full-feature-length film written and directed by Victor Buhler. In 2019, Gower also re-visited 19th century crime solving as he joined the cast of the upcoming period drama Miss Scarlet and The Duke which follows Eliza Scarlet (played by British actress Kate Phillips), the first female detective in the Victorian era. In 2020, Gower finished his first short film Humpty Fu*king Dumpty as an executive producer, an in-depth look at Merseybeat musician Tommy Quickly (played by Gower), which was written