Yorkers to help him stop the villainous Spider-Men by posing as another random spider-powered citizen. As Anti-Venom works on curing various Spider-People of their powers, Madame Web reflects on the need for both Venom and Anti-Venom to fix the Spider-Island problem. Meanwhile, Carlie and Peter attempt to investigate the Jackal's lab, reasoning that he is the most likely candidate to have caused this event, unaware that they are being watched. Jackal is seen working on the Spider King by filling with tiny spider embryos. Horizon Labs works with Reed Richards to find a cure for the spider-powered people while the Avengers and other heroes try to keep Manhattan quarantined. While at an abandoned lab at Empire University, Peter and Carlie are attacked by Chance, Scorcher, and White Rabbit, who all have spider powers. When White Rabbit attacks Carlie, Peter uses some moves he learned from Shang-Chi to knock out the villains. Carlie takes the villains to the precinct and tells Peter that she wants to have a talk with him and Spider-Man, to Peter's dismay. Jackal has been watching them and tells Tarantula to study the tape of the fight as he will soon be tested. The Avengers close off Manhattan keeping everyone in the city. Reed Richards develops a vaccine that can keep people from gaining spider powers, but does not cure people who already have them. Just as J. Jonah Jameson is about to get the vaccine, Reed tells him he has been infected. Anti-Venom continues to cure the victims of Manhattan, while Madame Web passes out from too many spiders accessing the web of life. Carlie is told that Spider-Man is waiting for her at the top of her precinct. Carlie and Spider-Man head to take down another spider-powered villain as Carlie becomes suspicious of where Peter is. When they arrive at the scene, they find a six-armed Shocker. Shocker reveals that he wants money so that Mad Thinker can cure him. Shocker then pulls off his mask to reveal he is slowly mutating into a spider-like creature. Just as Spider-Man tries to piece everything together, Carlie begins to mutate. The Spider-Queen tells the Jackal that all the infected people of Manhattan are beginning to mutate, and New York will soon belong to her. Mary Jane Watson evades the citizens who have been transformed into spider-like creatures. When Spider-Man tries to get a mutated Carlie to Mister